In situ gel formulations for delivery: Release and myotoxicity studies

Pharmaceutical Development and Technology

Volumn 5, Issue 3, 2000, Pages 391-397

  Ismail, Fatma A ^a   Napaporn, Jintana ^b   Hughes, Jeffrey A ^b   Brazeau, Gayle A ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Controlled delivery; DNA; In situ gel; In vitro release; Myotoxicity

Indexed keywords

CARBOMER; DNA; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; POLYMETHACRYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; GEL; GENE TARGETING; INJECTION SITE; MUSCLE INJURY; NONHUMAN; PLASMID; PRIORITY JOURNAL; RAT; SPECTROFLUOROMETRY; SPERM; STATISTICAL ANALYSIS;

ANIMALS; DNA; DRUG DELIVERY SYSTEMS; FEMALE; GELS; HYDROGEN-ION CONCENTRATION; MUSCLE, SKELETAL; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033866658     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100100555     Document Type: Article

References (17)

1. J. A. Wolff, R. W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P. L. Felgner, Direct gene transfer into mouse muscle in vivo, Science, 247, 1465-1468 (1990).
2. G. Acsadi, G. Dickson, D. R. Love, A. Jani, F. S. Walsh, A. Gurusinghe, J. A. Wolff, and K. E. Davies, Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs, Nature, 352, 815-818 (1991).
3. H. L. Davis, R. G. Whalen, and B. A. Demeneix, Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression, Hum. Gene Ther., 4(2), 151-159 (1993).
4. I. Danko, J. D. Fritz, S. Jiao, K. Hogan, J. S. Latendresse, and J. A. Wolff, Pharmacological enhancement of in vivo foreign gene expression in muscle, Gene Ther., 1(2), 114-121 (1994).
5. M. Vitadello, M. V. Schiaffino, A. Picard, M. Scarpa, and S. Schiaffino, Gene transfer in regenerating muscle, Hum. GeneTher., 5(1), 11-18 (1994).
6. R. J. Mumper, J. C. Duguid, K. Anewr, M. K. Barron, H. Nitta, and A. P. Rolland, Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle, Pharm. Res., 13, 701-709 (1996).
7. R. J. Mumper, J. Wang, S. L. Klakamp, H. Nitta, K. Anweer, F. Tagliaferri, and A. P. Rolland, Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle, J. Controlled Release, 52, 191-203 (1998).
8. Y. S. Jong, J. S. Jacob, K. Pyip, G. Gardner, E. Seitelman, M. Whitney, S. Montgomery, and E. Mathiowitz, Controlled release of plasmid DNA, J. Controlled Release, 47, 123-134 (1997).
9. P. Erbacher, S. Zou, T. Bettinger, A.-M. Steffan, and J.-S. Remy, Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability, Pharm. Res., 15(9), 1332-1339 (1998).
10. J. A. Wolff, P. Williams, G. Acsadi, S. Jiao, A. Jani, and W. Chong, Conditions affecting direct gene transfer into rodent muscle in vivo, BioTechniques, 11(4), 474-485 (1991).
11. R. Joshi, V. Arora, J. P. Desjardins, D. Robinson, K. J. Himmelstein, and P. L. Iversen, In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs, Pharm. Res., 15(8), 1189-1195 (1998).
12. B. O. Haglund, R. Joshi, and K. J. Himmelstein, An in situ gelling system for parenteral delivery, J. Controlled Release, 41, 229-235 (1996).
13. S. Kumar and K. J. Himmelstein, Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose, J. Pharm. Sci, 84(3), 344-348 (1995).
14. S. Al-Suwayeh, I. Tebbett, D. Wielbo, and G. A. Brazeau, In vitro-in vivo myotoxicity of intramuscular liposomal formulations, Pharm. Res., 13(9), 1384-1388 (1996).
15. G. A. Brazeau, S. Attia, S. Poxon, and J. A. Hughes, In vitro myotoxicity of selected cationic macromolecules used in non-viral gene delivery, Pharm. Res., 15(5). 680-683 (1998).
16. E. Mathiowitz , Y. S. Jong, and K. Boekelheide, Polymeric gene delivery systems, WO Patent 95/24929, September 21, 1995.
17. G. A. Brazeau and H. L. Fung, An in vitro model to evaluate muscle damage following intramuscular injections, Pharm. Res., 6, 167-179 (1989).