Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: Differential circulation in mice and rats and the implications for human gene therapy

Blood

Volumn 97, Issue 8, 2001, Pages 2221-2229

  Ward, Christopher M ^a,b   Read, Martin L ^a   Seymour, Leonard W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT RECEPTOR; IMMUNOGLOBULIN G; PLASMID DNA; POLYCATION; POLYLYSINE;

ANIMAL TISSUE; ARTICLE; CIRCULATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA VECTOR; ERYTHROCYTE ADHESIVENESS; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HEMATURIA; KUPFFER CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SOLUBILITY;

EID: 0035871674     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.8.2221     Document Type: Article

References (40)

1. Cystic fibrosis: A decade of progress
2. Interleukin 10 gene transfer prevents experimental colitis in rats
3. Glucose regulated production of human insulin in rat hepatocytes
4. Gene therapy for chronic granulomatous disease
5. The potential use of gene therapy in the control of hypertension
6. An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma
7. Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases
8. The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation
9. Transferrin polycation DNA complexes - The effect of polycations on the structure of the complex and delivery to cells
10. Influenza-virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin polylysine DNA complexes - Toward a synthetic virus-like gene-transfer vehicle
11. Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein polylysine DNA complexes
12. Polylysine-based transfection systems utilising receptor-mediated delivery
13. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery
14. Targeted delivery of plasmid DNA complexes with galactosylated poly(L-lysine)
15. Stabilisation of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver
16. Pharmacokinetics and in vivo gene transfer of plasmid DNA complexes with mannosylated poly(L-lysine) in mice
17. Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo
18. Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
19. Interactions of C-reactive protein with the complement system, II: C-reactive protein-mediated consumption of complement by poly-L-lysine polymers and other polycations
20. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA
21. Turbldometric analysis of polyelectrolyte complexes formed between poly(L-lysine) and DNA
22. pEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
23. Measurement of the immunoperoxidase staining of macrophages within liver granulomata of mice infected with Mycobacterium tuberculosis
24. Critical role of Kupffer cell CR3 (CD11b/CD18) in the clearance of IgM-opsonised erythrocytes or soluble betaglucan
25. CR3 (CD11b/CD18): A phagocyte and NK cell membrane receptor with multiple ligand specificities and functions
26. Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leucocyte complement receptor type 3 (CD11b/CD18)
27. Regulation of human neutrophil type 3 receptor (iC3b receptor) expression during phagocytosis of Staphylococcus aureus and Escherichia coli
28. Complement receptor type three-dependent degradation of opsonized erythrocytes by mouse macrophages
29. The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells
30. Contribution of CR3, CD11b/CD18 to cytolysis by human NK cells
31. Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells
32. Effect of DNA topology on the transfection efficiency of poly(2-dimethylamino)ethyl methacrylate)-plasmid complexes
33. Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid DNA complexes
34. Preclinical development strategies for novel gene therapeutic products
35. Plasma and red cell volumes of microwave irradiated mice tissues
36. Quantitation of epsilon-amino group using amino acids as reference standards by trinitrobenzene sulfonic acid: A simple spectrophotometric method for the estimation of hapten to carrier protein ratio
37. Estimation of avidin activity by two methods
38. Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, intravenous administration to rats
39. N-(2-hydroxypropyl)-methacrylamide copolymers targeted to the hepatocyte galactose-receptor: Pharmacokinetics in DBA2 mice