-
1
-
-
0021040946
-
Lysosomes revisited
-
de Duve C. Lysosomes revisited. Eur. J. Biochem. 137 (1983) 391-397
-
(1983)
Eur. J. Biochem.
, vol.137
, pp. 391-397
-
-
de Duve, C.1
-
2
-
-
0028222874
-
Autophagy and related mechanisms of lysosome-mediated protein degradation
-
Dunn Jr. W.A. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 4 (1994) 139-143
-
(1994)
Trends Cell Biol.
, vol.4
, pp. 139-143
-
-
Dunn Jr., W.A.1
-
3
-
-
4544385218
-
Autophagy: many paths to the same end
-
Cuervo A.M. Autophagy: many paths to the same end. Mol. Cell. Biochem. 263 (2004) 55-72
-
(2004)
Mol. Cell. Biochem.
, vol.263
, pp. 55-72
-
-
Cuervo, A.M.1
-
4
-
-
4344673498
-
Mechanisms of chaperone-mediated autophagy
-
Majeski A.E., and Dice J.F. Mechanisms of chaperone-mediated autophagy. Int. J. Biochem. Cell Biol. 36 (2004) 2435-2444
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2435-2444
-
-
Majeski, A.E.1
Dice, J.F.2
-
5
-
-
26844531363
-
Maturation of autophagic vacuoles in mammalian cells
-
Eskelinen E.L. Maturation of autophagic vacuoles in mammalian cells. Autophagy 1 (2005) 1-10
-
(2005)
Autophagy
, vol.1
, pp. 1-10
-
-
Eskelinen, E.L.1
-
8
-
-
3042793578
-
Linking albinism and immunity: the secrets of secretory lysosomes
-
Stinchcombe J., Bossi G., and Griffiths G.M. Linking albinism and immunity: the secrets of secretory lysosomes. Science 305 (2004) 55-59
-
(2004)
Science
, vol.305
, pp. 55-59
-
-
Stinchcombe, J.1
Bossi, G.2
Griffiths, G.M.3
-
9
-
-
0022572229
-
Trafficking of lysosomal enzymes in normal and disease states?
-
Kornfeld S. Trafficking of lysosomal enzymes in normal and disease states?. J. Clin. Invest. 77 (1986) 1-6
-
(1986)
J. Clin. Invest.
, vol.77
, pp. 1-6
-
-
Kornfeld, S.1
-
10
-
-
0021891884
-
Assembly of asparagine-linked oligosaccharides?
-
Kornfeld R., and Kornfeld S. Assembly of asparagine-linked oligosaccharides?. Annu. Rev. Biochem. 54 (1985) 631-664
-
(1985)
Annu. Rev. Biochem.
, vol.54
, pp. 631-664
-
-
Kornfeld, R.1
Kornfeld, S.2
-
11
-
-
0022555844
-
Lysosomal enzymes and their receptors?
-
von Figura K., and Hasilik A. Lysosomal enzymes and their receptors?. Annu. Rev. Biochem. 55 (1986) 167-193
-
(1986)
Annu. Rev. Biochem.
, vol.55
, pp. 167-193
-
-
von Figura, K.1
Hasilik, A.2
-
12
-
-
0019307389
-
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling?
-
Gonzalez-Noriega A., Grubb J.H., Talkad V., and Sly W.S. Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling?. J. Cell Biol. 85 (1980) 839-852
-
(1980)
J. Cell Biol.
, vol.85
, pp. 839-852
-
-
Gonzalez-Noriega, A.1
Grubb, J.H.2
Talkad, V.3
Sly, W.S.4
-
13
-
-
0023192368
-
Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor
-
Lobel P., Dahms N.M., Breitmeyer J., Chirgwin J.M., and Kornfeld S. Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 2233-2237
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 2233-2237
-
-
Lobel, P.1
Dahms, N.M.2
Breitmeyer, J.3
Chirgwin, J.M.4
Kornfeld, S.5
-
14
-
-
0023840372
-
Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor?
-
Lobel P., Dahms N.M., and Kornfeld S. Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor?. J. Biol. Chem. 263 (1988) 2563-2570
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 2563-2570
-
-
Lobel, P.1
Dahms, N.M.2
Kornfeld, S.3
-
15
-
-
0023658301
-
46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor
-
Dahms N.M., Lobel P., Breitmeyer J., Chirgwin J.M., and Kornfeld S. 46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor. Cell 50 (1987) 181-192
-
(1987)
Cell
, vol.50
, pp. 181-192
-
-
Dahms, N.M.1
Lobel, P.2
Breitmeyer, J.3
Chirgwin, J.M.4
Kornfeld, S.5
-
16
-
-
0023235167
-
Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor
-
Pohlmann R., Nagel G., Schmidt B., Stein M., Lorkowski G., Krentler C., Cully J., Meyer H.E., Grzeschik K.H., Mersmann G., et al. Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 5575-5579
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 5575-5579
-
-
Pohlmann, R.1
Nagel, G.2
Schmidt, B.3
Stein, M.4
Lorkowski, G.5
Krentler, C.6
Cully, J.7
Meyer, H.E.8
Grzeschik, K.H.9
Mersmann, G.10
-
17
-
-
0040679257
-
Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting
-
Gabel C.A., Goldberg D.E., and Kornfeld S. Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting. Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 775-779
-
(1983)
Proc. Natl. Acad. Sci. U. S. A.
, vol.80
, pp. 775-779
-
-
Gabel, C.A.1
Goldberg, D.E.2
Kornfeld, S.3
-
18
-
-
0023424545
-
Antibody to the phosphomannosyl receptor inhibits recycling of receptor in fibroblasts
-
Nolan C.M., Creek K.E., Grubb J.H., and Sly W.S. Antibody to the phosphomannosyl receptor inhibits recycling of receptor in fibroblasts. J. Cell. Biochem. 35 (1987) 137-151
-
(1987)
J. Cell. Biochem.
, vol.35
, pp. 137-151
-
-
Nolan, C.M.1
Creek, K.E.2
Grubb, J.H.3
Sly, W.S.4
-
19
-
-
0023411438
-
Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes
-
Stein M., Zijderhand-Bleekemolen J.E., Geuze H., Hasilik A., and von Figura K. Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes. EMBO J. 6 (1987) 2677-2681
-
(1987)
EMBO J.
, vol.6
, pp. 2677-2681
-
-
Stein, M.1
Zijderhand-Bleekemolen, J.E.2
Geuze, H.3
Hasilik, A.4
von Figura, K.5
-
20
-
-
0023745213
-
Expression of human cation-independent mannose 6-phosphate receptor cDNA in receptor-negative mouse P388D1 cells following gene transfer?
-
Kyle J.W., Nolan C.M., Oshima A., and Sly W.S. Expression of human cation-independent mannose 6-phosphate receptor cDNA in receptor-negative mouse P388D1 cells following gene transfer?. J. Biol. Chem. 263 (1988) 16230-16235
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 16230-16235
-
-
Kyle, J.W.1
Nolan, C.M.2
Oshima, A.3
Sly, W.S.4
-
21
-
-
0024361787
-
Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis
-
Lobel P., Fujimoto K., Ye R.D., Griffiths G., and Kornfeld S. Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis. Cell 57 (1989) 787-796
-
(1989)
Cell
, vol.57
, pp. 787-796
-
-
Lobel, P.1
Fujimoto, K.2
Ye, R.D.3
Griffiths, G.4
Kornfeld, S.5
-
22
-
-
0025743923
-
Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor?
-
Ma Z.M., Grubb J.H., and Sly W.S. Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor?. J. Biol. Chem. 266 (1991) 10589-10595
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 10589-10595
-
-
Ma, Z.M.1
Grubb, J.H.2
Sly, W.S.3
-
23
-
-
0027330919
-
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins
-
Koster A., Saftig P., Matzner U., von Figura K., Peters C., and Pohlmann R. Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J. 12 (1993) 5219-5223
-
(1993)
EMBO J.
, vol.12
, pp. 5219-5223
-
-
Koster, A.1
Saftig, P.2
Matzner, U.3
von Figura, K.4
Peters, C.5
Pohlmann, R.6
-
24
-
-
0027379702
-
Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes
-
Ludwig T., Ovitt C.E., Bauer U., Hollinshead M., Remmler J., Lobel P., Ruther U., and Hoflack B. Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes. EMBO J. 12 (1993) 5225-5235
-
(1993)
EMBO J.
, vol.12
, pp. 5225-5235
-
-
Ludwig, T.1
Ovitt, C.E.2
Bauer, U.3
Hollinshead, M.4
Remmler, J.5
Lobel, P.6
Ruther, U.7
Hoflack, B.8
-
25
-
-
0026059613
-
Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
-
Dennis P.A., and Rifkin D.B. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 580-584
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 580-584
-
-
Dennis, P.A.1
Rifkin, D.B.2
-
26
-
-
0344026339
-
M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1
-
Godar S., Horejsi V., Weidle U.H., Binder B.R., Hansmann C., and Stockinger H. M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1. Eur. J. Immunol. 29 (1999) 1004-1013
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 1004-1013
-
-
Godar, S.1
Horejsi, V.2
Weidle, U.H.3
Binder, B.R.4
Hansmann, C.5
Stockinger, H.6
-
27
-
-
0033603827
-
Cellular response to latent TGF-beta1 is facilitated by insulin-like growth factor-II/mannose-6-phosphate receptors on MS-9 cells
-
Ghahary A., Tredget E.E., Mi L., and Yang L. Cellular response to latent TGF-beta1 is facilitated by insulin-like growth factor-II/mannose-6-phosphate receptors on MS-9 cells. Exp. Cell Res. 251 (1999) 111-120
-
(1999)
Exp. Cell Res.
, vol.251
, pp. 111-120
-
-
Ghahary, A.1
Tredget, E.E.2
Mi, L.3
Yang, L.4
-
28
-
-
0034721646
-
Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
-
Motyka B., Korbutt G., Pinkoski M.J., Heibein J.A., Caputo A., Hobman M., Barry M., Shostak I., Sawchuk T., Holmes C.F., Gauldie J., and Bleackley R.C. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell 103 (2000) 491-500
-
(2000)
Cell
, vol.103
, pp. 491-500
-
-
Motyka, B.1
Korbutt, G.2
Pinkoski, M.J.3
Heibein, J.A.4
Caputo, A.5
Hobman, M.6
Barry, M.7
Shostak, I.8
Sawchuk, T.9
Holmes, C.F.10
Gauldie, J.11
Bleackley, R.C.12
-
29
-
-
0028575985
-
Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
-
Lau M.M., Stewart C.E., Liu Z., Bhatt H., Rotwein P., and Stewart C.L. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 8 (1994) 2953-2963
-
(1994)
Genes Dev.
, vol.8
, pp. 2953-2963
-
-
Lau, M.M.1
Stewart, C.E.2
Liu, Z.3
Bhatt, H.4
Rotwein, P.5
Stewart, C.L.6
-
30
-
-
0027999284
-
Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene
-
Wang Z.Q., Fung M.R., Barlow D.P., and Wagner E.F. Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature 372 (1994) 464-467
-
(1994)
Nature
, vol.372
, pp. 464-467
-
-
Wang, Z.Q.1
Fung, M.R.2
Barlow, D.P.3
Wagner, E.F.4
-
31
-
-
0032030786
-
Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice
-
Sohar I., Sleat D., Gong Liu C., Ludwig T., and Lobel P. Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice. Biochem. J. 330 (1998) 903-908
-
(1998)
Biochem. J.
, vol.330
, pp. 903-908
-
-
Sohar, I.1
Sleat, D.2
Gong Liu, C.3
Ludwig, T.4
Lobel, P.5
-
32
-
-
0031456570
-
Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid
-
Kang J.X., Li Y., and Leaf A. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13671-13676
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 13671-13676
-
-
Kang, J.X.1
Li, Y.2
Leaf, A.3
-
33
-
-
0032506124
-
Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes
-
Kang J.X., Bell J., Leaf A., Beard R.L., and Chandraratna R.A. Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13687-13691
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 13687-13691
-
-
Kang, J.X.1
Bell, J.2
Leaf, A.3
Beard, R.L.4
Chandraratna, R.A.5
-
34
-
-
0032766413
-
Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids
-
Kang J.X., Bell J., Beard R.L., and Chandraratna R.A. Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids. Cell Growth Differ 10 (1999) 591-600
-
(1999)
Cell Growth Differ
, vol.10
, pp. 591-600
-
-
Kang, J.X.1
Bell, J.2
Beard, R.L.3
Chandraratna, R.A.4
-
35
-
-
0037174862
-
The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration?
-
Leksa V., Godar S., Cebecauer M., Hilgert I., Breuss J., Weidle U.H., Horejsi V., Binder B.R., and Stockinger H. The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration?. J. Biol. Chem. 277 (2002) 40575-40582
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40575-40582
-
-
Leksa, V.1
Godar, S.2
Cebecauer, M.3
Hilgert, I.4
Breuss, J.5
Weidle, U.H.6
Horejsi, V.7
Binder, B.R.8
Stockinger, H.9
-
36
-
-
15144361572
-
Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction?
-
Nykjaer A., Christensen E.I., Vorum H., Hager H., Petersen C.M., Roigaard H., Min H.Y., Vilhardt F., Moller L.B., Kornfeld S., and Gliemann J. Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction?. J. Cell Biol. 141 (1998) 815-828
-
(1998)
J. Cell Biol.
, vol.141
, pp. 815-828
-
-
Nykjaer, A.1
Christensen, E.I.2
Vorum, H.3
Hager, H.4
Petersen, C.M.5
Roigaard, H.6
Min, H.Y.7
Vilhardt, F.8
Moller, L.B.9
Kornfeld, S.10
Gliemann, J.11
-
38
-
-
0026210548
-
The role of cell death genes during development
-
Schwartz L.M. The role of cell death genes during development. Bioessays 13 (1991) 389-395
-
(1991)
Bioessays
, vol.13
, pp. 389-395
-
-
Schwartz, L.M.1
-
39
-
-
0015880897
-
The morphology of various types of cell death in prenatal tissues
-
Schweichel J.U., and Merker H.J. The morphology of various types of cell death in prenatal tissues. Teratology 7 (1973) 253-266
-
(1973)
Teratology
, vol.7
, pp. 253-266
-
-
Schweichel, J.U.1
Merker, H.J.2
-
40
-
-
0025283961
-
Developmental cell death: morphological diversity and multiple mechanisms
-
Clarke P.G. Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol. (Berl.) 181 (1990) 195-213
-
(1990)
Anat. Embryol. (Berl.)
, vol.181
, pp. 195-213
-
-
Clarke, P.G.1
-
41
-
-
22544432640
-
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
-
Kroemer G., El-Deiry W.S., Golstein P., Peter M.E., Vaux D., Vandenabeele P., Zhivotovsky B., Blagosklonny M.V., Malorni W., Knight R.A., Piacentini M., Nagata S., and Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ. 12 Suppl. 2 (2005) 1463-1467
-
(2005)
Cell Death Differ.
, vol.12
, Issue.SUPPL. 2
, pp. 1463-1467
-
-
Kroemer, G.1
El-Deiry, W.S.2
Golstein, P.3
Peter, M.E.4
Vaux, D.5
Vandenabeele, P.6
Zhivotovsky, B.7
Blagosklonny, M.V.8
Malorni, W.9
Knight, R.A.10
Piacentini, M.11
Nagata, S.12
Melino, G.13
-
42
-
-
0015383455
-
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr J.F., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257
-
(1972)
Br. J. Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
43
-
-
2442480795
-
Multiple cell death pathways as regulators of tumour initiation and progression
-
Jäättelä M. Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 23 (2004) 2746-2756
-
(2004)
Oncogene
, vol.23
, pp. 2746-2756
-
-
Jäättelä, M.1
-
44
-
-
0033023992
-
Morphologic criteria and detection of apoptosis
-
Saraste A. Morphologic criteria and detection of apoptosis. Herz 24 (1999) 189-195
-
(1999)
Herz
, vol.24
, pp. 189-195
-
-
Saraste, A.1
-
45
-
-
0009357697
-
Phagocytosis, a cell biology view?
-
Sansonetti P.J. Phagocytosis, a cell biology view?. J. Cell Sci. 113 (2000) 3355-3356
-
(2000)
J. Cell Sci.
, vol.113
, pp. 3355-3356
-
-
Sansonetti, P.J.1
-
46
-
-
0034641918
-
The biochemistry of apoptosis
-
Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
47
-
-
0033009890
-
The central effectors of cell death in the immune system?
-
Rathmell J.C., and Thompson C.B. The central effectors of cell death in the immune system?. Annu. Rev. Immunol. 17 (1999) 781-828
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 781-828
-
-
Rathmell, J.C.1
Thompson, C.B.2
-
48
-
-
0034574306
-
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
-
Siegel R.M., Chan F.K., Chun H.J., and Lenardo M.J. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat. Immunol. 1 (2000) 469-474
-
(2000)
Nat. Immunol.
, vol.1
, pp. 469-474
-
-
Siegel, R.M.1
Chan, F.K.2
Chun, H.J.3
Lenardo, M.J.4
-
49
-
-
0242656497
-
Death receptor-induced cell killing
-
Thorburn A. Death receptor-induced cell killing. Cell Signal. 16 (2004) 139-144
-
(2004)
Cell Signal.
, vol.16
, pp. 139-144
-
-
Thorburn, A.1
-
50
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
-
Liu X., Kim C.N., Yang J., Jemmerson R., and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 (1996) 147-157
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
51
-
-
0034613302
-
Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1?
-
Jiang X., and Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1?. J. Biol. Chem. 275 (2000) 31199-31203
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31199-31203
-
-
Jiang, X.1
Wang, X.2
-
54
-
-
8344242220
-
Autophagy in health and disease: a double-edged sword
-
Shintani T., and Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 306 (2004) 990-995
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
56
-
-
12944308330
-
Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
-
Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120 (2005) 159-162
-
(2005)
Cell
, vol.120
, pp. 159-162
-
-
Levine, B.1
-
57
-
-
0034948738
-
The autophagosomal-lysosomal compartment in programmed cell death
-
Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ. 8 (2001) 569-581
-
(2001)
Cell Death Differ.
, vol.8
, pp. 569-581
-
-
Bursch, W.1
-
59
-
-
20344387475
-
Autophagy: dual roles in life and death?
-
Baehrecke E.H. Autophagy: dual roles in life and death?. Nat. Rev., Mol. Cell Biol. 6 (2005) 505-510
-
(2005)
Nat. Rev., Mol. Cell Biol.
, vol.6
, pp. 505-510
-
-
Baehrecke, E.H.1
-
61
-
-
27644585945
-
Redundant cell death mechanisms as relics and backups
-
Golstein P., and Kroemer G. Redundant cell death mechanisms as relics and backups. Cell Death Differ. 12 Suppl. 2 (2005) 1490-1496
-
(2005)
Cell Death Differ.
, vol.12
, Issue.SUPPL. 2
, pp. 1490-1496
-
-
Golstein, P.1
Kroemer, G.2
-
62
-
-
28544435485
-
Lysosomes and autophagy in cell death control
-
Kroemer G., and Jaattela M. Lysosomes and autophagy in cell death control. Nat. Rev., Cancer 5 (2005) 886-897
-
(2005)
Nat. Rev., Cancer
, vol.5
, pp. 886-897
-
-
Kroemer, G.1
Jaattela, M.2
-
63
-
-
25144506835
-
Autophagy in cell death: an innocent convict?
-
Levine B., and Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 115 (2005) 2679-2688
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2679-2688
-
-
Levine, B.1
Yuan, J.2
-
64
-
-
0001870749
-
-
Ciechanover A.J., and Schwartz A.L. (Eds), Wiley-Liss, New York, NY
-
Mortimore G.E., and Kadowaki M. In: Ciechanover A.J., and Schwartz A.L. (Eds). Cellular Proteolytic Systems (1994), Wiley-Liss, New York, NY 65-87
-
(1994)
Cellular Proteolytic Systems
, pp. 65-87
-
-
Mortimore, G.E.1
Kadowaki, M.2
-
65
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., Ohsumi Y., Tokuhisa T., and Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 432 (2004) 1032-1036
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
66
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum J.J., Bauer D.E., Kong M., Harris M.H., Li C., Lindsten T., and Thompson C.B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 (2005) 237-248
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
Lindsten, T.6
Thompson, C.B.7
-
67
-
-
19944434059
-
Inhibition of macroautophagy triggers apoptosis
-
Boya P., Gonzalez-Polo R.A., Casares N., Perfettini J.L., Dessen P., Larochette N., Metivier D., Meley D., Souquere S., Yoshimori T., Pierron G., Codogno P., and Kroemer G. Inhibition of macroautophagy triggers apoptosis. Mol. Cell. Biol. 25 (2005) 1025-1040
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 1025-1040
-
-
Boya, P.1
Gonzalez-Polo, R.A.2
Casares, N.3
Perfettini, J.L.4
Dessen, P.5
Larochette, N.6
Metivier, D.7
Meley, D.8
Souquere, S.9
Yoshimori, T.10
Pierron, G.11
Codogno, P.12
Kroemer, G.13
-
68
-
-
19344368318
-
Autophagy regulates programmed cell death during the plant innate immune response
-
Liu Y., Schiff M., Czymmek K., Talloczy Z., Levine B., and Dinesh-Kumar S.P. Autophagy regulates programmed cell death during the plant innate immune response. Cell 121 (2005) 567-577
-
(2005)
Cell
, vol.121
, pp. 567-577
-
-
Liu, Y.1
Schiff, M.2
Czymmek, K.3
Talloczy, Z.4
Levine, B.5
Dinesh-Kumar, S.P.6
-
69
-
-
0034509103
-
Programmed cell death (PCD). Apoptosis, autophagic PCD, or others?
-
Bursch W., Ellinger A., Gerner C., Frohwein U., and Schulte-Hermann R. Programmed cell death (PCD). Apoptosis, autophagic PCD, or others?. Ann. N. Y. Acad. Sci. 926 (2000) 1-12
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.926
, pp. 1-12
-
-
Bursch, W.1
Ellinger, A.2
Gerner, C.3
Frohwein, U.4
Schulte-Hermann, R.5
-
70
-
-
2442482810
-
Autophagy as a cell death and tumor suppressor mechanism
-
Gozuacik D., and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23 (2004) 2891-2906
-
(2004)
Oncogene
, vol.23
, pp. 2891-2906
-
-
Gozuacik, D.1
Kimchi, A.2
-
71
-
-
0034849783
-
Autophagic cell death and its execution by lysosomal cathepsins
-
Uchiyama Y. Autophagic cell death and its execution by lysosomal cathepsins. Arch. Histol. Cytol. 64 (2001) 233-246
-
(2001)
Arch. Histol. Cytol.
, vol.64
, pp. 233-246
-
-
Uchiyama, Y.1
-
72
-
-
0442323561
-
Autophagy: in sickness and in health
-
Cuervo A.M. Autophagy: in sickness and in health. Trends Cell Biol. 14 (2004) 70-77
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 70-77
-
-
Cuervo, A.M.1
-
73
-
-
7744235672
-
Death by design: apoptosis, necrosis and autophagy
-
Edinger A.L., and Thompson C.B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 16 (2004) 663-669
-
(2004)
Curr. Opin. Cell Biol.
, vol.16
, pp. 663-669
-
-
Edinger, A.L.1
Thompson, C.B.2
-
74
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., Baehrecke E.H., and Lenardo M.J. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304 (2004) 1500-1502
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehrecke, E.H.7
Lenardo, M.J.8
-
75
-
-
10344262564
-
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
-
Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C.B., and Tsujimoto Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat. Cell Biol. 6 (2004) 1221-1228
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1221-1228
-
-
Shimizu, S.1
Kanaseki, T.2
Mizushima, N.3
Mizuta, T.4
Arakawa-Kobayashi, S.5
Thompson, C.B.6
Tsujimoto, Y.7
-
76
-
-
14844310233
-
Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells
-
Thorburn J., Moore F., Rao A., Barclay W.W., Thomas L.R., Grant K.W., Cramer S.D., and Thorburn A. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol. Biol. Cell 16 (2005) 1189-1199
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 1189-1199
-
-
Thorburn, J.1
Moore, F.2
Rao, A.3
Barclay, W.W.4
Thomas, L.R.5
Grant, K.W.6
Cramer, S.D.7
Thorburn, A.8
-
77
-
-
2442485884
-
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
Scarlatti F., Bauvy C., Ventruti A., Sala G., Cluzeaud F., Vandewalle A., Ghidoni R., and Codogno P. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 279 (2004) 18384-18391
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
Sala, G.4
Cluzeaud, F.5
Vandewalle, A.6
Ghidoni, R.7
Codogno, P.8
-
78
-
-
0037193474
-
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death
-
Inbal B., Bialik S., Sabanay I., Shani G., and Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J. Cell Biol. 157 (2002) 455-468
-
(2002)
J. Cell Biol.
, vol.157
, pp. 455-468
-
-
Inbal, B.1
Bialik, S.2
Sabanay, I.3
Shani, G.4
Kimchi, A.5
-
79
-
-
0001488499
-
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
-
Liang X.H., Kleeman L.K., Jiang H.H., Gordon G., Goldman J.E., Berry G., Herman B., and Levine B. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72 (1998) 8586-8596
-
(1998)
J. Virol.
, vol.72
, pp. 8586-8596
-
-
Liang, X.H.1
Kleeman, L.K.2
Jiang, H.H.3
Gordon, G.4
Goldman, J.E.5
Berry, G.6
Herman, B.7
Levine, B.8
-
80
-
-
20144381544
-
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death
-
Pyo J.O., Jang M.H., Kwon Y.K., Lee H.J., Jun J.I., Woo H.N., Cho D.H., Choi B., Lee H., Kim J.H., Mizushima N., Oshumi Y., and Jung Y.K. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J. Biol. Chem. 280 (2005) 20722-20729
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20722-20729
-
-
Pyo, J.O.1
Jang, M.H.2
Kwon, Y.K.3
Lee, H.J.4
Jun, J.I.5
Woo, H.N.6
Cho, D.H.7
Choi, B.8
Lee, H.9
Kim, J.H.10
Mizushima, N.11
Oshumi, Y.12
Jung, Y.K.13
-
81
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S., Tassa A., Qu X., Garuti R., Liang X.H., Mizushima N., Packer M., Schneider M.D., and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122 (2005) 927-939
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
82
-
-
0141907718
-
Destination 'lysosome': a target organelle for tumour cell killing?
-
Castino R., Demoz M., and Isidoro C. Destination 'lysosome': a target organelle for tumour cell killing?. J. Mol. Recognit. 16 (2003) 337-348
-
(2003)
J. Mol. Recognit.
, vol.16
, pp. 337-348
-
-
Castino, R.1
Demoz, M.2
Isidoro, C.3
-
83
-
-
27644466759
-
Autophagy and signaling: their role in cell survival and cell death
-
Codogno P., and Meijer A.J. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ. 12 Suppl. 2 (2005) 1509-1518
-
(2005)
Cell Death Differ.
, vol.12
, Issue.SUPPL. 2
, pp. 1509-1518
-
-
Codogno, P.1
Meijer, A.J.2
-
84
-
-
0032575750
-
Caspases: enemies within
-
Thornberry N.A., and Lazebnik Y. Caspases: enemies within. Science 281 (1998) 1312-1316
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
85
-
-
0027940509
-
Domain structure of calpain: mapping the binding site for calpastatin
-
Croall D.E., and McGrody K.S. Domain structure of calpain: mapping the binding site for calpastatin. Biochemistry 33 (1994) 13223-13230
-
(1994)
Biochemistry
, vol.33
, pp. 13223-13230
-
-
Croall, D.E.1
McGrody, K.S.2
-
86
-
-
0033832629
-
Noncaspase proteases in apoptosis
-
Johnson D.E. Noncaspase proteases in apoptosis. Leukemia 14 (2000) 1695-1703
-
(2000)
Leukemia
, vol.14
, pp. 1695-1703
-
-
Johnson, D.E.1
-
87
-
-
0038375025
-
Regulation of apoptosis: the ubiquitous way
-
Yang Y., and Yu X. Regulation of apoptosis: the ubiquitous way. FASEB J. 17 (2003) 790-799
-
(2003)
FASEB J.
, vol.17
, pp. 790-799
-
-
Yang, Y.1
Yu, X.2
-
88
-
-
1942534018
-
Regulation of apoptosis proteins in cancer cells by ubiquitin
-
Zhang H.G., Wang J., Yang X., Hsu H.C., and Mountz J.D. Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene 23 (2004) 2009-2015
-
(2004)
Oncogene
, vol.23
, pp. 2009-2015
-
-
Zhang, H.G.1
Wang, J.2
Yang, X.3
Hsu, H.C.4
Mountz, J.D.5
-
89
-
-
1842583795
-
To live or die by the sword: the regulation of apoptosis by the proteasome
-
Friedman J., and Xue D. To live or die by the sword: the regulation of apoptosis by the proteasome. Dev. Cell 6 (2004) 460-461
-
(2004)
Dev. Cell
, vol.6
, pp. 460-461
-
-
Friedman, J.1
Xue, D.2
-
90
-
-
0028258577
-
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
-
Heusel J.W., Wesselschmidt R.L., Shresta S., Russell J.H., and Ley T.J. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76 (1994) 977-987
-
(1994)
Cell
, vol.76
, pp. 977-987
-
-
Heusel, J.W.1
Wesselschmidt, R.L.2
Shresta, S.3
Russell, J.H.4
Ley, T.J.5
-
91
-
-
14244260622
-
Molecular ordering of the caspase activation cascade initiated by the CTL/NK protease granzyme B
-
Adrain C., Murphy B.M., and Martin S.J. Molecular ordering of the caspase activation cascade initiated by the CTL/NK protease granzyme B. J. Biol. Chem. 280 (2005) 4663-4673
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4663-4673
-
-
Adrain, C.1
Murphy, B.M.2
Martin, S.J.3
-
92
-
-
20044381271
-
A central role for Bid in granzyme B-induced apoptosis
-
Waterhouse N.J., Sedelies K.A., Brown K.A., Wowk M.E., Newbold A., Sutton V.R., Clarke C.J., Oliaro J., Lindemann R.K., Bird P.I., Johnstone R.W., and Trapani J.A. A central role for Bid in granzyme B-induced apoptosis. J. Biol. Chem. 280 (2005) 4476-4482
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4476-4482
-
-
Waterhouse, N.J.1
Sedelies, K.A.2
Brown, K.A.3
Wowk, M.E.4
Newbold, A.5
Sutton, V.R.6
Clarke, C.J.7
Oliaro, J.8
Lindemann, R.K.9
Bird, P.I.10
Johnstone, R.W.11
Trapani, J.A.12
-
93
-
-
0141629512
-
Nuclear war: the granzyme A-bomb
-
Lieberman J., and Fan Z. Nuclear war: the granzyme A-bomb. Curr. Opin. Immunol. 15 (2003) 553-559
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 553-559
-
-
Lieberman, J.1
Fan, Z.2
-
94
-
-
0029965928
-
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)
-
Wright S.C., Zheng H., and Zhong J. Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). FASEB J. 10 (1996) 325-332
-
(1996)
FASEB J.
, vol.10
, pp. 325-332
-
-
Wright, S.C.1
Zheng, H.2
Zhong, J.3
-
96
-
-
0030757986
-
Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
-
Brunk U.T., Dalen H., Roberg K., and Hellquist H.B. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic. Biol. Med. 23 (1997) 616-626
-
(1997)
Free Radic. Biol. Med.
, vol.23
, pp. 616-626
-
-
Brunk, U.T.1
Dalen, H.2
Roberg, K.3
Hellquist, H.B.4
-
97
-
-
0036349181
-
Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting?
-
Terman A., Neuzil J., Kagedal K., Ollinger K., and Brunk U.T. Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting?. Exp. Cell Res. 274 (2002) 9-15
-
(2002)
Exp. Cell Res.
, vol.274
, pp. 9-15
-
-
Terman, A.1
Neuzil, J.2
Kagedal, K.3
Ollinger, K.4
Brunk, U.T.5
-
98
-
-
0041912315
-
Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D
-
Tardy C., Tyynela J., Hasilik A., Levade T., and Andrieu-Abadie N. Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D. Cell Death Differ. 10 (2003) 1090-1100
-
(2003)
Cell Death Differ.
, vol.10
, pp. 1090-1100
-
-
Tardy, C.1
Tyynela, J.2
Hasilik, A.3
Levade, T.4
Andrieu-Abadie, N.5
-
99
-
-
0034615570
-
Lysosomal cysteine proteases: more than scavengers
-
Turk B., Turk D., and Turk V. Lysosomal cysteine proteases: more than scavengers. Biochim. Biophys. Acta 1477 (2000) 98-111
-
(2000)
Biochim. Biophys. Acta
, vol.1477
, pp. 98-111
-
-
Turk, B.1
Turk, D.2
Turk, V.3
-
100
-
-
0030918546
-
Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors
-
Turk B., Turk V., and Turk D. Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors. Biol. Chem. 378 (1997) 141-150
-
(1997)
Biol. Chem.
, vol.378
, pp. 141-150
-
-
Turk, B.1
Turk, V.2
Turk, D.3
-
101
-
-
0039547996
-
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S
-
Guncar G., Pungercic G., Klemencic I., Turk V., and Turk D. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. EMBO J. 18 (1999) 793-803
-
(1999)
EMBO J.
, vol.18
, pp. 793-803
-
-
Guncar, G.1
Pungercic, G.2
Klemencic, I.3
Turk, V.4
Turk, D.5
-
103
-
-
0033756474
-
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
-
Guicciardi M.E., Deussing J., Miyoshi H., Bronk S.F., Svingen P.A., Peters C., Kaufmann S.H., and Gores G.J. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J. Clin. Invest. 106 (2000) 1127-1137
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1127-1137
-
-
Guicciardi, M.E.1
Deussing, J.2
Miyoshi, H.3
Bronk, S.F.4
Svingen, P.A.5
Peters, C.6
Kaufmann, S.H.7
Gores, G.J.8
-
104
-
-
0035947776
-
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
-
Foghsgaard L., Wissing D., Mauch D., Lademann U., Bastholm L., Boes M., Elling F., Leist M., and Jaattela M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J. Cell Biol. 153 (2001) 999-1010
-
(2001)
J. Cell Biol.
, vol.153
, pp. 999-1010
-
-
Foghsgaard, L.1
Wissing, D.2
Mauch, D.3
Lademann, U.4
Bastholm, L.5
Boes, M.6
Elling, F.7
Leist, M.8
Jaattela, M.9
-
105
-
-
0035879752
-
Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B
-
Mathiasen I.S., Hansen C.M., Foghsgaard L., and Jaattela M. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. Int. J. Cancer 93 (2001) 224-231
-
(2001)
Int. J. Cancer
, vol.93
, pp. 224-231
-
-
Mathiasen, I.S.1
Hansen, C.M.2
Foghsgaard, L.3
Jaattela, M.4
-
106
-
-
20444506408
-
TNF induces the loss of sphingosine kinase-1 by a cathepsin B dependent mechanism
-
Taha T.A., Kitatani K., Bielawski J., Cho W., Hannun Y.A., and Obeid L.M. TNF induces the loss of sphingosine kinase-1 by a cathepsin B dependent mechanism. J. Biol. Chem. 280 (2005) 17196-17202
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17196-17202
-
-
Taha, T.A.1
Kitatani, K.2
Bielawski, J.3
Cho, W.4
Hannun, Y.A.5
Obeid, L.M.6
-
107
-
-
3442880143
-
Sensitization to the lysosomal cell death pathway upon immortalization and transformation
-
Fehrenbacher N., Gyrd-Hansen M., Poulsen B., Felbor U., Kallunki T., Boes M., Weber E., Leist M., and Jaattela M. Sensitization to the lysosomal cell death pathway upon immortalization and transformation. Cancer Res. 64 (2004) 5301-5310
-
(2004)
Cancer Res.
, vol.64
, pp. 5301-5310
-
-
Fehrenbacher, N.1
Gyrd-Hansen, M.2
Poulsen, B.3
Felbor, U.4
Kallunki, T.5
Boes, M.6
Weber, E.7
Leist, M.8
Jaattela, M.9
-
108
-
-
2442494074
-
Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53
-
Taha T.A., Osta W., Kozhaya L., Bielawski J., Johnson K.R., Gillanders W.E., Dbaibo G.S., Hannun Y.A., and Obeid L.M. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J. Biol. Chem. 279 (2004) 20546-20554
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20546-20554
-
-
Taha, T.A.1
Osta, W.2
Kozhaya, L.3
Bielawski, J.4
Johnson, K.R.5
Gillanders, W.E.6
Dbaibo, G.S.7
Hannun, Y.A.8
Obeid, L.M.9
-
109
-
-
0030862412
-
Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
-
Roberts L.R., Kurosawa H., Bronk S.F., Fesmier P.J., Agellon L.B., Leung W.Y., Mao F., and Gores G.J. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes. Gastroenterology 113 (1997) 1714-1726
-
(1997)
Gastroenterology
, vol.113
, pp. 1714-1726
-
-
Roberts, L.R.1
Kurosawa, H.2
Bronk, S.F.3
Fesmier, P.J.4
Agellon, L.B.5
Leung, W.Y.6
Mao, F.7
Gores, G.J.8
-
110
-
-
0032919402
-
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
-
Faubion W.A., Guicciardi M.E., Miyoshi H., Bronk S.F., Roberts P.J., Svingen P.A., Kaufmann S.H., and Gores G.J. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J. Clin. Invest. 103 (1999) 137-145
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 137-145
-
-
Faubion, W.A.1
Guicciardi, M.E.2
Miyoshi, H.3
Bronk, S.F.4
Roberts, P.J.5
Svingen, P.A.6
Kaufmann, S.H.7
Gores, G.J.8
-
111
-
-
12344303157
-
Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury
-
Baskin-Bey E.S., Canbay A., Bronk S.F., Werneburg N., Guicciardi M.E., Nyberg S.L., and Gores G.J. Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury. Am. J. Physiol.: Gastrointest. Liver Physiol. 288 (2005) G396-G402
-
(2005)
Am. J. Physiol.: Gastrointest. Liver Physiol.
, vol.288
-
-
Baskin-Bey, E.S.1
Canbay, A.2
Bronk, S.F.3
Werneburg, N.4
Guicciardi, M.E.5
Nyberg, S.L.6
Gores, G.J.7
-
112
-
-
2942746586
-
Serum cathepsin B activity during regression of Morris hepatoma 5123 D
-
Fedorowski A., Steciwko A., and Rabczynski J. Serum cathepsin B activity during regression of Morris hepatoma 5123 D. Med. Sci. Monit. 10 (2004) BR144-BR150
-
(2004)
Med. Sci. Monit.
, vol.10
-
-
Fedorowski, A.1
Steciwko, A.2
Rabczynski, J.3
-
113
-
-
1642576236
-
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells
-
Broker L.E., Huisman C., Span S.W., Rodriguez J.A., Kruyt F.A., and Giaccone G. Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells. Cancer Res. 64 (2004) 27-30
-
(2004)
Cancer Res.
, vol.64
, pp. 27-30
-
-
Broker, L.E.1
Huisman, C.2
Span, S.W.3
Rodriguez, J.A.4
Kruyt, F.A.5
Giaccone, G.6
-
114
-
-
0031753981
-
Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line
-
Jones B., Roberts P.J., Faubion W.A., Kominami E., and Gores G.J. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line. Am. J. Physiol. 275 (1998) G723-G730
-
(1998)
Am. J. Physiol.
, vol.275
-
-
Jones, B.1
Roberts, P.J.2
Faubion, W.A.3
Kominami, E.4
Gores, G.J.5
-
115
-
-
0031817004
-
Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'
-
Yamashima T., Kohda Y., Tsuchiya K., Ueno T., Yamashita J., Yoshioka T., and Kominami E. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur. J. Neurosci. 10 (1998) 1723-1733
-
(1998)
Eur. J. Neurosci.
, vol.10
, pp. 1723-1733
-
-
Yamashima, T.1
Kohda, Y.2
Tsuchiya, K.3
Ueno, T.4
Yamashita, J.5
Yoshioka, T.6
Kominami, E.7
-
116
-
-
0032976738
-
Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors
-
Tsuchiya K., Kohda Y., Yoshida M., Zhao L., Ueno T., Yamashita J., Yoshioka T., Kominami E., and Yamashima T. Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors. Exp. Neurol. 155 (1999) 187-194
-
(1999)
Exp. Neurol.
, vol.155
, pp. 187-194
-
-
Tsuchiya, K.1
Kohda, Y.2
Yoshida, M.3
Zhao, L.4
Ueno, T.5
Yamashita, J.6
Yoshioka, T.7
Kominami, E.8
Yamashima, T.9
-
117
-
-
0037138438
-
Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas
-
Castino R., Pace D., Demoz M., Gargiulo M., Ariatta C., Raiteri E., and Isidoro C. Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas. Int. J. Cancer 97 (2002) 775-779
-
(2002)
Int. J. Cancer
, vol.97
, pp. 775-779
-
-
Castino, R.1
Pace, D.2
Demoz, M.3
Gargiulo, M.4
Ariatta, C.5
Raiteri, E.6
Isidoro, C.7
-
118
-
-
11144226381
-
Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts
-
Tardy C., Autefage H., Garcia V., Levade T., and Andrieu-Abadie N. Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts. J. Biol. Chem. 279 (2004) 52914-52923
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 52914-52923
-
-
Tardy, C.1
Autefage, H.2
Garcia, V.3
Levade, T.4
Andrieu-Abadie, N.5
-
119
-
-
0034485661
-
Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells
-
Zhu D.M., and Uckun F.M. Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells. Leuk. Lymphoma 39 (2000) 343-354
-
(2000)
Leuk. Lymphoma
, vol.39
, pp. 343-354
-
-
Zhu, D.M.1
Uckun, F.M.2
-
120
-
-
0034025876
-
Z-Phe-Gly-NHO-Bz, an inhibitor of cysteine cathepsins, induces apoptosis in human cancer cells
-
Zhu D.M., and Uckun F.M. Z-Phe-Gly-NHO-Bz, an inhibitor of cysteine cathepsins, induces apoptosis in human cancer cells. Clin. Cancer Res. 6 (2000) 2064-2069
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2064-2069
-
-
Zhu, D.M.1
Uckun, F.M.2
-
121
-
-
17144394796
-
Multiple roles for cysteine cathepsins in cancer
-
Joyce J.A., and Hanahan D. Multiple roles for cysteine cathepsins in cancer. Cell Cycle 3 (2004) 1516-1619
-
(2004)
Cell Cycle
, vol.3
, pp. 1516-1619
-
-
Joyce, J.A.1
Hanahan, D.2
-
122
-
-
0029968261
-
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C
-
Kummer J.A., Kamp A.M., Citarella F., Horrevoets A.J., and Hack C.E. Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C. J. Biol. Chem. 271 (1996) 9281-9286
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 9281-9286
-
-
Kummer, J.A.1
Kamp, A.M.2
Citarella, F.3
Horrevoets, A.J.4
Hack, C.E.5
-
123
-
-
0033587689
-
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
-
Pham C.T., and Ley T.J. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 8627-8632
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 8627-8632
-
-
Pham, C.T.1
Ley, T.J.2
-
124
-
-
0031941573
-
Production of fully active recombinant murine granzyme B in yeast
-
Pham C.T., Thomas D.A., Mercer J.D., and Ley T.J. Production of fully active recombinant murine granzyme B in yeast. J. Biol. Chem. 273 (1998) 1629-1633
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1629-1633
-
-
Pham, C.T.1
Thomas, D.A.2
Mercer, J.D.3
Ley, T.J.4
-
126
-
-
0029099845
-
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
-
Darmon A.J., Nicholson D.W., and Bleackley R.C. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377 (1995) 446-448
-
(1995)
Nature
, vol.377
, pp. 446-448
-
-
Darmon, A.J.1
Nicholson, D.W.2
Bleackley, R.C.3
-
127
-
-
0030702084
-
Caspases: intracellular signaling by proteolysis
-
Salvesen G.S., and Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell 91 (1997) 443-446
-
(1997)
Cell
, vol.91
, pp. 443-446
-
-
Salvesen, G.S.1
Dixit, V.M.2
-
128
-
-
0346850963
-
Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L
-
Bol B., and Campbell V. Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. Neurobiol. Aging 25 (2004) 83-91
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 83-91
-
-
Bol, B.1
Campbell, V.2
-
129
-
-
0038408712
-
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis
-
Welss T., Sun J., Irving J.A., Blum R., Smith A.I., Whisstock J.C., Pike R.N., von Mikecz A., Ruzicka T., Bird P.I., and Abts H.F. Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. Biochemistry 42 (2003) 7381-7389
-
(2003)
Biochemistry
, vol.42
, pp. 7381-7389
-
-
Welss, T.1
Sun, J.2
Irving, J.A.3
Blum, R.4
Smith, A.I.5
Whisstock, J.C.6
Pike, R.N.7
von Mikecz, A.8
Ruzicka, T.9
Bird, P.I.10
Abts, H.F.11
-
130
-
-
0037328905
-
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis
-
Levicar N., Dewey R.A., Daley E., Bates T.E., Davies D., Kos J., Pilkington G.J., and Lah T.T. Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Ther. 10 (2003) 141-151
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 141-151
-
-
Levicar, N.1
Dewey, R.A.2
Daley, E.3
Bates, T.E.4
Davies, D.5
Kos, J.6
Pilkington, G.J.7
Lah, T.T.8
-
131
-
-
0019765848
-
Cathepsin B, cathepsin H, and cathepsin L
-
Barrett A.J., and Kirschke H. Cathepsin B, cathepsin H, and cathepsin L. Methods Enzymol. 80 Pt. C (1981) 535-561
-
(1981)
Methods Enzymol.
, vol.80
, Issue.PART C
, pp. 535-561
-
-
Barrett, A.J.1
Kirschke, H.2
-
132
-
-
0022927903
-
Immunolocalization of cathepsin D in normal and neoplastic human tissues
-
Reid W.A., Valler M.J., and Kay J. Immunolocalization of cathepsin D in normal and neoplastic human tissues. J. Clin. Pathol. 39 (1986) 1323-1330
-
(1986)
J. Clin. Pathol.
, vol.39
, pp. 1323-1330
-
-
Reid, W.A.1
Valler, M.J.2
Kay, J.3
-
133
-
-
0023209825
-
Evolution in the structure and function of aspartic proteases
-
Tang J., and Wong R.N. Evolution in the structure and function of aspartic proteases. J. Cell. Biochem. 33 (1987) 53-63
-
(1987)
J. Cell. Biochem.
, vol.33
, pp. 53-63
-
-
Tang, J.1
Wong, R.N.2
-
134
-
-
0018821796
-
Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues
-
Hasilik A., and Neufeld E.F. Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues. J. Biol. Chem. 255 (1980) 4946-4950
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 4946-4950
-
-
Hasilik, A.1
Neufeld, E.F.2
-
135
-
-
0032580334
-
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity
-
Wu G.S., Saftig P., Peters C., and El-Deiry W.S. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene 16 (1998) 2177-2183
-
(1998)
Oncogene
, vol.16
, pp. 2177-2183
-
-
Wu, G.S.1
Saftig, P.2
Peters, C.3
El-Deiry, W.S.4
-
136
-
-
0037086662
-
Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability
-
Neuzil J., Zhao M., Ostermann G., Sticha M., Gellert N., Weber C., Eaton J.W., and Brunk U.T. Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem. J. 362 (2002) 709-715
-
(2002)
Biochem. J.
, vol.362
, pp. 709-715
-
-
Neuzil, J.1
Zhao, M.2
Ostermann, G.3
Sticha, M.4
Gellert, N.5
Weber, C.6
Eaton, J.W.7
Brunk, U.T.8
-
137
-
-
0029782494
-
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha
-
Deiss L.P., Galinka H., Berissi H., Cohen O., and Kimchi A. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J. 15 (1996) 3861-3870
-
(1996)
EMBO J.
, vol.15
, pp. 3861-3870
-
-
Deiss, L.P.1
Galinka, H.2
Berissi, H.3
Cohen, O.4
Kimchi, A.5
-
138
-
-
20044383567
-
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death
-
Emert-Sedlak L., Shangary S., Rabinovitz A., Miranda M.B., Delach S.M., and Johnson D.E. Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death. Mol. Cancer Ther. 4 (2005) 733-742
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 733-742
-
-
Emert-Sedlak, L.1
Shangary, S.2
Rabinovitz, A.3
Miranda, M.B.4
Delach, S.M.5
Johnson, D.E.6
-
139
-
-
0032500842
-
Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation
-
Shibata M., Kanamori S., Isahara K., Ohsawa Y., Konishi A., Kametaka S., Watanabe T., Ebisu S., Ishido K., Kominami E., and Uchiyama Y. Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation. Biochem. Biophys. Res. Commun. 251 (1998) 199-203
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 199-203
-
-
Shibata, M.1
Kanamori, S.2
Isahara, K.3
Ohsawa, Y.4
Konishi, A.5
Kametaka, S.6
Watanabe, T.7
Ebisu, S.8
Ishido, K.9
Kominami, E.10
Uchiyama, Y.11
-
140
-
-
0036310279
-
Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts
-
Roberg K., Kagedal K., and Ollinger K. Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts. Am. J. Pathol. 161 (2002) 89-96
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 89-96
-
-
Roberg, K.1
Kagedal, K.2
Ollinger, K.3
-
141
-
-
0036660887
-
Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D
-
Demoz M., Castino R., Cesaro P., Baccino F.M., Bonelli G., and Isidoro C. Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D. Biol. Chem. 383 (2002) 1237-1248
-
(2002)
Biol. Chem.
, vol.383
, pp. 1237-1248
-
-
Demoz, M.1
Castino, R.2
Cesaro, P.3
Baccino, F.M.4
Bonelli, G.5
Isidoro, C.6
-
142
-
-
2442661614
-
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
-
Heinrich M., Neumeyer J., Jakob M., Hallas C., Tchikov V., Winoto-Morbach S., Wickel M., Schneider-Brachert W., Trauzold A., Hethke A., and Schutze S. Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ. 11 (2004) 550-563
-
(2004)
Cell Death Differ.
, vol.11
, pp. 550-563
-
-
Heinrich, M.1
Neumeyer, J.2
Jakob, M.3
Hallas, C.4
Tchikov, V.5
Winoto-Morbach, S.6
Wickel, M.7
Schneider-Brachert, W.8
Trauzold, A.9
Hethke, A.10
Schutze, S.11
-
144
-
-
0031897739
-
Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
-
Roberg K., and Ollinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am. J. Pathol. 152 (1998) 1151-1156
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 1151-1156
-
-
Roberg, K.1
Ollinger, K.2
-
145
-
-
0034650786
-
Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes
-
Ollinger K. Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes. Arch. Biochem. Biophys. 373 (2000) 346-351
-
(2000)
Arch. Biochem. Biophys.
, vol.373
, pp. 346-351
-
-
Ollinger, K.1
-
146
-
-
0037209848
-
Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes
-
Takuma K., Kiriu M., Mori K., Lee E., Enomoto R., Baba A., and Matsuda T. Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes. Neurochem. Int. 42 (2003) 153-159
-
(2003)
Neurochem. Int.
, vol.42
, pp. 153-159
-
-
Takuma, K.1
Kiriu, M.2
Mori, K.3
Lee, E.4
Enomoto, R.5
Baba, A.6
Matsuda, T.7
-
147
-
-
21344469549
-
Lysosomal and mitochondrial pathways in H2O2-induced apoptosis of alveolar type II cells
-
Yin L., Stearns R., and Gonzalez-Flecha B. Lysosomal and mitochondrial pathways in H2O2-induced apoptosis of alveolar type II cells. J. Cell. Biochem. 94 (2005) 433-445
-
(2005)
J. Cell. Biochem.
, vol.94
, pp. 433-445
-
-
Yin, L.1
Stearns, R.2
Gonzalez-Flecha, B.3
-
148
-
-
0242609099
-
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
-
Johansson A.C., Steen H., Ollinger K., and Roberg K. Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine. Cell Death Differ. 10 (2003) 1253-1259
-
(2003)
Cell Death Differ.
, vol.10
, pp. 1253-1259
-
-
Johansson, A.C.1
Steen, H.2
Ollinger, K.3
Roberg, K.4
-
149
-
-
0035018235
-
Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells
-
Zang Y., Beard R.L., Chandraratna R.A., and Kang J.X. Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. Cell Death Differ. 8 (2001) 477-485
-
(2001)
Cell Death Differ.
, vol.8
, pp. 477-485
-
-
Zang, Y.1
Beard, R.L.2
Chandraratna, R.A.3
Kang, J.X.4
-
150
-
-
0035887215
-
Sphingosine-induced apoptosis is dependent on lysosomal proteases
-
Kagedal K., Zhao M., Svensson I., and Brunk U.T. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem. J. 359 (2001) 335-343
-
(2001)
Biochem. J.
, vol.359
, pp. 335-343
-
-
Kagedal, K.1
Zhao, M.2
Svensson, I.3
Brunk, U.T.4
-
151
-
-
2942746542
-
Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells
-
Li X., Rayford H., Shu R., Zhuang J., and Uhal B.D. Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells. Am. J. Physiol.: Lung Cell. Mol. Physiol. 287 (2004) L46-L51
-
(2004)
Am. J. Physiol.: Lung Cell. Mol. Physiol.
, vol.287
-
-
Li, X.1
Rayford, H.2
Shu, R.3
Zhuang, J.4
Uhal, B.D.5
-
152
-
-
3242808193
-
Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity
-
Thibodeau M.S., Giardina C., Knecht D.A., Helble J., and Hubbard A.K. Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity. Toxicol. Sci. 80 (2004) 34-48
-
(2004)
Toxicol. Sci.
, vol.80
, pp. 34-48
-
-
Thibodeau, M.S.1
Giardina, C.2
Knecht, D.A.3
Helble, J.4
Hubbard, A.K.5
-
153
-
-
0033214095
-
Cathepsin D targeted by acid sphingomyelinase-derived ceramide
-
Heinrich M., Wickel M., Schneider-Brachert W., Sandberg C., Gahr J., Schwandner R., Weber T., Saftig P., Peters C., Brunner J., Kronke M., and Schutze S. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 18 (1999) 5252-5263
-
(1999)
EMBO J.
, vol.18
, pp. 5252-5263
-
-
Heinrich, M.1
Wickel, M.2
Schneider-Brachert, W.3
Sandberg, C.4
Gahr, J.5
Schwandner, R.6
Weber, T.7
Saftig, P.8
Peters, C.9
Brunner, J.10
Kronke, M.11
Schutze, S.12
-
154
-
-
0036732169
-
Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage
-
Reiners Jr. J.J., Caruso J.A., Mathieu P., Chelladurai B., Yin X.M., and Kessel D. Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage. Cell Death Differ. 9 (2002) 934-944
-
(2002)
Cell Death Differ.
, vol.9
, pp. 934-944
-
-
Reiners Jr., J.J.1
Caruso, J.A.2
Mathieu, P.3
Chelladurai, B.4
Yin, X.M.5
Kessel, D.6
-
155
-
-
0032959390
-
Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
-
Isahara K., Ohsawa Y., Kanamori S., Shibata M., Waguri S., Sato N., Gotow T., Watanabe T., Momoi T., Urase K., Kominami E., and Uchiyama Y. Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases. Neuroscience 91 (1999) 233-249
-
(1999)
Neuroscience
, vol.91
, pp. 233-249
-
-
Isahara, K.1
Ohsawa, Y.2
Kanamori, S.3
Shibata, M.4
Waguri, S.5
Sato, N.6
Gotow, T.7
Watanabe, T.8
Momoi, T.9
Urase, K.10
Kominami, E.11
Uchiyama, Y.12
-
156
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
Santana P., Pena L.A., Haimovitz-Friedman A., Martin S., Green D., McLoughlin M., Cordon-Cardo C., Schuchman E.H., Fuks Z., and Kolesnick R. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86 (1996) 189-199
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
157
-
-
0346993514
-
Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis
-
Vit J.P., and Rosselli F. Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis. Oncogene 22 (2003) 8645-8652
-
(2003)
Oncogene
, vol.22
, pp. 8645-8652
-
-
Vit, J.P.1
Rosselli, F.2
-
158
-
-
0035853751
-
Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis
-
Zhang Y., Mattjus P., Schmid P.C., Dong Z., Zhong S., Ma W.Y., Brown R.E., Bode A.M., and Schmid H.H. Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J. Biol. Chem. 276 (2001) 11775-11782
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11775-11782
-
-
Zhang, Y.1
Mattjus, P.2
Schmid, P.C.3
Dong, Z.4
Zhong, S.5
Ma, W.Y.6
Brown, R.E.7
Bode, A.M.8
Schmid, H.H.9
-
159
-
-
20144367155
-
Acid sphingomyelinase is indispensable for UV-induced bax conformational change at the mitochondrial membrane
-
Kashkar H., Wiegmann K., Yazdanpanah B., Haubert D., and Kroenke M. Acid sphingomyelinase is indispensable for UV-induced bax conformational change at the mitochondrial membrane. J. Biol. Chem. 280 (2005) 20804-20813
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20804-20813
-
-
Kashkar, H.1
Wiegmann, K.2
Yazdanpanah, B.3
Haubert, D.4
Kroenke, M.5
-
160
-
-
0035968448
-
Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation
-
Komatsu M., Takahashi T., Abe T., Takahashi I., Ida H., and Takada G. Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation. Biochim. Biophys. Acta 1533 (2001) 47-54
-
(2001)
Biochim. Biophys. Acta
, vol.1533
, pp. 47-54
-
-
Komatsu, M.1
Takahashi, T.2
Abe, T.3
Takahashi, I.4
Ida, H.5
Takada, G.6
-
161
-
-
0033583789
-
Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis
-
Separovic D., Pink J.J., Oleinick N.A., Kester M., Boothman D.A., McLoughlin M., Pena L.A., and Haimovitz-Friedman A. Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis. Biochem. Biophys. Res. Commun. 258 (1999) 506-512
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.258
, pp. 506-512
-
-
Separovic, D.1
Pink, J.J.2
Oleinick, N.A.3
Kester, M.4
Boothman, D.A.5
McLoughlin, M.6
Pena, L.A.7
Haimovitz-Friedman, A.8
-
162
-
-
0028790239
-
Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal
-
Cifone M.G., Roncaioli P., De Maria R., Camarda G., Santoni A., Ruberti G., and Testi R. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J. 14 (1995) 5859-5868
-
(1995)
EMBO J.
, vol.14
, pp. 5859-5868
-
-
Cifone, M.G.1
Roncaioli, P.2
De Maria, R.3
Camarda, G.4
Santoni, A.5
Ruberti, G.6
Testi, R.7
-
163
-
-
0032536876
-
Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
-
De Maria R., Rippo M.R., Schuchman E.H., and Testi R. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J. Exp. Med. 187 (1998) 897-902
-
(1998)
J. Exp. Med.
, vol.187
, pp. 897-902
-
-
De Maria, R.1
Rippo, M.R.2
Schuchman, E.H.3
Testi, R.4
-
164
-
-
0035827632
-
CD95 signaling via ceramide-rich membrane rafts
-
Grassme H., Jekle A., Riehle A., Schwarz H., Berger J., Sandhoff K., Kolesnick R., and Gulbins E. CD95 signaling via ceramide-rich membrane rafts. J. Biol. Chem. 276 (2001) 20589-20596
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20589-20596
-
-
Grassme, H.1
Jekle, A.2
Riehle, A.3
Schwarz, H.4
Berger, J.5
Sandhoff, K.6
Kolesnick, R.7
Gulbins, E.8
-
165
-
-
0030784482
-
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
-
Haimovitz-Friedman A., Cordon-Cardo C., Bayoumy S., Garzotto M., McLoughlin M., Gallily R., Edwards III C.K., Schuchman E.H., Fuks Z., and Kolesnick R. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med. 186 (1997) 1831-1841
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1831-1841
-
-
Haimovitz-Friedman, A.1
Cordon-Cardo, C.2
Bayoumy, S.3
Garzotto, M.4
McLoughlin, M.5
Gallily, R.6
Edwards III, C.K.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
166
-
-
0036056177
-
Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells
-
Sawada M., Nakashima S., Kiyono T., Yamada J., Hara S., Nakagawa M., Shinoda J., and Sakai N. Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells. Exp. Cell Res. 273 (2002) 157-168
-
(2002)
Exp. Cell Res.
, vol.273
, pp. 157-168
-
-
Sawada, M.1
Nakashima, S.2
Kiyono, T.3
Yamada, J.4
Hara, S.5
Nakagawa, M.6
Shinoda, J.7
Sakai, N.8
-
167
-
-
0037189948
-
Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3
-
Colell A., Morales A., Fernandez-Checa J.C., and Garcia-Ruiz C. Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3. FEBS Lett. 526 (2002) 135-141
-
(2002)
FEBS Lett.
, vol.526
, pp. 135-141
-
-
Colell, A.1
Morales, A.2
Fernandez-Checa, J.C.3
Garcia-Ruiz, C.4
-
168
-
-
0032571251
-
CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
-
Cock J.G., Tepper A.D., de Vries E., van Blitterswijk W.J., and Borst J. CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase. J. Biol. Chem. 273 (1998) 7560-7565
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7560-7565
-
-
Cock, J.G.1
Tepper, A.D.2
de Vries, E.3
van Blitterswijk, W.J.4
Borst, J.5
-
169
-
-
0035259441
-
Lysosomal sphingomyelinase is not solicited for apoptosis signaling
-
Bezombes C., Segui B., Cuvillier O., Bruno A.P., Uro-Coste E., Gouaze V., Andrieu-Abadie N., Carpentier S., Laurent G., Salvayre R., Jaffrezou J.P., and Levade T. Lysosomal sphingomyelinase is not solicited for apoptosis signaling. FASEB J. 15 (2001) 297-299
-
(2001)
FASEB J.
, vol.15
, pp. 297-299
-
-
Bezombes, C.1
Segui, B.2
Cuvillier, O.3
Bruno, A.P.4
Uro-Coste, E.5
Gouaze, V.6
Andrieu-Abadie, N.7
Carpentier, S.8
Laurent, G.9
Salvayre, R.10
Jaffrezou, J.P.11
Levade, T.12
-
170
-
-
0034708831
-
Role of acidic sphingomyelinase in Fas/CD95-mediated cell death
-
Lin T., Genestier L., Pinkoski M.J., Castro A., Nicholas S., Mogil R., Paris F., Fuks Z., Schuchman E.H., Kolesnick R.N., and Green D.R. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. J. Biol. Chem. 275 (2000) 8657-8663
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8657-8663
-
-
Lin, T.1
Genestier, L.2
Pinkoski, M.J.3
Castro, A.4
Nicholas, S.5
Mogil, R.6
Paris, F.7
Fuks, Z.8
Schuchman, E.H.9
Kolesnick, R.N.10
Green, D.R.11
-
171
-
-
0034132082
-
Phthalocyanine 4-photodynamic therapy induces ceramide generation and apoptosis in acid sphingomyelinase-deficient mouse embryonic fibroblasts
-
Chiu S.M., Davis T.W., Meyers M., Ahmad N., Mukhtar H., and Separovic D. Phthalocyanine 4-photodynamic therapy induces ceramide generation and apoptosis in acid sphingomyelinase-deficient mouse embryonic fibroblasts. Int. J. Oncol. 16 (2000) 423-427
-
(2000)
Int. J. Oncol.
, vol.16
, pp. 423-427
-
-
Chiu, S.M.1
Davis, T.W.2
Meyers, M.3
Ahmad, N.4
Mukhtar, H.5
Separovic, D.6
-
172
-
-
0034017357
-
Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation
-
Nix M., and Stoffel W. Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation. Cell Death Differ. 7 (2000) 413-424
-
(2000)
Cell Death Differ.
, vol.7
, pp. 413-424
-
-
Nix, M.1
Stoffel, W.2
-
173
-
-
0032540959
-
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene
-
Schissel S.L., Keesler G.A., Schuchman E.H., Williams K.J., and Tabas I. The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J. Biol. Chem. 273 (1998) 18250-18259
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18250-18259
-
-
Schissel, S.L.1
Keesler, G.A.2
Schuchman, E.H.3
Williams, K.J.4
Tabas, I.5
-
174
-
-
22544470314
-
Caspase-dependent and-independent activation of acid sphingomyelinase signaling
-
Rotolo J.A., Zhang J., Donepudi M., Lee H., Fuks Z., and Kolesnick R. Caspase-dependent and-independent activation of acid sphingomyelinase signaling. J. Biol. Chem. 280 (2005) 26425-26434
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26425-26434
-
-
Rotolo, J.A.1
Zhang, J.2
Donepudi, M.3
Lee, H.4
Fuks, Z.5
Kolesnick, R.6
-
175
-
-
0035968191
-
Ceramide enables fas to cap and kill
-
Cremesti A., Paris F., Grassme H., Holler N., Tschopp J., Fuks Z., Gulbins E., and Kolesnick R. Ceramide enables fas to cap and kill. J. Biol. Chem. 276 (2001) 23954-23961
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23954-23961
-
-
Cremesti, A.1
Paris, F.2
Grassme, H.3
Holler, N.4
Tschopp, J.5
Fuks, Z.6
Gulbins, E.7
Kolesnick, R.8
-
176
-
-
4344697840
-
Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts
-
Abdel Shakor A.B., Kwiatkowska K., and Sobota A. Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts. J. Biol. Chem. 279 (2004) 36778-36787
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36778-36787
-
-
Abdel Shakor, A.B.1
Kwiatkowska, K.2
Sobota, A.3
-
177
-
-
0036134864
-
Ceramide-rich membrane rafts mediate CD40 clustering
-
Grassme H., Jendrossek V., Bock J., Riehle A., and Gulbins E. Ceramide-rich membrane rafts mediate CD40 clustering. J. Immunol. 168 (2002) 298-307
-
(2002)
J. Immunol.
, vol.168
, pp. 298-307
-
-
Grassme, H.1
Jendrossek, V.2
Bock, J.3
Riehle, A.4
Gulbins, E.5
-
178
-
-
2442693091
-
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells
-
Lacour S., Hammann A., Grazide S., Lagadic-Gossmann D., Athias A., Sergent O., Laurent G., Gambert P., Solary E., and Dimanche-Boitrel M.T. Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. Cancer Res. 64 (2004) 3593-3598
-
(2004)
Cancer Res.
, vol.64
, pp. 3593-3598
-
-
Lacour, S.1
Hammann, A.2
Grazide, S.3
Lagadic-Gossmann, D.4
Athias, A.5
Sergent, O.6
Laurent, G.7
Gambert, P.8
Solary, E.9
Dimanche-Boitrel, M.T.10
-
179
-
-
3843139379
-
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains
-
Bezombes C., Grazide S., Garret C., Fabre C., Quillet-Mary A., Muller S., Jaffrezou J.P., and Laurent G. Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains. Blood 104 (2004) 1166-1173
-
(2004)
Blood
, vol.104
, pp. 1166-1173
-
-
Bezombes, C.1
Grazide, S.2
Garret, C.3
Fabre, C.4
Quillet-Mary, A.5
Muller, S.6
Jaffrezou, J.P.7
Laurent, G.8
-
180
-
-
0035114217
-
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer
-
Selzner M., Bielawska A., Morse M.A., Rudiger H.A., Sindram D., Hannun Y.A., and Clavien P.A. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 61 (2001) 1233-1240
-
(2001)
Cancer Res.
, vol.61
, pp. 1233-1240
-
-
Selzner, M.1
Bielawska, A.2
Morse, M.A.3
Rudiger, H.A.4
Sindram, D.5
Hannun, Y.A.6
Clavien, P.A.7
-
181
-
-
1542287456
-
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts
-
Samsel L., Zaidel G., Drumgoole H.M., Jelovac D., Drachenberg C., Rhee J.G., Brodie A.M., Bielawska A., and Smyth M.J. The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts. Prostate 58 (2004) 382-393
-
(2004)
Prostate
, vol.58
, pp. 382-393
-
-
Samsel, L.1
Zaidel, G.2
Drumgoole, H.M.3
Jelovac, D.4
Drachenberg, C.5
Rhee, J.G.6
Brodie, A.M.7
Bielawska, A.8
Smyth, M.J.9
-
182
-
-
18344394549
-
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes
-
Raisova M., Goltz G., Bektas M., Bielawska A., Riebeling C., Hossini A.M., Eberle J., Hannun Y.A., Orfanos C.E., and Geilen C.C. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett. 516 (2002) 47-52
-
(2002)
FEBS Lett.
, vol.516
, pp. 47-52
-
-
Raisova, M.1
Goltz, G.2
Bektas, M.3
Bielawska, A.4
Riebeling, C.5
Hossini, A.M.6
Eberle, J.7
Hannun, Y.A.8
Orfanos, C.E.9
Geilen, C.C.10
-
183
-
-
0034605034
-
Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death
-
Strelow A., Bernardo K., Adam-Klages S., Linke T., Sandhoff K., Kronke M., and Adam D. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J. Exp. Med. 192 (2000) 601-612
-
(2000)
J. Exp. Med.
, vol.192
, pp. 601-612
-
-
Strelow, A.1
Bernardo, K.2
Adam-Klages, S.3
Linke, T.4
Sandhoff, K.5
Kronke, M.6
Adam, D.7
-
184
-
-
0035477979
-
Ceramide mediates tumor-induced dendritic cell apoptosis
-
Kanto T., Kalinski P., Hunter O.C., Lotze M.T., and Amoscato A.A. Ceramide mediates tumor-induced dendritic cell apoptosis. J. Immunol. 167 (2001) 3773-3784
-
(2001)
J. Immunol.
, vol.167
, pp. 3773-3784
-
-
Kanto, T.1
Kalinski, P.2
Hunter, O.C.3
Lotze, M.T.4
Amoscato, A.A.5
-
185
-
-
0035807229
-
The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells
-
Burek C., Roth J., Koch H.G., Harzer K., Los M., and Schulze-Osthoff K. The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells. Oncogene 20 (2001) 6493-6502
-
(2001)
Oncogene
, vol.20
, pp. 6493-6502
-
-
Burek, C.1
Roth, J.2
Koch, H.G.3
Harzer, K.4
Los, M.5
Schulze-Osthoff, K.6
-
186
-
-
0038035591
-
Stress-induced apoptosis is not mediated by endolysosomal ceramide
-
Ségui B., Bezombes C., Uro-Coste E., Medin J.A., Andrieu-Abadie N., Auge N., Brouchet A., Laurent G., Salvayre R., Jaffrezou J.P., and Levade T. Stress-induced apoptosis is not mediated by endolysosomal ceramide. FASEB J. 14 (2000) 36-47
-
(2000)
FASEB J.
, vol.14
, pp. 36-47
-
-
Ségui, B.1
Bezombes, C.2
Uro-Coste, E.3
Medin, J.A.4
Andrieu-Abadie, N.5
Auge, N.6
Brouchet, A.7
Laurent, G.8
Salvayre, R.9
Jaffrezou, J.P.10
Levade, T.11
-
187
-
-
0029843717
-
Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis
-
Hellsten E., Vesa J., Olkkonen V.M., Jalanko A., and Peltonen L. Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis. EMBO J. 15 (1996) 5240-5245
-
(1996)
EMBO J.
, vol.15
, pp. 5240-5245
-
-
Hellsten, E.1
Vesa, J.2
Olkkonen, V.M.3
Jalanko, A.4
Peltonen, L.5
-
188
-
-
0030009044
-
Lysosomal targeting of palmitoyl-protein thioesterase
-
Verkruyse L.A., and Hofmann S.L. Lysosomal targeting of palmitoyl-protein thioesterase. J. Biol. Chem. 271 (1996) 15831-15836
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15831-15836
-
-
Verkruyse, L.A.1
Hofmann, S.L.2
-
189
-
-
0027518208
-
Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras
-
Camp L.A., and Hofmann S.L. Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. J. Biol. Chem. 268 (1993) 22566-22574
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 22566-22574
-
-
Camp, L.A.1
Hofmann, S.L.2
-
190
-
-
0027989872
-
Molecular cloning and expression of palmitoyl-protein thioesterase
-
Camp L.A., Verkruyse L.A., Afendis S.J., Slaughter C.A., and Hofmann S.L. Molecular cloning and expression of palmitoyl-protein thioesterase. J. Biol. Chem. 269 (1994) 23212-23219
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23212-23219
-
-
Camp, L.A.1
Verkruyse, L.A.2
Afendis, S.J.3
Slaughter, C.A.4
Hofmann, S.L.5
-
191
-
-
0034624913
-
CSF insulin-like growth factor-1 in infantile neuronal ceroid lipofuscinosis
-
Riikonen R., Vanhanen S.L., Tyynela J., Santavuori P., and Turpeinen U. CSF insulin-like growth factor-1 in infantile neuronal ceroid lipofuscinosis. Neurology 54 (2000) 1828-1832
-
(2000)
Neurology
, vol.54
, pp. 1828-1832
-
-
Riikonen, R.1
Vanhanen, S.L.2
Tyynela, J.3
Santavuori, P.4
Turpeinen, U.5
-
192
-
-
0034924515
-
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis
-
Cho S., Dawson P.E., and Dawson G. Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis. Eur. J. Paediatr. Neurol. 5 Suppl. A (2001) 53-55
-
(2001)
Eur. J. Paediatr. Neurol.
, vol.5
, Issue.SUPPL. A
, pp. 53-55
-
-
Cho, S.1
Dawson, P.E.2
Dawson, G.3
-
193
-
-
0035684428
-
Neurodegenerative disease: the neuronal ceroid lipofuscinoses (Batten disease)
-
Mitchison H.M., and Mole S.E. Neurodegenerative disease: the neuronal ceroid lipofuscinoses (Batten disease). Curr. Opin. Neurol. 14 (2001) 795-803
-
(2001)
Curr. Opin. Neurol.
, vol.14
, pp. 795-803
-
-
Mitchison, H.M.1
Mole, S.E.2
-
194
-
-
0035221979
-
Neuronal ceroid lipofuscinoses: classification and diagnosis
-
Wisniewski K.E., Kida E., Golabek A.A., Kaczmarski W., Connell F., and Zhong N. Neuronal ceroid lipofuscinoses: classification and diagnosis. Adv. Genet. 45 (2001) 1-34
-
(2001)
Adv. Genet.
, vol.45
, pp. 1-34
-
-
Wisniewski, K.E.1
Kida, E.2
Golabek, A.A.3
Kaczmarski, W.4
Connell, F.5
Zhong, N.6
-
195
-
-
0035044121
-
Lysosomal ceroid depletion by drugs: therapeutic implications for a hereditary neurodegenerative disease of childhood
-
Zhang Z., Butler J.D., Levin S.W., Wisniewski K.E., Brooks S.S., and Mukherjee A.B. Lysosomal ceroid depletion by drugs: therapeutic implications for a hereditary neurodegenerative disease of childhood. Nat. Med. 7 (2001) 478-484
-
(2001)
Nat. Med.
, vol.7
, pp. 478-484
-
-
Zhang, Z.1
Butler, J.D.2
Levin, S.W.3
Wisniewski, K.E.4
Brooks, S.S.5
Mukherjee, A.B.6
-
196
-
-
0034667696
-
Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells
-
Cho S., Dawson P.E., and Dawson G. Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells. J. Neurosci. Res. 62 (2000) 234-240
-
(2000)
J. Neurosci. Res.
, vol.62
, pp. 234-240
-
-
Cho, S.1
Dawson, P.E.2
Dawson, G.3
-
197
-
-
0037058655
-
Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line
-
Dawson G., Dawson S.A., Marinzi C., and Dawson P.E. Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line. Cancer Lett. 187 (2002) 163-168
-
(2002)
Cancer Lett.
, vol.187
, pp. 163-168
-
-
Dawson, G.1
Dawson, S.A.2
Marinzi, C.3
Dawson, P.E.4
-
198
-
-
0034071270
-
Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells
-
Cho S., and Dawson G. Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. J. Neurochem. 74 (2000) 1478-1488
-
(2000)
J. Neurochem.
, vol.74
, pp. 1478-1488
-
-
Cho, S.1
Dawson, G.2
-
199
-
-
2642534561
-
An over-expression system for characterizing Ppt1 function in Drosophila
-
Korey C.A., and MacDonald M.E. An over-expression system for characterizing Ppt1 function in Drosophila. BMC Neurosci. 4 (2003) 30
-
(2003)
BMC Neurosci.
, vol.4
, pp. 30
-
-
Korey, C.A.1
MacDonald, M.E.2
-
200
-
-
0029147298
-
Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease Consortium
-
Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease Consortium. Cell 82 (1995) 949-957
-
(1995)
Cell
, vol.82
, pp. 949-957
-
-
-
201
-
-
0033808715
-
Neuronal ceroid lipofuscinoses and possible pathogenic mechanism
-
Zhong N. Neuronal ceroid lipofuscinoses and possible pathogenic mechanism. Mol. Genet. Metab. 71 (2000) 195-206
-
(2000)
Mol. Genet. Metab.
, vol.71
, pp. 195-206
-
-
Zhong, N.1
-
202
-
-
0030833658
-
Upregulation of Bcl-2 and elevation of ceramide in Batten disease
-
Puranam K., Qian W.H., Nikbakht K., Venable M., Obeid L., Hannun Y., and Boustany R.M. Upregulation of Bcl-2 and elevation of ceramide in Batten disease. Neuropediatrics 28 (1997) 37-41
-
(1997)
Neuropediatrics
, vol.28
, pp. 37-41
-
-
Puranam, K.1
Qian, W.H.2
Nikbakht, K.3
Venable, M.4
Obeid, L.5
Hannun, Y.6
Boustany, R.M.7
-
203
-
-
0032799217
-
CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide
-
Puranam K.L., Guo W.X., Qian W.H., Nikbakht K., and Boustany R.M. CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. Mol. Genet. Metab. 66 (1999) 294-308
-
(1999)
Mol. Genet. Metab.
, vol.66
, pp. 294-308
-
-
Puranam, K.L.1
Guo, W.X.2
Qian, W.H.3
Nikbakht, K.4
Boustany, R.M.5
-
204
-
-
0036468256
-
The CLN3 gene is a novel molecular target for cancer drug discovery
-
Rylova S.N., Amalfitano A., Persaud-Sawin D.A., Guo W.X., Chang J., Jansen P.J., Proia A.D., and Boustany R.M. The CLN3 gene is a novel molecular target for cancer drug discovery. Cancer Res. 62 (2002) 801-808
-
(2002)
Cancer Res.
, vol.62
, pp. 801-808
-
-
Rylova, S.N.1
Amalfitano, A.2
Persaud-Sawin, D.A.3
Guo, W.X.4
Chang, J.5
Jansen, P.J.6
Proia, A.D.7
Boustany, R.M.8
-
205
-
-
0036712747
-
Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis
-
Persaud-Sawin D.A., VanDongen A., and Boustany R.M. Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis. Hum. Mol. Genet. 11 (2002) 2129-2142
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2129-2142
-
-
Persaud-Sawin, D.A.1
VanDongen, A.2
Boustany, R.M.3
-
207
-
-
0034912692
-
Lamp-1 is upregulated in human glioblastoma cell lines induced to undergo apoptosis
-
Chen J.W., Madamanchi N., Madamanchi N.R., Trier T.T., and Keherly M.J. Lamp-1 is upregulated in human glioblastoma cell lines induced to undergo apoptosis. J. Biomed. Sci. 8 (2001) 365-374
-
(2001)
J. Biomed. Sci.
, vol.8
, pp. 365-374
-
-
Chen, J.W.1
Madamanchi, N.2
Madamanchi, N.R.3
Trier, T.T.4
Keherly, M.J.5
-
208
-
-
0037413688
-
Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor
-
Cuervo A.M., Mann L., Bonten E.J., d'Azzo A., and Dice J.F. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J. 22 (2003) 47-59
-
(2003)
EMBO J.
, vol.22
, pp. 47-59
-
-
Cuervo, A.M.1
Mann, L.2
Bonten, E.J.3
d'Azzo, A.4
Dice, J.F.5
-
209
-
-
23844483152
-
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
-
Gonzalez-Polo R.A., Boya P., Pauleau A.L., Jalil A., Larochette N., Souquere S., Eskelinen E.L., Pierron G., Saftig P., and Kroemer G. The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J. Cell Sci. 118 (2005) 3091-3102
-
(2005)
J. Cell Sci.
, vol.118
, pp. 3091-3102
-
-
Gonzalez-Polo, R.A.1
Boya, P.2
Pauleau, A.L.3
Jalil, A.4
Larochette, N.5
Souquere, S.6
Eskelinen, E.L.7
Pierron, G.8
Saftig, P.9
Kroemer, G.10
-
210
-
-
0037062449
-
Neuronal loss and brain atrophy in mice lacking cathepsins B and L
-
Felbor U., Kessler B., Mothes W., Goebel H.H., Ploegh H.L., Bronson R.T., and Olsen B.R. Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 7883-7888
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 7883-7888
-
-
Felbor, U.1
Kessler, B.2
Mothes, W.3
Goebel, H.H.4
Ploegh, H.L.5
Bronson, R.T.6
Olsen, B.R.7
-
211
-
-
0029083689
-
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
-
Saftig P., Hetman M., Schmahl W., Weber K., Heine L., Mossmann H., Koster A., Hess B., Evers M., von Figura K., et al. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J. 14 (1995) 3599-3608
-
(1995)
EMBO J.
, vol.14
, pp. 3599-3608
-
-
Saftig, P.1
Hetman, M.2
Schmahl, W.3
Weber, K.4
Heine, L.5
Mossmann, H.6
Koster, A.7
Hess, B.8
Evers, M.9
von Figura, K.10
-
212
-
-
0035478732
-
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice
-
Nakanishi H., Zhang J., Koike M., Nishioku T., Okamoto Y., Kominami E., von Figura K., Peters C., Yamamoto K., Saftig P., and Uchiyama Y. Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J. Neurosci. 21 (2001) 7526-7533
-
(2001)
J. Neurosci.
, vol.21
, pp. 7526-7533
-
-
Nakanishi, H.1
Zhang, J.2
Koike, M.3
Nishioku, T.4
Okamoto, Y.5
Kominami, E.6
von Figura, K.7
Peters, C.8
Yamamoto, K.9
Saftig, P.10
Uchiyama, Y.11
-
213
-
-
0037301337
-
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
-
Koike M., Shibata M., Ohsawa Y., Nakanishi H., Koga T., Kametaka S., Waguri S., Momoi T., Kominami E., Peters C., Figura K., Saftig P., and Uchiyama Y. Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol. Cell. Neurosci. 22 (2003) 146-161
-
(2003)
Mol. Cell. Neurosci.
, vol.22
, pp. 146-161
-
-
Koike, M.1
Shibata, M.2
Ohsawa, Y.3
Nakanishi, H.4
Koga, T.5
Kametaka, S.6
Waguri, S.7
Momoi, T.8
Kominami, E.9
Peters, C.10
Figura, K.11
Saftig, P.12
Uchiyama, Y.13
-
214
-
-
0036790377
-
Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model
-
Rakoczy P.E., Zhang D., Robertson T., Barnett N.L., Papadimitriou J., Constable I.J., and Lai C.M. Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am. J. Pathol. 161 (2002) 1515-1524
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1515-1524
-
-
Rakoczy, P.E.1
Zhang, D.2
Robertson, T.3
Barnett, N.L.4
Papadimitriou, J.5
Constable, I.J.6
Lai, C.M.7
-
215
-
-
0034659833
-
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration
-
Tyynela J., Sohar I., Sleat D.E., Gin R.M., Donnelly R.J., Baumann M., Haltia M., and Lobel P. A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. EMBO J. 19 (2000) 2786-2792
-
(2000)
EMBO J.
, vol.19
, pp. 2786-2792
-
-
Tyynela, J.1
Sohar, I.2
Sleat, D.E.3
Gin, R.M.4
Donnelly, R.J.5
Baumann, M.6
Haltia, M.7
Lobel, P.8
-
216
-
-
0035923662
-
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice
-
Gupta P., Soyombo A.A., Atashband A., Wisniewski K.E., Shelton J.M., Richardson J.A., Hammer R.E., and Hofmann S.L. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 13566-13571
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 13566-13571
-
-
Gupta, P.1
Soyombo, A.A.2
Atashband, A.3
Wisniewski, K.E.4
Shelton, J.M.5
Richardson, J.A.6
Hammer, R.E.7
Hofmann, S.L.8
-
217
-
-
0029014350
-
Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)
-
Otterbach B., and Stoffel W. Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease). Cell 81 (1995) 1053-1061
-
(1995)
Cell
, vol.81
, pp. 1053-1061
-
-
Otterbach, B.1
Stoffel, W.2
-
218
-
-
0029012443
-
Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease
-
Horinouchi K., Erlich S., Perl D.P., Ferlinz K., Bisgaier C.L., Sandhoff K., Desnick R.J., Stewart C.L., and Schuchman E.H. Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nat. Genet. 10 (1995) 288-293
-
(1995)
Nat. Genet.
, vol.10
, pp. 288-293
-
-
Horinouchi, K.1
Erlich, S.2
Perl, D.P.3
Ferlinz, K.4
Bisgaier, C.L.5
Sandhoff, K.6
Desnick, R.J.7
Stewart, C.L.8
Schuchman, E.H.9
-
219
-
-
0037194598
-
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis
-
Berchem G., Glondu M., Gleizes M., Brouillet J.P., Vignon F., Garcia M., and Liaudet-Coopman E. Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis. Oncogene 21 (2002) 5951-5955
-
(2002)
Oncogene
, vol.21
, pp. 5951-5955
-
-
Berchem, G.1
Glondu, M.2
Gleizes, M.3
Brouillet, J.P.4
Vignon, F.5
Garcia, M.6
Liaudet-Coopman, E.7
-
220
-
-
0027597695
-
Immunohistologic evaluation of invasion-associated proteases in breast carcinoma
-
Visscher D.W., Sarkar F., LoRusso P., Sakr W., Ottosen S., Wykes S., and Crissman J.D. Immunohistologic evaluation of invasion-associated proteases in breast carcinoma. Mod. Pathol. 6 (1993) 302-306
-
(1993)
Mod. Pathol.
, vol.6
, pp. 302-306
-
-
Visscher, D.W.1
Sarkar, F.2
LoRusso, P.3
Sakr, W.4
Ottosen, S.5
Wykes, S.6
Crissman, J.D.7
-
221
-
-
0036125256
-
Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes
-
Bremer C., Tung C.H., Bogdanov Jr. A., and Weissleder R. Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology 222 (2002) 814-818
-
(2002)
Radiology
, vol.222
, pp. 814-818
-
-
Bremer, C.1
Tung, C.H.2
Bogdanov Jr., A.3
Weissleder, R.4
-
222
-
-
1842784435
-
Evaluation of changes in the activity of proteolytic enzymes and their inhibitors in the processes that accompany the growth of gastric cancer
-
Kielan W., Suzanowicz J., SiewiNski M., Saleh Y., Janocha A., Skalski A., and Tarnawa R. Evaluation of changes in the activity of proteolytic enzymes and their inhibitors in the processes that accompany the growth of gastric cancer. Gastric Cancer 7 (2004) 17-23
-
(2004)
Gastric Cancer
, vol.7
, pp. 17-23
-
-
Kielan, W.1
Suzanowicz, J.2
SiewiNski, M.3
Saleh, Y.4
Janocha, A.5
Skalski, A.6
Tarnawa, R.7
-
223
-
-
15544384612
-
Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells
-
Nomura T., and Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J. Med. Invest. 52 (2005) 1-9
-
(2005)
J. Med. Invest.
, vol.52
, pp. 1-9
-
-
Nomura, T.1
Katunuma, N.2
-
224
-
-
0029021787
-
Tissue cathepsins as tumor markers
-
Schwartz M.K. Tissue cathepsins as tumor markers. Clin. Chim. Acta 237 (1995) 67-78
-
(1995)
Clin. Chim. Acta
, vol.237
, pp. 67-78
-
-
Schwartz, M.K.1
-
225
-
-
0030848054
-
Lysosomal cysteine peptidases and malignant tumours
-
Kirschke H. Lysosomal cysteine peptidases and malignant tumours. Adv. Exp. Med. Biol. 421 (1997) 253-257
-
(1997)
Adv. Exp. Med. Biol.
, vol.421
, pp. 253-257
-
-
Kirschke, H.1
-
226
-
-
0031932089
-
Cysteine proteinases in cancer progression and their clinical relevance for prognosis
-
Lah T.T., and Kos J. Cysteine proteinases in cancer progression and their clinical relevance for prognosis. Biol. Chem. 379 (1998) 125-130
-
(1998)
Biol. Chem.
, vol.379
, pp. 125-130
-
-
Lah, T.T.1
Kos, J.2
-
227
-
-
0034128337
-
Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer
-
Kos J., Werle B., Lah T., and Brunner N. Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer. Int. J. Biol. Markers 15 (2000) 84-89
-
(2000)
Int. J. Biol. Markers
, vol.15
, pp. 84-89
-
-
Kos, J.1
Werle, B.2
Lah, T.3
Brunner, N.4
-
228
-
-
0034651918
-
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview
-
Rochefort H., Garcia M., Glondu M., Laurent V., Liaudet E., Rey J.M., and Roger P. Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview. Clin. Chim. Acta 291 (2000) 157-170
-
(2000)
Clin. Chim. Acta
, vol.291
, pp. 157-170
-
-
Rochefort, H.1
Garcia, M.2
Glondu, M.3
Laurent, V.4
Liaudet, E.5
Rey, J.M.6
Roger, P.7
-
229
-
-
1542604677
-
Cysteine proteases as disease markers
-
Berdowska I. Cysteine proteases as disease markers. Clin. Chim. Acta 342 (2004) 41-69
-
(2004)
Clin. Chim. Acta
, vol.342
, pp. 41-69
-
-
Berdowska, I.1
-
230
-
-
0028284099
-
Evaluation of cathepsin D as prognostic predictor in breast cancer
-
Barbi G.P., Margallo E., Margiocco M., Paganuzzi M., Marroni P., Costanzi B., Gatteschi B., Tanara G., Spina B., and Nicolo G. Evaluation of cathepsin D as prognostic predictor in breast cancer. Oncology 51 (1994) 329-333
-
(1994)
Oncology
, vol.51
, pp. 329-333
-
-
Barbi, G.P.1
Margallo, E.2
Margiocco, M.3
Paganuzzi, M.4
Marroni, P.5
Costanzi, B.6
Gatteschi, B.7
Tanara, G.8
Spina, B.9
Nicolo, G.10
-
231
-
-
0029023660
-
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer
-
Thomssen C., Schmitt M., Goretzki L., Oppelt P., Pache L., Dettmar P., Janicke F., and Graeff H. Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer. Clin. Cancer Res. 1 (1995) 741-746
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 741-746
-
-
Thomssen, C.1
Schmitt, M.2
Goretzki, L.3
Oppelt, P.4
Pache, L.5
Dettmar, P.6
Janicke, F.7
Graeff, H.8
-
232
-
-
0842332175
-
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density
-
Losch A., Schindl M., Kohlberger P., Lahodny J., Breitenecker G., Horvat R., and Birner P. Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density. Gynecol. Oncol. 92 (2004) 545-552
-
(2004)
Gynecol. Oncol.
, vol.92
, pp. 545-552
-
-
Losch, A.1
Schindl, M.2
Kohlberger, P.3
Lahodny, J.4
Breitenecker, G.5
Horvat, R.6
Birner, P.7
-
233
-
-
0037298745
-
A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics
-
Musumarra G., Barresi V., Condorelli D.F., and Scire S. A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics. Biol. Chem. 384 (2003) 321-327
-
(2003)
Biol. Chem.
, vol.384
, pp. 321-327
-
-
Musumarra, G.1
Barresi, V.2
Condorelli, D.F.3
Scire, S.4
-
234
-
-
0031685364
-
Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)
-
Kos J., and Lah T.T. Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review). Oncol. Rep. 5 (1998) 1349-1361
-
(1998)
Oncol. Rep.
, vol.5
, pp. 1349-1361
-
-
Kos, J.1
Lah, T.T.2
-
236
-
-
10044296973
-
Cysteine cathepsins in human cancer
-
Jedeszko C., and Sloane B.F. Cysteine cathepsins in human cancer. Biol. Chem. 385 (2004) 1017-1027
-
(2004)
Biol. Chem.
, vol.385
, pp. 1017-1027
-
-
Jedeszko, C.1
Sloane, B.F.2
-
237
-
-
7544243714
-
The potentials of MS-based subproteomic approaches in medical science: the case of lysosomes and breast cancer
-
Journet A., and Ferro M. The potentials of MS-based subproteomic approaches in medical science: the case of lysosomes and breast cancer. Mass Spectrom. Rev. 23 (2004) 393-442
-
(2004)
Mass Spectrom. Rev.
, vol.23
, pp. 393-442
-
-
Journet, A.1
Ferro, M.2
-
238
-
-
1842404183
-
Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts
-
Isidoro C., Demoz M., De Stefanis D., Baccino F.M., Hasilik A., and Bonelli G. Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts. Int. J. Cancer 70 (1997) 310-314
-
(1997)
Int. J. Cancer
, vol.70
, pp. 310-314
-
-
Isidoro, C.1
Demoz, M.2
De Stefanis, D.3
Baccino, F.M.4
Hasilik, A.5
Bonelli, G.6
-
239
-
-
0032468335
-
Malignant transformation alters intracellular trafficking of lysosomal cathepsin D in human breast epithelial cells
-
Nishimura Y., Sameni M., and Sloane B.F. Malignant transformation alters intracellular trafficking of lysosomal cathepsin D in human breast epithelial cells. Pathol. Oncol. Res. 4 (1998) 283-296
-
(1998)
Pathol. Oncol. Res.
, vol.4
, pp. 283-296
-
-
Nishimura, Y.1
Sameni, M.2
Sloane, B.F.3
-
240
-
-
0345280022
-
Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D
-
Demoz M., Castino R., Dragonetti A., Raiteri E., Baccino F.M., and Isidoro C. Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D. J. Cell. Biochem. 73 (1999) 370-378
-
(1999)
J. Cell. Biochem.
, vol.73
, pp. 370-378
-
-
Demoz, M.1
Castino, R.2
Dragonetti, A.3
Raiteri, E.4
Baccino, F.M.5
Isidoro, C.6
-
241
-
-
0029889370
-
Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene
-
Donatien P.D., Diment S.L., Boissy R.E., and Orlow S.J. Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene. Int. J. Cancer 66 (1996) 557-563
-
(1996)
Int. J. Cancer
, vol.66
, pp. 557-563
-
-
Donatien, P.D.1
Diment, S.L.2
Boissy, R.E.3
Orlow, S.J.4
-
242
-
-
0028273525
-
Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene
-
Sloane B.F., Moin K., Sameni M., Tait L.R., Rozhin J., and Ziegler G. Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene. J. Cell Sci. 107 Pt. 2 (1994) 373-384
-
(1994)
J. Cell Sci.
, vol.107
, Issue.PART 2
, pp. 373-384
-
-
Sloane, B.F.1
Moin, K.2
Sameni, M.3
Tait, L.R.4
Rozhin, J.5
Ziegler, G.6
-
243
-
-
0028066935
-
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth
-
Weber E., Gunther D., Laube F., Wiederanders B., and Kirschke H. Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth. J. Cancer Res. Clin. Oncol. 120 (1994) 564-567
-
(1994)
J. Cancer Res. Clin. Oncol.
, vol.120
, pp. 564-567
-
-
Weber, E.1
Gunther, D.2
Laube, F.3
Wiederanders, B.4
Kirschke, H.5
-
244
-
-
0034075042
-
Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells
-
Kirschke H., Eerola R., Hopsu-Havu V.K., Bromme D., and Vuorio E. Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells. Eur. J. Cancer 36 (2000) 787-795
-
(2000)
Eur. J. Cancer
, vol.36
, pp. 787-795
-
-
Kirschke, H.1
Eerola, R.2
Hopsu-Havu, V.K.3
Bromme, D.4
Vuorio, E.5
-
245
-
-
0030320775
-
Tumor progression and angiogenesis: cathepsin B and Co
-
Keppler D., Sameni M., Moin K., Mikkelsen T., Diglio C.A., and Sloane B.F. Tumor progression and angiogenesis: cathepsin B and Co. Biochem. Cell. Biol. 74 (1996) 799-810
-
(1996)
Biochem. Cell. Biol.
, vol.74
, pp. 799-810
-
-
Keppler, D.1
Sameni, M.2
Moin, K.3
Mikkelsen, T.4
Diglio, C.A.5
Sloane, B.F.6
-
246
-
-
1842538729
-
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis
-
Yanamandra N., Gumidyala K.V., Waldron K.G., Gujrati M., Olivero W.C., Dinh D.H., Rao J.S., and Mohanam S. Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis. Oncogene 23 (2004) 2224-2230
-
(2004)
Oncogene
, vol.23
, pp. 2224-2230
-
-
Yanamandra, N.1
Gumidyala, K.V.2
Waldron, K.G.3
Gujrati, M.4
Olivero, W.C.5
Dinh, D.H.6
Rao, J.S.7
Mohanam, S.8
-
247
-
-
1342344183
-
Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma
-
Kruszewski W.J., Rzepko R., Wojtacki J., Skokowski J., Kopacz A., Jaskiewicz K., and Drucis K. Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma. Neoplasma 51 (2004) 38-43
-
(2004)
Neoplasma
, vol.51
, pp. 38-43
-
-
Kruszewski, W.J.1
Rzepko, R.2
Wojtacki, J.3
Skokowski, J.4
Kopacz, A.5
Jaskiewicz, K.6
Drucis, K.7
-
248
-
-
0032782127
-
Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases
-
Kostoulas G., Lang A., Nagase H., and Baici A. Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases. FEBS Lett. 455 (1999) 286-290
-
(1999)
FEBS Lett.
, vol.455
, pp. 286-290
-
-
Kostoulas, G.1
Lang, A.2
Nagase, H.3
Baici, A.4
-
249
-
-
3242740399
-
The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity
-
Tzanakakis G.N., Margioris A.N., Tsatsakis A.M., and Vezeridis M.P. The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity. Int. J. Gastrointest. Cancer 34 (2003) 27-38
-
(2003)
Int. J. Gastrointest. Cancer
, vol.34
, pp. 27-38
-
-
Tzanakakis, G.N.1
Margioris, A.N.2
Tsatsakis, A.M.3
Vezeridis, M.P.4
-
250
-
-
0034255167
-
Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma
-
Dohchin A., Suzuki J.I., Seki H., Masutani M., Shiroto H., and Kawakami Y. Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma. Cancer 89 (2000) 482-487
-
(2000)
Cancer
, vol.89
, pp. 482-487
-
-
Dohchin, A.1
Suzuki, J.I.2
Seki, H.3
Masutani, M.4
Shiroto, H.5
Kawakami, Y.6
-
251
-
-
0032834905
-
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C
-
Coulibaly S., Schwihla H., Abrahamson M., Albini A., Cerni C., Clark J.L., Ng K.M., Katunuma N., Schlappack O., Glossl J., and Mach L. Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C. Int. J. Cancer 83 (1999) 526-531
-
(1999)
Int. J. Cancer
, vol.83
, pp. 526-531
-
-
Coulibaly, S.1
Schwihla, H.2
Abrahamson, M.3
Albini, A.4
Cerni, C.5
Clark, J.L.6
Ng, K.M.7
Katunuma, N.8
Schlappack, O.9
Glossl, J.10
Mach, L.11
-
252
-
-
0038644575
-
Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors
-
Bervar A., Zajc I., Sever N., Katunuma N., Sloane B.F., and Lah T.T. Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors. Biol. Chem. 384 (2003) 447-455
-
(2003)
Biol. Chem.
, vol.384
, pp. 447-455
-
-
Bervar, A.1
Zajc, I.2
Sever, N.3
Katunuma, N.4
Sloane, B.F.5
Lah, T.T.6
-
253
-
-
9144231998
-
RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
-
Gondi C.S., Lakka S.S., Dinh D.H., Olivero W.C., Gujrati M., and Rao J.S. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 23 (2004) 8486-8496
-
(2004)
Oncogene
, vol.23
, pp. 8486-8496
-
-
Gondi, C.S.1
Lakka, S.S.2
Dinh, D.H.3
Olivero, W.C.4
Gujrati, M.5
Rao, J.S.6
-
254
-
-
3042551389
-
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas
-
Gondi C.S., Lakka S.S., Yanamandra N., Olivero W.C., Dinh D.H., Gujrati M., Tung C.H., Weissleder R., and Rao J.S. Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas. Cancer Res. 64 (2004) 4069-4077
-
(2004)
Cancer Res.
, vol.64
, pp. 4069-4077
-
-
Gondi, C.S.1
Lakka, S.S.2
Yanamandra, N.3
Olivero, W.C.4
Dinh, D.H.5
Gujrati, M.6
Tung, C.H.7
Weissleder, R.8
Rao, J.S.9
-
255
-
-
2942718949
-
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
-
Lakka S.S., Gondi C.S., Yanamandra N., Olivero W.C., Dinh D.H., Gujrati M., and Rao J.S. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 23 (2004) 4681-4689
-
(2004)
Oncogene
, vol.23
, pp. 4681-4689
-
-
Lakka, S.S.1
Gondi, C.S.2
Yanamandra, N.3
Olivero, W.C.4
Dinh, D.H.5
Gujrati, M.6
Rao, J.S.7
-
256
-
-
2342603891
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
-
Joyce J.A., Baruch A., Chehade K., Meyer-Morse N., Giraudo E., Tsai F.Y., Greenbaum D.C., Hager J.H., Bogyo M., and Hanahan D. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5 (2004) 443-453
-
(2004)
Cancer Cell
, vol.5
, pp. 443-453
-
-
Joyce, J.A.1
Baruch, A.2
Chehade, K.3
Meyer-Morse, N.4
Giraudo, E.5
Tsai, F.Y.6
Greenbaum, D.C.7
Hager, J.H.8
Bogyo, M.9
Hanahan, D.10
-
257
-
-
0032126503
-
Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells
-
Frade R., Rodrigues-Lima F., Huang S., Xie K., Guillaume N., and Bar-Eli M. Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells. Cancer Res. 58 (1998) 2733-2736
-
(1998)
Cancer Res.
, vol.58
, pp. 2733-2736
-
-
Frade, R.1
Rodrigues-Lima, F.2
Huang, S.3
Xie, K.4
Guillaume, N.5
Bar-Eli, M.6
-
258
-
-
1642535587
-
Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment
-
Rousselet N., Mills L., Jean D., Tellez C., Bar-Eli M., and Frade R. Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment. Cancer Res. 64 (2004) 146-151
-
(2004)
Cancer Res.
, vol.64
, pp. 146-151
-
-
Rousselet, N.1
Mills, L.2
Jean, D.3
Tellez, C.4
Bar-Eli, M.5
Frade, R.6
-
259
-
-
0037191505
-
Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines
-
Colella R., Goodwyn E., and Gopal P. Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines. Cancer Lett. 185 (2002) 163-172
-
(2002)
Cancer Lett.
, vol.185
, pp. 163-172
-
-
Colella, R.1
Goodwyn, E.2
Gopal, P.3
-
260
-
-
0041382248
-
Decreased activity of cathepsins L+B and decreased invasive ability of PC3 prostate cancer cells
-
Colella R., and Casey S.F. Decreased activity of cathepsins L+B and decreased invasive ability of PC3 prostate cancer cells. Biotech. Histochem. 78 (2003) 101-108
-
(2003)
Biotech. Histochem.
, vol.78
, pp. 101-108
-
-
Colella, R.1
Casey, S.F.2
-
261
-
-
1842591219
-
Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells
-
Shridhar R., Zhang J., Song J., Booth B.A., Kevil C.G., Sotiropoulou G., Sloane B.F., and Keppler D. Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells. Oncogene 23 (2004) 2206-2215
-
(2004)
Oncogene
, vol.23
, pp. 2206-2215
-
-
Shridhar, R.1
Zhang, J.2
Song, J.3
Booth, B.A.4
Kevil, C.G.5
Sotiropoulou, G.6
Sloane, B.F.7
Keppler, D.8
-
262
-
-
4944252978
-
Cystatin m: a novel candidate tumor suppressor gene for breast cancer
-
Zhang J., Shridhar R., Dai Q., Song J., Barlow S.C., Yin L., Sloane B.F., Miller F.R., Meschonat C., Li B.D., Abreo F., and Keppler D. Cystatin m: a novel candidate tumor suppressor gene for breast cancer. Cancer Res. 64 (2004) 6957-6964
-
(2004)
Cancer Res.
, vol.64
, pp. 6957-6964
-
-
Zhang, J.1
Shridhar, R.2
Dai, Q.3
Song, J.4
Barlow, S.C.5
Yin, L.6
Sloane, B.F.7
Miller, F.R.8
Meschonat, C.9
Li, B.D.10
Abreo, F.11
Keppler, D.12
-
263
-
-
0026753602
-
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma
-
Nazeer T., Malfetano J.H., Rosano T.G., and Ross J.S. Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma. Am. J. Clin. Pathol. 97 (1992) 764-769
-
(1992)
Am. J. Clin. Pathol.
, vol.97
, pp. 764-769
-
-
Nazeer, T.1
Malfetano, J.H.2
Rosano, T.G.3
Ross, J.S.4
-
264
-
-
0029099015
-
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors
-
Liaudet E., Derocq D., Rochefort H., and Garcia M. Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors. Cell Growth Differ. 6 (1995) 1045-1052
-
(1995)
Cell Growth Differ.
, vol.6
, pp. 1045-1052
-
-
Liaudet, E.1
Derocq, D.2
Rochefort, H.3
Garcia, M.4
-
265
-
-
0029838059
-
Biological and clinical significance of cathepsin D in breast cancer metastasis
-
Garcia M., Platet N., Liaudet E., Laurent V., Derocq D., Brouillet J.P., and Rochefort H. Biological and clinical significance of cathepsin D in breast cancer metastasis. Stem. Cells 14 (1996) 642-650
-
(1996)
Stem. Cells
, vol.14
, pp. 642-650
-
-
Garcia, M.1
Platet, N.2
Liaudet, E.3
Laurent, V.4
Derocq, D.5
Brouillet, J.P.6
Rochefort, H.7
-
266
-
-
0036676298
-
Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells
-
Glondu M., Liaudet-Coopman E., Derocq D., Platet N., Rochefort H., and Garcia M. Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells. Oncogene 21 (2002) 5127-5134
-
(2002)
Oncogene
, vol.21
, pp. 5127-5134
-
-
Glondu, M.1
Liaudet-Coopman, E.2
Derocq, D.3
Platet, N.4
Rochefort, H.5
Garcia, M.6
-
267
-
-
0030928653
-
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis
-
Yamada T., De Souza A.T., Finkelstein S., and Jirtle R.L. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 10351-10355
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 10351-10355
-
-
Yamada, T.1
De Souza, A.T.2
Finkelstein, S.3
Jirtle, R.L.4
-
268
-
-
0028804071
-
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
-
De Souza A.T., Hankins G.R., Washington M.K., Orton T.C., and Jirtle R.L. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Genet. 11 (1995) 447-449
-
(1995)
Nat. Genet.
, vol.11
, pp. 447-449
-
-
De Souza, A.T.1
Hankins, G.R.2
Washington, M.K.3
Orton, T.C.4
Jirtle, R.L.5
-
269
-
-
0034673761
-
M6P/IGF2R is mutated in squamous cell carcinoma of the lung
-
Kong F.M., Anscher M.S., Washington M.K., Killian J.K., and Jirtle R.L. M6P/IGF2R is mutated in squamous cell carcinoma of the lung. Oncogene 19 (2000) 1572-1578
-
(2000)
Oncogene
, vol.19
, pp. 1572-1578
-
-
Kong, F.M.1
Anscher, M.S.2
Washington, M.K.3
Killian, J.K.4
Jirtle, R.L.5
-
270
-
-
14444287748
-
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum
-
Ouyang H., Shiwaku H.O., Hagiwara H., Miura K., Abe T., Kato Y., Ohtani H., Shiiba K., Souza R.F., Meltzer S.J., and Horii A. The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum. Cancer Res. 57 (1997) 1851-1854
-
(1997)
Cancer Res.
, vol.57
, pp. 1851-1854
-
-
Ouyang, H.1
Shiwaku, H.O.2
Hagiwara, H.3
Miura, K.4
Abe, T.5
Kato, Y.6
Ohtani, H.7
Shiiba, K.8
Souza, R.F.9
Meltzer, S.J.10
Horii, A.11
-
271
-
-
16144368515
-
Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours
-
Souza R.F., Appel R., Yin J., Wang S., Smolinski K.N., Abraham J.M., Zou T.T., Shi Y.Q., Lei J., Cottrell J., Cymes K., Biden K., Simms L., Leggett B., Lynch P.M., Frazier M., Powell S.M., Harpaz N., Sugimura H., Young J., and Meltzer S.J. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat. Genet. 14 (1996) 255-257
-
(1996)
Nat. Genet.
, vol.14
, pp. 255-257
-
-
Souza, R.F.1
Appel, R.2
Yin, J.3
Wang, S.4
Smolinski, K.N.5
Abraham, J.M.6
Zou, T.T.7
Shi, Y.Q.8
Lei, J.9
Cottrell, J.10
Cymes, K.11
Biden, K.12
Simms, L.13
Leggett, B.14
Lynch, P.M.15
Frazier, M.16
Powell, S.M.17
Harpaz, N.18
Sugimura, H.19
Young, J.20
Meltzer, S.J.21
more..
-
272
-
-
0034322379
-
Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract
-
Caligo M.A., Ghimenti C., Sensi E., Marchetti A., Bertacca G., Giulianotti P.G., Fornaciari G., and Bevilacqua G. Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract. Oncol. Rep. 7 (2000) 1371-1375
-
(2000)
Oncol. Rep.
, vol.7
, pp. 1371-1375
-
-
Caligo, M.A.1
Ghimenti, C.2
Sensi, E.3
Marchetti, A.4
Bertacca, G.5
Giulianotti, P.G.6
Fornaciari, G.7
Bevilacqua, G.8
-
273
-
-
0033946516
-
Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: a study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR and BLM genes
-
Calin G.A., Gafa R., Tibiletti M.G., Herlea V., Becheanu G., Cavazzini L., Barbanti-Brodano G., Nenci I., Negrini M., and Lanza G. Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: a study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR and BLM genes. Int. J. Cancer 89 (2000) 230-235
-
(2000)
Int. J. Cancer
, vol.89
, pp. 230-235
-
-
Calin, G.A.1
Gafa, R.2
Tibiletti, M.G.3
Herlea, V.4
Becheanu, G.5
Cavazzini, L.6
Barbanti-Brodano, G.7
Nenci, I.8
Negrini, M.9
Lanza, G.10
-
274
-
-
0029934868
-
M6P/IGF2 receptor: a candidate breast tumor suppressor gene
-
Hankins G.R., De Souza A.T., Bentley R.C., Patel M.R., Marks J.R., Iglehart J.D., and Jirtle R.L. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene 12 (1996) 2003-2009
-
(1996)
Oncogene
, vol.12
, pp. 2003-2009
-
-
Hankins, G.R.1
De Souza, A.T.2
Bentley, R.C.3
Patel, M.R.4
Marks, J.R.5
Iglehart, J.D.6
Jirtle, R.L.7
-
275
-
-
0037402558
-
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines
-
Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.F., Schlag P.M., and Scherneck S. Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. Genes Chromosomes Cancer 37 (2003) 29-35
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 29-35
-
-
Seitz, S.1
Wassmuth, P.2
Plaschke, J.3
Schackert, H.K.4
Karsten, U.5
Santibanez-Koref, M.F.6
Schlag, P.M.7
Scherneck, S.8
-
276
-
-
3042831739
-
M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis
-
Jamieson T.A., Brizel D.M., Killian J.K., Oka Y., Jang H.S., Fu X., Clough R.W., Vollmer R.T., Anscher M.S., and Jirtle R.L. M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis. BMC Cancer 3 (2003) 4
-
(2003)
BMC Cancer
, vol.3
, pp. 4
-
-
Jamieson, T.A.1
Brizel, D.M.2
Killian, J.K.3
Oka, Y.4
Jang, H.S.5
Fu, X.6
Clough, R.W.7
Vollmer, R.T.8
Anscher, M.S.9
Jirtle, R.L.10
-
277
-
-
11244346678
-
Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2 receptor
-
Li J., and Sahagian G.G. Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2 receptor. Oncogene 23 (2004) 9359-9368
-
(2004)
Oncogene
, vol.23
, pp. 9359-9368
-
-
Li, J.1
Sahagian, G.G.2
-
278
-
-
0033566056
-
Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells
-
Souza R.F., Wang S., Thakar M., Smolinski K.N., Yin J., Zou T.T., Kong D., Abraham J.M., Toretsky J.A., and Meltzer S.J. Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells. Oncogene 18 (1999) 4063-4068
-
(1999)
Oncogene
, vol.18
, pp. 4063-4068
-
-
Souza, R.F.1
Wang, S.2
Thakar, M.3
Smolinski, K.N.4
Yin, J.5
Zou, T.T.6
Kong, D.7
Abraham, J.M.8
Toretsky, J.A.9
Meltzer, S.J.10
-
279
-
-
0036827629
-
Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo
-
O'Gorman D.B., Weiss J., Hettiaratchi A., Firth S.M., and Scott C.D. Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo. Endocrinology 143 (2002) 4287-4294
-
(2002)
Endocrinology
, vol.143
, pp. 4287-4294
-
-
O'Gorman, D.B.1
Weiss, J.2
Hettiaratchi, A.3
Firth, S.M.4
Scott, C.D.5
-
280
-
-
0142117228
-
Increased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo
-
Lee J.S., Weiss J., Martin J.L., and Scott C.D. Increased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo. Int. J. Cancer 107 (2003) 564-570
-
(2003)
Int. J. Cancer
, vol.107
, pp. 564-570
-
-
Lee, J.S.1
Weiss, J.2
Martin, J.L.3
Scott, C.D.4
-
281
-
-
0033571113
-
Decreased insulin-like growth factor-II/mannose 6-phosphate receptor expression enhances tumorigenicity in JEG-3 cells
-
O'Gorman D.B., Costello M., Weiss J., Firth S.M., and Scott C.D. Decreased insulin-like growth factor-II/mannose 6-phosphate receptor expression enhances tumorigenicity in JEG-3 cells. Cancer Res. 59 (1999) 5692-5694
-
(1999)
Cancer Res.
, vol.59
, pp. 5692-5694
-
-
O'Gorman, D.B.1
Costello, M.2
Weiss, J.3
Firth, S.M.4
Scott, C.D.5
-
282
-
-
3042714343
-
Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells
-
Chen Z., Ge Y., Landman N., and Kang J.X. Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells. BMC Cancer 2 (2002) 18
-
(2002)
BMC Cancer
, vol.2
, pp. 18
-
-
Chen, Z.1
Ge, Y.2
Landman, N.3
Kang, J.X.4
-
283
-
-
0027978109
-
Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital
-
Jirtle R.L., Hankins G.R., Reisenbichler H., and Boyer I.J. Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital. Carcinogenesis 15 (1994) 1473-1478
-
(1994)
Carcinogenesis
, vol.15
, pp. 1473-1478
-
-
Jirtle, R.L.1
Hankins, G.R.2
Reisenbichler, H.3
Boyer, I.J.4
-
284
-
-
0029010734
-
Mammary tumor suppression by transforming growth factor beta 1 transgene expression
-
Pierce Jr. D.F., Gorska A.E., Chytil A., Meise K.S., Page D.L., Coffey Jr. R.J., and Moses H.L. Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 4254-4258
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 4254-4258
-
-
Pierce Jr., D.F.1
Gorska, A.E.2
Chytil, A.3
Meise, K.S.4
Page, D.L.5
Coffey Jr., R.J.6
Moses, H.L.7
-
285
-
-
0029100622
-
Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma
-
Sue S.R., Chari R.S., Kong F.M., Mills J.J., Fine R.L., Jirtle R.L., and Meyers W.C. Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma. Ann. Surg. 222 (1995) 171-178
-
(1995)
Ann. Surg.
, vol.222
, pp. 171-178
-
-
Sue, S.R.1
Chari, R.S.2
Kong, F.M.3
Mills, J.J.4
Fine, R.L.5
Jirtle, R.L.6
Meyers, W.C.7
-
286
-
-
0030740663
-
Deficient transforming growth factor-beta1 activation and excessive insulin-like growth factor II (IGFII) expression in IGFII receptor-mutant tumors
-
Wang S., Souza R.F., Kong D., Yin J., Smolinski K.N., Zou T.T., Frank T., Young J., Flanders K.C., Sugimura H., Abraham J.M., and Meltzer S.J. Deficient transforming growth factor-beta1 activation and excessive insulin-like growth factor II (IGFII) expression in IGFII receptor-mutant tumors. Cancer Res. 57 (1997) 2543-2546
-
(1997)
Cancer Res.
, vol.57
, pp. 2543-2546
-
-
Wang, S.1
Souza, R.F.2
Kong, D.3
Yin, J.4
Smolinski, K.N.5
Zou, T.T.6
Frank, T.7
Young, J.8
Flanders, K.C.9
Sugimura, H.10
Abraham, J.M.11
Meltzer, S.J.12
-
287
-
-
0035298103
-
Loss of insulin-like growth factor II receptor expression promotes growth in cancer by increasing intracellular signaling from both IGF-I and insulin receptors
-
Osipo C., Dorman S., and Frankfater A. Loss of insulin-like growth factor II receptor expression promotes growth in cancer by increasing intracellular signaling from both IGF-I and insulin receptors. Exp. Cell Res. 264 (2001) 388-396
-
(2001)
Exp. Cell Res.
, vol.264
, pp. 388-396
-
-
Osipo, C.1
Dorman, S.2
Frankfater, A.3
-
288
-
-
0028880017
-
Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)
-
Bates P., Fisher R., Ward A., Richardson L., Hill D.J., and Graham C.F. Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). Br. J. Cancer 72 (1995) 1189-1193
-
(1995)
Br. J. Cancer
, vol.72
, pp. 1189-1193
-
-
Bates, P.1
Fisher, R.2
Ward, A.3
Richardson, L.4
Hill, D.J.5
Graham, C.F.6
-
289
-
-
0033869531
-
Invasive properties of murine squamous carcinoma cells: secretion of matrix-degrading cathepsins is attributable to a deficiency in the mannose 6-phosphate/insulin-like growth factor II receptor
-
Lorenzo K., Ton P., Clark J.L., Coulibaly S., and Mach L. Invasive properties of murine squamous carcinoma cells: secretion of matrix-degrading cathepsins is attributable to a deficiency in the mannose 6-phosphate/insulin-like growth factor II receptor. Cancer Res. 60 (2000) 4070-4076
-
(2000)
Cancer Res.
, vol.60
, pp. 4070-4076
-
-
Lorenzo, K.1
Ton, P.2
Clark, J.L.3
Coulibaly, S.4
Mach, L.5
-
290
-
-
0037451783
-
Autophagy: a barrier or an adaptive response to cancer
-
Ogier-Denis E., and Codogno P. Autophagy: a barrier or an adaptive response to cancer. Biochim. Biophys. Acta 1603 (2003) 113-128
-
(2003)
Biochim. Biophys. Acta
, vol.1603
, pp. 113-128
-
-
Ogier-Denis, E.1
Codogno, P.2
-
292
-
-
0346998038
-
Defective autophagy leads to cancer
-
Edinger A.L., and Thompson C.B. Defective autophagy leads to cancer. Cancer Cell 4 (2003) 422-424
-
(2003)
Cancer Cell
, vol.4
, pp. 422-424
-
-
Edinger, A.L.1
Thompson, C.B.2
-
293
-
-
4344595626
-
Regulation and role of autophagy in mammalian cells
-
Meijer A.J., and Codogno P. Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 36 (2004) 2445-2462
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2445-2462
-
-
Meijer, A.J.1
Codogno, P.2
-
294
-
-
0344142468
-
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
-
Aita V.M., Liang X.H., Murty V.V., Pincus D.L., Yu W., Cayanis E., Kalachikov S., Gilliam T.C., and Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 59 (1999) 59-65
-
(1999)
Genomics
, vol.59
, pp. 59-65
-
-
Aita, V.M.1
Liang, X.H.2
Murty, V.V.3
Pincus, D.L.4
Yu, W.5
Cayanis, E.6
Kalachikov, S.7
Gilliam, T.C.8
Levine, B.9
-
295
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., and Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402 (1999) 672-676
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
296
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X., Yu J., Bhagat G., Furuya N., Hibshoosh H., Troxel A., Rosen J., Eskelinen E.L., Mizushima N., Ohsumi Y., Cattoretti G., and Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112 (2003) 1809-1820
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
Rosen, J.7
Eskelinen, E.L.8
Mizushima, N.9
Ohsumi, Y.10
Cattoretti, G.11
Levine, B.12
-
297
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z., Jin S., Yang C., Levine A.J., and Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15077-15082
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
298
-
-
0035032723
-
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
-
Kihara A., Kabeya Y., Ohsumi Y., and Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2 (2001) 330-335
-
(2001)
EMBO Rep.
, vol.2
, pp. 330-335
-
-
Kihara, A.1
Kabeya, Y.2
Ohsumi, Y.3
Yoshimori, T.4
-
299
-
-
39049194057
-
The evolutionary conserved domain of Beclin 1 is required for Vps34 binding, autophagy, and tumor suppressor function
-
Furuya N., Yu J., Byfield M., and Levine B. The evolutionary conserved domain of Beclin 1 is required for Vps34 binding, autophagy, and tumor suppressor function. Autophagy 1 (2005) 46-52
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
Yu, J.2
Byfield, M.3
Levine, B.4
-
300
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
Di Cristofano A., and Pandolfi P.P. The multiple roles of PTEN in tumor suppression. Cell 100 (2000) 387-390
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
-
301
-
-
0034912744
-
PTEN and myotubularin: novel phosphoinositide phosphatases
-
Maehama T., Taylor G.S., and Dixon J.E. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu. Rev. Biochem. 70 (2001) 247-279
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 247-279
-
-
Maehama, T.1
Taylor, G.S.2
Dixon, J.E.3
-
302
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Arico S., Petiot A., Bauvy C., Dubbelhuis P.F., Meijer A.J., Codogno P., and Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 276 (2001) 35243-35246
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
Dubbelhuis, P.F.4
Meijer, A.J.5
Codogno, P.6
Ogier-Denis, E.7
-
303
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
Ogretmen B., and Hannun Y.A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev., Cancer 4 (2004) 604-616
-
(2004)
Nat. Rev., Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
304
-
-
3042562282
-
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
-
Daido S., Kanzawa T., Yamamoto A., Takeuchi H., Kondo Y., and Kondo S. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res. 64 (2004) 4286-4293
-
(2004)
Cancer Res.
, vol.64
, pp. 4286-4293
-
-
Daido, S.1
Kanzawa, T.2
Yamamoto, A.3
Takeuchi, H.4
Kondo, Y.5
Kondo, S.6
-
305
-
-
0032988381
-
Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
-
Brunk U.T., and Svensson I. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak. Redox Rep. 4 (1999) 3-11
-
(1999)
Redox Rep.
, vol.4
, pp. 3-11
-
-
Brunk, U.T.1
Svensson, I.2
-
306
-
-
0033436344
-
Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
-
Roberg K., Johansson U., and Ollinger K. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radic. Biol. Med. 27 (1999) 1228-1237
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 1228-1237
-
-
Roberg, K.1
Johansson, U.2
Ollinger, K.3
-
307
-
-
0034677741
-
Induction of cell death by the lysosomotropic detergent MSDH
-
Li W., Yuan X., Nordgren G., Dalen H., Dubowchik G.M., Firestone R.A., and Brunk U.T. Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett. 470 (2000) 35-39
-
(2000)
FEBS Lett.
, vol.470
, pp. 35-39
-
-
Li, W.1
Yuan, X.2
Nordgren, G.3
Dalen, H.4
Dubowchik, G.M.5
Firestone, R.A.6
Brunk, U.T.7
-
308
-
-
0034745672
-
Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy
-
Roberg K. Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy. Lab. Invest. 81 (2001) 149-158
-
(2001)
Lab. Invest.
, vol.81
, pp. 149-158
-
-
Roberg, K.1
-
310
-
-
0043234207
-
Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
-
Bidere N., Lorenzo H.K., Carmona S., Laforge M., Harper F., Dumont C., and Senik A. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J. Biol. Chem. 278 (2003) 31401-31411
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31401-31411
-
-
Bidere, N.1
Lorenzo, H.K.2
Carmona, S.3
Laforge, M.4
Harper, F.5
Dumont, C.6
Senik, A.7
-
311
-
-
11844294713
-
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
-
Erdal H., Berndtsson M., Castro J., Brunk U., Shoshan M.C., and Linder S. Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 192-197
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 192-197
-
-
Erdal, H.1
Berndtsson, M.2
Castro, J.3
Brunk, U.4
Shoshan, M.C.5
Linder, S.6
-
312
-
-
0029284365
-
Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins
-
Turk B., Bieth J.G., Bjork I., Dolenc I., Turk D., Cimerman N., Kos J., Colic A., Stoka V., and Turk V. Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins. Biol. Chem. Hoppe-Seyler 376 (1995) 225-230
-
(1995)
Biol. Chem. Hoppe-Seyler
, vol.376
, pp. 225-230
-
-
Turk, B.1
Bieth, J.G.2
Bjork, I.3
Dolenc, I.4
Turk, D.5
Cimerman, N.6
Kos, J.7
Colic, A.8
Stoka, V.9
Turk, V.10
-
313
-
-
0027459566
-
Kinetics of the pH-induced inactivation of human cathepsin L
-
Turk B., Dolenc I., Turk V., and Bieth J.G. Kinetics of the pH-induced inactivation of human cathepsin L. Biochemistry 32 (1993) 375-380
-
(1993)
Biochemistry
, vol.32
, pp. 375-380
-
-
Turk, B.1
Dolenc, I.2
Turk, V.3
Bieth, J.G.4
-
314
-
-
0037197938
-
Lysosomal destabilization in p53-induced apoptosis
-
Yuan X.M., Li W., Dalen H., Lotem J., Kama R., Sachs L., and Brunk U.T. Lysosomal destabilization in p53-induced apoptosis. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 6286-6291
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 6286-6291
-
-
Yuan, X.M.1
Li, W.2
Dalen, H.3
Lotem, J.4
Kama, R.5
Sachs, L.6
Brunk, U.T.7
-
315
-
-
0033538073
-
Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling
-
Schutze S., Machleidt T., Adam D., Schwandner R., Wiegmann K., Kruse M.L., Heinrich M., Wickel M., and Kronke M. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. J. Biol. Chem. 274 (1999) 10203-10212
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10203-10212
-
-
Schutze, S.1
Machleidt, T.2
Adam, D.3
Schwandner, R.4
Wiegmann, K.5
Kruse, M.L.6
Heinrich, M.7
Wickel, M.8
Kronke, M.9
-
317
-
-
26244443655
-
Lysosomal membrane permeabilization during apoptosis-involvement of Bax?
-
Kagedal K., Johansson A.C., Johansson U., Heimlich G., Roberg K., Wang N.S., Jurgensmeier J.M., and Ollinger K. Lysosomal membrane permeabilization during apoptosis-involvement of Bax?. Int. J. Exp. Pathol. 86 (2005) 309-321
-
(2005)
Int. J. Exp. Pathol.
, vol.86
, pp. 309-321
-
-
Kagedal, K.1
Johansson, A.C.2
Johansson, U.3
Heimlich, G.4
Roberg, K.5
Wang, N.S.6
Jurgensmeier, J.M.7
Ollinger, K.8
-
318
-
-
22344435528
-
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis
-
Guicciardi M.E., Bronk S.F., Werneburg N.W., Yin X.M., and Gores G.J. Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis. Gastroenterology 129 (2005) 269-284
-
(2005)
Gastroenterology
, vol.129
, pp. 269-284
-
-
Guicciardi, M.E.1
Bronk, S.F.2
Werneburg, N.W.3
Yin, X.M.4
Gores, G.J.5
-
319
-
-
0034711474
-
Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2?
-
Zhao M., Eaton J.W., and Brunk U.T. Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2?. FEBS Lett. 485 (2000) 104-108
-
(2000)
FEBS Lett.
, vol.485
, pp. 104-108
-
-
Zhao, M.1
Eaton, J.W.2
Brunk, U.T.3
-
320
-
-
0035861890
-
Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis
-
Zhao M., Eaton J.W., and Brunk U.T. Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis. FEBS Lett. 509 (2001) 405-412
-
(2001)
FEBS Lett.
, vol.509
, pp. 405-412
-
-
Zhao, M.1
Eaton, J.W.2
Brunk, U.T.3
-
322
-
-
0035877037
-
Methylmercury and H(2)O(2) provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
-
Dare E., Li W., Zhivotovsky B., Yuan X., and Ceccatelli S. Methylmercury and H(2)O(2) provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis. Free Radic. Biol. Med. 30 (2001) 1347-1356
-
(2001)
Free Radic. Biol. Med.
, vol.30
, pp. 1347-1356
-
-
Dare, E.1
Li, W.2
Zhivotovsky, B.3
Yuan, X.4
Ceccatelli, S.5
-
323
-
-
0037448064
-
Prevention of oxidant-induced cell death by lysosomotropic iron chelators
-
Persson H.L., Yu Z., Tirosh O., Eaton J.W., and Brunk U.T. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic. Biol. Med. 34 (2003) 1295-1305
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 1295-1305
-
-
Persson, H.L.1
Yu, Z.2
Tirosh, O.3
Eaton, J.W.4
Brunk, U.T.5
-
324
-
-
0014878377
-
Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver
-
Brun A., and Brunk U. Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver. J. Histochem. Cytochem. 18 (1970) 820-827
-
(1970)
J. Histochem. Cytochem.
, vol.18
, pp. 820-827
-
-
Brun, A.1
Brunk, U.2
-
326
-
-
0029133790
-
Cellular injury induced by oxidative stress is mediated through lysosomal damage
-
Ollinger K., and Brunk U.T. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic. Biol. Med. 19 (1995) 565-574
-
(1995)
Free Radic. Biol. Med.
, vol.19
, pp. 565-574
-
-
Ollinger, K.1
Brunk, U.T.2
-
327
-
-
0032557458
-
Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1
-
Manna S.K., Zhang H.J., Yan T., Oberley L.W., and Aggarwal B.B. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J. Biol. Chem. 273 (1998) 13245-13254
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13245-13254
-
-
Manna, S.K.1
Zhang, H.J.2
Yan, T.3
Oberley, L.W.4
Aggarwal, B.B.5
-
328
-
-
0000912176
-
Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses
-
Wang J.H., Redmond H.P., Watson R.W., and Bouchier-Hayes D. Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses. Am. J. Physiol. 272 (1997) C1543-C1551
-
(1997)
Am. J. Physiol.
, vol.272
-
-
Wang, J.H.1
Redmond, H.P.2
Watson, R.W.3
Bouchier-Hayes, D.4
-
329
-
-
0035736259
-
Organelle-specific initiation of cell death pathways
-
Ferri K.F., and Kroemer G. Organelle-specific initiation of cell death pathways. Nat. Cell Biol. 3 (2001) E255-E263
-
(2001)
Nat. Cell Biol.
, vol.3
-
-
Ferri, K.F.1
Kroemer, G.2
-
330
-
-
0141447370
-
Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis
-
Zhao M., Antunes F., Eaton J.W., and Brunk U.T. Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur. J. Biochem. 270 (2003) 3778-3786
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 3778-3786
-
-
Zhao, M.1
Antunes, F.2
Eaton, J.W.3
Brunk, U.T.4
-
331
-
-
4344651318
-
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
-
Nylandsted J., Gyrd-Hansen M., Danielewicz A., Fehrenbacher N., Lademann U., Hoyer-Hansen M., Weber E., Multhoff G., Rohde M., and Jaattela M. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J. Exp. Med. 200 (2004) 425-435
-
(2004)
J. Exp. Med.
, vol.200
, pp. 425-435
-
-
Nylandsted, J.1
Gyrd-Hansen, M.2
Danielewicz, A.3
Fehrenbacher, N.4
Lademann, U.5
Hoyer-Hansen, M.6
Weber, E.7
Multhoff, G.8
Rohde, M.9
Jaattela, M.10
-
332
-
-
0141753121
-
NF-kappaB protects from the lysosomal pathway of cell death
-
Liu N., Raja S.M., Zazzeroni F., Metkar S.S., Shah R., Zhang M., Wang Y., Bromme D., Russin W.A., Lee J.C., Peter M.E., Froelich C.J., Franzoso G., and Ashton-Rickardt P.G. NF-kappaB protects from the lysosomal pathway of cell death. EMBO J. 22 (2003) 5313-5322
-
(2003)
EMBO J.
, vol.22
, pp. 5313-5322
-
-
Liu, N.1
Raja, S.M.2
Zazzeroni, F.3
Metkar, S.S.4
Shah, R.5
Zhang, M.6
Wang, Y.7
Bromme, D.8
Russin, W.A.9
Lee, J.C.10
Peter, M.E.11
Froelich, C.J.12
Franzoso, G.13
Ashton-Rickardt, P.G.14
-
333
-
-
0035808388
-
Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells
-
Hirpara J.L., Clement M.V., and Pervaiz S. Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J. Biol. Chem. 276 (2001) 514-521
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 514-521
-
-
Hirpara, J.L.1
Clement, M.V.2
Pervaiz, S.3
-
334
-
-
7444223594
-
Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells
-
Ahmad K.A., Iskandar K.B., Hirpara J.L., Clement M.V., and Pervaiz S. Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res. 64 (2004) 7867-7878
-
(2004)
Cancer Res.
, vol.64
, pp. 7867-7878
-
-
Ahmad, K.A.1
Iskandar, K.B.2
Hirpara, J.L.3
Clement, M.V.4
Pervaiz, S.5
-
335
-
-
0031873505
-
Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance
-
Haq R., and Zanke B. Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance. Cancer Metastasis Rev. 17 (1998) 233-239
-
(1998)
Cancer Metastasis Rev.
, vol.17
, pp. 233-239
-
-
Haq, R.1
Zanke, B.2
-
336
-
-
0032126479
-
Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta-converting enzyme inhibition
-
Zanke B.W., Lee C., Arab S., and Tannock I.F. Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta-converting enzyme inhibition. Cancer Res. 58 (1998) 2801-2808
-
(1998)
Cancer Res.
, vol.58
, pp. 2801-2808
-
-
Zanke, B.W.1
Lee, C.2
Arab, S.3
Tannock, I.F.4
-
338
-
-
0027164993
-
Identification of deoxyribonuclease II as an endonuclease involved in apoptosis
-
Barry M.A., and Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch. Biochem. Biophys. 300 (1993) 440-450
-
(1993)
Arch. Biochem. Biophys.
, vol.300
, pp. 440-450
-
-
Barry, M.A.1
Eastman, A.2
-
339
-
-
0038823547
-
Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway
-
Altairac S., Zeggai S., Perani P., Courtois Y., and Torriglia A. Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway. Cell Death Differ. 10 (2003) 548-557
-
(2003)
Cell Death Differ.
, vol.10
, pp. 548-557
-
-
Altairac, S.1
Zeggai, S.2
Perani, P.3
Courtois, Y.4
Torriglia, A.5
-
340
-
-
0942265544
-
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins
-
Cirman T., Oresic K., Mazovec G.D., Turk V., Reed J.C., Myers R.M., Salvesen G.S., and Turk B. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J. Biol. Chem. 279 (2004) 3578-3587
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3578-3587
-
-
Cirman, T.1
Oresic, K.2
Mazovec, G.D.3
Turk, V.4
Reed, J.C.5
Myers, R.M.6
Salvesen, G.S.7
Turk, B.8
-
341
-
-
0035793580
-
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route
-
Stoka V., Turk B., Schendel S.L., Kim T.H., Cirman T., Snipas S.J., Ellerby L.M., Bredesen D., Freeze H., Abrahamson M., Bromme D., Krajewski S., Reed J.C., Yin X.M., Turk V., and Salvesen G.S. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J. Biol. Chem. 276 (2001) 3149-3157
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3149-3157
-
-
Stoka, V.1
Turk, B.2
Schendel, S.L.3
Kim, T.H.4
Cirman, T.5
Snipas, S.J.6
Ellerby, L.M.7
Bredesen, D.8
Freeze, H.9
Abrahamson, M.10
Bromme, D.11
Krajewski, S.12
Reed, J.C.13
Yin, X.M.14
Turk, V.15
Salvesen, G.S.16
-
342
-
-
0348038755
-
Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1)
-
Houseweart M.K., Vilaythong A., Yin X.M., Turk B., Noebels J.L., and Myers R.M. Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1). Cell Death Differ. 10 (2003) 1329-1335
-
(2003)
Cell Death Differ.
, vol.10
, pp. 1329-1335
-
-
Houseweart, M.K.1
Vilaythong, A.2
Yin, X.M.3
Turk, B.4
Noebels, J.L.5
Myers, R.M.6
-
343
-
-
12144291516
-
JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways
-
Dietrich N., Thastrup J., Holmberg C., Gyrd-Hansen M., Fehrenbacher N., Lademann U., Lerdrup M., Herdegen T., Jaattela M., and Kallunki T. JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways. Cell Death Differ. 11 (2004) 301-313
-
(2004)
Cell Death Differ.
, vol.11
, pp. 301-313
-
-
Dietrich, N.1
Thastrup, J.2
Holmberg, C.3
Gyrd-Hansen, M.4
Fehrenbacher, N.5
Lademann, U.6
Lerdrup, M.7
Herdegen, T.8
Jaattela, M.9
Kallunki, T.10
-
344
-
-
0038529617
-
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion
-
Boya P., Andreau K., Poncet D., Zamzami N., Perfettini J.L., Metivier D., Ojcius D.M., Jaattela M., and Kroemer G. Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J. Exp. Med. 197 (2003) 1323-1334
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1323-1334
-
-
Boya, P.1
Andreau, K.2
Poncet, D.3
Zamzami, N.4
Perfettini, J.L.5
Metivier, D.6
Ojcius, D.M.7
Jaattela, M.8
Kroemer, G.9
-
345
-
-
0032500886
-
Cathepsin B-mediated activation of the proinflammatory caspase-11
-
Schotte P., Van Criekinge W., Van de Craen M., Van Loo G., Desmedt M., Grooten J., Cornelissen M., De Ridder L., Vandekerckhove J., Fiers W., Vandenabeele P., and Beyaert R. Cathepsin B-mediated activation of the proinflammatory caspase-11. Biochem. Biophys. Res. Commun. 251 (1998) 379-387
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 379-387
-
-
Schotte, P.1
Van Criekinge, W.2
Van de Craen, M.3
Van Loo, G.4
Desmedt, M.5
Grooten, J.6
Cornelissen, M.7
De Ridder, L.8
Vandekerckhove, J.9
Fiers, W.10
Vandenabeele, P.11
Beyaert, R.12
-
346
-
-
0031793017
-
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity
-
Vancompernolle K., Van Herreweghe F., Pynaert G., Van de Craen M., De Vos K., Totty N., Sterling A., Fiers W., Vandenabeele P., and Grooten J. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett. 438 (1998) 150-158
-
(1998)
FEBS Lett.
, vol.438
, pp. 150-158
-
-
Vancompernolle, K.1
Van Herreweghe, F.2
Pynaert, G.3
Van de Craen, M.4
De Vos, K.5
Totty, N.6
Sterling, A.7
Fiers, W.8
Vandenabeele, P.9
Grooten, J.10
-
347
-
-
0033494227
-
Participation of a cathepsin L-type protease in the activation of caspase-3
-
Ishisaka R., Utsumi T., Kanno T., Arita K., Katunuma N., Akiyama J., and Utsumi K. Participation of a cathepsin L-type protease in the activation of caspase-3. Cell Struct. Funct. 24 (1999) 465-470
-
(1999)
Cell Struct. Funct.
, vol.24
, pp. 465-470
-
-
Ishisaka, R.1
Utsumi, T.2
Kanno, T.3
Arita, K.4
Katunuma, N.5
Akiyama, J.6
Utsumi, K.7
-
348
-
-
0036910734
-
Programmed cell death: many ways for cells to die decently
-
Jaattela M. Programmed cell death: many ways for cells to die decently. Ann. Med. 34 (2002) 480-488
-
(2002)
Ann. Med.
, vol.34
, pp. 480-488
-
-
Jaattela, M.1
-
349
-
-
17144361820
-
Lysosomes as targets for cancer therapy
-
Fehrenbacher N., and Jaattela M. Lysosomes as targets for cancer therapy. Cancer Res. 65 (2005) 2993-2995
-
(2005)
Cancer Res.
, vol.65
, pp. 2993-2995
-
-
Fehrenbacher, N.1
Jaattela, M.2
-
350
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
Kondo Y., Kanzawa T., Sawaya R., and Kondo S. The role of autophagy in cancer development and response to therapy. Nat. Rev., Cancer 5 (2005) 726-734
-
(2005)
Nat. Rev., Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
351
-
-
0001646169
-
Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation
-
Boesen-de Cock J.G., Tepper A.D., de Vries E., van Blitterswijk W.J., and Borst J. Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation. J. Biol. Chem. 274 (1999) 14255-14261
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14255-14261
-
-
Boesen-de Cock, J.G.1
Tepper, A.D.2
de Vries, E.3
van Blitterswijk, W.J.4
Borst, J.5
-
352
-
-
0030736420
-
Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase
-
Huang C., Ma W., Ding M., Bowden G.T., and Dong Z. Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 272 (1997) 27753-27757
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27753-27757
-
-
Huang, C.1
Ma, W.2
Ding, M.3
Bowden, G.T.4
Dong, Z.5
-
353
-
-
0031092630
-
Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway
-
Woodle E.S., Smith D.M., Bluestone J.A., Kirkman III W.M., Green D.R., and Skowronski E.W. Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J. Immunol. 158 (1997) 2156-2164
-
(1997)
J. Immunol.
, vol.158
, pp. 2156-2164
-
-
Woodle, E.S.1
Smith, D.M.2
Bluestone, J.A.3
Kirkman III, W.M.4
Green, D.R.5
Skowronski, E.W.6
-
354
-
-
0035808364
-
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts
-
Lozano J., Menendez S., Morales A., Ehleiter D., Liao W.C., Wagman R., Haimovitz-Friedman A., Fuks Z., and Kolesnick R. Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts. J. Biol. Chem. 276 (2001) 442-448
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 442-448
-
-
Lozano, J.1
Menendez, S.2
Morales, A.3
Ehleiter, D.4
Liao, W.C.5
Wagman, R.6
Haimovitz-Friedman, A.7
Fuks, Z.8
Kolesnick, R.9
-
355
-
-
1242294416
-
Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation
-
Gupta S., Natarajan R., Payne S.G., Studer E.J., Spiegel S., Dent P., and Hylemon P.B. Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation. J. Biol. Chem. 279 (2004) 5821-5828
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5821-5828
-
-
Gupta, S.1
Natarajan, R.2
Payne, S.G.3
Studer, E.J.4
Spiegel, S.5
Dent, P.6
Hylemon, P.B.7
-
356
-
-
0034282716
-
CD95-mediated apoptosis in vivo involves acid sphingomyelinase
-
Kirschnek S., Paris F., Weller M., Grassme H., Ferlinz K., Riehle A., Fuks Z., Kolesnick R., and Gulbins E. CD95-mediated apoptosis in vivo involves acid sphingomyelinase. J. Biol. Chem. 275 (2000) 27316-27323
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27316-27323
-
-
Kirschnek, S.1
Paris, F.2
Weller, M.3
Grassme, H.4
Ferlinz, K.5
Riehle, A.6
Fuks, Z.7
Kolesnick, R.8
Gulbins, E.9
-
357
-
-
0035896515
-
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes
-
Paris F., Grassme H., Cremesti A., Zager J., Fong Y., Haimovitz-Friedman A., Fuks Z., Gulbins E., and Kolesnick R. Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J. Biol. Chem. 276 (2001) 8297-8305
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8297-8305
-
-
Paris, F.1
Grassme, H.2
Cremesti, A.3
Zager, J.4
Fong, Y.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Gulbins, E.8
Kolesnick, R.9
-
358
-
-
19944392879
-
Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death
-
Otala M., Pentikainen M.O., Matikainen T., Suomalainen L., Hakala J.K., Perez G.I., Tenhunen M., Erkkila K., Kovanen P., Parvinen M., and Dunkel L. Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death. Biol. Reprod. 72 (2005) 86-96
-
(2005)
Biol. Reprod.
, vol.72
, pp. 86-96
-
-
Otala, M.1
Pentikainen, M.O.2
Matikainen, T.3
Suomalainen, L.4
Hakala, J.K.5
Perez, G.I.6
Tenhunen, M.7
Erkkila, K.8
Kovanen, P.9
Parvinen, M.10
Dunkel, L.11
-
359
-
-
4944245910
-
Reactive oxygen species limit neutrophil life span by activating death receptor signaling
-
Scheel-Toellner D., Wang K., Craddock R., Webb P.R., McGettrick H.M., Assi L.K., Parkes N., Clough L.E., Gulbins E., Salmon M., and Lord J.M. Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood 104 (2004) 2557-2564
-
(2004)
Blood
, vol.104
, pp. 2557-2564
-
-
Scheel-Toellner, D.1
Wang, K.2
Craddock, R.3
Webb, P.R.4
McGettrick, H.M.5
Assi, L.K.6
Parkes, N.7
Clough, L.E.8
Gulbins, E.9
Salmon, M.10
Lord, J.M.11
-
360
-
-
0742324394
-
Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes
-
Lang K.S., Myssina S., Brand V., Sandu C., Lang P.A., Berchtold S., Huber S.M., Lang F., and Wieder T. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ. 11 (2004) 231-243
-
(2004)
Cell Death Differ.
, vol.11
, pp. 231-243
-
-
Lang, K.S.1
Myssina, S.2
Brand, V.3
Sandu, C.4
Lang, P.A.5
Berchtold, S.6
Huber, S.M.7
Lang, F.8
Wieder, T.9
-
361
-
-
0035175328
-
Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells
-
Esen M., Schreiner B., Jendrossek V., Lang F., Fassbender K., Grassme H., and Gulbins E. Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells. Apoptosis 6 (2001) 431-439
-
(2001)
Apoptosis
, vol.6
, pp. 431-439
-
-
Esen, M.1
Schreiner, B.2
Jendrossek, V.3
Lang, F.4
Fassbender, K.5
Grassme, H.6
Gulbins, E.7
-
362
-
-
0030670626
-
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
-
Herr I., Wilhelm D., Bohler T., Angel P., and Debatin K.M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16 (1997) 6200-6208
-
(1997)
EMBO J.
, vol.16
, pp. 6200-6208
-
-
Herr, I.1
Wilhelm, D.2
Bohler, T.3
Angel, P.4
Debatin, K.M.5
-
363
-
-
18644376106
-
Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis
-
Paquet C., Sane A.T., Beauchemin M., and Bertrand R. Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis. Leukemia 19 (2005) 784-791
-
(2005)
Leukemia
, vol.19
, pp. 784-791
-
-
Paquet, C.1
Sane, A.T.2
Beauchemin, M.3
Bertrand, R.4
-
364
-
-
25444483322
-
Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress
-
Ostenfeld M.S., Fehrenbacher N., Hoyer-Hansen M., Thomsen C., Farkas T., and Jaattela M. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res. 65 (2005) 8975-8983
-
(2005)
Cancer Res.
, vol.65
, pp. 8975-8983
-
-
Ostenfeld, M.S.1
Fehrenbacher, N.2
Hoyer-Hansen, M.3
Thomsen, C.4
Farkas, T.5
Jaattela, M.6
-
365
-
-
4344606268
-
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis
-
Hara S., Nakashima S., Kiyono T., Sawada M., Yoshimura S., Iwama T., Banno Y., Shinoda J., and Sakai N. p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Cell Death Differ. 11 (2004) 853-861
-
(2004)
Cell Death Differ.
, vol.11
, pp. 853-861
-
-
Hara, S.1
Nakashima, S.2
Kiyono, T.3
Sawada, M.4
Yoshimura, S.5
Iwama, T.6
Banno, Y.7
Shinoda, J.8
Sakai, N.9
-
366
-
-
3442875279
-
Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators
-
Batra S., Reynolds C.P., and Maurer B.J. Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. Cancer Res. 64 (2004) 5415-5424
-
(2004)
Cancer Res.
, vol.64
, pp. 5415-5424
-
-
Batra, S.1
Reynolds, C.P.2
Maurer, B.J.3
-
367
-
-
3042777753
-
Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal
-
Yu Z., Li W., Hillman J., and Brunk U.T. Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal. Brain Res. 1016 (2004) 163-169
-
(2004)
Brain Res.
, vol.1016
, pp. 163-169
-
-
Yu, Z.1
Li, W.2
Hillman, J.3
Brunk, U.T.4
-
368
-
-
0038641715
-
3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin
-
Li W., Yuan X.M., Ivanova S., Tracey K.J., Eaton J.W., and Brunk U.T. 3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin. Biochem. J. 371 (2003) 429-436
-
(2003)
Biochem. J.
, vol.371
, pp. 429-436
-
-
Li, W.1
Yuan, X.M.2
Ivanova, S.3
Tracey, K.J.4
Eaton, J.W.5
Brunk, U.T.6
-
369
-
-
1842480983
-
Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents
-
Caruso J.A., Mathieu P.A., Joiakim A., Leeson B., Kessel D., Sloane B.F., and Reiners Jr. J.J. Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents. Mol. Pharmacol. 65 (2004) 1016-1028
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 1016-1028
-
-
Caruso, J.A.1
Mathieu, P.A.2
Joiakim, A.3
Leeson, B.4
Kessel, D.5
Sloane, B.F.6
Reiners Jr., J.J.7
-
370
-
-
0142026431
-
Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1
-
Nakashima S., Hiraku Y., Tada-Oikawa S., Hishita T., Gabazza E.C., Tamaki S., Imoto I., Adachi Y., and Kawanishi S. Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1. J. Biochem. (Tokyo) 134 (2003) 359-364
-
(2003)
J. Biochem. (Tokyo)
, vol.134
, pp. 359-364
-
-
Nakashima, S.1
Hiraku, Y.2
Tada-Oikawa, S.3
Hishita, T.4
Gabazza, E.C.5
Tamaki, S.6
Imoto, I.7
Adachi, Y.8
Kawanishi, S.9
-
371
-
-
0035811582
-
Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-A methylester photosensitization
-
Matroule J.Y., Carthy C.M., Granville D.J., Jolois O., Hunt D.W., and Piette J. Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-A methylester photosensitization. Oncogene 20 (2001) 4070-4084
-
(2001)
Oncogene
, vol.20
, pp. 4070-4084
-
-
Matroule, J.Y.1
Carthy, C.M.2
Granville, D.J.3
Jolois, O.4
Hunt, D.W.5
Piette, J.6
-
372
-
-
0033052252
-
Alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation
-
Neuzil J., Svensson I., Weber T., Weber C., and Brunk U.T. Alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. FEBS Lett. 445 (1999) 295-300
-
(1999)
FEBS Lett.
, vol.445
, pp. 295-300
-
-
Neuzil, J.1
Svensson, I.2
Weber, T.3
Weber, C.4
Brunk, U.T.5
-
373
-
-
0033118229
-
Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
-
Chi S., Kitanaka C., Noguchi K., Mochizuki T., Nagashima Y., Shirouzu M., Fujita H., Yoshida M., Chen W., Asai A., Himeno M., Yokoyama S., and Kuchino Y. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Oncogene 18 (1999) 2281-2290
-
(1999)
Oncogene
, vol.18
, pp. 2281-2290
-
-
Chi, S.1
Kitanaka, C.2
Noguchi, K.3
Mochizuki, T.4
Nagashima, Y.5
Shirouzu, M.6
Fujita, H.7
Yoshida, M.8
Chen, W.9
Asai, A.10
Himeno, M.11
Yokoyama, S.12
Kuchino, Y.13
-
374
-
-
0036294944
-
Lysosomal enzymes, cathepsins in brain tumour invasion
-
Levicar N., Strojnik T., Kos J., Dewey R.A., Pilkington G.J., and Lah T.T. Lysosomal enzymes, cathepsins in brain tumour invasion. J. Neuro-Oncol. 58 (2002) 21-32
-
(2002)
J. Neuro-Oncol.
, vol.58
, pp. 21-32
-
-
Levicar, N.1
Strojnik, T.2
Kos, J.3
Dewey, R.A.4
Pilkington, G.J.5
Lah, T.T.6
-
375
-
-
0342545909
-
Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency
-
Pena L.A., Fuks Z., and Kolesnick R.N. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res. 60 (2000) 321-327
-
(2000)
Cancer Res.
, vol.60
, pp. 321-327
-
-
Pena, L.A.1
Fuks, Z.2
Kolesnick, R.N.3
-
376
-
-
0038626211
-
Tumor response to radiotherapy regulated by endothelial cell apoptosis
-
Garcia-Barros M., Paris F., Cordon-Cardo C., Lyden D., Rafii S., Haimovitz-Friedman A., Fuks Z., and Kolesnick R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300 (2003) 1155-1159
-
(2003)
Science
, vol.300
, pp. 1155-1159
-
-
Garcia-Barros, M.1
Paris, F.2
Cordon-Cardo, C.3
Lyden, D.4
Rafii, S.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Kolesnick, R.8
-
377
-
-
0141619303
-
Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation
-
Li Y.Q., Chen P., Haimovitz-Friedman A., Reilly R.M., and Wong C.S. Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res. 63 (2003) 5950-5956
-
(2003)
Cancer Res.
, vol.63
, pp. 5950-5956
-
-
Li, Y.Q.1
Chen, P.2
Haimovitz-Friedman, A.3
Reilly, R.M.4
Wong, C.S.5
-
378
-
-
0033786639
-
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
-
Morita Y., Perez G.I., Paris F., Miranda S.R., Ehleiter D., Haimovitz-Friedman A., Fuks Z., Xie Z., Reed J.C., Schuchman E.H., Kolesnick R.N., and Tilly J.L. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat. Med. 6 (2000) 1109-1114
-
(2000)
Nat. Med.
, vol.6
, pp. 1109-1114
-
-
Morita, Y.1
Perez, G.I.2
Paris, F.3
Miranda, S.R.4
Ehleiter, D.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Xie, Z.8
Reed, J.C.9
Schuchman, E.H.10
Kolesnick, R.N.11
Tilly, J.L.12
-
379
-
-
0037227626
-
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo
-
Takai Y., Canning J., Perez G.I., Pru J.K., Schlezinger J.J., Sherr D.H., Kolesnick R.N., Yuan J., Flavell R.A., Korsmeyer S.J., and Tilly J.L. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology 144 (2003) 69-74
-
(2003)
Endocrinology
, vol.144
, pp. 69-74
-
-
Takai, Y.1
Canning, J.2
Perez, G.I.3
Pru, J.K.4
Schlezinger, J.J.5
Sherr, D.H.6
Kolesnick, R.N.7
Yuan, J.8
Flavell, R.A.9
Korsmeyer, S.J.10
Tilly, J.L.11
-
380
-
-
0037237733
-
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice
-
Garcia-Ruiz C., Colell A., Mari M., Morales A., Calvo M., Enrich C., and Fernandez-Checa J.C. Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J. Clin. Invest. 111 (2003) 197-208
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 197-208
-
-
Garcia-Ruiz, C.1
Colell, A.2
Mari, M.3
Morales, A.4
Calvo, M.5
Enrich, C.6
Fernandez-Checa, J.C.7
-
381
-
-
0034488193
-
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
-
Yu Z.F., Nikolova-Karakashian M., Zhou D., Cheng G., Schuchman E.H., and Mattson M.P. Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J. Mol. Neurosci. 15 (2000) 85-97
-
(2000)
J. Mol. Neurosci.
, vol.15
, pp. 85-97
-
-
Yu, Z.F.1
Nikolova-Karakashian, M.2
Zhou, D.3
Cheng, G.4
Schuchman, E.H.5
Mattson, M.P.6
-
382
-
-
0142095498
-
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
-
Grassme H., Jendrossek V., Riehle A., von Kurthy G., Berger J., Schwarz H., Weller M., Kolesnick R., and Gulbins E. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat. Med. 9 (2003) 322-330
-
(2003)
Nat. Med.
, vol.9
, pp. 322-330
-
-
Grassme, H.1
Jendrossek, V.2
Riehle, A.3
von Kurthy, G.4
Berger, J.5
Schwarz, H.6
Weller, M.7
Kolesnick, R.8
Gulbins, E.9
-
383
-
-
0035854479
-
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
-
Paris F., Fuks Z., Kang A., Capodieci P., Juan G., Ehleiter D., Haimovitz-Friedman A., Cordon-Cardo C., and Kolesnick R. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293 (2001) 293-297
-
(2001)
Science
, vol.293
, pp. 293-297
-
-
Paris, F.1
Fuks, Z.2
Kang, A.3
Capodieci, P.4
Juan, G.5
Ehleiter, D.6
Haimovitz-Friedman, A.7
Cordon-Cardo, C.8
Kolesnick, R.9
|