Autophagy in health and disease: A double-edged sword

Science

Volumn 306, Issue 5698, 2004, Pages 990-995

  Shintani, Takahiro ^a   Klionsky, Daniel J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DISEASE CONTROL; GENES; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; PROTEINS; YEAST;

AUTOPHAGY; CYTOPLASMS; MOLECULAR GENETICS;

GENETIC ENGINEERING;

3 METHYLADENINE; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; CARBOXYPEPTIDASE C; CASPASE; CATHEPSIN B; CHLORAMPHENICOL; CHLOROQUINE; DEATH ASSOCIATED PROTEIN KINASE; HUNTINGTIN; INITIATION FACTOR; LYSOSOME ENZYME; MUTANT PROTEIN; PDZ PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ATG7; PROTEIN BECLIN 1; PROTEIN KINASE; PROTEIN KINASE B; RAPAMYCIN; SOMATOMEDIN C; TAMOXIFEN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; WORTMANNIN;

MEDICINE;

AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; AUTOPHAGY; BACTERIAL INFECTION; CANCER; CANCER CHEMOTHERAPY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUNTINGTON CHOREA; LIVER DISEASE; MYOPATHY; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; RNA INTERFERENCE;

ANIMALS; APOPTOSIS; AUTOPHAGY; HUMANS; INFECTION; MUSCULAR DISEASES; NEOPLASMS; NEURODEGENERATIVE DISEASES; PHAGOSOMES;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 8344242220     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099993     Document Type: Review

References (64)

1. D. J. Klionsky, Ed., Autophagy (Landes Bioscience, Georgetown, TX, 2004), pp. 1-303.
2. B. Levine, D. J. Klionsky, Dev. Cell 6, 463 (2004).
3. L Yu et al., Science 304, 1500 (2004).
4. T. Raveh, G. Droguett, M. S. Horwitz, R. A. DePinho, A. Kimchi, Nature Cell Biol. 3, 1 (2001).
5. B. Inbal, S. Bialik, I. Sabanay, G. Shani, A. Kimchi, J. Cell Biol. 157, 455 (2002).
6. K. R. Mills, M. Reginato, j. Debnath, B. Queenan, J. S. Brugge, Proc. Natl. Acad. Sci. U.S.A. 101, 3438 (2004).
7. S. Rodriguez-Enriquez, L. He, J. J. Lemasters, Int. J. Biochem. Cell Biol. 36, 2463 (2004).
8. C.-Y. Lee, E. H. Baehrecke, Development 128, 1443 (2001).
9. F. K.-M. Chan et al., J. Biol. Chem. 278, 51613 (2003).
10. D. Gozuacik, A. Kimchi, Oncogene 23, 2891 (2004).
11. E. Ogier-Denis, P. Codogno, Biochim. Biophys. Acta 1603, 113 (2003).
12. A. M. Cuervo, Trends Cell Biol. 14, 70 (2004).
13. S. Paglin et al., Cancer Res. 61, 439 (2001).
14. A. S. Alva, S. H. Gultekin, E. H. Baehrecke, Cell Death Differ. 11, 1046 (2004).
15. P. Blume-Jensen, T. Hunter, Nature 411, 355 (2001).
16. A. J. Meijer, P. Codogno, Int. J. Biochem. Cell Biol. 36, 2445 (2004).
17. S. Arico et al. J. Biol. Chem. 276, 35243 (2001).
18. M. Hanada, J. Feng, B. A. Hemmings, Biochim. Biophys. Acta 1697, 3 (2004).
19. X. H. Liang et al., Nature 402, 672 (1999).
20. X. Qu et al., J. Clin. Invest. 112, 1809 (2003).
21. Z. Yue, S. Jin, C. Yang, A. J. Levine, N. Heintz, Proc. Natl. Acad. Sci. U.S.A. 100, 15077 (2003).
22. F. Scarlatti et al., J. Biol. Chem. 279, 18384 (2004).
23. T. Ueno, I. Tanida, E. Kominami, in Autophagy, D. J. Klionsky, Ed. (Landes Bioscience, Geogetown, TX, 2004), pp. 264-286.
24. I. Nishino et al., Nature 406, 906 (2000).
25. Y. Tanaka et al., Nature 406, 902 (2000).
26. E.-L. Eskelinen et al., Mol. Biol. Cell 15, 3132 (2004).
27. T. Suzuki et al., J. Biochem. (Tokyo) 131, 647 (2002).
28. T. Kumamoto, H. Ueyama, H. Tsumura, I. Toyoshima, T. Tsuda, Acta Neuropathol. (Berlin) 107, 59 (2004).
29. M. M. Lipinski, J. Yuan, Curr. Opin. Pharmacol. 4, 85 (2004).
30. L. Stefanis, K. E. Larsen, H. J. Rideout, D. Sulzer, L. A. Creene, J. Neurosci. 21, 9549 (2001).
31. P. Venkatraman, R. Wetzel, M. Tanaka, N. Nukina, A. L. Goldberg, Mol. Cell 14, 95 (2004).
32. N. F. Bence, R. M. Sampat, R. R. Kopito, Science 292, 1552 (2001).
33. M. Diaz-Hernandez et al., J. Neurosci. 23, 11653 (2003).
34. X.-M. Sun et al., Mol. Cell 14, 81 (2004).
35. K. B. Kegel et al., J. Neurosci. 20, 7268 (2000).
36. B. Ravikumar, R. Duden, D. C. Rubinsztein, Hum. Mol. Genet. 11, 1107 (2002).
37. J. L. Webb, B. Ravikumar, J. Atkins, J. N. Skepper, D. C. Rubinsztein J. Biol. Chem. 278, 25009 (2003).
38. B. Ravikumar et al., Nature Genet. 36, 585 (2004).
39. J. Yuan, M. Lipinski, A. Degterev, Neuron 40, 401 (2003).
40. Z. Yue et al., Neuron 35, 921 (2002).
41. F. Selimi, M. W. Vogel, J. Mariani, J. Neurosci. 20, 5339 (2000).
42. L. Xue, G. C. Fletcher, A. M. Tolkovsky, Curr. Biol. 11, 361 (2001).
43. A. M. Cataldo, J. L. Barnett, C. Pieroni, R. A. Nixon, J. Neurosci. 17, 6142 (1997).
44. J. Fortun, W. A. Dunn Jr., S. Joy, J. Li, L. Notterpek, J. Neurosci. 23, 10672 (2003).
45. K. A. Rich, C. Burkett, P. Webster, Cell. Microbiol. 5, 455 (2003).
46. K. Kirkegaard, M. P. Taylor, W. T. Jackson, Nature Rev. Microbiol. 2, 301 (2004).
47. I. Nakagawa et al., Science 306, 1037 (2004).
48. B. R. Dorn, W. A. Dunn Jr., A. Progulske-Fox, Cell. Microbiol. 4. 1 (2002).
49. J. P. Vogel, H. L Andrews, S. K. Wong, R. R. Isberg, Science 279, 873 (1998).
50. J. Coers, C. Monahan, C. R. Roy, Nature Cell Biol. 1, 451 (1999).
51. M. S. Swanson, R. R. Isberg, Infect. Immun. 63, 3609 (1995).
52. G. P. Otto et al., Mol. Microbiol. 51, 63 (2004).
53. D. A. Suhy, T. H. Ciddings Jr, K. Kirkegaard, J. Virol. 74, 8953 (2000).
54. Z. Tallóczy et al., Proc. Natl. Acad. Sci. U.S.A. 99, 190 (2002).
55. D. A. Leib, M. A. Machalek, B. R. G. Williams, R. H. Silverman, H. W. Virgin, Proc. Natl. Acad. Sci. U.S.A. 97, 6097 (2000).
56. E. Prentice, W. G. Jerome, T. Yoshimori, N. Mizushima, M. R. Denison J. Biol. Chem. 279, 10136 (2004).
57. V. D. Longo, C. E. Finch, Science 299, 1342 (2003).
58. T. Vellai et al., Nature 426, 620 (2003).
59. A. Melendez et al., Science 301, 1387 (2003).
60. E. Bergamini, G. Cavallini, A. Donati, Z. Gori, Int. J. Biochem. Cell Biol. 36, 2392 (2004).
61. A. Terman, U. T. Brunk, Exp. Gerontol. 39, 701 (2004).
62. N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, Y. Ohsumi, Mol. Biol. Cell 15, 1101 (2004).
63. G. Juhász, G. Csikós, R. S̀inka, M. Erdélyi, M. Sass, FEBS Lett. 543, 154 (2003).
64. The authors would like to thank P. Saftig, M. Vogel, and J. Yuan for reading the manuscript; A. Amer, E. Baehrecke, P. Codogno, A. M. Cuervo, K. Kirkegaard, B. Levine, T. Neufeld, F. Reggiori, D. Rubinsztein, P. Saftig, and M. Swanson for helpful comments and/or providing information before publication; and J. E. Fairman, CMI, for the illustrations (copyrighted); however, none of the preceding people should be held responsible for incorrect information or interpretations of the published literature. D.J.K. is supported by Public Health Service grant GM53396 from NIH.