Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells

Leukemia and Lymphoma

Volumn 39, Issue 3-4, 2000, Pages 343-354

  Zhu, D M ^a   Uckun, F M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Apoptosis; Cathepsin; Death human leukemia; Inhibition; Lymphoma cells

Indexed keywords

CASPASE; CASPASE INHIBITOR; CATHEPSIN; CATHEPSIN INHIBITOR 1; HYDROLASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPERIMENT; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOMA CELL; PRIORITY JOURNAL;

EID: 0034485661     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190009065834     Document Type: Article

References (31)

1. Cysteine proteinase and their endogenous inhibitors: Target proteins for prognosis, diagnosis and therapy in cancer
2. Cathepsin B and human tumor progression
3. Proteases and their inhibitors in human brain tumors: A review
4. Cathepsin B and cysteine protease inhibitors in human lung cancer cell lines
5. Tumor progression and angiogenesis: Cathepsin B & Co
6. The role of proteolytic enzymes in cancer invasion and metastasis
7. N-peptidyl, O-acyl hydroxamates: Comparison of the selective inhibition of serine and cysteine proteinases
8. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells
9. A requirement for protein kinase C inhibition for calcium-triggered apoptosis in Acute lymphoblastic leukemia cells
10. p53-dependent apoptosis modulates the cytotoxicity of anti-cancer agents
11. p53 is required for radiation-induced apoptosis in mouse thymocytes
12. Clinical implications of p53: Effect on prognosis, tumor progression and chemotherapy response
13. Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
14. JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosis
15. p53 expression in B-cell chronic lymphocytic leukemia: A marker of disease progression and poor prognosis
16. Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis
17. Hematopoietic malignancies demonstrate loss-of-function mutations of BAX
18. BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability
19. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
20. Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes
21. An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes
22. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER
23. Inhibition of human caspases by peptide-based and macromolecular inhibitors
24. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
25. Cytochrome c and dATP-dependent formation of Apaf-1/caspasc-9 complex initiates an apoptotic protease cascade
26. CPP32/apopain is a key interleukin 1 deta converting enzyme-like protease involved in Fas-mediated apoptosis
27. Caspases: Enemies within
28. Mitochondria and apoptosis
29. ICE family protease: Mediators of all apoptotic death?
30. Mitogen-activated protein kinases and apoptosis in PIN
31. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis