Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: A novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'

European Journal of Neuroscience

Volumn 10, Issue 5, 1998, Pages 1723-1733

  Yamashima, Tetsumori ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Cathepsin B; Hippocampus; Ischaemia; Neuronal death; Primate

Indexed keywords

CALPAIN; CATHEPSIN B; ENZYME INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; HYPOTHESIS; IMMUNOCYTOCHEMISTRY; LYSOSOME MEMBRANE; MONKEY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIMATE; PRIORITY JOURNAL;

ANIMALS; CALPAIN; CATHEPSIN B; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; MACACA; NEUROPROTECTIVE AGENTS; SUBCELLULAR FRACTIONS;

EID: 0031817004     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00184.x     Document Type: Article

References (1)

1. Arai, A., Vanderklish, P., Kessler, M., Lee, K. & Lynch, G. (1991) A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices. Brain Res., 555, 276-280.