Evidence of a lysosomal pathway for apoptosis is induced by the synthetic retinoid CD437 in human leukemia HL-60 cells

Cell Death and Differentiation

Volumn 8, Issue 5, 2001, Pages 477-485

  Zang, Y ^a   Beard, R L ^b   Chandraratna, R A S ^b   Kang, J X ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ALLERGAN INC   (United States)

Author keywords

Apoptosis; Cathepsin D; CD437; Free radicals; Lysosomes

Indexed keywords

6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; ALPHA TOCOPHEROL; CASPASE; CATHEPSIN D; CELL NUCLEUS RECEPTOR; FREE RADICAL; PEPSTATIN; PHOSPHATIDYLSERINE; RECEPTOR BLOCKING AGENT; RETINOIC ACID RECEPTOR; RETINOID DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HL 60; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEUKEMIA CELL; LYSOSOME; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CATHEPSIN D; CELL SIZE; CYTOSOL; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FREE RADICALS; HL-60 CELLS; HUMANS; LYSOSOMES; MEMBRANE POTENTIALS; MITOCHONDRIA; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PEPSTATINS; PHOSPHATIDYLSERINES; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RECEPTORS, RETINOIC ACID; RETINOIDS; VITAMIN E;

EID: 0035018235     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400843     Document Type: Article

References (41)

1. Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437
2. Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells
3. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines
4. Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells
5. Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells
6. Implication of c-Myc in apoptosis induced by the retinoid CD437 in human lung carcinoma cells
7. Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast Carcinoma cells
8. Activity of retinoic acid receptor-gamma selectively binding retinoids alone and in combination with interferon-gamma in breast cancer cell lines
9. Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437
10. Bcl-X(L) expression and its downregulation by a novel retinoid in breast carcinoma cells
11. Growth-inhibitory effects of the synthetic retinoid CD437 against ovarian carcinoma models in vitro and in vivo
12. Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl hydroxyphenyl]-2-naphtalene carboxylic acid (CD437)
13. Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3
14. Effects of various synthetic retinoids on proliferation and immunophenotype of human melanoma cells in vitro
15. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo
16. Positive and negative interaction of 1,25-dihydroxyvitamin D3 and the retinoid CD437 in the induction of human melanoma cell apoptosis
17. Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma
18. Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway
19. The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases
20. In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies
21. Induction of apoptosis by the novel retinoid AHPN in human T-cell lymphoma cells involves caspase-dependent and independent pathways
22. S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid
23. Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid
24. Involvement of cyclin-dependent kinase activities in CD437-induced apoptosis
25. Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid
26. The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus
27. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha
28. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
29. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
30. Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation
31. Death associated proteins (DAPs): From gene identification to the analysis of their apoptotic and tumor suppressive functions
32. Cathepsins as effector proteases in hepatocyte apoptosis
33. Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
34. Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes
35. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
36. α-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation
37. Induction of cell death by the lysosomotropic detergent MSDH
38. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid
39. Mannose-6-phosphate/insulin-like growth factor-II receptor mediates the growth-inhibitory effects of retinoids
40. Mitochondria and apoptosis
41. The biogenesis of lysosomes