Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis

Journal of Molecular Neuroscience

Volumn 15, Issue 2, 2000, Pages 85-97

  Yu, Z F ^a   Nikolova Karakashian, M ^a   Zhou, D ^a   Cheng, G ^a   Schuchman, E H ^a   Mattson, M P ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Apoptosis; Calcium; Excitotoxicity; Interleukin; Stroke; Tumor necrosis factor

Indexed keywords

CALCIUM; CERAMIDE; CYTOKINE; OXYGEN RADICAL; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR; BRAIN ISCHEMIA; CELL HYPOXIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; INFLAMMATION; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PHOSPHOLIPID METABOLISM; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BRAIN; BRIDGED COMPOUNDS; CALCIUM; CELL SURVIVAL; CERAMIDES; CEREBRAL CORTEX; CEREBRAL INFARCTION; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HOMEOSTASIS; ISCHEMIC ATTACK, TRANSIENT; KINETICS; MICE; MICE, KNOCKOUT; NEURONS; PHOSPHODIESTERASE INHIBITORS; SECOND MESSENGER SYSTEMS; SPHINGOMYELIN PHOSPHODIESTERASE; THIONES;

EID: 0034488193     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:15:2:85     Document Type: Article

References (50)

1. Ceramide kinase
2. Ceramide signalling and the immune response
3. Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury
4. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
5. Ceramide induces apoptosis in cultured mesencephalic neurons
6. Regulation of cytochrome p450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes
7. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal
8. Dexamethasone-induced thymocyte apoptosis: Apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases
9. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
10. Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: Relevance to ceramide induced apoptosis
11. The role of inflammation after acute stroke: Utility of pursuing anti-adhesion molecule therapy
12. Pathobiology of ischaemic stroke: An integrated view
13. Neuroprotective effects of gelsolin during murine stroke
14. Role of colony stimulating factor-1 in brain damage caused by ischemia
15. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation
16. Mitochondrial free radical signal in ceramide-dependent apoptosis: A putative mechanism for neuronal death in Parkinson's disease
17. Direct effect of ceramide on the mitochondrial electron transport chain lead s to generation of reactive oxygen species. Role of mitochondrial glutathione
18. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor
19. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity
20. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation
21. Ceramide and the eukaryotic stress response
22. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein
23. Ceramide induces apoptosis in PC12 cells
24. FK506 prevents stroke-induced generation of ceramide and apoptosis signaling
25. Ceramide inhibits inwardly rectifying K+ currents via a Ras-and Raf-1-dependent pathway in cultured oligodendrocytes
26. Ceramide in apoptosis: Does it really matter?
27. Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease
28. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway
29. Mito-chondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
30. Ceramide triggers intracellular calcium release via the IP(3) receptor in Xenopus laevis oocytes
31. Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion
32. Cerebral interleukin-6 is neuroprotective during permanent focal cerebralischemia in the rat
33. Lipid mediators of insulin resistance: Ceramide signalling down regulates GLUT4 gene transcription in 3T3-L1 adipocytes
34. Oxidative stress in brain ischemia
35. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin
36. Signal transduction of stress via ceramide
37. Neuroprotective signal transduction: Relevance to stroke
38. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
39. Quantitation of free sphingosine in liver by high-performance liquid chromatography
40. Bimodal regulation of ceramidase by interleukin-1β: Implication for the regulation of cytochrome P450 2C11 (CYP2C11)
41. Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells
42. Interleukin-1 receptor antagonist inhibits ischaemic and excito-toxic neuronal damage in the rat
43. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
44. Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival
45. Reduced ischemic brain injury in inter-leukin-1β converting enzyme-deficient mice
46. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induce acidic sphingomyelin breakdown
47. PACAP protects hippocampal neurons against apoptosis: Involvement of JNK/SAPK signaling pathway
48. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-κB/JNK kinase and cell survival
49. Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death
50. Lack of the p50 subunit of nuclear factor-κB increases the vulnerability o f hippocampal neurons to excitotoxic injury