-
1
-
-
0030595340
-
FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase
-
Adam-Klages, S., Adam, D., Wiegmann, K., Struve, S., Kolanus, W., Schneider-Mergener, J. and Krönke, M. (1996) FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell, 86, 937-947.
-
(1996)
Cell
, vol.86
, pp. 937-947
-
-
Adam-Klages, S.1
Adam, D.2
Wiegmann, K.3
Struve, S.4
Kolanus, W.5
Schneider-Mergener, J.6
Krönke, M.7
-
2
-
-
0032515162
-
Selective involvement of caspase 3 in ceramide induced apoptosis in AK-5 tumor cells
-
Anjum, R., Ali, A.M., Begum, Z., Vanaja, J. and Kharm, A. (1998) Selective involvement of caspase 3 in ceramide induced apoptosis in AK-5 tumor cells. FEBS Lett., 439, 81-84.
-
(1998)
FEBS Lett.
, vol.439
, pp. 81-84
-
-
Anjum, R.1
Ali, A.M.2
Begum, Z.3
Vanaja, J.4
Kharm, A.5
-
3
-
-
0029953972
-
Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, 'short' pseudocathepsin D
-
Beyer, B.M. and Dunn, B.M. (1996) Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, 'short' pseudocathepsin D. J. Biol Chem., 271, 15590-15596.
-
(1996)
J. Biol Chem.
, vol.271
, pp. 15590-15596
-
-
Beyer, B.M.1
Dunn, B.M.2
-
4
-
-
0027527545
-
Selectivity of ceramide-mediated biology. Lack of activity of erythrodihydroceramide
-
Bielawska, A., Crane, H.M., Liotta, D., Obeid, L. and Hannun, J. (1993) Selectivity of ceramide-mediated biology. Lack of activity of erythrodihydroceramide. J. Biol. Chem., 268, 26226-26232.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 26226-26232
-
-
Bielawska, A.1
Crane, H.M.2
Liotta, D.3
Obeid, L.4
Hannun, J.5
-
5
-
-
0030757986
-
Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
-
Brunk, U.T., Dalen, H., Roberg, K. and Hellquist, H.B. (1997) Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts, Free Radical Biol. Med., 23, 616-626.
-
(1997)
Free Radical Biol. Med.
, vol.23
, pp. 616-626
-
-
Brunk, U.T.1
Dalen, H.2
Roberg, K.3
Hellquist, H.B.4
-
6
-
-
0028095477
-
Apoptotic signaling through CD95 (Fas/APO-1) activates an acidic sphingomyelinase
-
Cifone, M.G., De Maria, R., Roncaioli, P., Rippo, M.R., Azuma, M., Lanier, L.L., Santoni, A. and Testi, R. (1995) Apoptotic signaling through CD95 (Fas/APO-1) activates an acidic sphingomyelinase. J. Exp. Med., 177, 1547-1552.
-
(1995)
J. Exp. Med.
, vol.177
, pp. 1547-1552
-
-
Cifone, M.G.1
De Maria, R.2
Roncaioli, P.3
Rippo, M.R.4
Azuma, M.5
Lanier, L.L.6
Santoni, A.7
Testi, R.8
-
7
-
-
0024451999
-
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme
-
Conner, G.E. (1989) Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme. Biochem. J., 263, 601-604.
-
(1989)
Biochem. J.
, vol.263
, pp. 601-604
-
-
Conner, G.E.1
-
8
-
-
0028839609
-
High-titer packaging cells producing recombinant retroviruses resistant to human serum
-
Cosset, F.-L., Takeuchi, Y., Battini, J.-L., Weiss, R.A. and Collins, M.K.L. (1995) High-titer packaging cells producing recombinant retroviruses resistant to human serum. J. Virol., 69, 7430-7436.
-
(1995)
J. Virol.
, vol.69
, pp. 7430-7436
-
-
Cosset, F.-L.1
Takeuchi, Y.2
Battini, J.-L.3
Weiss, R.A.4
Collins, M.K.L.5
-
9
-
-
0029782494
-
Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α
-
Deiss, L.P., Galinka, H., Berissi, H., Cohen, O. and Kimchi, A. (1996) Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α. EMBO J., 15, 3861-3870.
-
(1996)
EMBO J.
, vol.15
, pp. 3861-3870
-
-
Deiss, L.P.1
Galinka, H.2
Berissi, H.3
Cohen, O.4
Kimchi, A.5
-
10
-
-
0032536876
-
Acidic sphingomyelinase (ASM) is necessary for FAS-induced GD3 ganglioside accumulation and efficient apoptosis in lymphoid cells
-
De Maria, R., Rippo, M.R., Schuchmann, E.H. and Testi, R. (1998) Acidic sphingomyelinase (ASM) is necessary for FAS-induced GD3 ganglioside accumulation and efficient apoptosis in lymphoid cells, J. Exp. Med., 187, 897-902.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 897-902
-
-
De Maria, R.1
Rippo, M.R.2
Schuchmann, E.H.3
Testi, R.4
-
11
-
-
0024382416
-
Cleavage of parathyroid hormone in macrophage endosomes illustrates a novel pathway for intracellular processing of proteins
-
Diment, S., Martin, K.L. and Stahl, P.D. (1989) Cleavage of parathyroid hormone in macrophage endosomes illustrates a novel pathway for intracellular processing of proteins. J. Biol. Chem., 264, 13403-13406.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 13403-13406
-
-
Diment, S.1
Martin, K.L.2
Stahl, P.D.3
-
12
-
-
0027202552
-
Ceramide activates heterotrimeric protein phosphatase 2A
-
Dobrowski, R.T., Kamibayashi, C., Mumby, M.C. and Hannun, Y. (1993) Ceramide activates heterotrimeric protein phosphatase 2A. J. Biol. Chem., 268, 15523-15530.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15523-15530
-
-
Dobrowski, R.T.1
Kamibayashi, C.2
Mumby, M.C.3
Hannun, Y.4
-
13
-
-
0011288815
-
Cloning and sequence analysis of cDNA for human cathepsin D
-
Faust, P.L., Kornfeld, S. and Chirgwin, J.M. (1985) Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Natl Acad. Sci. USA, 82, 4910-4914.
-
(1985)
Proc. Natl Acad. Sci. USA
, vol.82
, pp. 4910-4914
-
-
Faust, P.L.1
Kornfeld, S.2
Chirgwin, J.M.3
-
14
-
-
0032577211
-
Cathepsin D is a good candidate for the specific release of stable hemorphin from hemoglobin in vivo: VV-hemorphin-7
-
Fruitier, I., Garreau, I. and Piot, J.M. (1998) Cathepsin D is a good candidate for the specific release of stable hemorphin from hemoglobin in vivo: VV-hemorphin-7. Biochem. Biophys. Res. Commun., 246, 719-724.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.246
, pp. 719-724
-
-
Fruitier, I.1
Garreau, I.2
Piot, J.M.3
-
15
-
-
0020538837
-
Biosynthesis and transport of cathepsin D in cultured human fibroblasts
-
Gieselmann, V., Pohlmann, R., Hasilik, A. and von Figura, K. (1983) Biosynthesis and transport of cathepsin D in cultured human fibroblasts. J. Cell Biol., 97, 1-5.
-
(1983)
J. Cell Biol.
, vol.97
, pp. 1-5
-
-
Gieselmann, V.1
Pohlmann, R.2
Hasilik, A.3
Von Figura, K.4
-
16
-
-
0030784482
-
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
-
Haimovitz-Friedmann, A. et al. (1997) Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med., 186, 1831-1841.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1831-1841
-
-
Haimovitz-Friedmann, A.1
-
17
-
-
0022631529
-
Formation of parathormone 8-34 by cathepsin D digestion of parathormone and its efficacy as a hormone antagonist
-
Hamilton, J.W., MacGregor, R.R. and Jilka, R.L. (1986) Formation of parathormone 8-34 by cathepsin D digestion of parathormone and its efficacy as a hormone antagonist. Mol. Cell. Endocrinol., 44, 179-183.
-
(1986)
Mol. Cell. Endocrinol.
, vol.44
, pp. 179-183
-
-
Hamilton, J.W.1
MacGregor, R.R.2
Jilka, R.L.3
-
18
-
-
0028855405
-
Ceramide: An intracellular signal for apoptosis
-
Hannun, Y.A. and Obeid, L.M. (1995) Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci., 20, 73-77.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 73-77
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
19
-
-
0030670626
-
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
-
Herr, I., Wilhelm, D., Böhler, T., Angel, P. and Debatin, K.-M. (1997) Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J., 16, 6200-6208.
-
(1997)
EMBO J.
, vol.16
, pp. 6200-6208
-
-
Herr, I.1
Wilhelm, D.2
Böhler, T.3
Angel, P.4
Debatin, K.-M.5
-
20
-
-
0030736420
-
Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-jun N-terminal kinase
-
Huang, C., Ma, W., Ding, M., Bowden, G.T. and Dong, Z. (1997) Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-jun N-terminal kinase. J. Biol. Chem., 272, 27753-27757.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27753-27757
-
-
Huang, C.1
Ma, W.2
Ding, M.3
Bowden, G.T.4
Dong, Z.5
-
21
-
-
0028468309
-
The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts
-
Hurwitz, R., Ferlinz, K. and Sandhoff, K. (1994) The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol. Chem. Hoppe Seyler, 375, 447-450.
-
(1994)
Biol. Chem. Hoppe Seyler
, vol.375
, pp. 447-450
-
-
Hurwitz, R.1
Ferlinz, K.2
Sandhoff, K.3
-
22
-
-
0029951162
-
Ceramide binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase
-
Huwiler, A., Brunner, J., Hummel, R., Vervoodeldonk, M., Stabel, S., van den Bosch, H. and Pfeilschifter, J. (1996) Ceramide binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc. Natl Acad. Sci. USA, 93, 6959-6963.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 6959-6963
-
-
Huwiler, A.1
Brunner, J.2
Hummel, R.3
Vervoodeldonk, M.4
Stabel, S.5
Van Den Bosch, H.6
Pfeilschifter, J.7
-
23
-
-
0026072245
-
Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D
-
Johnson, G.V., Litersky, J.M. and Whitaker, J.N. (1991) Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D. J. Neurochem., 57, 1577-1583.
-
(1991)
J. Neurochem.
, vol.57
, pp. 1577-1583
-
-
Johnson, G.V.1
Litersky, J.M.2
Whitaker, J.N.3
-
24
-
-
0029994456
-
Valvular interstitial cells express angiotensinogen and cathepsin D and generate angiotensin peptides
-
Katawa, L.C, Tyagi, S.C., Cambell, S.E., Lee, S.J., Cicila, G.T. and Weber, K.T. (1996) Valvular interstitial cells express angiotensinogen and cathepsin D and generate angiotensin peptides. Int. J. Biochem. Cell Biol., 28, 807-821.
-
(1996)
Int. J. Biochem. Cell Biol.
, vol.28
, pp. 807-821
-
-
Katawa, L.C.1
Tyagi, S.C.2
Cambell, S.E.3
Lee, S.J.4
Cicila, G.T.5
Weber, K.T.6
-
25
-
-
0030774852
-
Degradation of tau by lysosomal enzyme cathepsin C: Implication for Alzheimer neurofibrillary degeneration
-
Kenessey, A, Nacharaju, P., Ko, L.W. and Yen, S.H. (1997) Degradation of tau by lysosomal enzyme cathepsin C: implication for Alzheimer neurofibrillary degeneration. J. Neurochem., 69, 2026-2038.
-
(1997)
J. Neurochem.
, vol.69
, pp. 2026-2038
-
-
Kenessey, A.1
Nacharaju, P.2
Ko, L.W.3
Yen, S.H.4
-
26
-
-
0031919157
-
Regulation of ceramide production and apoptosis
-
Kolesnick, R.N. and Krönke, M. (1998) Regulation of ceramide production and apoptosis. Annu. Rev. Physiol., 60, 643-665.
-
(1998)
Annu. Rev. Physiol.
, vol.60
, pp. 643-665
-
-
Kolesnick, R.N.1
Krönke, M.2
-
27
-
-
0033522399
-
Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice
-
Kreder, D. et al. (1999) Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J., 18, 2472-2479.
-
(1999)
EMBO J.
, vol.18
, pp. 2472-2479
-
-
Kreder, D.1
-
28
-
-
0342601448
-
The mode of ceramide action: The alkyl chain protrusion model
-
Krönke, M. (1997) The mode of ceramide action: the alkyl chain protrusion model. Cytokine Growth Factor Rev., 8, 103-107.
-
(1997)
Cytokine Growth Factor Rev.
, vol.8
, pp. 103-107
-
-
Krönke, M.1
-
30
-
-
17344370810
-
Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and translocation
-
Li, W., Yuan, X.M., Olsson, A.G. and Brunk, U.T. (1998) Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and translocation. Arterioscler. Thromb. Vasc. Biol., 18, 177-184.
-
(1998)
Arterioscler. Thromb. Vasc. Biol.
, vol.18
, pp. 177-184
-
-
Li, W.1
Yuan, X.M.2
Olsson, A.G.3
Brunk, U.T.4
-
31
-
-
0000993166
-
Sphingomyelinases in cell regulation
-
Liu, B., Obeid, L.M. and Hannun, Y.A. (1997) Sphingomyelinases in cell regulation. Semin. Cell Dev. Biol., 8, 311-322.
-
(1997)
Semin. Cell Dev. Biol.
, vol.8
, pp. 311-322
-
-
Liu, B.1
Obeid, L.M.2
Hannun, Y.A.3
-
32
-
-
0028784298
-
Compartmentalized production of ceramide at the cell surface
-
Liu, P. and Anderson, G.G.W. (1995) Compartmentalized production of ceramide at the cell surface. J. Biol. Chem., 270, 27179-27185.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27179-27185
-
-
Liu, P.1
Anderson, G.G.W.2
-
33
-
-
0031572448
-
Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells
-
Lutz, M.B. et al. (1997) Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC Class II-positive vesicles in immature dendritic cells. J. Immunol., 159, 3707-3716.
-
(1997)
J. Immunol.
, vol.159
, pp. 3707-3716
-
-
Lutz, M.B.1
-
34
-
-
0025889011
-
Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor α
-
Mathias, S., Dressler, K.A. and Kolesnick, R.N. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor α. Proc. Natl Acad. Sci. USA, 88, 1009-10013.
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 1009-10013
-
-
Mathias, S.1
Dressler, K.A.2
Kolesnick, R.N.3
-
35
-
-
0027358029
-
Fumonisins and other inhibitors of de novo sphingolipid biosynthesis
-
Merrill, A.H., Jr, Wang, E., Gilchrist, D.G. and Riley, R.T. (1993) Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. Adv. Lipid Res., 26, 215-234.
-
(1993)
Adv. Lipid Res.
, vol.26
, pp. 215-234
-
-
Merrill A.H., Jr.1
Wang, E.2
Gilchrist, D.G.3
Riley, R.T.4
-
36
-
-
0027414640
-
Two crystal structures for cathepsin D: The lysosomal targeting signal and active site
-
Metcalf, P. and Fusek, M. (1993) Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. EMBO J., 14, 1293-1302.
-
(1993)
EMBO J.
, vol.14
, pp. 1293-1302
-
-
Metcalf, P.1
Fusek, M.2
-
37
-
-
0030597153
-
Ceramide induces apotosis via CPP32 activation
-
Mizushima, N., Koike, R., Kohsaka, H., Kushi, Y., Handa, S., Yagita, H. and Miyasaka, N. (1996) Ceramide induces apotosis via CPP32 activation. FEBS Lett, 395, 267-271.
-
(1996)
FEBS Lett
, vol.395
, pp. 267-271
-
-
Mizushima, N.1
Koike, R.2
Kohsaka, H.3
Kushi, Y.4
Handa, S.5
Yagita, H.6
Miyasaka, N.7
-
38
-
-
0032518448
-
Role of an acidic compartment in tumor necrosis factor α-induced production of ceramide, activation of caspase-3 and apoptosis
-
Monney, L., Olivier, R., Otter, I., Jansen, B., Poirier, G.G. and Borner, C. (1998) Role of an acidic compartment in tumor necrosis factor α-induced production of ceramide, activation of caspase-3 and apoptosis. Eur. J. Biochem., 251, 295-303.
-
(1998)
Eur. J. Biochem.
, vol.251
, pp. 295-303
-
-
Monney, L.1
Olivier, R.2
Otter, I.3
Jansen, B.4
Poirier, G.G.5
Borner, C.6
-
39
-
-
0031716017
-
Hydrolysis of androgen receptor by cathepsin D: Its biological significance in human prostate cancer
-
Mordente, J.H., Choudhury, M.S., Tazaki, H., Mallouh, C. and Konno, S. (1998) Hydrolysis of androgen receptor by cathepsin D: its biological significance in human prostate cancer. Br. J. Urol., 82, 431-435.
-
(1998)
Br. J. Urol.
, vol.82
, pp. 431-435
-
-
Mordente, J.H.1
Choudhury, M.S.2
Tazaki, H.3
Mallouh, C.4
Konno, S.5
-
40
-
-
0029003788
-
PKCζ is a molecular switch in signal transduction of TNFα, bifunctionally regulated by ceramide and arachidonic acid
-
Müller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D. and Pfizenmaier, K. (1995) PKCζ is a molecular switch in signal transduction of TNFα, bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 14, 1961-1996.
-
(1995)
EMBO J.
, vol.14
, pp. 1961-1996
-
-
Müller, G.1
Ayoub, M.2
Storz, P.3
Rennecke, J.4
Fabbro, D.5
Pfizenmaier, K.6
-
41
-
-
0040885889
-
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
-
Müller, G., Storz, P., Bourteele, S., Döppler, H. and Pfizenmaier, K. (1998). Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling. EMBO J., 17, 732-742.
-
(1998)
EMBO J.
, vol.17
, pp. 732-742
-
-
Müller, G.1
Storz, P.2
Bourteele, S.3
Döppler, H.4
Pfizenmaier, K.5
-
42
-
-
0028811653
-
Protein kinase C: Structure, function and regulation
-
Newton, A.C. (1995) Protein kinase C: structure, function and regulation. J. Biol. Chem., 270, 28495-28498.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 28495-28498
-
-
Newton, A.C.1
-
43
-
-
0027511687
-
Programmed cell death induced by ceramide
-
Obeid, L.M., Linardic, C.M., Karolak, L.A. and Hannun, J.A. (1993) Programmed cell death induced by ceramide. Science, 259, 1769-1771.
-
(1993)
Science
, vol.259
, pp. 1769-1771
-
-
Obeid, L.M.1
Linardic, C.M.2
Karolak, L.A.3
Hannun, J.A.4
-
44
-
-
0032455357
-
An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum depriviation with special reference to autophagy and lysosomal cathepsins
-
Ohsawa, Y., Isahara, K., Kanamori, S., Shibata, M., Kametaka, S., Gotow, T., Watanabe, T., Kominami, E. and Uchiyama, Y. (1999) An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum depriviation with special reference to autophagy and lysosomal cathepsins. Arch. Histol. Cytol., 61, 395-403.
-
(1999)
Arch. Histol. Cytol.
, vol.61
, pp. 395-403
-
-
Ohsawa, Y.1
Isahara, K.2
Kanamori, S.3
Shibata, M.4
Kametaka, S.5
Gotow, T.6
Watanabe, T.7
Kominami, E.8
Uchiyama, Y.9
-
45
-
-
0032497837
-
The role of ceramide in cell sinaling
-
Perry, D.K. and Hannun, Y.A. (1998) The role of ceramide in cell sinaling. Biochim. Biophys. Acta, 1436, 233-243.
-
(1998)
Biochim. Biophys. Acta
, vol.1436
, pp. 233-243
-
-
Perry, D.K.1
Hannun, Y.A.2
-
46
-
-
0026653849
-
Identification of subcellular compartments involved in biosynthetic processing of cathepsin D
-
Rijnboutt, S., Stoorvogel, W., Geuze, H. and Strous, G.J. (1992) Identification of subcellular compartments involved in biosynthetic processing of cathepsin D. J. Biol. Chem., 267, 15665-15672.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 15665-15672
-
-
Rijnboutt, S.1
Stoorvogel, W.2
Geuze, H.3
Strous, G.J.4
-
47
-
-
0031897739
-
Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
-
Roberg, K. and Öllinger, K. (1998) Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am. J. Pathol., 152, 1151-1156.
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 1151-1156
-
-
Roberg, K.1
Öllinger, K.2
-
48
-
-
0029083689
-
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atropy of the intestinal mucosa and profound destruction of lymphoid cells
-
Saftig, P. et al. (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atropy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J., 14, 3599-3608.
-
(1995)
EMBO J.
, vol.14
, pp. 3599-3608
-
-
Saftig, P.1
-
49
-
-
0029970783
-
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D
-
Saftig, P., Peters, C., von Figura, K., Craessaerts, K., Van Leuven, F. and De Strooper, B. (1996) Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. J. Biol. Chem., 271, 27241-27244.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27241-27244
-
-
Saftig, P.1
Peters, C.2
Von Figura, K.3
Craessaerts, K.4
Van Leuven, F.5
De Strooper, B.6
-
50
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
Santana, P. et al. (1996) Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 86, 189-199.
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
-
51
-
-
0026458406
-
TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
-
Schütze, S., Potthoff, K., Machleidt, T., Berkovic, D., Wiegmann, K. and Krönke, M. (1992) TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell, 71, 765-776.
-
(1992)
Cell
, vol.71
, pp. 765-776
-
-
Schütze, S.1
Potthoff, K.2
Machleidt, T.3
Berkovic, D.4
Wiegmann, K.5
Krönke, M.6
-
52
-
-
0033538073
-
Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling
-
Schütze, S., Machleidt, T., Adam, D., Schwandner, R., Wiegmann, K., Kruse, M.-L., Heinrich, M., Wickel, M. and Krönke, M. (1999) Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. J. Biol. Chem., 274, 10203-10212.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10203-10212
-
-
Schütze, S.1
Machleidt, T.2
Adam, D.3
Schwandner, R.4
Wiegmann, K.5
Kruse, M.-L.6
Heinrich, M.7
Wickel, M.8
Krönke, M.9
-
53
-
-
0032489554
-
TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
-
Schwandner, R., Wiegmann, K., Bernado, K., Kreder, D. and Krönke, M. (1998) TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase. J. Biol. Chem., 273, 5916-5922.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5916-5922
-
-
Schwandner, R.1
Wiegmann, K.2
Bernado, K.3
Kreder, D.4
Krönke, M.5
-
54
-
-
0032500842
-
Participation of cathepsin D and B in apoptosis of PC12 cells following serum depriviation
-
Shibata, M. et al. (1998) Participation of cathepsin D and B in apoptosis of PC12 cells following serum depriviation. Biochem. Biophys. Res. Commun., 251, 199-203.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 199-203
-
-
Shibata, M.1
-
55
-
-
0029949938
-
prICE: A downstream target for ceramide-induced apoptosis and the inhibitory action of Bcl-2
-
Smyth, M.J., Perry, D.K., Zhang, J., Poirier, G.G., Hannun, Y. and Obeid, L.M. (1996) prICE: a downstream target for ceramide-induced apoptosis and the inhibitory action of Bcl-2. Biochem. J., 316, 25-28.
-
(1996)
Biochem. J.
, vol.316
, pp. 25-28
-
-
Smyth, M.J.1
Perry, D.K.2
Zhang, J.3
Poirier, G.G.4
Hannun, Y.5
Obeid, L.M.6
-
56
-
-
0029862561
-
Sphingolipid metabolism and growth regulation
-
Spiegel, S. and Merrill, A.H., Jr (1996) Sphingolipid metabolism and growth regulation. FASEB J., 10, 1388-1397.
-
(1996)
FASEB J.
, vol.10
, pp. 1388-1397
-
-
Spiegel, S.1
Merrill A.H., Jr.2
-
57
-
-
0025323408
-
Release of acid phosphatase from lysosomal membranes by cathepsin D
-
Tanaka, Y., Himeno, M. and Kato, K. (1990) Release of acid phosphatase from lysosomal membranes by cathepsin D. J. Biochem. (Tokyo), 108, 287-291.
-
(1990)
J. Biochem. (Tokyo)
, vol.108
, pp. 287-291
-
-
Tanaka, Y.1
Himeno, M.2
Kato, K.3
-
58
-
-
0025463841
-
Catheptic processing of protein antigens: Enzymatic and molecular aspects
-
van der Drift, A.C.M., van Noort, J.M. and Krüse, J. (1990) Catheptic processing of protein antigens: enzymatic and molecular aspects. Semin. Immunol., 2, 255-271.
-
(1990)
Semin. Immunol.
, vol.2
, pp. 255-271
-
-
Van Der Drift, A.C.M.1
Van Noort, J.M.2
Krüse, J.3
-
59
-
-
0031459957
-
Turnover of endogenous ceramide in cultured normal and Farber fibroblasts
-
van Echten-Deckert, G., Klein, A., Linke, T., Heinemann, T., Weisgerber, J. and Sandhoff, K. (1997) Turnover of endogenous ceramide in cultured normal and Farber fibroblasts. J. Lipid Res., 38, 2569-2579.
-
(1997)
J. Lipid Res.
, vol.38
, pp. 2569-2579
-
-
Van Echten-Deckert, G.1
Klein, A.2
Linke, T.3
Heinemann, T.4
Weisgerber, J.5
Sandhoff, K.6
-
61
-
-
0028905325
-
2-(Tributylstannyl)-4-[3-(trifluoro-methyl)-3H-diazirin-3-yl]benzyl alcohol: A building block for photolabeling and cross-linking reagents of very high specific radioactivity
-
Weber, T. and Brunner, J. (1995) 2-(Tributylstannyl)-4-[3-(trifluoro-methyl)-3H-diazirin-3-yl]benzyl alcohol: a building block for photolabeling and cross-linking reagents of very high specific radioactivity. J. Am. Chem. Soc., 117, 3084-3095.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 3084-3095
-
-
Weber, T.1
Brunner, J.2
-
62
-
-
0028981358
-
Ceramide activates the stress-activated protein kinases
-
Westwick, J.K., Bielawska, A.E., Dbaibo, G., Hannun, Y.A. and Brenner, D.A. (1995) Ceramide activates the stress-activated protein kinases. J. Biol Chem., 270, 22689-22692.
-
(1995)
J. Biol Chem.
, vol.270
, pp. 22689-22692
-
-
Westwick, J.K.1
Bielawska, A.E.2
Dbaibo, G.3
Hannun, Y.A.4
Brenner, D.A.5
-
63
-
-
0028108015
-
Functional dichotomy of neutral and acidic sphingomyelinase in tumor necrosis factor signaling
-
Wiegmann, K., Schütze, S., Machleidt, T., Witte, D. and Krönke, M. (1994) Functional dichotomy of neutral and acidic sphingomyelinase in tumor necrosis factor signaling. Cell, 78, 1005-1015.
-
(1994)
Cell
, vol.78
, pp. 1005-1015
-
-
Wiegmann, K.1
Schütze, S.2
Machleidt, T.3
Witte, D.4
Krönke, M.5
-
64
-
-
0033605293
-
Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase
-
Wiegmann, K., Schwandner, R., Krut, O., Yeh, W.-C., Mak, T.W. and Krönke, M. (1999) Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase. J. Biol. Chem., 274, 5267-2570.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5267-12570
-
-
Wiegmann, K.1
Schwandner, R.2
Krut, O.3
Yeh, W.-C.4
Mak, T.W.5
Krönke, M.6
-
65
-
-
0032514902
-
Lysosomal degradation on vesicular membrane surfaces. Enhanced glucosylceramide degeneration by lysosomal anionic lipids and activators
-
Wilkening, G., Linke, T. and Sandhoff, K. (1998) Lysosomal degradation on vesicular membrane surfaces. Enhanced glucosylceramide degeneration by lysosomal anionic lipids and activators. J. Biol. Chem., 273, 30271-03278.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30271-103278
-
-
Wilkening, G.1
Linke, T.2
Sandhoff, K.3
-
66
-
-
0032580334
-
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity
-
Wu, S.H., Saftig, P., Peters, C. and El-Deiry, W. (1998) Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene, 16, 2177-2183.
-
(1998)
Oncogene
, vol.16
, pp. 2177-2183
-
-
Wu, S.H.1
Saftig, P.2
Peters, C.3
El-Deiry, W.4
-
67
-
-
15144359445
-
Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death
-
Yoshimura, S. et al. (1998) Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. J. Biol. Chem., 273, 6921-6927.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 6921-6927
-
-
Yoshimura, S.1
-
68
-
-
0001712708
-
The toxicity of oxidized low-density lipoprotein is mediated through lysosomal damage
-
Yuan, X.M., Li, W., Olsson, A.G. and Brunk, U.T. (1997) The toxicity of oxidized low-density lipoprotein is mediated through lysosomal damage. Arteriosclerosis, 133, 153-161.
-
(1997)
Arteriosclerosis
, vol.133
, pp. 153-161
-
-
Yuan, X.M.1
Li, W.2
Olsson, A.G.3
Brunk, U.T.4
-
69
-
-
9344222195
-
Bcl-2 interrupts the ceramide-mediated pathway of cell death
-
Zhang, J., Alter, N., Reed, J.C., Borner, C., Obeid, L.M. and Hannun, Y. (1996) Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc. Natl Acad Sci. USA, 93, 5325-5328.
-
(1996)
Proc. Natl Acad Sci. USA
, vol.93
, pp. 5325-5328
-
-
Zhang, J.1
Alter, N.2
Reed, J.C.3
Borner, C.4
Obeid, L.M.5
Hannun, Y.6
-
70
-
-
0343742670
-
Kinase supressor of Ras is ceramide activated protein kinase
-
Zhang, Y. et al. (1997). Kinase supressor of Ras is ceramide activated protein kinase. Cell, 89, 63-72.
-
(1997)
Cell
, vol.89
, pp. 63-72
-
-
Zhang, Y.1
-
71
-
-
0021928938
-
Characterization of parathyroid hormone fragments produced by cathepsin D
-
Zull, J.E. and Chuang, J. (1985) Characterization of parathyroid hormone fragments produced by cathepsin D. J. Biol. Chem., 260, 1608-1613.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 1608-1613
-
-
Zull, J.E.1
Chuang, J.2
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