Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes

Radiology

Volumn 222, Issue 3, 2002, Pages 814-818

  Bremer, Christoph ^a   Tung, Ching Hsuan ^a   Bogdanov Jr , Alex ^a   Weissleder, Ralph ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Animals; Breast neoplasms, experimental studies; Infrared and near infrared spectroscopy

Indexed keywords

CATHEPSIN B; CY5; FLUOROCHROME; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER INVASION; ENZYME ACTIVITY; EQUIPMENT; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFRARED SPECTROSCOPY; METASTASIS; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; NUDE MOUSE; PHENOTYPE; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; WESTERN BLOTTING;

EID: 0036125256     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiol.2223010812     Document Type: Article

References (31)

1. Cancer: Proteases - Invasion and more
2. Molecular regulation, membrane association and secretion of tumor cathepsin B
3. Cytochemical and biochemical evidence of cathepsin B in malignant, transformed and normal breast epithelial cells
4. Evaluation of cathepsin D as prognostic predictor in breast cancer
5. Proteinases and sialyltransferase in human breast tumors
6. Control of breast tumor cell growth using a targeted cysteine protease inhibitor
7. High levels of cathepsin B predict poor outcome in patients with breast cancer
8. Proteinase activity in invasive cancer of the breast: Correlation with tumor progression
9. Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls
10. Secretion of proteinases from malignant and nonmalignant human breast tissue
11. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
12. Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging
13. Near-infrared optical imaging of protease activity for tumor detection
14. BT20
15. Morphological and biochemical properties of a new human breast cancer cell line
16. Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas
17. Tissue cathepsins as tumor markers
18. Imaging proteolysis by living human breast cancer cells
19. Light scanning versus mammography in breast cancer detection
20. Light scan evaluation of nonpalpable breast lesions
21. Diaphanography in the diagnosis of breast cancer
22. Transillumination in breast cancer detection: Screening failures and potential
23. Probing physiology and molecular function using optical imaging: Applications to breast cancer
24. Experimental three-dimensional fluorescence reconstruction of diffuse media using a normalized born approximation
25. Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast
26. Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
27. In vivo imaging of proteolytic activity using a novel molecular reporter
28. Control of matrix metalloproteinase activity in cancer
29. Proteases and their inhibitors in human brain tumours: A review
30. Matrix metalloproteinase inhibitors
31. In vivo molecular target assessment of matrix metalloproteinase inhibition