DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

Journal of Cell Biology

Volumn 157, Issue 3, 2002, Pages 455-468

  Inbal, Boaz ^a   Bialik, Shani ^a   Sabanay, Ilana ^a   Shani, Gidi ^a   Kimchi, Adi ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Autophagy; DAP kinase; DRP 1; Membrane blebbing; Programmed cell death

Indexed keywords

ANTIESTROGEN; CASPASE; DAPK RELATED PROTEIN KINASE 1; DEATH ASSOCIATED PROTEIN KINASE; GAMMA INTERFERON; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN P55; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN MCF 7; ENZYME ACTIVITY; ENZYME KINETICS; HELA CELL; HUMAN; HUMAN CELL; MEMBRANE VESICLE; PRIORITY JOURNAL; PROTEIN MALNUTRITION; STAINING;

ANTIGENS, CD; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASPASES; CELL LINE; CELL MEMBRANE; HELA CELLS; HUMANS; INTERFERON TYPE II; NERVE TISSUE PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RNA, ANTISENSE; TRANSPORT VESICLES; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0037193474     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109094     Document Type: Article

References (48)

1. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
2. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles
3. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
4. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
5. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
6. Staurosporine-induced cell death in Tetrahymena thermophila has mixed characteristics of both apoptotic and autophagic degeneration
7. Developmental cell death: Morphological diversity and multiple mechanisms
8. DAPk is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
9. DAPk participates in TNF-α- and Fas-induced apoptosis and its function requires the death domain
10. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
11. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
12. Autophagy and related mechanisms of lysosome-mediated protein degradation
13. The death domain: A module shared by proteins with diverse cellular functions
14. Oxidative phosphorylation and ultrastructural transformation in mitochondria in the intact ascites tumor cell
15. DAP kinase links the control of apoptosis to metastasis
16. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis
17. TGF-beta induces apoptosis through Smad-mediated expression of DAPk
18. Inhibition of autophagy abrogates turnout necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells
19. Identification of a new form of death associated protein kinase that promotes cell survival
20. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
21. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity
22. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
23. DAPk loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
24. Autophagy as a regulated pathway of cellular degradation
25. The DAP kinase family of proapoptotic proteins: Novel players in the apoptotic game
26. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
27. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein
28. Induction of autophagy and inhibition of tumorigenesis by beclin 1
29. Inhibition of Ced-3/ ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
30. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
31. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
32. ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells
33. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe
34. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
35. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons
36. DAP kinase-a proapoptotic gene that functions as a tumor suppressor
37. A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity
38. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
39. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
40. 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
41. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding
42. A novel mechanism of negative autophosphorylation restrains the pro-apoptotic function of DAPk J
43. Immunochemistry on ultrathin frozen sections
44. Cell death: The significance of apoptosis
45. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
46. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
47. Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis
48. Cell death: Programmed, apoptosis, necrosis, or other?