Cysteine proteinases in cancer progression and their clinical relevance for prognosis

Biological Chemistry

Volumn 379, Issue 2, 1998, Pages 125-130

  Lah, Tamara T ^a   Kos, Janko ^b,c  

^a NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c KRKA D D   (Slovenia)

Author keywords

Cancer; Cathepsins; Cystatins; Prognosis; Stefins

Indexed keywords

CATHEPSIN; CYSTATIN; CYSTEINE PROTEINASE; KININOGEN; LYSOSOME ENZYME;

BREAST CARCINOMA; CANCER GROWTH; COLORECTAL CARCINOMA; HEAD AND NECK CARCINOMA; HUMAN; LUNG CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; REVIEW;

ANIMALS; CATHEPSINS; CYSTEINE PROTEINASE INHIBITORS; DISEASE PROGRESSION; HUMANS; NEOPLASMS; PROGNOSIS;

FELIS CATUS;

EID: 0031932089     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. Berquin, I.M., and Sloane, B.F. (1995). Cysteine proteases and tumor progression. Perspectives in drug discovery and design 2, 371-388.
2. Budihna, M., Škrk, J., Zakotnik, B., Gabrijelčič, D., and Lindner, J. (1995). Prognostic value of total cathepsin B in invasive ductal carcinoma of the breast. Eur. J. Cancer 31, 661-664.
3. Budihna, M., Strojan, P., Šmid, L., Škrk, J., Vrhovec, I., Rudolf, Z., Žargi, M., Krašovec, M., Svetic, B., Kopita-Jerala, N., and Kos, J. (1996). Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma. Biol. Chem. 377, 385-390.
4. Calkins, C.C., and Sloane, B.F. (1995). Mammalian cysteine protease inhibitors: Biochemical properties and possible roles in tumor progression. Biol. Chem. 376, 71-80.
5. Campo, E., Munoz, J., Miquel, R., Palacin, A., Cardesa, A., and Sloane, B.F. (1994). Cathepsin B expression in colorectal carcinoma correlates with tumor progression and shortened patient survival. Am. J. Pathol. 145, 301-309.
6. Chapman, H.A., Riese, J.R., and Shi, G.-P. (1997). Emerging role for cysteine proteases in human biology. Ann. Rev. Physiol. 59, 63-88.
7. Ebert, W., Knoch, H., Werle, B., Trefz, G., Muley, T., and Spiess, E. (1994). Prognostic value of increase lung tumor tissue cathepsin B. Anticancer Res. 14, 895-890.
8. Ebert, E., Werle, B., Juelke, B., Kopitar-Jerala, N., Kos, J., Lah, T., Abrahamson, M., Spiess, E., and Ebert, W. (1997). Expression of cysteine proteinase inhibitors Stefin A, Stefin B and Cystatin C in human lung tumors. Adv. Exp. Med. Biol. 421, 259-265.
9. Emmert-Buck, M.R., Roth, M.J., Zhuang, Z., Champo, E., Rozhin, J., Sloane, B.F., Liotta, L.A., and Stetler-Stevenson, W.G. (1994). Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. Am. J. Pathol. 145, 1285-1290.
10. Foekens, J., Kos, J., Peters, H.A., Krašovec, M., Look, M.P., Cimerman, N., Meijer-van-Gelder, M., Henzen Logmans, S.C., Putten, W.L.J., and Klijn, J.G.M. (1997). Prognostic significance of cathepsins B and L in primary human breast cancer. J. Clin. Oncol., in press.
11. Graeff, H., Harbeck, N., Pache, L., Wilhem, O., Janicke, F., and Schmitt, M. (1992). Prognostic impact and clinical relevance of tumor-associated proteases in breast cancer. Fibrinolysis 6, 45-53.
12. Henskens, Y.M.C., Veerman, E.C.I., and Amerogen, A.V.N. (1996). Cystatins in health and disease. Biol. Chem. 377, 71-86.
13. Heuser, J. (1989). Changes in lysosomal shape and distribution correlated with changes in cytoplasmic pH. J. Cell Biol. 108, 855-864.
14. Honn, K.V., Timar, J., Rozhin, J., Bazaz, R., Sameni, M., Ziegler, G., and Sloane, B.F. (1994). A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Exp. Cell Res. 214, 120-130.
15. Inoue, T., Ishida, K., Sugio, K., and Sugimachi, K. (1994). Cathepsin B expression and laminin degradation as factors influencing prognosis of surgically treated patients with lung adenocarcinoma. Cancer Res. 54, 6133-6136.
16. Jaervinen, M., Rinne, A., and Hopsu-Havu, V.K. (1989). Human cystatins in normal and diseased tissues: a review. Acta Histochem. 82, 5-18.
17. Keppler, D., Fondaneche, M.C., Dalet-Fumeron, V., Pagano, M., and Burtin, P. (1988). Immunohistochemical and biochemical study of a cathepsin B like proteinase in human colonic cancers. Cancer Res. 48, 6855-6862.
18. Keppler, D., and Sloane, B.F. (1996). Cathepsin B: Multiple enzyme forms from a single gene and their relation to cancer. Enzyme Protein 49, 94-105.
19. Knoch, H., Werle, B., Ebert, W., and Spiess, E. (1994). Imbalance between cathepsin B and cysteine proteinase inhibitors is of prognostic significance in human lung cancer. Int. J. Oncol. 5, 77-85.
20. Kos, J., Šmid, A., Krašovec, M., Svetic, B., Lenarčič, B., Vrhovec, I., Škrk, J., and Turk, V. (1995). Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer. Biol. Chem. 376, 401-405.
21. Kos, J. (1996a). Cathepsins and their inhibitors-new factors for prognosis in cancer. Europ. Clin. Laboratory 15, 16-17.
22. Kos, J., Štabuc, B., Krašovec, M., Schweiger, A., Svetic, B., Kopita-Jerala, N., Ocvirk, J., Cimerman, N., Rudolf, Z., and Vrhovec, I. (1996b). Lysosomal proteases cathepsins B, H, L and their inhibitors stefin A and cystatin C in sera of patients with metastatic melanoma. In: Molecular Oncology Today, J. Škrk and M. Osmak, eds. (Zagreb: Croatian League against Cancer), pp. 97-103.
23. Kos, J., Štabuc, B., Schweiger, A., Krašovec, M., Cimerman, N., Kopitar-Jerala, N., and Vrhovec, I. (1997). Cathepsins B, H, L, and their inhibitors stefin A and cystatin C in sera of melanoma patients. Clin. Cancer Res. 3, 1815-1822.
24. Lah, T.T., Kokalj-Kunovar, M., Kastelic, L., Babnik, J., Štolfa, A., Rainer, S., and Turk, V. (1991). Cystatins and stefins in ascites fluid from ovarian carcinoma. Cancer Lett. 67, 243-253.
25. Lah, T.T., Kokalj-Kunovar, M., Štrukelj, B., Pungerčar, J., Maganja, D.-B., Drobnič-Košorok, M., Kastelic, L., Babnik, J., Golouh, R., and Turk, V. (1992). Stefins and lysosomal cathepsins B, L and D in human breast carcinoma. Int. J. Cancer 50, 36-44.
26. Lah, T.T., Calaf, G., Kalman, E., Shinde, B.G., Somers, R., Russo, J., Jarocz, D., Zabrecky, J., and Daskal, I. (1995). Cathepsins D, B and L in human breast carcinoma and in transformed cells. Biol. Chem. 376, 357-363.
27. Lah, T.T., Calaf, G., Kalman, E., Shinde, G., Somers, R., Estrada, S., Salero, E., Russo, J., Jarocz, D., Zabrecky, J., and Daskal, I. (1996). Differential regulation of cathepsins D, B and L in transformed human breast epithelial cells (HBEC) with increased invasiveness. Breast Cancer Research and Treatment 39, 221-233.
28. Lah, T.T., Kos, J., Blejec, A., Frkovič-Gergios, S., Golouh, R., Vrhovec, I., and Turk, V. (1997). The expression of lysosomal proteinases and their inhibitors in breast cancer: possible relationship to prognosis of the disease. Path. Oncol. Res. 3, 89-99.
29. Mansourm, E.G., Ravdin, P., and Dressier, L. (1994). Prognostic factors in early breast carcinoma. Cancer 74, 381-400.
30. McGuire, W.L., Tandon, A.K., Allred, D.C., Chamnes, G.C., and Clark, G.M. (1990). Commentaries: How to use prognostic factors in axillary node-negative breast cancer patients. J. Nat. Cancer Inst. 82, 12.
31. Mori, M., Kohli, A., Baker, S.R. Savas, L., and Fraire, A.E. (1997). Laminin and cathepsin B as prognostic factors in stage I non-small cell lung cancer: are they useful? Mod. Pathol. 70, 572-577.
32. Murnane, M.J., Sheahan, K., Ozdemirli, M., and Shuja, S. (1991). Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma. Cancer Res. 51, 1137-1142.
33. Poole, A.R., Tiltman, K.J., Recklies, A.S., and Stoker, T.A.M. (1987). Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinoma and fibroadenoma. Nature 273, 545-547.
34. Rochefort, H., Capony, F., and Garcia, M. (1990). Cathepsin D: A proteinase involved in breast cancer metastasis. Cancer and Metastasis Rev. 9, 321-331.
35. Sameni, M., Elliot, E., Ziegler, G., Fortgens, P.H., Dennison, C., and Sloane, B.F. (1995). Cathepsin D and B are localized at the surface of human breast cancer cells. Path. Oncol. Res. 7, 43-53.
36. Schmitt, M., Jaenicke, F., and Graeff, H. (1992). Pretease, matrix degradation and tumor-cell spread. Fibrinolysis 6, Suppl. 4, 1-17.
37. Schweiger, A., Štabuc, B., Popović, T., Turk, V., and Kos, J. (1997). Enzyme linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. J. Immunol. Methods 201, 165-172.
38. Sheahan, K., Shuja, S., and Murnane, M.J. (1989). Cysteine protease activities and tumor development in human colorectal carcinoma. Cancer Res. 49, 3809-3814.
39. Sloane, B.F., Rozhin, J., Moin, K., Ziegler, G., Fong, D., and Muschel, R.J. (1992). Cysteine endopeptidases and their inhibitors in malignant progression of rat embryo fibroblasts. Biol. Chem. 373, 589-594.
40. Sloane, B.F., Moin, K., and Lah, T.T. (1994a). Lysosomal enzymes and their endogenous inhibitors in neoplasia. In: Biochemical and Molecular Aspects of Selected Cancers, T.G. Pretlow and T.P. Pretlow, eds. (New York: Academic Press), pp. 411-466.
41. Sloane, B.F., Moin, K., Sameni, M., Tait, L.R., Rozhin, J., and Ziegler, G. (1994b). Membrane association of cathepsins B can be induced by transfection of human breast epithelial cells with c-Ha-Ras oncogene. J. Cell Science 107, 373-384.
42. Šmid, L., Strojan, P., Budihna, M., Škrk, J., Vrhovec, J., Žargi, M., and Kos, J. (1997). Prognostic value of cathepsins B, D, and stefins A and B in laryngeal carcinoma. Eur. Arch. Otolaryngol. 254, 150-153.
43. Sukoh, N., Abe, S., Ogura, S., Isobe, H., Takekawa, H., and Inoue, K. (1994). Immunohistochemical study of cathepsin B. Cancer 74, 46-51.
44. Thomssen, C., Schmitt, M., Goretzki, L., Oppelt, P., Jänicke, F., Pache, L., and Graeff, H. (1995). Prognostic values of the cysteine protease cathepsin B and L in human breast cancer. Clin. Cancer Res. 1, 741-746.
45. Thomssen, C., Oppelt, P., Jaenicke, F. et al. (1997). Identification of low-risk node negative breast cancer patients by tumor biological factors PAI-I and cathepsin L. Anticancer Res., in press.
46. Turk, B., Turk, V., and Turk, D. (1997). Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors. Biol. Chem. 378, 141-150.
47. Werle, B., Julke, B., Lah, T., Kos, J., Spiess, E., and Ebert, W. (1997a). Cathepsin B and cathepsin L: Prognostic factors in human lung cancer. In: Proteolysis in Cell Function. V.K. Hopsu-Havu, M. Jarvinen and H. Kirschke, eds. (Amsterdam, The Netherlands: IOS Press), pp. 472-478.
48. Werle, B., Julke, B., Lah, T., Spiess, E., and Ebert, W. (1997b). Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung. British J. Cancer 75, 1137-1143.