Protection against fatal sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein

Journal of Virology

Volumn 72, Issue 11, 1998, Pages 8586-8596

  Liang, Xiao Huan ^a   Kleeman, Linda K ^a   Jiang, Hui Hui ^d   Gordon, Gerald ^b   Goldman, James E ^a   Berry, Gail ^b   Herman, Brian ^b,c   Levine, Beth ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN; GENE PRODUCT; PROTEIN BCL 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HOST RESISTANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINDBIS VIRUS; STOP CODON; VIRUS ENCEPHALITIS; VIRUS INFECTION; VIRUS REPLICATION; VIRUS TITRATION;

EID: 0001488499     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.11.8586-8596.1998     Document Type: Article

References (42)

1. Allsopp, T. E., M. F. Scallan, A. Williams, and J. K. Fazakerley. 1998. Virus infection induces neuronal apoptosis: a comparison with trophic factor withdrawal. Cell Death Differ. 5:50-59.
2. Altshul, S. F., W. Gish, W. Miller, E. W. Meyers, and D. J. Lipman. 1990. Basic local alignment tool. J. Mol. Biol. 215:403-410.
3. Antoni, B. A., P. A. Sabbatini, A. B. Rabson, and E. White. 1995. Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection. J. Virol. 69:2384-2392.
4. L, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608.
5. L. Nature 379: 554-556.
6. Clegg, R. M. 1992. Fluorescence resonance energy transfer and nucleic acids. Methods Enzymol. 211:353-388.
7. Clem, R., and L. K. Miller. 1993. Apoptosis reduces both the in vitro replication and the in vivo infectivity of baculovirus. J. Virol. 67:3730-3738.
8. Friedman, L. S., E. A. Ostermeyer, E. D. Lynch, C. I. Szabo, L. A. Anderson, P. Dowd, M. K. Lee, S. E. Rowell, J. M. Boyd and M.-C. King. 1994. The search for BRCA1. Cancer Res. 54:6374-6382.
9. Gordon, G. W., G.-Berry, X. H. Liang, B. Levine, and B. Herman. 1998. Quantitative fluorescence resonance energy transfer (FRET) measurements using fluorescence microscopy. Biophys. J. 74:2702-2713.
10. Grandgirard, D., E. Studer, L. Monney, T. Belser, I. Fellay, C. Borner, and M. R. Michel. 1998. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J. 17:1268-1278.
11. Hardwick, J. M. 1997. Virus-induced apoptosis. Adv. Pharmacol. 41:295-336.
12. Herman, B. 1996. Fluorescence microscopy: state of the art, p. 1-14. In J. Slavik (ed.), Fluorescent microscopy and fluorescent probes. Plenum Press, New York, N.Y.
13. Hinshaw, V. S., C. W. Olsen, N. Dybdahl-Sissoko, and D. Evans. 1994. Apoptosis: a mechanism of cell killing by influenza A and B viruses. J. Virol. 68:3667-3673.
14. Jiang, H. H., and B. Levine. Unpublished data.
15. Joe, A. K. H. H. Foo, L. Kleeman, and B. Levine. 1998. The transmembrane domains of Sindbis virus envelope glycoproteins induce cell death. J. Virol. 72:3935-3943.
16. Krakauer, D. C., and R. J. Payne. 1997. The evolution of virus-induced apoptosis. Proc. R. Soc. Lond. Ser. B 264:1757-1762.
17. Levine, B., J. E. Goldman, H. H. Jiang, D. E. Griffin, and J. M. Hardwick. 1996. Bcl-2 protects mice against fatal alphavirus encephalitis. Proc. Natl. Acad. Sci. USA 93:4810-4815.
18. Levine, B., Q. Huang, J. T. Isaacs, J. C. Reed, D. E. Griffin, and J. M. Hardwick. 1993. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature 361:739-742.
19. Lewis, J., S. L. Wesslingh, D. E. Griffin, and J. M. Hardwick. 1996. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence. J. Virol. 70:1828-1835.
20. Liang, X. H., M. Volkmann, R. Klein, B. Herman, and B. Lockett. 1994. Colocalization of tumor suppressor protein p53 and human papillomavirus E6 protein in human cervical carcinoma cell lines. Oncogene 8:2645-2652.
21. Liao, C. L., Y. L. Lin, J. J. Wang, Y. L. Huang, C. T. Yeh, S. H. Ma, and L. K. Chen. 1997. Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells. J. Virol. 71:5963-5971.
22. Lupas, A., M. Van Dyke, and M. J. Stock. 1991. Predicting coiled coils from protein sequences. Science 252:1162-1164.
23. Merry, D. E., and S. J. Korsmeyer. 1997. Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20:245-267.
24. Nava, V. E., A. Rosen, M. A. Veliuona, R. J. Clem, B. Levine, and J. M. Hardwick. 1998. Sindbis virus induces apoptosis through a caspase-dependent CrmA-sensitive pathway. J. Virol. 72:452-459.
25. Oberhaus, S. M., R. L. Smith, G. W. Clayton, T. S. Dermody, and K. L. Tyler. 1997. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J. Virol. 71:2100-2106.
26. Olsen, C. W., J. C. Kehren, N. R. Dybdahl-Sissoki, and V. S. Hinshaw. 1996. bcl-2 alters influenza virus, yield, spread, and hemagglutinin glycosylation. J. Virol. 80:663-666.
27. Oltvai, Z., C. L. Milliman, and S. J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
28. Park, J. R., and D. M. Hockenbery. 1996. Bcl-2, a novel regulator of apoptosis. J. Cell. Biochem. 60:12-17.
29. Pekosz, A., J. Phillips, D. Pleasure, D. Merry, and F. Gonzalez-Scarano. 1996. Induction of apoptosis by LaCrosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention. J. Virol. 70: 5329-5335.
30. Reed, J. C. 1997. Double identity for proteins of the Bcl-2 family. Nature. 387:773-776.
31. Rodgers, S. E., E. S. Barton, S. M. Oberhaus, B. Pike, C. A. G. Terence, K. L. Tyler, and T. S. Dermody. 1997. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J. Virol. 71:2540-2546.
32. Rommens, J. M., F. Durocher, J. McArthur, P. Tonin, J.-F. LeBlanc, T. Allen, C. Samson, L. Ferri, S. Narod, K. Morgan, and J. Simard. 1995. Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. Genomics 28:530-542.
33. Root, D. D. 1997. In situ molecular association of dystrophin with actin revealed by sensitized emission immuno-resonance energy transfer. Proc. Natl. Acad. Sci. USA 94:5685-5690.
34. Scallan, M. F., T. E. Allsopp, and J. K. Fazakerley. 1997. bcl-2 acts early to restrict Semliki Forest virus replication and delays virus-induced programmed cell death. J. Virol. 71:1583-1590.
35. Selvin, P. R. 1995. Fluorescence resonance energy transfer. Methods Enzymol. 246:300-333.
36. Shen, Y., and T. E. Shenk. 1995. Viruses and apoptosis. Curr. Opin. Genet. Dev. 5:105-111.
37. Soares, M. B., M. F. Bonaldo, P. Jelene, L. Su, L. Lawton, and A. Efstradiadis. 1994. Construction and characterization of a normalized cDNA library. Proc. Natl. Acad. Sci. USA 91:9228-9232.
38. Tangir, J., M. G. Muto, R. S. Berkowitz, W. R. Welch, D. A. Bell, and S. C. Mok. 1996. A 400 kb novel deletion unit centromeric to the BRCA1 gene in sporadic epithelial ovarian cancer. Oncogene 12:735-740.
39. Teodoro, J. G., and P. E. Branton. 1997. Regulation of apoptosis by viral gene products. J. Virol. 71:1739-1746.
40. Tucker, P. C., E. G. Strauss, R. J. Kuhn, J. H. Strauss, and D. E. Griffin. 1993. Viral determinants of age-dependent virulence of Sindbis virus for mice. J. Virol. 67:4605-4610.
41. Ubol, S., P. C. Tucker, D. E. Griffin, and J. M. Hardwick. 1994. Neurovirulent strains of alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein. Proc. Natl. Acad. Sci. USA 91:5202-5206.
42. Yin, X.-M., Z. N. Oltvai, and S. J. Korsmeyer. 1994. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with BAX. Nature 369:321-323.