메뉴 건너뛰기




Volumn 86, Issue 2, 1996, Pages 189-199

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; COMPLEMENTARY DNA; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 16044364385     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80091-4     Document Type: Article
Times cited : (741)

References (68)
  • 1
    • 0026649127 scopus 로고
    • Radiation-induced apoptosis: Its role in a MADCaT (mitosis-apoptosis-differentiation-calcium toxicity) scheme of cytotoxicity mechanisms
    • Allan, D.J. (1992). Radiation-induced apoptosis: its role in a MADCaT (mitosis-apoptosis-differentiation-calcium toxicity) scheme of cytotoxicity mechanisms. Int. J. Radiat. Biol. 62, 145-152.
    • (1992) Int. J. Radiat. Biol. , vol.62 , pp. 145-152
    • Allan, D.J.1
  • 2
    • 0021688283 scopus 로고
    • Use of cyclosporin A in establishing Epstein-Barr virus-transformed human lymphoblastoid cell lines
    • Anderson, M.A., and Gusella, J.F. (1984). Use of cyclosporin A in establishing Epstein-Barr virus-transformed human lymphoblastoid cell lines. In Vitro 20, 856-858.
    • (1984) In Vitro , vol.20 , pp. 856-858
    • Anderson, M.A.1    Gusella, J.F.2
  • 3
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, A., Fuks, Z., and Kolesnick, R.N. (1995). Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82, 405-414.
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, A.4    Fuks, Z.5    Kolesnick, R.N.6
  • 5
    • 0025836802 scopus 로고
    • Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiation
    • Bradford, J.S. (1991). Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 21, 1457-1469.
    • (1991) Int. J. Radiat. Oncol. Biol. Phys. , vol.21 , pp. 1457-1469
    • Bradford, J.S.1
  • 6
    • 0013881132 scopus 로고
    • The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick disease
    • Brady, R.O., Kanfer, J.N., Mock, M.B., and Fredrickson, D.S. (1966). The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick disease. Proc. Natl. Acad. Sci. USA 55, 366-369.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.55 , pp. 366-369
    • Brady, R.O.1    Kanfer, J.N.2    Mock, M.B.3    Fredrickson, D.S.4
  • 7
    • 4244120872 scopus 로고
    • Microdetermination of phosphorus
    • Chen, J.P.S., Toribara, T.Y., and Warner, H. (1956). Microdetermination of phosphorus. Anal. Chem. 28, 1756-1758.
    • (1956) Anal. Chem. , vol.28 , pp. 1756-1758
    • Chen, J.P.S.1    Toribara, T.Y.2    Warner, H.3
  • 9
    • 0028790239 scopus 로고
    • Multiple pathways originate at the Fas/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal
    • Cifone, M.G., Roncaioli, P., De Maria, R., Camarda, G., Santoni, A., Ruberti, G., and Testi, R. (1995). Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J. 14, 5859-5868.
    • (1995) EMBO J. , vol.14 , pp. 5859-5868
    • Cifone, M.G.1    Roncaioli, P.2    De Maria, R.3    Camarda, G.4    Santoni, A.5    Ruberti, G.6    Testi, R.7
  • 10
    • 0027428950 scopus 로고
    • Beneficial liaisons: Radiobiology meets cellular and molecular biology
    • Coleman, C.N. (1993). Beneficial liaisons: radiobiology meets cellular and molecular biology. Radiother. Oncol. 28, 1-15.
    • (1993) Radiother. Oncol. , vol.28 , pp. 1-15
    • Coleman, C.N.1
  • 11
    • 0015026984 scopus 로고
    • Chromosomal aberrations and mortality of x-irradiated mammalian cells: Emphasis on repair
    • Dewey, W.C., Miller, H.H., and Leeper, D.B. (1971). Chromosomal aberrations and mortality of x-irradiated mammalian cells: emphasis on repair. Proc. Natl. Acad. Sci. USA 68, 667-671.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 667-671
    • Dewey, W.C.1    Miller, H.H.2    Leeper, D.B.3
  • 13
    • 0026723048 scopus 로고
    • Ceramide stimulates a cytosolic protein phosphatase
    • Dobrowsky, R.T., and Hannun, Y.A. (1992). Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem. 267, 5048-5051.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5048-5051
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 14
    • 0027428283 scopus 로고
    • Ceramide-activated protein phosphatase: Partial purification and relationship to protein phosphatase 2A
    • Dobrowsky, R.T., and Hannun, Y.A. (1993). Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv. Lipid Res. 25, 91-104.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 91-104
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 15
    • 0025168334 scopus 로고
    • Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells synthesis via ceramide from sphingomyelin
    • Dressler, K.A., and Kolesnick, R.N. (1990). Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells synthesis via ceramide from sphingomyelin. J. Biol. Chem. 256, 14917-14921.
    • (1990) J. Biol. Chem. , vol.256 , pp. 14917-14921
    • Dressler, K.A.1    Kolesnick, R.N.2
  • 16
    • 0026560014 scopus 로고
    • Tumor necrosis factor-α activates the sphingomyelin signal transduction pathway in a cell-free system
    • Dressler, K.A., Mathias, S., and Kolesnick, R.N. (1992). Tumor necrosis factor-α activates the sphingomyelin signal transduction pathway in a cell-free system. Science 255, 1715-1718.
    • (1992) Science , vol.255 , pp. 1715-1718
    • Dressler, K.A.1    Mathias, S.2    Kolesnick, R.N.3
  • 17
    • 33750132435 scopus 로고
    • Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo
    • Fuks, Z., Alfieri, A., Haimovitz-Friedman, A., Seddon, A., and Cordon-Cardo, C. (1995). Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo. Cancer J. 1, 62-72.
    • (1995) Cancer J. , vol.1 , pp. 62-72
    • Fuks, Z.1    Alfieri, A.2    Haimovitz-Friedman, A.3    Seddon, A.4    Cordon-Cardo, C.5
  • 21
    • 0028019213 scopus 로고
    • Molecular biology in radiation therapy: The potential impact of recombinant technology on clinical practice
    • Hall, E.J. (1994). Molecular biology in radiation therapy: the potential impact of recombinant technology on clinical practice. Int. J. Radiat. Oncol. Biol. Phys. 30, 1919-1928.
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.30 , pp. 1919-1928
    • Hall, E.J.1
  • 22
    • 0028855405 scopus 로고
    • Ceramide: An intracellular signal for apoptosis
    • Hannun, Y.A., and Obeid, L.M. (1995). Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci. 20, 73-77.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 73-77
    • Hannun, Y.A.1    Obeid, L.M.2
  • 23
    • 0028596368 scopus 로고
    • The nature of ataxia-telangiectasia: Problems and perspectives
    • Harnden, D.G. (1994). The nature of ataxia-telangiectasia: problems and perspectives. Int. J. Radiat. Biol. 66, 9-13.
    • (1994) Int. J. Radiat. Biol. , vol.66 , pp. 9-13
    • Harnden, D.G.1
  • 25
    • 0014493255 scopus 로고
    • Time-lapse cinemicrographic studies of x-irradiated HeLa S3 cells
    • Hurwitz, C., and Tolmach, J.T. (1969). Time-lapse cinemicrographic studies of x-irradiated HeLa S3 cells. Biophys. J. 6, 607-633.
    • (1969) Biophys. J. , vol.6 , pp. 607-633
    • Hurwitz, C.1    Tolmach, J.T.2
  • 28
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp, C.J., Donehower, L.A., Bradley, A., and Balmain, A. (1993). Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74, 813-822.
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 29
    • 0025944874 scopus 로고
    • Sphingomyelin and derivatives as cellular signals
    • Kolesnick, R.N. (1991). Sphingomyelin and derivatives as cellular signals. Prog. Lipid Res. 30, 1-38.
    • (1991) Prog. Lipid Res. , vol.30 , pp. 1-38
    • Kolesnick, R.N.1
  • 30
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
    • Kuida, K., Lippke, J.A., Ku, G., Harding, M.W., Livingston, D.J., Su, M.S.-S., and Flavell, R.A. (1995). Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267, 2000-2003.
    • (1995) Science , vol.267 , pp. 2000-2003
    • Kuida, K.1    Lippke, J.A.2    Ku, G.3    Harding, M.W.4    Livingston, D.J.5    Su, M.S.-S.6    Flavell, R.A.7
  • 31
    • 0025933937 scopus 로고
    • Niemann-Pick type B disease: Identification of a single codon deletion in the acid sphingomyelinase gene and genotype/phenotype correlations in type A and B patients
    • Levran, O., Desnick, R.J., and Schuchman, E.H. (1991a). Niemann-Pick type B disease: identification of a single codon deletion in the acid sphingomyelinase gene and genotype/phenotype correlations in type A and B patients. J. Clin. Invest. 88, 806-810.
    • (1991) J. Clin. Invest. , vol.88 , pp. 806-810
    • Levran, O.1    Desnick, R.J.2    Schuchman, E.H.3
  • 32
    • 0025870103 scopus 로고
    • Niemann-Pick disease: Afrequent missense mutation in the acid sphingomyelinase gene of Ashkenazi Jewish type A and B patients
    • Levran, O., Desnick, R.J., and Schuchman, E.H. (1991b). Niemann-Pick disease: afrequent missense mutation in the acid sphingomyelinase gene of Ashkenazi Jewish type A and B patients. Proc. Natl. Acad. Sci. USA 88, 3748-3752.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3748-3752
    • Levran, O.1    Desnick, R.J.2    Schuchman, E.H.3
  • 33
    • 0027968517 scopus 로고
    • Renaturation and TNFα stimulation of a 97 kDa ceramide-activated protein kinase
    • Liu, J., Mathias, S., Yang, Z., and Kolesnick, R.N. (1994). Renaturation and TNFα stimulation of a 97 kDa ceramide-activated protein kinase. J. Biol. Chem. 269, 3047-3052.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3047-3052
    • Liu, J.1    Mathias, S.2    Yang, Z.3    Kolesnick, R.N.4
  • 34
    • 0028784298 scopus 로고
    • Compartmentalized production of ceramide at the cell surface
    • Liu, P., and Anderson, R.G.W. (1995). Compartmentalized production of ceramide at the cell surface. J. Biol. Chem. 270, 27179-27185.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27179-27185
    • Liu, P.1    Anderson, R.G.W.2
  • 35
    • 0028884525 scopus 로고
    • Cancer therapy and p53
    • Lowe, S.W. (1995). Cancer therapy and p53. Curr. Opin. Oncol. 7, 547-553.
    • (1995) Curr. Opin. Oncol. , vol.7 , pp. 547-553
    • Lowe, S.W.1
  • 36
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S.W., Ruley, H.E., Jacks, T., and Housman, D.E. (1993). p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 37
    • 0027965006 scopus 로고
    • Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase
    • Lozano, J., Berra, E., Municio, M.M., Diaz-Meco, M.T., Dominguez, I., Sanz, L., and Moscat, J. (1994). Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269, 19200-19202.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19200-19202
    • Lozano, J.1    Berra, E.2    Municio, M.M.3    Diaz-Meco, M.T.4    Dominguez, I.5    Sanz, L.6    Moscat, J.7
  • 38
    • 0024543412 scopus 로고
    • Purification and characterization of neutral and acid sphingomyelinases from rat brain
    • Maruyama, E.N., and Arima, M. (1989). Purification and characterization of neutral and acid sphingomyelinases from rat brain. J. Neurochem. 52, 611-618.
    • (1989) J. Neurochem. , vol.52 , pp. 611-618
    • Maruyama, E.N.1    Arima, M.2
  • 39
    • 0027461121 scopus 로고
    • Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β
    • Mathias, S., Younes, A., Kan, C.-C., Orlow, I., Joseph, C., and Kolesnick, R.N. (1993). Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259, 519-522.
    • (1993) Science , vol.259 , pp. 519-522
    • Mathias, S.1    Younes, A.2    Kan, C.-C.3    Orlow, I.4    Joseph, C.5    Kolesnick, R.N.6
  • 40
    • 0026593215 scopus 로고
    • Residual DNA damage: What is left over and how does this determine cell fate
    • McMillan, T.J. (1992). Residual DNA damage: what is left over and how does this determine cell fate. Eur. J. Cancer 28, 267-269.
    • (1992) Eur. J. Cancer , vol.28 , pp. 267-269
    • McMillan, T.J.1
  • 42
    • 0029003788 scopus 로고
    • PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid
    • Muller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D., and Pfizenmaier, K. (1995). PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14, 1961-1969.
    • (1995) EMBO J. , vol.14 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, D.5    Pfizenmaier, K.6
  • 46
    • 0027094804 scopus 로고
    • Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts
    • Olivera, A., Buckley, N.E., and Spiegel, S. (1992). Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts. J. Biol. Chem. 267, 26121 -26127.
    • (1992) J. Biol. Chem. , vol.267 , pp. 26121-26127
    • Olivera, A.1    Buckley, N.E.2    Spiegel, S.3
  • 47
    • 0029014350 scopus 로고
    • Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)
    • Otterbach, B., and Stoffel, W. (1995). Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease). Cell 81, 1053-1061.
    • (1995) Cell , vol.81 , pp. 1053-1061
    • Otterbach, B.1    Stoffel, W.2
  • 48
    • 0022650296 scopus 로고
    • Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after x-irradiation of mammalian cells
    • Radford, I.R. (1986). Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after x-irradiation of mammalian cells. Int. J. Radiat. Biol. 49, 611-620.
    • (1986) Int. J. Radiat. Biol. , vol.49 , pp. 611-620
    • Radford, I.R.1
  • 49
    • 0017183372 scopus 로고
    • Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0
    • Rao, B.G., and Spence, M.W. (1976). Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0. J. Lipid Res. 17, 506-515.
    • (1976) J. Lipid Res. , vol.17 , pp. 506-515
    • Rao, B.G.1    Spence, M.W.2
  • 50
    • 0014083339 scopus 로고
    • Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease
    • Schneider, P.B., and Kennedy, E.P. (1967). Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease. J. Lipid Res. 8, 202-209.
    • (1967) J. Lipid Res. , vol.8 , pp. 202-209
    • Schneider, P.B.1    Kennedy, E.P.2
  • 51
    • 0025819971 scopus 로고
    • Human acid sphingomyelinase: Isolation, nucleotide sequence, and expression of the full-length and alternatively spliced cDNAs
    • Schuchman, E.H., Suchi, M., Takahahi, T., Sandhoff, K., and Desnick, R.J. (1991). Human acid sphingomyelinase: isolation, nucleotide sequence, and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. 266, 8531-8539.
    • (1991) J. Biol. Chem. , vol.266 , pp. 8531-8539
    • Schuchman, E.H.1    Suchi, M.2    Takahahi, T.3    Sandhoff, K.4    Desnick, R.J.5
  • 52
    • 0026577992 scopus 로고
    • Structural organization and complete nucleotide sequence of the gene encoding human acid sphingomyelinase
    • Schuchman, E.H., Levran, O., and Desnick, R.J. (1992). Structural organization and complete nucleotide sequence of the gene encoding human acid sphingomyelinase. Genomics 12, 197-205.
    • (1992) Genomics , vol.12 , pp. 197-205
    • Schuchman, E.H.1    Levran, O.2    Desnick, R.J.3
  • 53
    • 0028149271 scopus 로고
    • Ionizing radiation induces apoptotic cell death in human TcR-γ/δ+ T and natural killer cells without detectable p53 protein
    • Seki, H., Kanegane, H., Iwai, K., Konno, A., Ohta, K., Yachie, A., Taniguchi, N., and Miyawaki, T. (1994). Ionizing radiation induces apoptotic cell death in human TcR-γ/δ+ T and natural killer cells without detectable p53 protein. Eur. J. Immunol. 24, 2914-2917.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2914-2917
    • Seki, H.1    Kanegane, H.2    Iwai, K.3    Konno, A.4    Ohta, K.5    Yachie, A.6    Taniguchi, N.7    Miyawaki, T.8
  • 55
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser, A., Harris, A.W., Jacks, T., and Cory, S. (1994). DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 79, 329-339.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 56
    • 0026607916 scopus 로고
    • Retroviral-mediated transfer of the human acid sphingomyelinase cDNA: Correction of the metabolic defect in cultured Niemann-Pick disease cells
    • Suchi, M., Dinur, T., Desnick, R., Gatt, S., Pereira, L., Gilboa, E., and Schuchman, E. (1992). Retroviral-mediated transfer of the human acid sphingomyelinase cDNA: correction of the metabolic defect in cultured Niemann-Pick disease cells. Proc. Natl. Acad. Sci. USA 89, 3227-3231.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3227-3231
    • Suchi, M.1    Dinur, T.2    Desnick, R.3    Gatt, S.4    Pereira, L.5    Gilboa, E.6    Schuchman, E.7
  • 58
    • 0025831290 scopus 로고
    • Properties and applications of human DNA repair genes
    • Thompson, L.H. (1991). Properties and applications of human DNA repair genes. Mutat. Res. 247, 213-219.
    • (1991) Mutat. Res. , vol.247 , pp. 213-219
    • Thompson, L.H.1
  • 59
    • 0014461346 scopus 로고
    • Proliferation kinetics of x-irradiated mouse L cells studied with time-lapse photography
    • Thompson, L.H., and Suit, H.D. (1969). Proliferation kinetics of x-irradiated mouse L cells studied with time-lapse photography. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 15, 347-362.
    • (1969) Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. , vol.15 , pp. 347-362
    • Thompson, L.H.1    Suit, H.D.2
  • 60
    • 0024341209 scopus 로고
    • Enzymatic quantitation of sphingosine in the picomole range in cultured cells
    • Van Veldhoven, P., Bishop, W.R., and Bell, R.M. (1989). Enzymatic quantitation of sphingosine in the picomole range in cultured cells. Anal. Biochem 183, 177-189.
    • (1989) Anal. Biochem , vol.183 , pp. 177-189
    • Van Veldhoven, P.1    Bishop, W.R.2    Bell, R.M.3
  • 62
    • 0028922462 scopus 로고
    • Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
    • Wang, Z.-Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M., and Wagner, E.F. (1995). Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 9, 509-520.
    • (1995) Genes Dev. , vol.9 , pp. 509-520
    • Wang, Z.-Q.1    Auer, B.2    Stingl, L.3    Berghammer, H.4    Haidacher, D.5    Schweiger, M.6    Wagner, E.F.7
  • 63
    • 0027973491 scopus 로고
    • The complexity of DNA damage: Relevance to biological consequences
    • Ward, J.F. (1994). The complexity of DNA damage: relevance to biological consequences. Int. J. Radiat. Biol. 66, 427-432.
    • (1994) Int. J. Radiat. Biol. , vol.66 , pp. 427-432
    • Ward, J.F.1
  • 64
    • 0028108015 scopus 로고
    • Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
    • Wiegmann, K., Schutze, S., Machleidt, T., Witte, D., and Kronke, M. (1994). Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78, 1005-1015.
    • (1994) Cell , vol.78 , pp. 1005-1015
    • Wiegmann, K.1    Schutze, S.2    Machleidt, T.3    Witte, D.4    Kronke, M.5
  • 65
    • 0028838235 scopus 로고
    • Ceramide-activated protein kinase is a Raf kinase
    • Yao, B., Zhang, Y., Delikat, S., Basu, S., and Kolesnick, R. (1995). Ceramide-activated protein kinase is a Raf kinase. Nature 378, 307-310.
    • (1995) Nature , vol.378 , pp. 307-310
    • Yao, B.1    Zhang, Y.2    Delikat, S.3    Basu, S.4    Kolesnick, R.5
  • 66
    • 0017081232 scopus 로고
    • Effect of Triton X-100 on the hydrolysis of sphingomyelin by sphingomyelinase of rat brain
    • Yedger, S., and Gatt, S. (1976). Effect of Triton X-100 on the hydrolysis of sphingomyelin by sphingomyelinase of rat brain. Biochemistry 15, 2570-2573.
    • (1976) Biochemistry , vol.15 , pp. 2570-2573
    • Yedger, S.1    Gatt, S.2
  • 67
    • 0028979815 scopus 로고
    • Fluorescence-based selection of retrovirally transduced cells in the absence of a gene marker: Direct selection of transduced type B Niemann-Pick disease cells and evidence for bystander correction
    • Yeyati, P.L., Agmon, V., Fillat, C., Dinor, T., Dagan, A., Desnick, R.J., Gatt, S., and Schuchman, E.H. (1995). Fluorescence-based selection of retrovirally transduced cells in the absence of a gene marker: direct selection of transduced type B Niemann-Pick disease cells and evidence for bystander correction. Hum. Gene Ther. 6, 975-983.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 975-983
    • Yeyati, P.L.1    Agmon, V.2    Fillat, C.3    Dinor, T.4    Dagan, A.5    Desnick, R.J.6    Gatt, S.7    Schuchman, E.H.8
  • 68
    • 0029391135 scopus 로고
    • Signaling through the sphingomyelin pathway
    • Zhang, Y., and Kolesnick, R.N. (1995). Signaling through the sphingomyelin pathway. Endocrinology 136, 4157-4160.
    • (1995) Endocrinology , vol.136 , pp. 4157-4160
    • Zhang, Y.1    Kolesnick, R.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.