Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death

Molecular Cancer Therapeutics

Volumn 4, Issue 5, 2005, Pages 733-742

  Emert Sedlak, Lori ^a   Shangary, Sanjeev ^b   Rabinovitz, Asaf ^b   Miranda, Michelle B ^b   Delach, Scott M ^b   Johnson, Daniel E ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CATHEPSIN D; CISPLATIN; CYTOCHROME C; ETOPOSIDE; FLUOROURACIL; PEPSTATIN; SMALL INTERFERING RNA; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ARTICLE; CELL DEATH; CELL STRAIN U937; CHEMOTHERAPY; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HELA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASES; CATHEPSIN D; CISPLATIN; CYTOCHROMES C; CYTOSOL; ENZYME ACTIVATION; ETOPOSIDE; FLUOROURACIL; HELA CELLS; HUMANS; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; U937 CELLS;

EID: 20044383567     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-04-0301     Document Type: Article

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