Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors

Biological Chemistry

Volumn 384, Issue 3, 2003, Pages 447-455

  Bervar, Aleš ^a   Zajc, Irena ^a   Sever, Nataša ^a   Katunuma, Nobuhiko ^b   Sloane, Bonnie F ^c   Lah, Tamara T ^a  

^a NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^c WAYNE STATE UNIVERSITY   (United States)

Author keywords

Cathepsin; Cystatin; Human tumor breast cells; Invasion; Stefin; Tumorigenicity

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CYSTATIN C; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; MESSENGER RNA; STEFIN A; STEFIN B;

ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST CANCER; BREAST EPITHELIUM; CARCINOGENICITY; CELL IMMORTALIZATION; CELL INVASION; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE H RAS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TUMOR CELL LINE;

BREAST NEOPLASMS; CATHEPSIN B; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CYSTEINE PROTEINASE INHIBITORS; HUMANS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0038644575     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.050     Document Type: Review

References (33)

1. Ahram, M., Sameni, M., Qiu, R.-G., Linebaugh, B., Kim, D., and Sloane, B. F. (2000). Rac1-induced endocytosis is associated with intracellular proteolysis during migration through a 3-dimensional matrix. Exp. Cell Res. 260, 292-303.
2. Albini, A., Iwamoto, Y., Kleinman, H. K., Martin, G. R., Aaronson, S. A., Kozlowski, J. M., and McEwan, R. N. (1987). A rapid in vitro assay for quantitation of the invasive potential of tumor cells. Cancer Res. 47, 3239-3245.
3. Basolo, F., Elliott, J., Tait, L., Chen, X. Q., Maloney, T., Russo, I. H., Pauley, R. J., Momiki, S., Caamano, J., Klien-Szanto, A. J. P., Koszalka, M., and Russo, J. (1991). Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol. Carcinogen. 4, 25-35.
4. Boike, G., Lah, T. T., Sloane, B. F., Rozhin, J., Honn, K., Guirguis, R., Stracke, M. L., Liotta, L. A., and Schiffmann, E. (1991). A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells. Melanoma Res. 1, 333-340.
5. Calkins, C. C. and Sloane, B. F. (11995). Mammalian cysteine proteinase inhibitors: biochemical properties and possible roles in tumor progression. Biol. Chem. 376, 71-80.
6. Dawson, P. J., Wolman, S. R., Tait, L., Heppner, G., and Miller, F. R. (1996). MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am. J. Pathol. 148, 313-319.
7. Demchik, L. L., Sameni, M., Nelson, K., Mikkelsen, T., and Sloane, B. F. (1999). Cathepsin B and glioma invasion. Int. J. Dev. Neurosci. 17, 483-494.
8. Foekens, J. A., Kos, J., Peters, H. A., Krašovec, M., Look, M. P., Cimerman, N., Meijer-van Gelder, M. E., Henzen-Longmans, S. C., van Putten, W. L. J., and Klijn, J. G. M. (1998). Prognostic significance of cathepsins B and L in primary human breast cancer. J. Clin. Oncol. 16, 1013-1021.
9. Hawley-Nelson, P., Roop, D. R., Cheng, C. K., Krieg, T. M., and Yuspa, S. H. (1988). Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis. Mol. Carcinogen. 1, 202-211.
10. Henskens, Y. M. C., Veerman, E. C. I., and Amerongen, A. V. N. (1996). Cystatins in health-and disease. Biol. Chem. 377, 71-86.
11. Hirai, K., Yokoyama, M., Asano, G., and Tanaka, S. (1999). Expression of cathepsin B and cystatin C in human colorectal cancer. Human Pathol. 30, 680-686.
12. Holst-Hansen, C., Johannessen, B., Hoyer-Hansen, G., Romer, J., Ellis, V., and Brunner, N. (1996). Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasiveness. Clin. Exp. Metastasis 14, 279-307.
13. Kirschke, H., Eerola, R., Hopsu-Havu, V. K., Brömme, D., and Vuorio, E. (2000). Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells. Eur. J. Cancer 36, 787-795.
14. Koblinski, J. E., Ahram, M., and Sloane, B. F. (2000). Unraveling the role of proteinases in cancer. Clin. Chem. Acta 291, 113-135.
15. Kos, J. and Lah, T. T. (1998). Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer. Oncol. Rep. 5, 1349-1361.
16. Kuopio, T., Kankaanranta, A., Jalava, P., Kronqvist, P., Kotkansalo, T., Weber, E., and Collan, Y. (1998). Cysteine proteinase inhibitor cystatin A in breast cancer. Cancer Res. 58, 432-436.
17. Lah, T. T., Kokalj-Kunovar, M., Štrukelj, B., Pungerčar, J., Barlič Maganja, D., Drobnič-Košorok, M., Kastelic, L., Babnik, J., Golouh, R., and Turk, V. (1992). Stefins and lysosomal cathepsins B, L, and D in human breast carcinoma. Int. J. Cancer 50, 36-44.
18. Lah, T. T., Calaf, G., Kalman, E., Shinde, B. G., Somers, R., Estrada, S., Salero, E., Russo, J., and Daskal, I. (1996). Cathepsins D, B and L in transformed human breast epithelial cells. Breast Cancer Res. Treat. 39, 221-233.
19. Lah, T. T., Kos, J., Blejec, A., Frkovič-Georgio, S., Golouh, R., Vrhovec, I., and Turk, V. (1997). The expression of lysosomal proteinases and their inhibitors in breast cancer: possible relationship to prognosis of the disease. Pathol. Oncol. Res. 3, 221-233.
20. Lah, T. T., Čerček, M., Blejec, A., Kos, J., Gorodetsky, E., Somers, R., and Daskal, I. (2000). Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L and other clinical indicators. Clin. Cancer Res. 6, 578-584.
21. Levičar, N., Kos, J., Blejec, A., Golouh, R., Vrhovec, I., Frkovič-Grazio, S., and Lah, T. T. (2002). Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients. Cancer Det. Prev. 26, 42-49.
22. Miller, F. R., Soule H. D., Tait, L., Pauley, R. J., Wollman S. R., Dawson, P. J., and Heppner, G. H. (1993). Xenograft model of progressive human proliferative breast disease. J. Natl. Cancer Inst. 85, 1725-1732.
23. Sameni, M., Moin, K., and Sloane, B.F (2000). Imaging proteolysis by living breast cancer cells. Neoplasia 2, 496-504.
24. Sameni, M., Dosescu, J., and Sloane, B. F. (2001). Imaging proteolysis by living human glioma cells. Biol. Chem. 382, 785-788.
25. Santner, S. J., Miller, F., Dawson, P. J., Tait, L., Soule, H., Eliason, J., Heppner, G. (1998). MCF-10CA1 cell lines: new highly tumorigenic derivatives of the MCF-10AT system. Proc. Am. Assoc. Cancer Res. 39, 202-203.
26. Schmitt, M., Janicke, F., and Graeff, F. (1992). Tumor-associated proteinases. Fibrinolysis 6, 3-26.
27. Sloane, B. F., Moin, K,. Sameni, M., Tait, L. R., Rozhin, J., and Ziegler, G. (1994). Membrane association of cathepsin B can be influenced by transfection of human breast epithelial cell lines with c-Ha-ras oncogene. J. Cell Sci. 107, 373-384.
28. Soderstrom, K. O., Laato, M., Wu, P., Hopsu-Havu, V. K., Nurmi, R., and Rinne, A. (1996). Expression of acid cysteine proteinase inhibitor (ACPI) in the normal human prostate, benign prostatic hyperplasia and adenocarcinoma. Int. J. Cancer. 62, 1-4.
29. Soule, H. D., Maloney, T. M., Wolman, S. R., Peterson, W. D. Jr., Brenz, R., McGrath, C. M., Russo, J., Pauley, R. J., Jones, R. F., and Brooks, S. C. (1990). Isolation and characterization of a spontaneously immortalized human breast epithelial cell line MCF10. Cancer Res. 50, 6075-6086.
30. Thomssen, C., Schmitt, M., Goretzki, L., Oppelt, P., Pache, L., Dettmar, P., Janicke, F., and Graeff, H. (1995). Prognostic value of the cysteine proteases cathepsin B and cathepsin L in human breast cancer. Clin. Cancer Res. 1, 741-746.
31. Thomssen, C., Oppelt, P., Janicke, F., Ulm, K., Harbeck, N., Hofler, H., Kuhn, W., Graeff, H, and Schmitt, M. (1998). Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L. Anticancer Res. 18, 2173-2180.
32. Turk, B., Turk, V., and Turk, D. (1997). Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors. Biol. Chem. 378, 141-150.
33. Yan, S.-Q., Berquin, I. M., Troen, B. R., and Sloane, B. F. (2000). Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma DNA. Cell Biol. 19, 79-91.