Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3578-3587

  Cirman, Tina ^a   Orešić, Kristina ^a   Mazovec, Gabriela Droga ^a   Turk, Vito ^a   Reed, John C ^b   Myers, Richard M ^c   Salvesen, Guy S ^b   Turk, Boris ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b BURNHAM INSTITUTE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; KETONES; PH EFFECTS; PROTEINS;

MITOCHONDRIA;

BIOCHEMISTRY;

CARRIER PROTEIN; CASPASE; CASPASE 8; CATHEPSIN; CYTOCHROME C; KETONE; PAPAIN; PROTEIN BCL 2; PROTEIN BID; RECOMBINANT PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; DNA CLEAVAGE; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE DISRUPTION; GENETIC TRANSFECTION; HEART MITOCHONDRION; HEART MUSCLE; HELA CELL; HUMAN; HUMAN CELL; LIVER; LYSOSOME; LYSOSOME MEMBRANE; MEDIATOR RELEASE; METABOLISM; MITOCHONDRION; MOUSE; OXIDATIVE STRESS; PH; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FAMILY; PROTEIN SECONDARY STRUCTURE; PROTEIN TRANSPORT; T LYMPHOCYTE ACTIVATION; TEMPERATURE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 8; CASPASES; CATHEPSINS; CELL LINE; CELL LINE, TUMOR; CYTOCHROMES C; CYTOSOL; FLOW CYTOMETRY; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIVER; LYSOSOMES; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MYOCARDIUM; PAPAIN; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; TEMPERATURE; TRANSFECTION;

ANIMALIA;

EID: 0942265544     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308347200     Document Type: Article

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