Death by design: Apoptosis, necrosis and autophagy

Current Opinion in Cell Biology

Volumn 16, Issue 6, 2004, Pages 663-669

  Edinger, Aimee L ^a   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOKINE; IMATINIB; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN BAX; TUMOR NECROSIS FACTOR;

APOPTOSIS; AUTOPHAGY; CANCER CHEMOTHERAPY; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; INFLAMMATION; METAZOON; NECROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL DEATH; DNA DAMAGE; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MODELS, BIOLOGICAL; NECROSIS;

METAZOA;

EID: 7744235672     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2004.09.011     Document Type: Review

References (28)

1. N.N. Danial, and S.J. Korsmeyer Cell death: critical control points Cell 116 2004 205 219
2. R.A. Lockshin, and Z. Zakeri Caspase-independent cell death? Oncogene 23 2004 2766 2773
3. W. Fiers, R. Beyaert, W. Declercq, and P. Vandenabeele More than one way to die: apoptosis, necrosis and reactive oxygen damage Oncogene 18 1999 7719 7730
4. M. Jaattela, and J. Tschopp Caspase-independent cell death in T lymphocytes Nat Immunol 4 2003 416 423
5. S.Y. Proskuryakov, A.G. Konoplyannikov, and V.L. Gabai Necrosis: a specific form of programmed cell death? Exp Cell Res 283 2003 1 16
6. C. Kitanaka, and Y. Kuchino Caspase-independent programmed cell death with necrotic morphology Cell Death Differ 6 1999 508 515
7. B. Levine, and D.J. Klionsky Development by self-digestion: molecular mechanisms and biological functions of autophagy Dev Cell 6 2004 463 477
8. E.H. Baehrecke Autophagic programmed cell death in Drosophila Cell Death Differ 10 2003 940 945
9. D. Gozuacik, and A. Kimchi Autophagy as a cell death and tumor suppressor mechanism Oncogene 23 2004 2891 2906
10. J. Yuan, M. Lipinski, and A. Degterev Diversity in the mechanisms of neuronal cell death Neuron 40 2003 401 413
11. N. Holler, R. Zaru, O. Micheau, M. Thome, A. Attinger, S. Valitutti, J.L. Bodmer, P. Schneider, B. Seed, and J. Tschopp Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule Nat Immunol 1 2000 489 495
12. H.C. Ha, and S.H. Snyder Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion Proc Natl Acad Sci USA 96 1999 13978 13982
13. D. Vercammen, R. Beyaert, G. Denecker, V. Goossens, G. Van Loo, W. Declercq, J. Grooten, W. Fiers, and P. Vandenabeele Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor J Exp Med 187 1998 1477 1485
14. W.X. Zong, D. Ditsworth, D.E. Bauer, Z.Q. Wang, and C.B. Thompson Alkylating DNA damage stimulates a regulated form of necrotic cell death Genes Dev 18 2004 1272 1282 This work demonstrates how alkylating agents can selectively kill transformed cells that are resistant to apoptosis. In addition, it was found that eliminating cells through this form of programmed necrosis stimulates an immune response. These results have important implications for cancer chemotherapy.
15. F.K. Chan, J. Shisler, J.G. Bixby, M. Felices, L. Zheng, M. Appel, J. Orenstein, B. Moss, and M.J. Lenardo A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses J Biol Chem 278 2003 51613 51621 Programmed necrosis has long been discounted as a tissue culture phenomenon. The observations in this article that virally infected cells undergo this form of cell death and that viruses produce proteins that modulate the necrotic program and the implication that the inflammation resulting from the necrotic death of infected cells can have biologic consequences place programmed necrosis in a physiologic setting and should stimulate further research.
16. M. Okada, S. Adachi, T. Imai, K. Watanabe, S.Y. Toyokuni, M. Ueno, A.S. Zervos, G. Kroemer, and T. Nakahata A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity Blood 103 2004 2299 2307 These authors demonstrate that the Abl kinase inhibitor Gleevec kills cells not only by activating the apoptotic pathway but also by initiating programmed necrosis. In addition, a role for the serine protease HtrA2 in the necrotic process is suggested which should help to direct future studies to further elucidate the signaling pathways that are activated in this form of cell death.
17. Y. Suzuki, Y. Imai, H. Nakayama, K. Takahashi, K. Takio, and R. Takahashi A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death Mol Cell 8 2001 613 621
18. L. Foghsgaard, D. Wissing, D. Mauch, U. Lademann, L. Bastholm, M. Boes, F. Elling, M. Leist, and M. Jaattela Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor J Cell Biol 153 2001 999 1010
19. E.F. Blommaart, U. Krause, J.P. Schellens, H. Vreeling-Sindelarova, and A.J. Meijer The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes Eur J Biochem 243 1997 240 246
20. •].
21. •] definitively link autophagy to the development of cancer. However, whether autophagy plays a role in eliminating transformed cells remains an open question as the mechanism for tumor suppression through the autophagic pathway remains elusive.
22. D.J. Klionsky, and S.D. Emr Autophagy as a regulated pathway of cellular degradation Science 290 2000 1717 1721
23. A.L. Edinger, and C.B. Thompson Defective autophagy leads to cancer Cancer Cell 4 2003 422 424
24. T.L. Deckwerth, R.M. Easton, C.M. Knudson, S.J. Korsmeyer, and E.M. Johnson Jr. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation Exp Neurol 152 1998 150 162
25. T. Lindsten, J.A. Golden, W.X. Zong, J. Minarcik, M.H. Harris, and C.B. Thompson The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool J Neurosci 23 2003 11112 11119
26. L. Yu, A. Alva, H. Su, P. Dutt, E. Freundt, S. Welsh, E.H. Baehrecke, and M.J. Lenardo Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8 Science 304 2004 1500 1502 This work links autophagy and necrosis and makes a case in favor of autophagy as an alternative death pathway.
27. K.R. Mills, M. Reginato, J. Debnath, B. Queenan, and J.S. Brugge Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro Proc Natl Acad Sci USA 101 2004 3438 3443 TRAIL receptor ligation induces autophagy linking this process to tissue remodeling.
28. J. Debnath, K.R. Mills, N.L. Collins, M.J. Reginato, S.K. Muthuswamy, and J.S. Brugge The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini Cell 111 2002 29 40