α-Tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability

Biochemical Journal

Volumn 362, Issue 3, 2002, Pages 709-715

  Neuzil, Jiri ^a   Zhao, Ming ^a   Ostermann, Georg ^a   Sticha, Martin ^a   Gellert, Nina ^a   Weber, Christian ^a   Eaton, John W ^a   Brunk, Ulf T ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Cathepsin D; Lysosomes; pH; Programmed cell death

Indexed keywords

CELL MEMBRANES; CELLS; PH EFFECTS; TUMORS;

LYSOSOMAL INSTABILITY;

BIOCHEMISTRY;

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ALPHA TOCOPHEROL SUCCINATE; BETA GALACTOSIDASE; BETA TOCOPHEROL; BETA TOCOPHEROL SUCCINATE; CASPASE; CATHEPSIN D; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; ENZYME SPECIFICITY; HEMOLYSIS; HUMAN; HUMAN CELL; INTERSTITIUM; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE STABILIZATION; MOLECULAR STABILITY; PH; PRIORITY JOURNAL; SOLID TUMOR; VITAMIN METABOLISM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR MEMBRANES; JURKAT CELLS; KINETICS; LYSOSOMES; VITAMIN E;

TOSCANA VIRUS;

EID: 0037086662     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3620709     Document Type: Article

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