The autophagosomal-lysosomal compartment in programmed cell death

Cell Death and Differentiation

Volumn 8, Issue 6, 2001, Pages 569-581

  Bursch, W ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Autophagic cell death; Autophagic vacuoles; BID; Caspase independent PCD; Cytoplasmic vacuolisation; Endoplasmic reticulum

Indexed keywords

CASPASE; CATHEPSIN; CYSTEINE PROTEINASE;

ANIMAL CELL; APOPTOSIS; AUTOPHAGY; BIOCHEMISTRY; CELL COMPARTMENTALIZATION; CELL DEATH; CELL DESTRUCTION; CELL STRUCTURE; CHROMATIN CONDENSATION; CLASSIFICATION; CONTROLLED STUDY; DEATH; ENVIRONMENT; HUMAN; HUMAN CELL; LIGHT DAMAGE; LYSOSOME; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PATHOLOGY; PHAGOSOME; PHYLOGENY; PHYSICAL DISEASE; PHYSIOLOGY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SUICIDE; SURVIVAL;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL SIZE; HUMANS; LYSOSOMES; MODELS, BIOLOGICAL; NECROSIS; PHAGOCYTOSIS;

ANIMALIA;

EID: 0034948738     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400852     Document Type: Review

References (120)

1. Cell death in the third millennium
2. The biochemistry of apoptosis
3. Apoptosis in the nervous system
4. CD95's deadly mission in the immune system
5. Corpse clearance defines the meaning of cell death
6. From bench to clinic with apoptosis-based therapeutic agents
7. The relation of programmed cell death to development and reproduction: Comparative studies and an attempt at classification
8. The morphology of various types of cell death in prenatal tissues
9. Developmental cell death: Morphological diversity and multiple mechanisms
10. Do all programmed cell deaths occur via apoptosis?
11. Cell death: Programmed apoptosis, necrosis, or other?
12. Programmed cell death (PCD): Apoptosis, autophagic PCD or others?
13. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
14. Cell death: The significance of apoptosis
15. Programmed cell death in Dictyostelium
16. Apparent caspase independence of programmed cell death in Dictyostelium
17. Neurology of degenerative cell death in Caenorhabditis elegans
18. Ultrastructural study of the normal degeneration of the intersegmental muscles of Anthereae polyphemus and Manduca sexta (Insecta, Lepidoptera) with particular reference of cellular autophagy
19. Protein synthesis, DNA degradation, and morphological changes during programmed cell death in labial glands of Manduca sexta
20. Programmed cell death of the prothoracic glands of Manduca sexta during pupal-adult metamorphosis
21. An in vitro analysis of ecdysteroid-elicited cell death in the prothoracic gland of Manduca Sexta
22. Programmed cell death during metamorphosis in the blow-fly Calliphora vomitoria
23. Acid phosphatase activity in the larval salivary glands of developing Drosophila melanogaster
24. Programmed cell death in the wing of Orgyia leucostigma (Lepidoptera: Lymantriidae)
25. Cell death in embryogenesis
26. Ultrastructure of mullerian and wolffian ducts of fetal rabbit in vivo and in organ culture
27. Cell death during tooth eruption in the rat: Surrounding tissues of the crown
28. Subtypes of active cell death in the granulosa of ovarian atretic follicles in the quail (Coturnix coturnix japonica)
29. Progressive involution and physiological death of smooth muscle cells of rat incisal arterioles
30. The fate of effete epithelial cells at the villus tips of the human small intestine
31. Ultrastructural changes in human endometrium at different phases of the menstrual cycle and their functional significance
32. Diverse cell death pathways result from a single missense mutation in weaver mouse
33. Gene expression and cellular content of cathepsin D in Alzheimer's Disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
34. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
35. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
36. On the nature of cell death during remodeling of hypertrophied human myocardium
37. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
38. Occurrence and inhibition by cycloheximide of apoptosis in vinblastine-treated murine pancreas. A role for autophagy?
39. Autophagy as a regulated pathway of cellular degradation
40. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
41. Five-lipoxygenase inhibitors reduce Panc-1 survival: The mode of cell death and synergism of MK886 with gamma linolenic acid
42. Changes in cellular ultrastructure induced by gamma-interferon in K562 cells may be prerequisite for apoptosis
43. Euchromatin megabase cleavages and conjoint apoptotic-autophagic death expression with nucleolar ball-and-socket joint dislocations in human Chang liver cells arrested in S-phase by etoposide
44. Active cell death induced by antiestrogens tamoxifen and ICI 164384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
45. Autophagic proteolysis: Ccontrol and specificity
46. Autophagy, Cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
47. The proteasome, a novel protease regulated by multiple mechanisms
48. Calpain-a protease in search and function
49. 3-Methyladenine, a specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
50. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells
51. Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide
52. Caspase-independent programmed cell death with necrotic morphology
53. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
54. Distinct classes of phosphatidylinositol 3′-kinases are involved in signalling pathways that control macroautophagy in HT-29 cells
55. Lysosome-endosome fusion and lysosomes biogeneses
56. The regression process in hormone-dependent mammary carcinomas
57. Origin of the increased activity of beta-glucuronidase in the soluble fraction of rat mammary tumors during ovariectomy-induced regression
58. Different fates of cytoskeletal filaments during autophagic and apoptotic types of programmed cell death in mammary carcinoma cells (MCF-7) and colon carcinoma cells (HT29HI1)
59. Apoptosis ("programmed" cell death) and its relevance in liver injury and carcinogenesis
60. Protein conjugation system essential for autophagy
61. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
62. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast
63. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
64. Induction of autophagy and inhibition of tumorigenesis by beclin 1
65. Immunosuppressive drugs: The first 50 years and a glance forward
66. Induction of apoptosis and inhibition of signalling pathways by alkylated purines
67. Regulation of translational effectors by amino acid and mammalian target of rapamycin signalling pathways. Possible involvement of autophagy in cultured hepatoma cells
68. Regulation of apoptosis by phosphatidylinositol 4,5 bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5 kinase
69. Apoptosis without caspases: An inefficient molecular guillotine?
70. PML induces a novel caspase-independent death process
71. The Fas-induced apoptosis analyzed by high-throughput proteome analysis
72. Phagosome dynamics and function
73. Signalling pathways in phagocytosis
74. Quantitative Histological and Histochemical Studies on the Occurrence and Stages of Apoptosis (Controlled Cell Death) during Regression of Rat Liver Hyperplasia
75. Cell death by apoptosis and its protective role against disease
76. Regression of rat liver autophagic vacuoles by locally applied cycloheximide
77. An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells
78. Cytoplasmic vacuolation, adaptation and cell death: A view on new perspectives and features
79. Functions of lysosomes
80. Christian de Duve and the discovery of lysosomes and peroxisomes
81. The pathways of cell death. Oncosis, apoptosis, and necrosis
82. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study
83. Determinants of the apoptotic response to lysosomal photodamage
84. Alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation
85. Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis
86. Minute oxidative stress is sufficient to induce apoptotic death of NIT-1 insulinoma cells
87. Photosensitization of human skin cell lines by ATMPn (9-acetoxy-2,7, 12, 17-tetrakis-(beta-methoxyethyl)-porphycene) in vitro: Mechanism of action
88. Induction of cell death by the lysosomotropic detergent MSDH
89. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis by oxidative stress
90. Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes
91. Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress
92. Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
93. OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron
94. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
95. Sites of photodamage induced by photodynamic therapy with a chlorin 36 triacetoxymethyl ester (CAME)
96. Death associated proteins (DAPs): From gene identification to the analysis of their apoptotic and tumor suppressive functions
97. Lysosomal cysteine proteases: More than scavengers
98. Overexpression of cation-dependent mannose 6-phosphate receptor prevents cell death induced by serum deprivation in PC12 cells
99. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity
100. Cathepsin D proteases mediates programmed cell death induced by interferon-y, FAS/APO-1 and TNF-a
101. Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation
102. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity
103. Activation of caspase-3-like protease by digitonin-treated lysosomes
104. Lysosomal protease pathways to apoptosis: Cleavage of Bid, not pro-caspases, is the most likely route
105. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
106. Activation of Caspase-3 by Lysosomal Cysteine Proteases and Its Role in 2, 2′-Azobis-(2-Amidinopropane)Dihydrochloride (AAPH)-Induced Apoptosis in HL-60 Cells
107. Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
108. Induction of apoptosis in primary culture of rat hepatocytes by protease inhibitors
109. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells
110. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells
111. Gene therapy for acute hepatitis using CrmA gene transduction
112. Regulated secretion of conventional lysosomes
113. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
114. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
115. When lysosomes get old
116. The Origin of Programmed Cell death
117. Stage-specific hypermutability of the regA locus of Volvox, a gene regulating the germ-soma dichotomy
118. The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects
119. Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311
120. Effects of retinol on follicular porcine thyrocytes in culture