Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors

Experimental Neurology

Volumn 155, Issue 2, 1999, Pages 187-194

  Tsuchiya, Katsuhiro ^a   Kohda, Yukihiko ^a   Yoshida, Masaki ^b   Zhao, Liang ^a   Ueno, Takashi ^c   Yamashita, Junkoh ^a   Yoshioka, Tohru ^d   Kominami, Eiki ^c   Yamashima, Tetsumori ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d WASEDA UNIVERSITY   (Japan)

Author keywords

CA 074; Cathepsin inhibitor; E 64c; Hippocampus; Ischemic neuronal death; Primate

Indexed keywords

CATHEPSIN B; HALOTHANE; N (LEVO 3 CARBOXYOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; N (LEVO 3 CARBOXYOXIRANE 2 CARBONYL)LEUCINE 3 METHYLBUTYLAMIDE; NITRIC OXIDE; PEPTIDE HYDROLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL COUNT; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYSOSOME MEMBRANE; MONKEY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0032976738     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6988     Document Type: Article

References (29)

1. Bando Y., Kominami E., Katunuma N. Purification and tissue distribution of cathepsin L. J. Biochem. Tokyo. 100:1986;35-42.
2. Bednarski E., Ribak E. C., Lynch G. Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. J. Neurosci. 17:1997;4006-4021.
3. Bernstein H. G., Kirschke H., Wiederanders B., Schmidt D., Rinne A. Antigenic expression of cathepsin B in aged human brain. Brain Res. Bull. 24:1990;543-549.
4. 3in vitro. J. Biochem. 91:1982;1373-1380.
5. Hashida S., Towatari T., Kominami E., Katunuma N. Inhibitions by E-64 derivatives of rat liver cathepsin B and cathepsin Lin vitroin vivo. J. Biochem. 88:1980;1805-1811.
6. Hong C. S., Goto Y., Lanzino G., Soleau S., Kassell F. N., Lee S. K. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischmia. Stroke. 25:1994;663-669.
7. Inuzuka T., Tamura A., Sato S., Kirino T., Toyoshima I., Miyatake T. Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rat. Brain Res. 526:1990;177-179.
8. Katunuma N., Kominami E. Structure, properties, action mechanism and assay method of specific cysteine protease inhibitors: Cystatins and E-64 derivatives. Methods Enzymol. 251:1995;382-397.
9. Kohda Y., Yamashima T., Sakuda K., Yamashita J., Ueno T., Kominami E., Yoshioka T. Dynamic changes of cathepsins B and L expression in the monkey hippocampus after transient ischemia. Biochem. Biophys. Res. Commun. 228:1996;616-622.
10. Kominami E., Ueno T., Muno D., Katunuma N. The selective role of cathepsins B and D in the lysosomal degradation of endogenous proteins. FEBS Lett. 287:1991;189-192.
11. Kominami E., Tsukahara T., Bando Y., Katunuma N. Distribution of cathepsins B and H in rat tissues and peripheral blood cells. J. Biochem. Tokyo. 98:1985;87-93.
12. Kominami E., Bando Y., Wakamatsu N., Katunuma N. Different tissue distributions of two types of thiol proteinase inhibitors from rat liver and epidermis. J. Biochem. Tokyo. 98:1984;87-93.
13. Lee K. S., Frank S., Vanderklsh P., Arai A., Lynch G. Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. Natl. Acad. Sci. USA. 88:1991;7233-7237.
14. 2+. Brain Res. 601:1993;103-110.
15. Murata M., Miyashita S., Yokoo C., Tamai M., Hanada K., Hatayama K., Towatari N., Nikawa T., Katunuma N. Novel epoxysuccinyl peptides: Selective inhibitors of cathepsin B, in vitro. FEBS Lett. 280:1991;307-310.
16. Nakamura Y., Takeda M., Suzuki H., Morita H., Tada K., Hariguchi S., Nishimura T. Lysosome instability in aged rat brain. Neurosci. Lett. 97:1989;215-220.
17. Nakanishi H., Amano T., Sastradipura D. F., Yoshimine Y., Tsukuba T., Tanabe K., Hirotsu I., Ohono T., Yamamoto K. Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J. Neurochem. 68:1997;739-749.
18. Nakanishi H., Tominaga K., Amano T., Hirotsu I., Inoue T., Yamamoto K. Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues. Exp. Neurol. 126:1994;119-128.
19. Nakanishi H., Tsukuba T., Kondou T., Tanaka T., Yamamoto K. Transient forbrain ischemia induces increased expression and specific localization of cathepsins E and D in rat hippocampus and neostriatum. Exp. Neurol. 121:1993;215-223.
20. Nemoto M. E., Bleyaert L. A., Stezoski W. S., Rao R. G., Safar P. Global brain ischemia: A reproducible monkey model. Stroke. 8:1977;558-564.
21. Nishijo H., Tabuchi E., Ono T., Fukuda M., Kuze S., Endo S. Physiological results of monkey brain ischemia, and protection by a calcium blocker. Brain Res. Bull. 37:1995;89-101.
22. Nitatori T., Sato N., Waguri S., Karasawa Y., Araki S., Shibanai K., Kominami E., Uchiyama Y. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15:1995;1001-1011.
23. Nixon R. A., Cataldo A. M. The lysosomal system in neuronal cell death: A review. Ann. N.Y. Acad. Sci. 679:1993;87-109.
24. Ritonja A., Kopitar M., Jerala R., Turk V. Primary structure of a new cysteine proteinase inhibitor from pig leucocytes. FEBS Lett. 255:1989;211-214.
25. Thilman R., Xie Y., Kleihues P., Kiessling M. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. Acta Neuropathol. (Berl.). 71:1986;88-93.
26. Towatari T., Nikawa T., Murata M., Yokoo C., Tamai M., Hanada K., Katunuma N. Novel epoxysuccinyl peptides: A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280:1991;311-315.
27. Towatari T., Tanaka K., Yoshikawa K., Katunuma N. Purification and properties of a new cathepsin from rat liver. J. Biochem. 84:1978;659-671.
28. 2. Eur. J. Neurosci. 8:1996;1932-1944.
29. 2+. Biochem. Biophys. Res. Commun. 205:1994;1843-1849.