Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

Nature Medicine

Volumn 6, Issue 10, 2000, Pages 1109-1114

  Morita, Yutaka ^a   Perez, Gloria I ^a   Paris, Francois ^b   Miranda, Silvia R ^c   Ehleiter, Desiree ^b   Haimovitz Friedman, Adrianna ^b   Fuks, Zvi ^b   Xie, Zhihua ^d   Reed, John C ^d   Schuchman, Edward H ^c   Kolesnick, Richard N ^b   Tilly, Jonathan L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE 1 PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GRANULOSA CELL; MOUSE; NECROSIS; NONHUMAN; OOCYTE; OVARY DISEASE; OVARY FOLLICLE; OVARY FUNCTION; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; FEMALE; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, MUTANT STRAINS; OOCYTES; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; SPHINGOSINE;

EID: 0033786639     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/80442     Document Type: Article

References (46)

1. Regulation of ovarian follicular development in primates: Facts and hypotheses
2. A quantitative and cytological study of germ cells in human ovaries
3. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
4. Oocyte apoptosis: Like sand through an hourglass
5. Biological basis of premature ovarian failure
6. Menopause and hormone replacement therapy: An overview
7. Chemotherapythe adult gonad: A review
8. Radiation-induced changes in long-term survivors of childhood cancer after treatment with radiation therapy
9. Preservation of fertility and ovarian function and minimizing chemotherapy-induced gonadotoxicity in young women
10. Cell death genes may hold clues to preserving fertility after chemotherapy
11. Apoptosis and disease: Regulation and clinical relevance of programmed cell death
12. Caspases: Enemies within
13. Proteases to die for
14. BAX-induced cell death may not require interleukin-1β-converting enzyme-like proteases
15. Regulation of ceramide production and apoptosis
16. Sphingosine-1-phosphate in cell growth and death
17. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
18. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
19. Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease
20. Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse
21. Inhibition of sphingolipid biosynthesis by fumonisins
22. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
23. Fragmentation and death (a.k.a. apoptosis) of ovulated oocytes
24. Dual actions of sphingosine-1-phosphate: Extracellular through the G(i)-coupled receptor Edg-1 and intracellular to regulate proliferation and survival
25. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218
26. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation
27. A subfamily of G protein-coupled cellular receptors for lysophospholipids and lysosphingolipids
28. Sphingosine-1-phosphate: Extracellular mediator or intracellular second messenger?
29. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
30. Growth differentiation factor-9 is required during early ovarian folliculogenesis
31. The vocabulary of the egg
32. Involvement of programmed cell death in preimplantation embryo demise
33. Apoptosis in the human embryo
34. Mitochondria and the death of oocytes
35. Ablation of bcl-2 gene expression decreases the number of oocytes and primordial follicles established in the post-natal female mouse gonad
36. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
37. Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro
38. Defects in regulation of apoptosis in caspase-2-deficient mice
39. Mechanisms of p53-mediated apoptosis
40. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Iurkat T lymphocytes
41. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore
42. Segregation of retinoic acid effects on fetal ovarian germ cell mitosis versus apoptosis by requirement for new macromolecular synthesis
43. Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells
44. Bax directly induces release of cytochrome c from isolated mitochondria
45. The comet assay: A comprehensive overview