Chemokines, chemokine receptors and hematopoiesis

Immunological Reviews

Volumn 177, Issue , 2000, Pages 150-174

  Youn, Byung S ^a,b   Mantel, Charlie ^a,b   Broxmeyer, Hal E ^a  

^a INDIANA UNIVERSITY   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; BETA CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR; GROWTH FACTOR;

ANIMAL CELL; BONE MARROW CELL; CELL PROLIFERATION; CELL SURVIVAL; CHEMOTAXIS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL;

EID: 0033668778     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.17701.x     Document Type: Review

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78. Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2
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80. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1
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89. A p53-dependent mouse spindle checkpoint
90. p53 And Rb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest
91. Characterization of the p53-dependent post mitotic checkpoint following spindle disruption
92. P21(waf-1/cip1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells
93. Interleukin-2-mediated elimination of the p27(kip-1) cyclin-dependent kinase inhibitor prevented by rapamycin
94. Inactivation of a cdk2 inhibitor during interleukin 2-induced proliferation of human T-lymphocytes
95. Induction of WAF1/CIP 1 by a p53 independent pathway
96. Regulation of p2(waf1/cip1) expression through mitogen-activated protein kinase signaling pathway
97. A positive effect of p21(cip1/waf1) in the proliferation of murine myeloid progenitor cells as assessed by retroviral mediated gene transfer
98. New functional activities for the p21 family of CDK inhibitors
99. 1-phase progression
100. The p21(cip1) and p27(kip1) cdk inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts
101. How MAP kinases are regulated
102. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
103. Transformation of mammalian cells by constitutively active MAP kinase kinase
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109. Positive versus negative signaling by lymphocyte antigen receptors
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111. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
112. Expression and catalytic activity of the tyrosine phosphatase PTP1 C is severely impaired in motheaten and viable motheaten mice
113. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
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124. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis
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126. The inositol 5-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation
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141. Dominant negative mutants implicate Stat5 in myeloid cell proliferation and neutrophil differentiation
142. Jak2 is essential for signaling through a variety of cytokine receptors
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150. The exodus subfamily of CC chemokines inhibit the proliferation of chronic myelogenous leukemia progenitors
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156. IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity
157. Comparison of flow cytometry and laser scanning cytometry for the intracellular evaluation of adenoviral infectivity and p53 protein expression in gene therapy
158. Subcellular and cell-cycle expression profiles and CDK-inhibitors in normal differentiating myeloid cells
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162. Apoptosis
163. Apoptosis: A basis biological phenomenon with wide-ranging implications in tissue kinetics
164. Apoptosis: Cell death in tissue regulation
165. Microfilament-disrupting agents prevent formation of apoptotic bodies in tumor cells undergoing apoptosis
166. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
167. Early distribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
168. Oxidative stress and apoptosis in neurodegeneration
169. Apoptosis in the generation and prevention of cancer
170. Apoptosis in the pathogenesis and treatment of disease
171. Cell death: Current difficulties in discriminating apoptosis from necrosis in the content of pathological processes in vivo
172. Apoptosis, oncosis, and necrosis. An overview of cell death
173. Periodicity of DNA folding in higher order chromatin structures
174. Apoptosis: Mechanisms and roles in pathology
175. + cells and their granulocytic descendents
176. Activation of caspase-2 in apoptosis
177. Combined Hoechst 33342 and merocyanine 540 staining to examine murine B cell cycle stage, viability and apoptosis
178. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
179. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
180. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transference and nick translation assays
181. Labeling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation
182. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
183. Signaling through the lipid products of phosphoinositide-3-OH kinase
184. The role of phosphoinositide-3-kinase lipid products in cell function
185. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
186. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
187. Cellular survival: A play in three Akts
188. A retroviral oncogene, akt. Encoding a serine threonine kinase containing an SH2-like region
189. Molecular cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
190. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
191. Dual role of phosphatidylinositol-3,4,5-triphosphate in the activation of protein kinase B
192. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
193. The structural basis for 14-3-3. Phosphopeptide binding specificity
194. Caspase: Executioner and undertaker of apoptosis
195. Regulation of cell death protease caspase-9 by phosphorylation
196. The opposing roles of the Akt and c-Myc signaling pathways in survival from CD95-mediated apoptosis
197. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHRI
198. Akt promotes cell survival by phosphorylation and inhibiting a Forkhead transcription factor
199. Rel/NF-κβ- and IκB proteins: An overview
200. Multiple signals converging on NF-κB
201. Akt is more than just a Bad kinase
202. NF-κB activation by tumor neurosis factor requires the Akt serine-threonine kinase
203. CREB is a regulatory target of the protein kinase Akt/PKE
204. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and independent mechanisms
205. The protein kinase p 20 Rsk as an essential mediator of cytostatic factor activity
206. Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase P 20 Rsk
207. Cell survival demands from Rsk
208. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
209. A MAP kinase docking site is required for phosphorylation and activation of p90 (rsk)/MAPKAP kinase-1
210. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1
211. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK
212. The inhibitors of apoptosis (IAPs) and their emerging role in cancer
213. IAP family proteins - Suppressors of apoptosis
214. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
215. Control of apoptosis during angiogenesis by survivin expression in endothelial cells
216. IAP - Family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD15), Bax, caspases, and anticancer drugs
217. Control of apoptosis and mitotic spindle checkpoint by survivin
218. Thrombopoietin upregulates the promoter conformation of p53 in a proliferation independent manner coincident with a decreased expression of Bax: Potential mechanisms for survival enhancing effects
219. Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07 e
220. Genetic determinants of P53 induced apoptosis and growth arrest
221. p21 (waf1/cip1) protects against p53 mediated apoptosis of human melanoma cells
222. Cell proliferation and apoptosis
223. Pleiotrophic cell-division defects and apoptosis induced by interference with survivin function
224. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with cdK4 to resist Fas-mediated cell death
225. Enhanced myelopoiesis in SDF-1 transgenic mice: SDF-1 modulates myelopoiesis by regulating progenitor cell survival and inhibitory effects of myelosuppressive chemokines
226. Defects of B lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
227. Impaired B lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-deficient mice
228. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
229. Survival of human leukemia B-cell precursors is supported by stromal cells and cytokines: Association with the expression of bcl-2 protein
230. + cell proliferation in synergy with cytokines: Possible role in progenitor survival
231. Signal sequence trap: A cloning strategy for secreted protein and type 1 membrane proteins
232. Molecular cloning and structure of a pre-B-cell growth stimulating factor
233. Recent advances in chemokines and chemokine receptors
234. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
235. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor-1 (SDF-1)
236. Crystal structure of chemically synthesized (N33A) stromal-cell derived factor α, a potent ligand for the HIV-1 'fusion' coreceptor
237. The α-chemokine, stromal cell derived factor-1α binds to the transmembrane G-protein-coupled CXCR4 receptor and activates multiple signal transduction pathways
238. Stromal cell-derived factor 1α and stem cell factor/kit ligand share signaling pathways in hematopoietic progenitors: A potential mechanism for cooperative induction of chemotaxis
239. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1α-induced lymphocyte polarization and chemotaxis
240. The chemokine SDF-1α triggers CXCR4 receptor dimerization and activates the Jak/Stat pathway
241. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T-lymphocytes
242. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells
243. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation of adults
244. + progenitors to peripheral blood
245. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: Stromal cell-derived factor-1, steel factor and the bone marrow environment
246. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
247. The α-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion
248. CKβ-11/MIP-3β/ELC, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors amongst myeloid progenitor cells
249. CCR7 and CXCR3 ligand SLC/Exodus 2/6 Ckine induces chemotaxis of hematopoietic progenitor cells: Differential activity of ligands of CCR7, CXCR3, or CXCR4 in chemotaxis/actin polymerization vs suppression of progenitor proliferation
250. SDF-1 suppresses cytokine-induced adhesion of human hematopoietic progenitor cells to immobilized fibronectin
251. Differential chemotactic behavior of developing T cells in response to thymic chemokines
252. G protein-coupled receptors
253. The molecular biology of leukocyte chemoattractant receptors
254. Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK
255. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2,CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
256. G-protein-coupled receptors: Molecular mechanisms involved in receptor activation and selectivity of G-protein recognition
257. The family of G-protein-coupled receptors
258. Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: Conserved aspartic acids play important roles in receptor function
259. HIV-1 entry and macrophage inflammatory proetin-1β-mediated signaling are independent functions of the chemokine receptor CCR5
260. The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1
261. Identification of Gβγ binding sites in the third intracellular loop of the M3-muscarinic receptor and their role in receptor regulation
262. Chemokines
263. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
264. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1α receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation
265. The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1α and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation
266. Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding
267. Multiple extracellular elements of CCR5 and HIV-1 entry: Dissociation from response to chemokines
268. CC chemokine receptor 5-mediated signaling and HIV-1 co-receptor activity share common structural determinants
269. Rhodopsin-family receptors associated with small G proteins to activate phospholipase D
270. G protein-coupled receptor kinases
271. Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: A novel inhibitory mechanism of HIV infectivity
272. Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B. Evidence that directed migration does not require rapid modulation of signaling at the receptor level
273. B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1α chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4
274. Differential modes of regulation of cxc chemokine-induced internalization and recycling of human CXCR1 and CXCR2
275. Beta-arrestins regulate interleukin-8-induced CXCR1 internalization
276. G protein-coupled receptors
277. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords
278. Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin
279. A pertussis toxin-sensitive process controls thymocyte emigration
280. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication
281. Beta-arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor
282. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
283. Role of arrestins in G-protein-coupled receptor endocytosis
284. Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization
285. +- CXC chemokines and mechanisms regulating CXCR2 internalization and recycling
286. β-arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
287. G proteins: Critical control points for transmembrane signals
288. New roles for G protein βγ dimers in transmembrane signaling
289. Heterotrimeric G proteins: Organizers of transmembrane signals
290. Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of Gαi-coupled receptors
291. Receptors induce chemotaxis by releasing the βγ subunit of Gi, not by activating Gq or Gs
292. Gαi is not required for chemotaxis mediated by Gi-coupled receptors
293. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
294. Bidirectional signaling between the cytoskeleton and integrins
295. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes
296. Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway
297. Signal transduction from multiple Ras effectors
298. A new family of G-protein regulators - The RGS proteins
299. Mammalian RGS proteins: Barbarians at the gate
300. Isolation and characterization of a novel B cell activation gene
301. RGS proteins and signaling by heterotrimeric G proteins
302. GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein α subunits
303. RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits
304. Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members
305. Regulator of G protein signaling 1 (RGS1) markedly impairs Giα signaling responses of B lymphocytes
306. Diversity of G proteins in signal transduction
307. Modular binding domains in signal transduction proteins
308. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
309. Binding of G protein βγ-subunits to pleckstrin homology domains
310. Gβγ interactions with PH domains and Ras-MAPK signaling pathways
311. Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of the catalytic p110 subunit
312. Dbl family proteins
313. The Dbl family of oncogenes
314. av2 Is an activator of Cdc42, Rac1, and RhoA
315. Rho GTPases
316. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
317. Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes
318. Signaling by distinct classes of phosphoinositide 3-kinases
319. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
320. The G βγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
321. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinase γ
322. Activation of Akt/protein kinase B by G protein-coupled receptors
323. Function of P13Kγ in thymocyte development, T cell activation, and neutrophil migration
324. Roles of PLC-β2 and -β3 and P13Kγ in chemoattractant-mediated signal transduction
325. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
326. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production
327. MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation
328. The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation
329. I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis
330. Regulation of neuronal survival by the serine-threonine protein kinase Akt
331. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
332. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
333. G-protein-coupled receptors and Fcγ-receptors mediate activation of Akt/protein kinase B in human phagocytes
334. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
335. Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5
336. Localization of the G protein βγ complex in living cells during chemotaxis
337. G protein signaling events are activated at the leading edge of chemotactic cells
338. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
339. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
340. Regulation mechanism of E/R/M (ezrin/radixin/moesin) protein/plasma membrane association: Possible involvement of phosphatidylinositol turnover and rho-dependent signaling pathway
341. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
342. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
343. Heptahelical receptor signaling: Beyond the G protein paradigm
344. The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor