Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

Journal of Clinical Investigation

Volumn 100, Issue 10, 1997, Pages 2552-2561

  Boring, Landin ^a   Gosling, Jennifa ^a   Chensue, Stephen W ^c   Kunkel, Steven L ^d   Farese Jr , Robert V ^a,b   Broxmeyer, Hal E ^e   Charo, Israel F ^a,b,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

Chemokine receptor; Chemokines; Homologous recombination; Inflammation; MCP 1

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL MIGRATION; CONTROLLED STUDY; HELPER CELL; IMMUNOMODULATION; INFLAMMATION; LEUKOCYTE MIGRATION; LUNG GRANULOMA; MONOCYTE; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

EID: 0030809822     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119798     Document Type: Article

References (45)

1. Murphy, P.M. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593-633.
2. Schall, T.J. 1994. The chemokines. In The Cytokine Handbook. 2nd ed. A.W. Thomson, editor. Academic Press, London. 419-460.
3. Gerard, C. and N.P. Gerard. 1994. C5a anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12:775-808.
4. Baggiolini, M., B. Dewald, and B. Moser. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675-705.
5. Hedrick, J.A., and A. Zlotnik. 1996. Chemokines and lymphocyte biology. Curr. Opin. Immunol. 8:343-347.
6. Furutani, Y., H. Nomura, M. Notake, Y. Oyamada, T. Fukui, M. Yamada, C.G. Larsen, J.J. Oppenheim, and K. Matsushima. 1989. Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). Biochem. Biophys. Res. Commun. 159:249-255.
7. Carr, M.W., S.J. Roth, E. Luther, S.S. Rose, and T.A. Springer. 1994. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. USA. 91:3652-3656.
8. Kuna, P., S.R. Reddigari, T.J. Schall, D. Rucinski, M. Sadick, and A.P. Kaplan. 1993. Characterization of the human basophil response to cytokines, growth factors, and histamine releasing factors of the intercrine/chemokine family. J. Immunol. 150:1932-1943.
9. Ylä-Herttuala, S., B. A. Lipton, M.E. Rosenfeld, T. Särkioja, T. Yoshimura, E.J. Leonard, J.L. Witzrum, and D. Steinberg. 1991. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 88:5252-5256.
10. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:801-809.
11. Nelken, N. A., S.R. Coughlin, D. Gordon, and J.N. Wilcox. 1991. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88:1121-1127.
12. Koch, A.E., S.L. Kunkel, L.A. Harlow, B. Johnson, H.L. Evanoff, G.K. Haines, M.D. Burdick, R.M. Pope, and R.M. Strieter. 1992. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J. Clin. Invest. 90:772-779.
13. Chensue, S.W., K.S. Warmington, J.H. Ruth, P.S. Sanghi, P. Lincoln, and S.L. Kunkel. 1996. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation. Relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157:4602-4608.
14. + T cells in response to MIP-1α and MIP-1β. Science. 260:355-358.
15. Taub, D.D., J.R. Ortaldo, S.M. Turcovski-Corrales, M.L. Key, D.L. Longo, and W.J. Murphy. 1996. β Chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production. J. Leukocyte Biol. 59:81-89.
16. Broxmeyer, H.E., S. Cooper, N. Hague, L. Benninger, A. Sarris, K. Cornetta, S. Vadhan-Raj, P. Hendrie, and C. Mantel. 1995. Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor-dependent cell line and in vivo in mice. Ann. Hematol. 71:235-246.
17. Charo, I.F., S.J. Myers, A. Herman, C. Franci, A.J. Connolly, and S.R. Coughlin. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA. 91:2752-2756.
18. Franci, C., L.M. Wong, J. Van Damme, P. Proost, and I.F. Charo. 1995. Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. J. Immunol. 154:6511-6517.
19. Combadiere, C., S.K. Ahuja, J. Van Damme, H.L. Tiffany, J.-L. Gao, and P.M. Murphy. 1995. Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. J. Biol. Chem. 270:29671-29675.
20. Garcia-Zepeda, E.A., C. Combadiere, M.E. Rothenberg, M.N. Sarafi, F. Lavigne, Q. Hamid, P.M. Murphy, and A.D. Luster. 1996. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J. Immunol. 157:5613-5626.
21. Stellato, C., P. Collins, P.D. Ponath, D. Soler, W. Newman, G. La Rosa, H. Li, J. White, L.M. Schwiebert, C. Bickel, et al. 1997. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J. Clin. Invest. 99:926-936.
22. Sarafi, M.N., E.A. Garcia-Zepeda, J. A. MacLean, I.F. Charo, and A.D. Luster. 1997. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J. Exp. Med. 185:99-109.
23. Boring, L., J. Gosling, F.S. Monteclaro, A.J. Lusis, C-L. Tsou, and I.F. Charo. 1996. Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1α receptors. Evidence for two closely linked C-C chemokine receptors on chromosome 9. J. Biol. Chem. 271:7551-7558.
24. Ishibashi, S., M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92.883-893.
25. Meiner, V.L., S. Cases, H.M. Myers, E.R. Sande, S. Bellosta, M. Schamhelan, R.E. Pitas, J. McGuire, J. Herz, and R.V. Farese, Jr. 1996. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc. Natl. Acad. Sci. USA. 93:14041-14046.
26. Mage, M.G., L.L. McHugh, and T.L. Rothstein. 1977. Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin. J. Immunol. Methods. 15:47-56.
27. Hathcock, K.S., A. Singer, and R.J. Hodes. 1981. Passage over sephadex G-10 columns. In Manual of Macrophage Methodology: Collection, Characterization and Function. H.H. Herskowitz, H.T. Holden, J.A. Eelanti, and A. Ghaffer, editors. Marcel Dekker, New York. 127-133.
28. Maze, R., B. Sherry, B.S. Kwon, A. Cerami, and H.E. Broxmeyer. 1992. Myelosuppressive effects in vivo of purified recombinant murine macrophage inflammatory protein-1α. J. Immunol. 149:1004-1009.
29. Kruisheek, A.M. 1992. Isolation of mouse mononuclear cells. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. Greene Publishing and Wiley-Interscience, New York. 3.1.2-3.1.5.
30. Raport, C.J., J. Gosling, V.L. Schweickart, P.W. Gray, and I.F. Charo. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J. Biol. Chem. 271:17161-17166.
31. Ernst, C.A., Y.J. Zhang, P.R. Hancock, B.J. Rutledge, C.L. Corless, and B.J. Rollins. 1994. Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. J. Immunol. 152:3541-3549.
32. Yoshimura, T., E.A. Robinson, S. Tanaka, E. Appella, J.-I. Kuratsu, and E.J. Leonard. 1989. Purification and amino acid analysis of two human gliomaderived monocyte chemoattractants. J. Exp. Med. 169:1449-1459.
33. Grewal, I.S., B.J. Rutledge, J.A. Fiorillo, L. Gu, R.P. Gladue, R.A. Flavell, and B.J. Rollins. 1997. Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes. Abrogation by a second transgene expressing systemic MCP-1. J. Immunol. 159:401-408.
34. Gunn, M.D., N.A. Nelken, X. Liao, and L.T. Williams. 1997. Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J. Immunol. 158:376-383.
35. Rollins, B.J., T. Yoshimura, E.J. Leonard, and J.S. Pober. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol. 136:1229-1233.
36. Wang, J.M., A. Sica, G. Peri, S. Walter, I.M. Padura, P. Libby, M. Ceska, I. Lindley, F. Colotta, and A. Mantovani. 1991. Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells. Arterioscler. Thromb. 11:1166-1174.
37. Graham, G.J., E.G. Wright, R. Hewick, S.D. Wolpe, N.M. Wilkie, D. Donaldson, S. Lorimore, and I.B. Pragnell. 1990. Identification and characterization of an inhibitor of haemopoietic stem cell proliferation. Nature (Lond.). 344:442-444.
38. Paul, W.E., and R.A. Seder. 1994. Lymphocyte responses and cytokines. Cell. 76:241-251.
39. Wong, L.-M., S.J. Myers, C.-L. Tsou, J. Gosling, H. Arai, and I.F. Charo. 1997. Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J. Biol. Chem. 272:1038-1045.
40. Cook, D.N., M.A. Beck, T.M. Coffman, S.L. Kirby, J.F. Sheridan, I.B. Pragnell, and O. Smithies. 1995. Requirement of MIP-1α for an inflammatory response to viral infection. Science. 269:1583-1585.
41. Karpus, W.J., N.W. Lukacs, K.J. Kennedy, W.S. Smith, S.D. Hurst, and T.A. Barrett. 1997. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158:4129-4136.
42. Karpus, W.J., N.W. Lukacs, B.L. McRae, R.M. Strieter, S.L. Kunkel, and S.D. Miller. 1995. An important role for the chemokine macrophage inflammatory protein-1α in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J. Immunol. 155:5003-5010.
43. Karpus, W.J., and N.W. Lukacs. 1996. The role of chemokines in oral tolerance: Abrogation of nonresponsiveness by treatment with anti-monocyte chemotactic protein-1. Ann. NY Acad. Sci. 778:133-144.
44. Kurihara, T., and R. Bravo. 1996. Cloning and functional expression of mCCR2, a murine receptor for the chemokines JE and FIC. J. Biol. Chem. 271:11603-11607.
45. Loetscher, P., M. Seitz, M. Baggiolini, and B. Moser. 1996. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp. Med. 184:569-577.