The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1α and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation

Journal of Biological Chemistry

Volumn 273, Issue 32, 1998, Pages 19972-19976

  Pease, James E ^a,b,d   Wang, Juan ^c   Ponath, Paul D ^c   Murphy, Philip M ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

^d IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR 1; CHEMOKINE RECEPTOR CCR3; EOTAXIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BASOPHIL; CALCIUM TRANSPORT; ENZYME ACTIVATION; EOSINOPHIL; HELPER CELL; INFLAMMATION; LIGAND BINDING; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ANIMALS; B-LYMPHOCYTES; BINDING SITES; CHEMOKINES, CC; CYTOKINES; GTP-BINDING PROTEINS; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; PROTEIN BINDING; RECEPTORS, CHEMOKINE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032493767     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.32.19972     Document Type: Article

References (12)

1. Baggiolini, M., Dewald, B., and Moser, B. (1994) Adv. Immunol. 55, 97-179
2. Baggiolini, M., Dewald, B., and Moser, B. (1997) Annu. Rev. Immunol. 15, 675-705
3. Murphy, P. M. (1996) Cytokine Growth Factor Rev. 12, 593-633
4. Pease, J. E., and Murphy, P. M. (1998) Semin. Immunol., in press
5. Berger, E. A. (1997) AIDS 11, Supple. A, S3-S16
6. Neote, K., DiGregorio, D., Mak, J. Y., Horuk, R., and Schall, T. J. (1993) Cell 72, 415-425
7. Gao, J.-L., Kuhns, D. B.,Tiffany, H. L., McDermott, D., Li, X., Francke, U., and Murphy, P. M. (1993) J. Exp. Med. 177, 1421-1427
8. Combadiere, C., Ahuja, S. K., Van Damme, J., Tiffany, H. L., Gao, J.-L., and Murphy, P. M. (1995) J. Biol. Chem. 270, 29671-29675
9. Combadiere, C., Ahuja, S. K., and Murphy, P. M. (1995) J. Biol. Chem. 270, 16491-16494; Correction (1995) J. Biol. Chem. 270, 30235
10. Kitaura, M., Nakajima, T., Imai, T., Harada, S., Combadiere, C., Tiffany, H. L., Murphy, P. M., and Yoshie, O. (1996) J. Biol. Chem. 271, 7725-7730
11. Daugherty, B. L., Siciliano, S. J., DeMartino, J. A., Malkowitz, L., Sirotina, A., and Springer, M. S. (1996) J. Exp. Med. 183, 2349-2354
12. Ponath, P. D., Qin, S., Post, T. W., Wang, J., Wu, L., Gerard, N. P., Newman, W., Gerard, C., and Mackay, C. R. (1996) J. Exp. Med. 183, 2437-2448