The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

Journal of Immunology

Volumn 161, Issue 2, 1998, Pages 805-813

  Mellado, M ^a   Rodriguez Frade J M ^a   Aragay, A ^b   Del Real, G ^a   Martin A M ^a   Vila Coro, A J ^a   Serrano, A ^a   Mayor Jr , F ^b   Martinez A C ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE;

ARTICLE; CALCIUM MOBILIZATION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; CALCIUM; CELL LINE; CHEMOKINE CCL2; ENZYME ACTIVATION; HUMANS; JANUS KINASE 2; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; TYROSINE; VIRULENCE FACTORS, BORDETELLA;

EID: 2642641315     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Murphy, P. M. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593.
2. Hedrick, J. A., and A. Zlotnik. 1996. Chemokines and lymphocyte biology. Curr. Opin. Immunol. 8:343.
3. Howard, O. M. Z., A. Ben-Baruch, and J. J. Oppenheim. 1996. Chemokines: progress toward identifying molecular targets for therapeutic agents. Trends Biotechnol. 14:46.
4. Baggiolini, M., and C. A. Dahinden. 1994. CC Chemokines in allergic inflammation. Immunol. Today 15:127.
5. Kunkel, S. L., R. M. Stricter, I. J. D. Lindley, and J. Westwick. 1995. Chemokines: new ligands, receptors and activities. Immunol. Today 16:559.
6. Downey, G. P. 1994. Mechanisms of leukocyte motility and chemotaxis. Curr. Opin. Immunol. 6:113.
7. Schall, T. J. 1994. The Chemokines. In The Cytokine Handbook. A. W. Thompson, ed. Academic Press, London, pp. 181-272.
8. Kelner, G. S., J. Kennedy, K. B. Bacon, S. Kleyensteuber, D. A. Largaespada, N. A. Jenkins, N. G. Copeland, J. F. Bazan, K. W. Moore, T. J. Schall, and A. Zlotnik. 1994. Lymphotactin: a cytokine that represents a new class of chemokine. Science 266:1395.
9. 3C motif. Nature 385:640.
10. Matsushima, K., C. Larsen, G. C. DuBois, and J. J. Oppenheim. 1989. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J. Exp. Med. 169:1485.
11. Sylvester, J., A. F. Suffredini, A. J. Boujoukos, G. D. Martich, R. L. Danner, T. Yochimura, and E. J. Leonard. 1993. Neutrophil attractant protein-A 1 and monocyte chemoattractant protein-1 in human serum. J. Immunol. 151:3292.
12. Van Damme, J., P. Proost, W. Put, S. Arens, J.-P. Lenaerts, R. Conings, G. Opdemakker, H. Heremans, and A. Billau. 1994. Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers. J. Immunol. 152:5495.
13. Carr, M. W., S. J. Roth, E. Luther, S. S. Rose, and T. A. Springer. 1994. Monocyte chemoattractant protein-1 acts as a T-lymphocyte. Proc. Natl. Acad. Sci. USA 91:3652.
14. Flory, C. M., M. L. Jones, and J. S. Warren. 1993. Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1. Lab. Invest. 69:396.
15. Frade, J. M. R., M. Llorente, M. Mellado, J. Alcamí, J. C. Gutierrez-Ramos, A. Zaballos, G. del Real, and C. Martinez-A. 1997. The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection. J. Clin. Invest. 100:1.
16. Schröder, A. E., A. Greiner, C. Seyfert, and C. Berek. 1996. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 93:221.
17. Bossink, A. W. J., L. Paemaen, P. M. Jansen, C. E. Hack, L. G. Thijs, and J. Van Damme. 1995. Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Blood 86:3841.
18. Yoshida, R., T. Imai, K. Hieshima, J. Kusuda, M. Baba, M. Kitaura, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie. 1997. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272:13803.
19. Gayle, R. B., III, P. R. Sleath, S. Srinivason, C. W. Birks, K. S. Weerawarna, D. P. Cerreti, C. J. Kozlosky, N. Nelson, T. Vanden Boss, and M. P. Beckmann. 1993. Importance of the amino terminus of the interleukin-8 receptor in ligand interactions. J. Biol. Chem. 268:7283.
20. Monteclaro, F. S., and I. F. Charo. 1996. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1α receptor, confers chemokine selectivity: evidence for a two-step mechanism for MCP-1 receptor activation. J. Biol. Chem. 271:19084.
21. Bokoch, G. M. 1995. Chemoattractant signaling and leukocyte activation. Blood 86:1649.
22. Amatruda, T. T., N. P. Gerard, C. Gerard, and M. I. Simon. 1993. Specific interactions of chemoattractant receptors with G-proteins. J. Biol. Chem. 268:10139.
23. 2+ influx. J. Biol. Chem. 270:23816.
24. Bacon, K. B., L. Flores-Romo, P. F. Life, D. D. Taub, B. A. Premack, S. J. Arkinstall, T. N. C. Wells, T. J. Schall, and C. A. Power. 1995. IL-8-induced signal transduction in T lymphocytes involves receptor-mediated activation of phospholipases C and D. J. Immunol. 154:3654.
25. FAK and ZAP-70 in human T cells. J. Exp. Med. 184:873.
26. Worthen, G. S., N. Avdi, A. M. Buhl, N. Suzuki, and G. L. Johnson. 1994. FMLP activates Ras and Raf in human neutrophils: potential role in activation of MAP kinase. J. Clin. Invest. 94:815.
27. Jones, S. A., B. Moser, and M. Thelen. 1995. A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2 chemokine mediated activation of p42/p44 MAP-kinase (ERK-2). FEBS Lett. 364:211.
28. Arai, H., and I. F. Charo. 1996. Differential regulation of G-protein-mediated signaling by chemokine receptors. J. Biol. Chem. 271:21814.
29. Meydan, N., T. Grunberger, H. Dadi, M. Shahar, E. Arpaia, Z. Lapidot, J. S. Leeder, M. Freedman, A. Cohen, A. Gazit, A. Levitzki, and C. M. Roifman. 1996. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379:645.
30. Frade, J. M. R., M. Mellado, G. del Real, J. C. Gutierrez-Ramos, P. Lind, and C. Martinez-A. 1997. Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells. J. Immunol. 159:5576.
31. Carrera, A. C., S.-B. Wee, T. M. Roberts, and D. M. Pardoll. 1992. Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection. J. Immunol. 149: 3142.
32. Mellado, M., J. M. Rodríguez-Frade, L. Kremer, C. von Kobbe, A. Martín de Ana, I. Mérida, and C. Martinez-A. 1997. Conformational changes required in the human growth hormone receptor for growth hormone signaling J. Biol. Chem. 272:9189.
33. Charo, I. F., S. J. Myers, A. Herman, C. Franci, A. J. Connolly, and S. R. Coughlin. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA 91:2752.
34. del Pozo, M. A., P. Sanchez-Mateos, and F. Sanchez-Madrid. 1996. Cellular polarization induced by chemokines: a mechanism for leukocyte recruitment? Immunology Today 17, 127.
35. Scheer, A., F. Fanelli, T. Costa, P. G. De Benedetti, and S. Cotecchia. 1996. Constitutively active mutants of the alpha 1β-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO J. 15:3566.
36. Power, C. A., A. Meyer, K. Nemeth, K. B. Bacon, A. J. Hoogewerf, A. E. I. Proudfoot, and T. N. C. Wells. 1995. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 270:19495.
37. Damaj, B. B., S. R. McColl, K. Neote, N. Songquing, K. T. Ogborn, C. A. Hebert, and P. H. Naccache. 1996. Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops. FASEB J. 12:1426.
38. Lütticken, C., U. M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A. J. Harpur, A. F. Wilks, K. Yasukawa, T. Taga, T. Kishimoto, G. Barbieri, S. Pellegrin, M. Sendtner, P. C. Heinrich, and F. Horn. 1994. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89.
39. Siciliano, S. J., T. E. Rollins, and M. S. Springer. 1990. Interaction between the C5a receptor and Gi in both the membrane-bound and detergent-solubilized states. J. Biol. Chem. 265:19568.
40. Karoor, V., and C. C. Malbon. 1996. Insulin-like growth factor receptor-1 stimulates phosphorylation of the beta2-adrenergic receptor in vivo on sites distinct from those phosphorylated in response to insulin. J. Biol. Chem. 271:29347.
41. Marrero, M. B., B. Schieffer, W. G. Paxton, L. H. Eerdt, B. C. Berk, P. Delafontaine, and K. E. Bernstein. 1995. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375:247.
42. Hebert, T. E., S. Moffett, J. P. Morello, T. P. Loisel, D. G. Bichet, C. Barret, and M. Bouvier. 1996. A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J. Biol. Chem. 271:16384.
43. Benkirane, M., D.-Y. Jin, R. F. Chun, R. A. Koup, and K.-T. Jeang. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32. J. Biol. Chem. 272:30602.