β-arrestin-dependent formation of β2 adrenergic receptor-src protein kinase complexes

Science

Volumn 283, Issue 5402, 1999, Pages 655-661

  Luttrell, L M ^a   Ferguson, S S G ^b   Daaka, Y ^a   Miller, W E ^a   Maudsley, S ^a   Della Rocca, G J ^a   Lin, F T ^a   Kawakatsu, H ^c   Owada, K ^d   Luttrell, D K ^e   Caron, M G ^a   Lefkowitz, R J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^e GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN KINASE; RETINA S ANTIGEN;

ANIMAL CELL; ARTICLE; CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ARRESTINS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CELL MEMBRANE; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HUMANS; ISOPROTERENOL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHORYLATION; POINT MUTATION; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECEPTOR CROSS-TALK; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION;

ANIMALIA;

EID: 0033613938     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5402.655     Document Type: Article

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58. R.J.L. and M.G.C. are investigators with the Howard Hughes Medical Institute. Supported in part by NIH grants DK02352 and DK55524 (L.M.L.), HL 16037 (R.J.L.), NS19576 (M.G.C.), and Heart and Stroke Foundation of Ontario Grant NA3349 (S.S.G.F.). G.J.D.R. is supported by NIH Medical Scientist Training Program Grant T32GM-07171. We thank M. J. Eck for purified recombinant c-Src and D. Addison and M. Holben for excellent secretarial assistance.