Linkage of g protein-coupled receptors to the MAPK signaling pathway through Pl 3-kinase γ

Science

Volumn 275, Issue 5298, 1997, Pages 394-397

  Lopez Ilasaca, Marco ^a   Crespo, Piero ^b   Pellici, P Giuseppe ^c   Gutkind, J Silvio ^b   Wetzker, Reinhard ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANDROSTADIENES; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARBACHOL; CELL MEMBRANE; COS CELLS; ENZYME ACTIVATION; GRB2 ADAPTOR PROTEIN; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TYROSINE;

EID: 0031037296     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5298.394     Document Type: Article

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29. We thank A. Gazit and A. Levitzki for supplying PP1. M.L.I. and R.W. are supported by grants SFB 197 and We 1565/1-2 from the Deutsche Forschungsgemeinschaft.