Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

Science

Volumn 277, Issue 5325, 1997, Pages 567-570

  Stokoe, David ^a,f   Stephens, Leonard R ^b   Copeland, Terry ^c   Gaffney, Piers R J ^d   Reese, Colin B ^d   Painter, Gavin F ^e   Holmes, Andrew B ^e   McCormick, Frank ^a,f   Hawkins, Phillip T ^b  

^a ONYX PHARMACEUTICALS   (United States)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE KINASE; CREATINE PHOSPHATE; MAGNESIUM CHLORIDE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PLECKSTRIN; PROTEIN KINASE B; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BLOOD PROTEINS; BRAIN; COS CELLS; CYTOSOL; ENZYME ACTIVATION; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STEREOISOMERISM;

ANIMALIA;

EID: 0030799706     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5325.567     Document Type: Article

References (29)

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29. This research is supported in part by the National Cancer Institute, NIH, Department of Health and Human Services under contract with ABL. P. Hawkins is a Biotechnology and Biological Sciences Research Council Research Fellow. We thank B. Burgering for the PSG5(HA)PKB, E. Porfiri for critical reading of the manuscript and helpful suggestions, D. Morrison for helpful suggestions, and Bayer Corporation for interactive support.