Hetahelical receptor signaling: Beyond the G protein paradigm

Journal of Cell Biology

Volumn 145, Issue 5, 1999, Pages 927-932

  Hall, Randy A ^a   Premont, Richard T ^a   Lefkowitz, Robert J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; PROLINE DERIVATIVE; PROTEIN KINASE; PROTEIN KINASE P60; RECEPTOR PROTEIN; RETINA S ANTIGEN; CELL SURFACE RECEPTOR; PROTEIN TYROSINE KINASE;

ALPHA HELIX; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SHORT SURVEY; SIGNAL TRANSDUCTION; ANIMAL; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; GTP-BINDING PROTEINS; HUMANS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0033620487     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.145.5.927     Document Type: Short Survey

References (66)

1. Alcedo, J., M. Ayzenzon, T. Von Ohlen, M. Noll, and J.E. Hooper. 1996. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell. 86:221-232.
2. 1 receptor. J. Biol. Chem. 272:23382-23388.
3. Baltensperger, K., V. Karoor, H. Paul, A. Ruoho, M.P. Czech, and C.C. Malbon. 1996. The β-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. J. Biol. Chem. 271:1061-1064.
4. Bargmann, C.I. 1998. Neurobiology of the Caenorhabditis elegans genome. Science. 282:2028-2033.
5. Bello-Reuss, E. 1980. Effect of catecholamines on fluid reabsorption by the isolated proximal convoluted tubule. Am. J. Physiol. 238:F347-F352.
6. Bhanot, P., M. Brink, C.H. Samos, J.C. Hsieh, Y. Wang, J.P Macke, D. Andrew, J. Nathans, and R. Nusse. 1996. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature. 382:225-230.
7. Brakeman, P.R., A.A. Lanahan, R. O'Brien, K. Roche, C.A. Barnes, R.L. Huganir, and P.F. Worley. 1997. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 386:284-288.
8. Buhl, A.M., N.L. Johnson, N. Dhanasekaran, and G.L. Johnson. 1995. Gα12 and Gα13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J. Biol. Chem. 270:24631-24634.
9. Carman, C.V., T. Som, C.M. Kim, and J.L. Benovic. 1998. Binding and phosphorylation of tubulin by G protein-coupled receptor kinases. J. Biol. Chem. 273:20308-20316.
10. Chen. C.-Y., S.B. Dion, C.M. Kim, and J.L. Benovic. 1993. β-adrenergic receptor kinase: agonist-dependent receptor binding promotes kinase activation. J. Biol. Chem. 268:7825-7831.
11. Chen, Y., and G. Struhl. 1996. Dual roles for patched in sequestering and transducing Hedgehog. Cell. 87:553-563.
12. Chevesich, J., A.J. Kreuz, and C. Montell. 1997. Requirement for the PDZ domain protein, InaD, for localization of the TRP store-operated channel to a signaling complex. Neuron. 18:95-105.
13. Dale, T.C. 1998. Signal transduction by the Wn1 family of ligands. Biochem. J. 329:209-223.
14. Devreotes, P.N. 1994. G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron. 12:235-241.
15. Freeman, J.L., E.M. De La Cruz, T.D. Pollard, R.J. Lefkowitz, and J.A. Pitcher. 1998. Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. J. Biol. Chem. 273:20653-20657.
16. 2-adrenergic receptor. Nature. 383:447-450.
17. 2-adrenergic receptors in response to insulin. J. Biol. Chem. 267:26017-26022.
18. Haga, K., H. Ogawa, T. Haga, and H. Murofushi. 1998. GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin. Eur. J. Biochem. 255:363-368.
19. + exchange. Nature. 392:626-630.
20. + exchanger regulatory factor family of PDZ proteins. Proc. Natl. Acad. Sci. USA. 95:8496-8501.
21. He. X., J.P. Saint-Jeannet, Y. Wang, J. Nathans, I. Dawid, and H. Varmus. 1997. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. 275:1652-1654.
22. 2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO (Eur. Mol. Biol. Organ.) J. 15:7036-7045.
23. Ingham, P.W. 1998. Transducing Hedgehog: the story so far. EMBO (Eur. Mol. Biol. Organ.) J. 17:3505-3511.
24. Jin, T., R.D.M. Soede, J. Liu, A.R. Kimmel, P.N. Devreotes, and P. Schaap. 1998. Temperature-sensitive Gβ mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors. EMBO (Eur Mol. Biol. Organ.) J. 17:5076-5084.
25. Joly, C., J. Gomeza, I. Brabel, K. Curry, J. Bockaert, and J.-P. Pin. 1995. Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. J. Neurosci. 15:3970-3981.
26. Ju, H., V.J. Venema, M.B. Marrero, and R.C. Venema. 1998. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric oxide synthase. J. Biol. Chem. 273:24025-24029.
27. Karoor, V., K. Baltensperger, H. Paul, M.P. Czech, and C.C. Malbon. 1995. Phosphorylation of tyrosyl residues 350/354 of the beta-adrenergic receptor is obligatory for counterregulatory effects of insulin. J. Biol. Chem. 270: 25305-25308.
28. Karoor, V., L. Wang, H.-Y. Wang, and C.C. Malbon. 1998. Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptor with Grb2 via tyrosine 350. J. Biol. Chem. 273: 33035-33041.
29. Kinzler, K.W., and B. Vogelstein. 1996. Lessons from hereditary colorectal cancer. Cell. 87:159-170.
30. Klein, W., M.T. Ramirez, B.K. Kobilka, and M. von Zastrow. 1997. A novel interaction between adrenergic receptors and the α-subunit of the eukaryotic initiation factor 2B. J. Biol. Chem. 272:19099-19102.
31. Kornau, H.-C., L.T. Schenker, M.B. Kennedy, and P.H. Seeburg. 1995. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 269:1737-1740.
32. Kozasa, T., X. Jiang, M.J. Hart, P.C. Sternweis, W.D. Singer, A.G. Gilman, G. Bollag, and P.C. Sternweis. 1998. p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13. Science. 280:2109-2111.
33. 2-adrenergic receptor/B-arrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc. Natl. Acad. Sci. USA. 96:3712-3717.
34. Lefkowitz, R.J. 1998. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J. Biol. Chem. 273:18677-18680.
35. Luttrell, L.M., B.E. Hawes, T. van Biesen, D.K. Luttrell, T.J. Lansing, and R.J. Lefkowitz. 1996. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. J. Biol. Chem. 271:19443-19450.
36. 2-adrenergic receptor-Src protein kinase complexes. Science. 283:655-661.
37. Maeda, M., L. Aubry, R. Insall, C. Gaskins, P.N. Devreotes, and R.A. Firtel. 1996. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. J. Biol. Chem. 271:3351-3354.
38. 1 receptor. Nature. 375:247-250.
39. Marrero, M.B., V.J. Venema, H. Ju, D.C. Eaton, and R.C. Venema. 1998. Regulation of angiotensin II-induced Jak2 tyrosine phosphorylation: roles of SHP-1 and SHP-2. Am. J. Physiol. 275:C1216-C1223.
40. 2-adrenergic receptor regulation. J. Biol. Chem. 274:10677-10680.
41. Milne, J.L., L. Wu, M.J. Caterina, and P.N. Devreotes. 1995. Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium. J. Biol. Chem. 270:5926-5931.
42. Mitchell, R., D. McCulloch, E. Lutz, M. Johnson, C. MacKenzie, M. Fennell, G. Fink, W. Zhou, and S.C. Sealfon. 1998. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature. 392:411-414.
43. Oldenhof, J., R. Vickery, M. Anafi, J. Oak, A. Ray, O. Schoots, T. Pawson, M. von Zastrow, and H.H. Van Tol. 1998. SH3 binding domains in the dopamine D4 receptor. Biochemistry. 37:15726-15736.
44. Palczewski, K., J. Buczylko, M.W. Kaplan, A.S. Polans, and J.W. Crabb. 1991. Mechanism of rhodopsin kinase activation. J. Biol. Chem. 266:12949-12955.
45. Pawson, T., and J.D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:2075-2080.
46. Pin, J.-P., C. Waeber, L. Prezeau, J. Bockaert, and S.F. Heineman. 1992. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 89:10331-10335.
47. Pitcher, J.A., R.A. Hall, Y. Daaka, J. Zhang, S.S. Ferguson, S. Hester, S. Miller, M.G. Caron, R.J. Lefkowitz, and L.S. Barak. 1998. The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. J. Biol. Chem. 273:12316-12324.
48. Premont, R.T., W.J. Koch, J. Inglese, and R.J. Lefkowitz. 1994. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem. 269:6832-6841.
49. 2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc. Natl. Acad. Sci. USA. 95: 14082-14087.
50. Schnitzler, G.R., C. Briscoe, J.M. Brown, and R.A. Firtel. 1995. Serpentine cAMP receptors may act through a G-protein-independent pathway to induce postaggregative development in Dictyostelium. Cell. 81:737-745.
51. Scott, K., and C.S. Zuker. 1998. Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses. Nature. 395: 805-808.
52. 2+ channel by InaD in Drosophila photoreceptors. Neuron. 16:991-998.
53. Slusarski, D.C., V.G. Corces, and R.T. Moon. 1997 Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signaling. Nature. 390:410-413.
54. Songyang, Z., A.S. Fanning, C. Fu, J. Xu, S.M. Marfatia, A.H. Chishti, A. Crompton, A.C. Chan, J.M. Anderson, and L.C. Cantley. 1997. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science. 275: 73-77.
55. Stone, D.M., M. Hynes, M. Armanini, T.A. Swanson, Q. Gu, R.L. Johnson, M.P. Scott, D. Pennica, A. Goddard, H. Phillips, et al. 1996. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 384:129-134.
56. Tsunoda, S., J. Sierralta, Y. Sun, R. Bodner, E. Suzuki, A. Becker, M. Socolich, and C.S. Zuker. 1997. A mullivalent PDZ-domain protein assembles signaling complexes in a G-protein-coupled cascade. Nature. 388:243-249.
57. Tu, J.C., B. Xiao, J.P. Yuan, A.A. Lanahan, K. Leoffert, M. Li, D.J. Linden, and P.F. Worley. 1998. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 21: 717-726.
58. 2-adrenergic receptor. EMBO (Eur. Mol. Biol. Organ.) J. 14:5542-5549.
59. Van den Heuvel, M., and P.W. Ingham. 1996. Smoothened encodes a receptor-like serpentine protein required for hedgehog signaling. Nature. 382:547-551.
60. 1 receptor. J. Biol. Chem. 273: 7703-7708.
61. + exchanger. Annu. Rev. Physiol. 55:289-304.
62. Weinman, E.J., S.C. Sansom, T.F. Knight, and H.O. Senekjian. 1982. Alpha and beta adrenergic agonists stimulate water absorption in the rat proximal tubule. J. Memb. Biol. 69:107-111.
63. Xiao, B., J.C. Tu, R.S. Petralia, J.P. Yuan, A. Doan, C.D. Breder, A. Ruggiero, A.A. Lanahan, R.J. Wenthold, and P.F. Worley. 1998. Homer regulates the association of Group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. Neuron. 21:707-716.
64. Xie, J., M. Murone, S.M. Luoh, A. Ryan, Q. Gu, C. Zhang, J.M. Bonifas, C.W. Lam, M. Hynes, A. Goddard, et al. 1998. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. 391:90-92.
65. Xu, X.-Z.S., A. Choudhury, X. Li, and C. Montell. 1998. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J. Cell Biol. 142:545-555.
66. Yang-Snyder, J., J.R. Miller, L.D. Brown, C.J. Lai, and R.T. Moon. 1996. A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6:1302-1306.