Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

Nature Cell Biology

Volumn 1, Issue 8, 1999, Pages 461-466

  Li, Fengzhi ^a   Ackermann, Elizabeth J ^b   Bennett, C Frank ^b   Rothermel, Annette L ^a   Plescia, Janet ^a   Tognin, Simona ^c   Villa, Antonello ^c,d   Marchisio, Pier Carlo ^c   Altieri, Dario C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BIRC5 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CELL DIVISION; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CENTROSOME; CHEMISTRY; DOMINANT GENE; DRUG ANTAGONISM; ENZYMOLOGY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; METABOLISM; MITOSIS; MITOSIS SPINDLE; MUTATION; POLYPLOIDY;

APOPTOSIS; CASPASE 3; CASPASES; CELL DIVISION; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CENTROSOME; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENES, DOMINANT; HELA CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; NEOPLASM PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; POLYPLOIDY; PROTEINS; TRANSFECTION;

EID: 0033258543     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/70242     Document Type: Article

References (35)

1. Vaux, D. L. & Korsmeyer, S. J. Cell dealth in development. Cell 96, 245-254 (1999).
2. Raff, M. Cell suicide for beginners. Nature 396, 119-122 (1998).
3. Evan, G. & Littlewood, T. A matter of life and cell death. Science 281, 1317-1322 (1998).
4. Linette, G. P., Li, Y., Roth, K. & Korsmeyer, S. J. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proc. Natl Acad. Sci. USA 93, 9545-9552 (1996).
5. Minn, A. J., Boise, L. H. & Thompson, C. B. Expression of Bcl-XL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev. 10, 2621-2631 (1996).
6. Ambrosini, G., Adida, C. & Altieri, D. C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med. 3, 917-921 (1997).
7. Deveraux, Q. L. & Reed, J. C. IAP family proteins - suppressors of apoptosis. Genes Dev. 13, 239-252 (1999).
8. Li, F. et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396, 580-584 (1998).
9. McKay, R. A. et al. Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression. J. Biol. Chem. 274, 1715-1722 (1999).
10. Hinds, M. G., Norton, R. S., Vaux, D. L. & Day, C. L. Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. Nature Struct. Biol. 6, 648-651 (1999).
11. Ambrosini, G., Adida, C., Sirugo, G. & Altieri, D. C. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J. Biol. Chem. 273, 11177-11182 (1998).
12. Pihan, G. A. et al. Centrosome defects and genetic instability in malignant tumors. Cancer Res. 58, 3974-3985 (1998).
13. 2-M cell cycle checkpoint induce genetic instability in BRCA1 isoform-deficient cells. Mol. Cell 3, 389-395 (1999).
14. Lingle, W. L., Lutz, W. H., Ingle, J. N., Maihle, N. J. & Salisbury, J. L. Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc. Natl Acad. Sci. USA 95, 2950-2955 (1998).
15. Winey, M. Cell cycle: driving the centrosome cycle. Curr. Biol. 9, R449-R452 (1999).
16. Lacey, K. R., Jackson, P. K. & Stearns, T. Cyclin-dependent kinase control of centrosome duplication. Proc. Natl Acad. Sci. USA 96, 2817-2822 (1999).
17. Matsumoto, Y., Hayashi, K. & Nishida, E. Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr. Biol. 9, 425-428 (1999).
18. 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18, 629-643 (1998).
19. Gervais, J. L., Seth, P. & Zhang, H. Cleavage of CDK inhibitor p21 (Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis. J. Biol. Chem. 273, 19207-19212 (1998).
20. Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672 (1996).
21. Urbani, L. & Stearns, T. The centrosome. Curr. Biol. 9, R315-R317 (1999).
22. Hsu, L.-C. & White, R. L. BRCA1 is associated with the centrosome during mitosis. Proc. Natl Acad. Sci. USA 95, 12983-12988 (1998).
23. Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol. Cell 1, 553-563 (1998).
24. cip-1/waf-1 deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 93, 1390-1398 (1999).
25. Waldman, T., Lengauer, C., Kinzler, K. W. & Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713-716 (1996).
26. Waf1/Cip1 inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell. Biol. 19, 205-215 (1999).
27. Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S. & Vande Woude, G. F. Abnormal centrosome amplification in the absence of p53. Science 271, 1744-1747 (1996).
28. Field, C., Li, R. & Oegema, K. Cytokinesis in eukaryotes: a mechanistic comparison. Curr. Opin. Cell Biol. 11, 68-80 (1999).
29. Terada, Y. et al. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J. 17, 667-676 (1998).
30. Madaule, P. et al. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature 394, 491-494 (1998).
31. Fraser, A. G., James, C., Evan, G. I. & Hengartner, M. O. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr. Biol. 9, 292-301 (1999).
32. Bennett, C. F., Chiang, M. Y., Chan, H., Shoemaker, J. E. & Mirabelli, C. K. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 41, 1023-1033 (1992).
33. Ackermann, E. J., Taylor, J. K., Narayana, R. & Bennett, C. F. The role of antiapoptotic bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides. J. Biol. Chem. 274, 11245-11252 (1999).
34. Moudjou, M. & Bornens, M. in Cell Biology: A Laboratory Handbook 111-119 (Academic, New York, 1998).
35. Krajewska, M. et al. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res. 57, 1605-1613 (1997).