p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells

Blood

Volumn 93, Issue 4, 1999, Pages 1390-1398

  Mantel, Charlie ^a   Braun, Stephen E ^b   Reid, Suzanna ^b   Henegariu, Octavian ^b   Liu, Lisa ^b   Hangoc, Giao ^b   Broxmeyer, Hal E ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21;

ARTICLE; CELL CYCLE; CENTRIOLE; GROWTH REGULATION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL;

EID: 0033557572     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.4.1390.404k25_1390_1398     Document Type: Article

References (26)

1. Hartwell LH, Weinert TA: Checkpoints: Controls that ensure the order of cell cycle events. Science 246:629, 1989
2. Murray AW: Creative blocks: Cell cycle checkpoints and feedback controls. Nature 359:599, 1992
3. Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tristy TD: Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70:923, 1992
4. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB: Wild type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89:7491, 1992
5. Waldman T, Zhang Y, Dillehay JY, Kinzler K, Vogelstein B, Williams J: Cell cycle arrest versus cell death in cancer therapy. Nat Med 3:1034, 1997
6. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAF1, a potential mediator of p53 tumor suppression. Cell 75:817, 1993
7. Harper JW, Adami GR, Wei N, Keyomarski K, Elledge SJ: The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805, 1993
8. Elledge SJ: Cell cycle checkpoints: Preventing an identity crisis. Science 274:1664, 1996
9. Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ: A p53-dependent mouse spindle checkpoint. Science 267:1353, 1995
10. Khan SH, Wahl GM: p53 and Rb prevent re-replication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res 58:396, 1998
11. Lanni JS, Jacks T: Characterization of the p53-dependent post mitotic checkpoint following spindle disruption. Mol Cell Biol 18:1055, 1998
12. Mantel CR, Luo Z, Canfield J, Braun S, Deng C, Broxmeyer HE: Involvement of p21 and p27 in the molecular mechanisms of steel factor-induced proliferative synergy in-vitro and of p21 in the maintenance of stem/progenitor cells in-vivo. Blood 88:3710, 1996
13. cip-1/waf-1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer. Blood Cells Mol Dis 24:137, 1998.
14. Hendrie PC, Miyazawa K, Yang YC, Langefeld CD, Broxmeyer HE: Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of human factor dependent cell line, MO7e. Exp Hematol 19:1031, 1991
15. Waldman T, Kenzler KW, Vogelstein B: p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55:5187, 1995
16. Miller AD, Roseman GJ: Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980, 1989
17. Miller AD, Buttimore C: Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 6:2895, 1986
18. Kikuchi J, Furukawa Y, Iwase S, Terui Y, Nakamura M, Kitagawa S, Kitagawa M, Komatsu N, Miura Y: Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: Involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. Blood 89:3980, 1997
19. Tishler RB, Lamppu DM, Price BD: Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53. Cancer Res 55:6021, 1995
20. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF: Abnormal centrosome amplification in the absence of p53. Science 271:1744, 1996
21. Robbins E, Jentzsch G, Micali A: The centriole cycle in synchronized HELA cells. J Cell Biol 36:329, 1968
22. waf1 reorganizes the nucleus in tumor suppression. Proc Natl Acad Sci USA 95:1131, 1998
23. waf1. Cancer Res 55:4536, 1995
24. Schliwa M: The Cytoskeleton. New York, NY, Springer-Verlag, 1986
25. Mitchison T, Kirschner M: Microtubule assembly nucleated by isolated centrosomes. Nature 312:232, 1984
26. Stearns T, Winey M: The cell center at 100. Cell 91:303, 1997