p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest

Cancer Research

Volumn 58, Issue 3, 1998, Pages 396-401

  Khan, Shireen Hussain ^a,b   Wahl, Geoffrey M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; NOCODAZOLE; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL GROWTH; CELL SYNCHRONIZATION; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; FIBROBLAST CULTURE; FLOW CYTOMETRY; GENOTYPE; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANEUPLOIDY; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA REPLICATION; FIBROBLASTS; G1 PHASE; HUMANS; MICROTUBULES; NOCODAZOLE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032005132     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Cross, S. M., Sanchez, C. A., Morgan, C. A., Schimke, M. K., Ramel, S., Idzerda, R. L., Raskind, W. H., and Reid, B. J. A p53-dependent mouse spindle checkpoint. Science (Washington DC), 267: 1353-1356, 1995.
2. Minn, A. J., Boise, L. H., and Thompson, C. B. Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev., 10: 2621-2631, 1996.
3. Di Leonardo, A., Hussain-Khan, S., Linke, S. P., Greco, V., Seidita, G., and Wahl, G. M. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res., 57: 1013-1019, 1997.
4. Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S., and Vande Woude, G. F. Abnormal centrosome amplification in the absence of p53. Science (Washington DC) 271-1744-1747, 1996.
5. Hoyt, M. A., Totis, L., and Roberts, B. T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell, 66: 507-517, 1991.
6. Goodrich, D. W., Wang, N. P., Qian, Y. W., Lee, E. Y., and Lee, W. H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell, 67: 293-302, 1991.
7. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
8. Chamla, Y., Roumy, M., Lassegues, M., and Battin, J. Altered sensitivity to cholchicine and PHA in human cultured cells. Hum. Genet., 53: 249-253, 1980.
9. Kung, A. L., Sherwood, S. W., and Schimke, R. T. Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc. Natl. Acad. Sci. USA, 87: 9553-9557, 1990.
10. Rieder, C. L., and Palazzo, R. E. Colcemid and the mitotic cycle. J. Cell Sci., 102: 387-392, 1992.
11. Andreassen, P. R., and Margolis, R. L. Microtubule dependency of p34cdc2 inactivation and milotic exit in mammalian cells. J. Cell Biol.. 127: 789-802, 1994.
12. Linke, S. P., Clarkin, K. C., Di Leonardo, A., Tsou, A., and Wahl, G. M. A reversible p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev., 10: 934-947, 1996.
13. Huang, L-c., Clarkin, K. C., and Wahl, G. M. p53 dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res., 56: 2940-2944, 1996.
14. Deng, C., Zhang, P., Harper, J. W., Elledge, S. J., and Leder, P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell, 82: 675-684, 1995.
15. Tommasino, M., and Crawford, L. Human papillomavirus E6 and E7: proteins which deregulate the cell cycle. Bioessays, 17: 509-518, 1995.
16. Vandre, D. D., and Borisy, G. G. Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly. J. Cell Sci., 94: 245-258, 1989.
17. Ludlow, J. W., Glendening, C. L., Livingston, D. M., and DeCaprio, J. A. Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol. Cell. Biol., 13: 367-372, 1993.
18. Blake, M. C., and Azizkhan, J. C. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol., 9: 4994-5002, 1989.
19. Ohtani, K., DeGregori, J., Leone, G., Herendeen, D. R., Kelly, T. J., and Nevins, J. R. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol. Cell. Biol., 16: 6977-6984, 1996.
20. Bell, S. P., Kobayashi, R., and Stillman, B. Yeast origin recognition complex functions in transcription silencing and DNA replication [see comments]. Science (Washington DC), 262: 1844-1849, 1993.
21. Micklem, G., Rowley, A., Harwood, J., Nasmyth, K., and Diffley, J. F. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature (Lond.), 366: 87-89, 1993.
22. Bagchi, S., Weinmann, R., and Raychaudhuri, P. The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F. Cell, 65: 1063-1072, 1991.
23. Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M., and Nevins, J. R. The E2F transcription factor is a cellular target for the RB protein. Cell, 65: 1053-1061, 1991.
24. Bandara, L. R., and La, T. N. Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Nature (Lond.), 351: 494-497, 1991.
25. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-25, 1993.
26. Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366: 704-707, 1993.
27. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88: 593-602, 1997.
28. Holloway, S. L., Glotzer, M., King, R. W., and Murray, A. W. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell, 73: 1393-1402, 1993.
29. Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., and Nasmyth, K. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J., 12: 1969-1978, 1993.
30. Hartwell, L. H., and Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science (Washington DC), 246: 629-634, 1989.
31. Weinen, T. A., and Hartwell, L. H. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science (Washington DC), 241: 317-322, 1988.
32. Linke, S. P., Clarkin, K. C., and Wahl, G. M. p53 mediates permanent arrest over multiple cell cycles in response to gamma irradiation. Cancer Res., 57: 1171-1179, 1997.
33. Di Leonardo, A., Linke, S. P., Clarkin, K., and Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev., 8: 2540-2551, 1994.
34. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71: 587-597, 1992.
35. Trielli, M. O., Andreassen, P. R., Lacroix, F. B., and Margolis, R. L. Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells. J. Cell Biol., 135: 689-700, 1996.
36. Allen, R. D., Weiss, D. G., Hayden, J. H., Brown, D. T., Fujiwake, H., and Simpson, M. Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport. J. Cell Biol., 100: 1736-1752, 1985.
37. Fukasawa, K., and Vande Woude, G. F. Synergy between the mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Mol. Cell. Biol., 17: 506-518, 1997.
38. Rowinsky, E. K., and Donehower, R. C. The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics. Pharmacol. Ther., 52: 35-84, 1991.