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I thank T. Weinert, A. Murray, A. Carr, C. Sherr, N. Walworth, J. W. Harper, S. Sazer, M. Kuroda, and members of the Elledge laboratory for criticism of the manuscript; A. Murray, T. Carr, T. Weinert, P. Russell, M. Hoekstra, V. Lundblad, L. Hartwell, H. Leiberman, O. Koshland, and O. Cohen-Fix for sharing unpublished results, and all my colleagues in the cell cycle field for stimulating discussions. Supported by grants from the NIH (GM44664) and the Robert Welch Foundation (01187). S.J.E. is an Investigator of the Howard Hughes Medical Institute and a PEW Scholar in the Biomedical Sciences.
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