Functional roles of STAT family proteins: Lessons from knockout mice

Stem Cells

Volumn 17, Issue 3, 1999, Pages 138-146

  Akira, Shizuo ^a,b  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Conditional knockout; Cre loxP system; Cytokine; JAK kinase; Signal transduction; STAT

Indexed keywords

CYTOKINE;

APOPTOSIS; CELL GROWTH; CELL MOTILITY; GENE LOCATION; IMMUNE RESPONSE; KNOCKOUT MOUSE; LIGAND BINDING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032934156     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.170138     Document Type: Review

References (80)

1. Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-1421.
2. Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-1635.
3. Ihle JN. STATs: signal transducers and activators of transcription. Cell 1996;84:331-334.
4. Horvath CM, Wen Z, Darnell JE Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev 1995;9:984-994.
5. Xu X, Sun Y-L, Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 1996;273:794-797.
6. Copeland NG, Gilbert DJ, Schindler C et al. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 1995;29:225-228.
7. Kawata T, Shevchenko A, Fukuzawa M et al. SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in Dictyostelium. Cell 1997;89:909-916.
8. Rodig SJ, Meraz MA, White JM et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998;93:373-383.
9. Nosaka T, van Deursen JM, Tripp RA et al. Defective lymphoid development in mice lacking Jak3. Science 1995;270:800-802.
10. Thomis DC, Gurniak CB, Tivol E et al. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995;270:794-797.
11. Vignais ML, Sadowski HB, Watling D et al. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol Cell Biol 1996;16:1759-1769.
12. Novak U, Harpur AG, Paradiso L et al. Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. Blood 1995;86:2948-2956.
13. Marrero MB, Schieffer B, Paxton WG et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 1995;373:247-250.
14. Guillet-Deniau I, Burnol A-F, Girard J. Identification and localization of a skeletal muscle serotonin 5-HT2A receptor coupled to the Jak/STAT pathway. J Biol Chem 1997;272:14825-14829.
15. Welte T, Leitenberg D, Dittel BN et al. STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 1999;283:222-225.
16. Karras JG, Wang Z, Huo L et al. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement. J Immunol 1997;159:4350-4355.
17. Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosphorylation. Cell 1995;82:241-250.
18. Zhang X, Blenis J, Li HC et al. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 1995;267:1990-1994.
19. Kim TK, Maniatis T. Regulation of interferon-gamma-activated STAT1 by die ubiquitin-proteasome pathway. Science 1996;273:1717-1719.
20. Starr R, Willson TA, Viney EM. A family of cytokine-inducible inhibitors of signalling. Nature 1997;387:917-921.
21. Endo TA, Masuhara M, Yokouchi M et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997;386:921-924.
22. Naka T, Narazaki M, Hirata M et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997;383:924-929.
23. Chung CD, Liao J, Liu B et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997;278:1803-1805.
24. Liu B, Liao J, Rao X et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci USA 1998;95:10626-10631.
25. Chin YE, Kitagawa M, Su WC et al. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 1996;272:719-722.
26. Kaplan MH, Daniel C, Schindler U et al. Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol Cell Biol 1998;18:1996-2003.
27. Kumar A, Commane M, Flickinger TW et al. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 1997;278:1630-1632.
28. Chin YE, Kitagawa M, Kuida K et al. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol 1997;17:5328-5337.
29. Migone TS, Lin JX, Cereseto A et al. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 1995;269:79-81.
30. Hilbert DM, Migone TS, Kopf M et al. Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathways. Immunity 1996;5:81-89.
31. Ohashi T, Masuda M, Ruscetti SK. Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus. Blood 1995;85:1454-1462.
32. Yu CL, Meyer DJ, Campbell GS et al. Enhanced DNA-binding activity of a Stat-3-related protein in cells transformed by the Src oncoprotein. Science 1995;269:81.
33. Cao X, Tay A, Guy GR et al. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol 1996;16:1595-1603.
34. Turkson J, Bowman T, Garcia R et al. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998;18:2545-2552.
35. Daniel NN, Pernis A, Rothman PB. Jak-STAT signaling induced by the v-abl oncogene. Science 1995;269:1875-1877.
36. Shuai K, Halpern J, ten Hoeve J et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996;13:247-254.
37. Nielsen M, Kaltoft K, Nordahl M et al. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin Ag490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc Natl Acad Sci USA 1997;94:6764-6769.
38. Gouilleux-Gruart V, Gouilleux F, Desaint C et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 1996;87:1692-1697.
39. Zong C, Yan R, August A et al. Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J 1996;15:4515-4525.
40. Grandis JR, Drenning SD, Chakraborty A et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 1998;102:1385-1392.
41. Meraz MA, White JM, Sheehan KCF et al. Targeted disruption of Stat1 gene in mice reveals unexpected physiologic specificity in the JAK STAT signaling pathway. Cell 1996;84:431-442.
42. Durbin JE, Hackenmiller R, Simon MC et al. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996;84:443-450.
43. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
44. Zhong Z, Wen Z, Darnell JE Jr. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 1994;91:4806-4810.
45. Yamamoto K, Quelle FW, Thierfelder WE et al. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol 1994;14:4342-4349.
46. Jacobson NG, Szabo SJ, Weber-Nordt RM et al. Interleukin 12 signaling in T helper type (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995;181:1755-1762.
47. Thierfelder WE, van Deursen JM, Yamamoto K et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996;382:171-174.
48. Kaplan MH, Sun Y-L, Hoey T et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996;382:174-177.
49. Hou J, Schindler U, Henzel WJ et al. An interleukin-4-induced transcription factor: IL-4 Stat. Science 1994;265:1701-1706.
50. Takeda K, Tanaka T, Shi W et al. Essential role of Stat6 in IL-4 signalling. Nature 1996;380:627-630.
51. Shimoda K, Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-633.
52. Kaplan MH, Schindler U, Smiley ST et al. Stat 6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 1996;4:313-319.
53. Takeda K, Kamanaka M, Tanaka T et al. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 1996;157:3220-3222.
54. Akimoto T, Numata F, Tamura M et al. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med 1998;187:1537-1542.
55. Kuperman D, Schofield B, Wills-Karp M et al. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 1998;187:939-948.
56. Wakao H, Gouilleuz F, Groner B. Mammary gland factor(MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 1994;13:2182-2191.
57. Liu X, Robinson GW, Gouilleux F et al. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 1995;92:8831-8835.
58. Boucheron C, Dumon S, Santos SCR et al. A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities. J Biol Chem 1998;273:33936-33941.
59. Liu X, Robinson GW, Wagner KU et al. Stat5a is mandatory for adult mammary gland development and lactogenesis. Gene Dev 1997;11:179-186.
60. Udy GB, Towers RP, Snell RG et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 1997;94:7239-7244.
61. Teglund S, McKay C, Schuetz E et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998;93:841-850.
62. Nakajima H, Liu X, Wynshaw-Boris A et al. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction, Immunity 1997;7:691.
63. Imada K, Bloom ET, Nakajima H et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med 1998;188:2067-2074.
64. Feldman GM, Rosenthal LA, Liu X et al. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 1997;90:1768-1776.
65. Kishimoto T, Akira S, Narazaki M et al. Interleukin-6 family of cytokines and gp130. Blood 1995;86:1243-1254.
66. Akira S. IL-6-regulated transcription factors. Int J Biochem Cell Biol 1997;29:1401-1418.
67. Akira S, Nishio Y, Inoue M et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994;77:63-71.
68. Zhong Z, Wen Z, Darnell JE. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-98.
69. Stahl N, Farruggella TJ, Boulton TG et al. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 1995;267:1349-1353.
70. Duncan SA, Zhong Z, Wen Z et al. STAT signaling is active during early mammalian development. Dev Dyn 1997;208:190-198.
71. Takeda K, Noguchi K, Shi W et al. Targeted disruption of the mouse Stat3 gene leads to embryonic lethality. Proc Natl Acad Sci USA 1997;94:3801-3804.
72. Minami M, Inoue M, Wei S et al. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci USA 1996;93:3963-3966.
73. Nakajima K, Yamanaka Y, Nakae K et al. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J 1996;15:3651-3658.
74. Boeuf H, Hauss H, De Graeve F et al. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J Cell Biol 1997;138:1207-1217.
75. Niwa H, Burdon T, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998;12:2048-2060.
76. Bonni A, Sun Y, Nadal-Vicens M et al. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 1998;276:477-483.
77. Boccaccio C, Ando M, Tamagnone L et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 1998;391:285-288.
78. Takeda K, Kaisho T, Yoshida N et al. STAT3 activation is responsible for IL-6-dependent T cell prolieration through preventing apoptosis: generation and characterization of T cell specific Stat3-deficient mice. J Immunol 1998;161:4652-4660.
79. Akaishi H, Takeda K, Kaisho T et al. Defective IL-2-mediated IL-2 receptor a chain expression in Stat3 deficient T lymphocytes. Int Immunol 1998;10:1747-1751.
80. Takeda K, Clausen BE, Kaisho T et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.