HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

Journal of Experimental Medicine

Volumn 186, Issue 1, 1997, Pages 139-146

  Amara, Ali ^a   Le Gall, Sylvie ^a   Schwartz, Olivier ^a   Salamero, Jean ^b   Montes, Monica ^c   Loetscher, Pius ^d   Baggiolini, Marco ^d   Virelizier, Jean Louis ^a   Arenzana Seisdedos, Fernando ^a  

^a INSTITUT PASTEUR   (France)

^b INSTITUT CURIE   (France)

^c Laboratoire d'Immunologie Cellulaire et Tissulaire CNRS URA 625   (France)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; RANTES; VIRUS RECEPTOR;

ANIMAL CELL; ARTICLE; BORDETELLA PERTUSSIS; CONTROLLED STUDY; ENDOSOME; EXPRESSION VECTOR; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOFLUORESCENCE; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION;

ANIMALS; CHEMOKINES, CXC; CHO CELLS; CRICETINAE; CYTOKINES; DOWN-REGULATION; FLOW CYTOMETRY; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; MEMBRANE PROTEINS; RECEPTORS, CXCR4; RECEPTORS, HIV; VIRUS REPLICATION;

EID: 0030745286     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.1.139     Document Type: Article

References (31)

1. Maddon, P.J., A.G. Dalgleish, J.S. McDougal, P.R. Clapham, R.A. Weiss, and R. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 47:333-348.
2. Ashorn, P.A., E.A. Berger, and B. Moss. 1990. Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells. J. Virol. 64: 2149-2156.
3. Dragic, T., P. Charneau, F. Clavel, and M. Alizon. 1992. Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryons. J. Virol. 66:4794-4802.
4. Broder, C.C., D.S. Dimitrov, R. Blumenthal, and E.A. Berger. 1993. The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s). Virology. 193: 483-491.
5. Feng, Y., C.C. Broder, P.E. Kennedy, and E.A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science (Wash. DC). 272:872-877.
6. Dragic, T., V. Litwin, G.P. Allaway, S.R. Martin, Y. Huang, K.A. Nagashima, C. Cayanan, P.J. Maddon, R.A. Koup, J.P. Moore, and W.A. Paxton. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature (Lond.). 381:667-673.
7. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Barkhart, P. Di Marzio, S. Marmon, R.E. Sutton, C.M. Hill et al. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature (Lond.). 381:661-666.
8. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P.D. Ponath, L. Wu, C.R. Mackay, G. LaRosa, W. Newman et al. 1996. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 85:1135-1148.
9. Doranz, B.J., J. Rucker, Y. Yi, R.J. Smyth, M. Samson, S.C. Peiper, M. Parmentier, R.G. Collman, and R.W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell. 85:1149-1158.
10. Alkhatib, G., C. Combadiere, C.C. Broder, Y. Feng, P.E. Kennedy, P.M. Murphy, and E.A. Berger. 1996. CC CKR5: a RANTES, MIP-1αlpha, MIP-1βeta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science (Wash. DC). 272: 1955-1958.
11. Cocchi, F., A.L. DeVico, A. Garzino-Demo, S.K. Arya, R.C. Gallo, and P. Lusso. 1995. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science (Wash. DC). 270: 1811-1815.
12. Bleul, C.C., M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T.A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for lestr/fusin and blocks hiv-1 entry. Nature (Lond.). 382:829-833.
13. Oberlin, E., A. Amara, F. Bachelerie, C. Bessia, J.L. Virelizier, F. Arenzana-Seisdedos, O. Schwartz, J.M. Heard, I. Clark-Lewis, D.F. Legler et al. 1996. The CXC chemokine SDF-1 is the ligand for lestr/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature (Lond.). 382:833-835.
14. Oravecz, T., M. Pall, and M.A. Norcross. 1996. Beta-chemokine inhibition of monocytotropic HIV-1 infection. Interference with a postbinding fusion step. J. Immunol. 157: 1329-1332.
15. D'souza, M.P., and V.A. Harden. 1996. Chemokines and HIV-1 second receptors - confluence of two fields generates optimism in AIDSresearch. Nat. Med. 2:1293-1300.
16. Arenzana-Seisdedos, F., J.L. Virelizier, D. Rousset, I. Clark-Lewis, P. Loetscher, B. Moser, and M. Baggiolini. 1996. HIV blocked by chemokine antagonist. Nature (Lond.). 383:400.
17. Samanta, A.K., J.J. Oppenheim, and K. Matsushima. 1990. Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils. J. Biol. Chem. 265:183-189.
18. Fanci, C., J. Gosling, C.L Tsou, S.R. Coughlin, and I.F. Charo. 1996. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. J. Immunol. 157:5606-5612.
19. Loetscher, M., T. Geiser, T. O'Reilly, R. Zwahlen, M. Baggiolini, and B. Moser. 1994. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J. Biol. Chem. 269:232-237.
20. Harrington, R.D., and A.P. Geballe. 1993. Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line. J. Virol. 67:5939-5947.
21. Pleskoff, O., N. Sol, B. Labrosse, and M. Alizon. 1997. Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR4 (Fusin). J. Virol. In press.
22. Clavel, F., and P. Charneau. 1994. Fusion from without directed by human immunodeficiency virus particles. J. Virol. 68:1179-1185.
23. Clark-Lewis, I., B. Moser, A. Walz, M. Baggiolini, G.J. Scott, and R. Aebersold. 1991. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. Biochemistry, 30:3128-3135.
24. Endres, M.J., P.R. Clapham, M. Marsh, M. Ahuja, J.D. Turner, A. McKnight, J.F. Thomas, B. Stoebenauhaggarty, S. Choe, P.J. Vance et al. 1996. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell. 87:745-756.
25. Donnadieu, E., G. Bismuth, and A. Trautmann. 1994. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium. Curr. Biol. 4: 584-595.
26. Prado, G.N., H. Suzuki, N. Wilkinson, B. Cousins, and J. Navarro. 1996. Role of the C terminus of the interleukin 8 receptor in signal transduction and internalization. J. Biol. Chem. 271:19186-19190.
27. Lapham, C.K., J. Ouyang, B. Chandrasekhar, N.Y. Nguyen, D.S. Dimitrov, and H. Golding. 1996. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science (Wash. DC). 274:602-605.
28. 2-adrenergic receptor. Nature (Lond.). 383:447-450.
29. Ferguson, S.S.G., W.E. Downey, A.M. Colapietro, L.S. Barak, L. Ménard, and M.G. Caron. 1996. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science (Wash. DC). 271:363-366.
30. Wu, L., N.P. Gerard, R. Wyatt, H. Choe, C. Parolin, N. Ruffing, A. Borsetti, A.A. Cardoso, E. Desjardin, W. Newman et al. 1996. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR5. Nature (Lond.). 384:179-183.
31. Trkola, A., T. Dragic, J. Arthos, J. Binley, W.C. Olson, G.P. Allaway, C. Cheng-Mayer, J. Robinson, P.J. Maddon, and J.P. Moore. 1996. CD4-dependent, antibody-sensitive interaction between HIV-1 and its co-receptor CCR5. Nature (Lond.). 384:184-187.