In vivo effects of Flt3/Flk2 ligand on mobilization of hematopoietic progenitors in primates and potent synergistic enhancement with granulocyte colony-stimulating factor

Blood

Volumn 90, Issue 2, 1997, Pages 620-629

  Papayannopoulou, Thalia ^a   Nakamoto, Betty ^b   Andrews, Robert G ^b   Lyman, Stewart D ^b   Lee, Minako Y ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; LIGAND;

ANIMAL CELL; ARTICLE; BURST FORMING UNIT; CELL PROLIFERATION; GENE EXPRESSION; GENE TRANSFER; HEMATOPOIETIC STEM CELL; MAST CELL; MONONUCLEAR CELL; NONHUMAN; OSTEOCLAST; PRIMATE; PRIORITY JOURNAL; STEM CELL;

EID: 0030755511     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.2.620.620_620_629     Document Type: Article

References (59)

1. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203, 1990
2. Rosnet O, Birnbaum D: hematopoietic receptors of class III of receptor-type tyrosine kinases. Crit Rev Oncogen 4:595, 1993
3. Lyman SD, James L, Vanden-Bos T, de Vries P, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR, Fletcher FA, Maraskovsky E, Farrah T, Foxworthe D, Williams DE, Beckman: Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells. Cell 75:1157, 1993
4. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J, Luh J, Duda G, Martina N, Peterson D, Menon S, Shanafelt A, Muench MO, Kelner GS, Namikawa R, Rennick D, Roncarolo M-G, Zlotnik A, Rosnet O, Dubreuil P, Birnbaum D, Lee F: Ligand for FLT3/ FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368:643, 1994
5. Lyman SD, James L, Johnson L, Brasel K, De Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ: Cloning of the human homolog of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells. Blood 83:2795, 1994
6. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459, 1994
7. Jacobsen SE, Okkenhaug C, Myklebust J, Veiby OP, Lyman SD: The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: Synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. J Exp Med 181:1357, 1995
8. Hudak S, Hunte B, Culpepper J, Menon S, Hannum C, Thompson-Snipes L, Rennick D: FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units. Blood 85:2747, 1995
9. Piacibello W, Fubini L, Sanavio F, Brizzi MF, Severine A, Garetto L, Stacchini A, Pegoraro L, Aglietta M: Effects of human FLT3 ligand on myeloid leukemia cell growth: Heterogeneity in response and synergy with other hematopoietic growth factors. Blood 86:4105, 1995
10. Muench MO, Roncarolo MG, Menon S, Xu Y, Kastelein R, Zurawski S, Hannum CH, Culpepper J, Lee F, Namikawa R: FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood 85:963, 1995
11. + hematopoietic progenitor cells. Blood 86:3413, 1995
12. Lyman SD: Biology of flt3 ligand and receptor. Int J Hematol 62:63, 1995.
13. + bone marrow progenitor cells in vitro. Blood 87:1317, 1996
14. Rasko JE, Metcalf D, Rossner MT, Begley CG, Nicola NA: The flt3/flk-2 ligand: Receptor distribution and action on murine haemopoietic cell survival and proliferation. Leukemia 9:2058, 1995
15. +++ human umbilical cord blood myeloid progenitors in serum-depleted culture medium. Ann Hematol 72:131, 1996
16. Rosnet O, Schiff C, Pébusque M-J, Marchetto S, Tonnelle C, Toiron Y, Birg F, Birnbaum D: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood 82:1110, 1993
17. Hjertson M, Sundström C, Lyman SD, Nilsson K, Nilsson G: Stem cell factor, but not flt3 ligand, induces differentiation and activation of human mast cells. Exp Hematol 24:748, 1996
18. Costa JJ, Demetri GD, Harrist TJ, Dvorak AM, Hayes DF, Merica EA, Menchaca DM, Gringeri AJ, Schwartz LB, Galli SJ: Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 183:2681, 1996
19. Mackarehtschian K, Hardin JD, Moore KA, Boast S, Goff SP, Lemischka IR: Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3:147, 1995
20. Maraskovsky E, Brasel K, Teepe M, Roux ER, Lyman SD, Shortman K, McKenna HJ: Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified. J Exp Med 184:1953, 1996
21. 4 integrin. Proc Natl Acad Sci USA 90:9374, 1993
22. Andrews RG, Bridell RA, Knitter GH, Opie T, Bronsden M, Myerson D, Appelbaum FR, McNiece IK: In vivo synergy between recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in baboons: Enhanced circulation of progenitor cells. Blood 84:800, 1994
23. Papayannopoulou T, Brice M, Farrer D, Kaushansky K: Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy. Exp Hematol 24:660 1996
24. Lee MY, Lottsfeldt JL, Fevold KL: Identification and characterization of osteclast progenitors by clonal analysis of hematopoietic cells. Blood 80:1710, 1992
25. Purton LE, Lee MY, Torok-Storb B: Normal human peripheral blood mononuclear cells mobilized with granulocyte colony-stimulating factor have increased osteoclastogenic potential compared to nonmobilized blood. Blood 87:1802, 1996
26. Andrews RG, Briddell RA. Knitter GH, Rowley SD, Appelbaum FR, McNiece IK: Rapid engraftment by peripheral blood progenitor cells mobilized by recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in nonhuman primates. Blood 85:15, 1995
27. Bodine DM, Seidel NE, Orlic D: Bone marrow collected 14 days after in vivo administration of granutocyte colony-stimulating factor and stem cell factor to mice has 10-fold more repopulating ability than untreated bone marrow. Blood 88:89, 1996
28. Drize N, Chertkov J, Samoilina N, Zander A: Effect of cytokine treatment (granulocyte colony-stimulating factor and stem cell factor) on hematopoiesis and the circulating pool of hematopoietic stem cells in mice. Exp Hematol 24:816, 1996
29. Goldman J: Peripheral blood stem cells for allografting. Blood 85:1413, 1995
30. Neben S, Marcus K, Mauch P: Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 81:1960, 1993
31. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR: Haematopoietic colony-stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76, 1990
32. 1 phase of cell cycle independently of the expression of myeloid antigens. Br J Haematol 93:737, 1996
33. Roberts AW, Metcalf D: Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines. Blood 86:1600, 1995
34. + cells in cord blood and in cytokine-mobilized blood. Br J Haematol 92:255, 1996
35. + hematopoietic progenitor cells: Comparison of cytokine-mobilized blood stem cells with normal bone marrow and peripheral blood. J Hematother 2:483, 1993
36. + hemopoietic progenitor cells. J Immunol 153:4673, 1994
37. + cells predict a rapid platelet recovery after peripheral blood stem cell transplantation. Blood 85:3313, 1995
38. Turner ML, McIlwaine K, Anthony RS, Parker AC: Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood. Stem Cells 13:311, 1995
39. + progenitor cells from bone marrow and peripheral blood during G-CSF-enhanced recovery. Exp Hematol 23:1535, 1995
40. + cells. Blood 84:2930, 1994
41. Prosper E, Stroncek D, Verfaillie CM: Cytokine induced proliferation of G-CSF mobilized PBPC is inhibited by adhesion to BM stroma through a β1 integrin dependent mechanism. Blood 88:532a, 1996 (suppl, abstr)
42. + cells requires prior activation by growth factors and is mediated by PECAM-1. Blood 88:475a, 1996 (suppl, abstr)
43. Fibbe WE, Hamilton MS, Laterveer LL, Kibbelaar RE, Falkenburg JHF, Visser JWM, Willemze R: Sustained engraftment of mice transplanted with IL-1 primed blood-derived stem cells. J Immunol 148:417, 1992
44. Laterveer L, Lindley IJ, Hamilton MS, Willemze R, Fibbe WE: Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability. Blood 85:2269, 1995
45. Bodine DM, Seidel NE, Zsebo KM, Orlic D: In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells. Blood 82:445, 1993
46. Grigg AP, Roberts AW, Raunow H, Houghton S, Layton JE, Boyd AW, McGrath KM, Maher D: Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood 86:4437, 1995
47. Tanaka R, Matsudaira T, Aizawa J, Ebihara Y, Muraoka K, Tsuji K, Ikebuchi K, Kodama K, Takaku F, Nakahata T: Characterization of peripheral blood progenitor cells (PBPC) mobilized by filgrastim (rHuG-CSF) in normal volunteers: Dose-effect relationship for filgrastim with the character of mobilized PBPC. Br J Haematol 92:795, 1996
48. Gheilmini M, Pettengell R, Coutinho LH, Testa N, Crowther D: The effect of the GM-CSF/IL-3 fusion protein PIXY321 on bone marrow and circulating haemopoietic cells of previously untreated patients with cancer. Br J Haematol 93:6, 1996
49. Ottmann OG, Ganser A, Seipelt G, Eder M, Schulz G, Hoelzer D: Effects of recombinant human interleukin-3 on human hematopoietic progenitor and precursor cells in vivo. Blood 76:1494, 1990
50. Tong J, Gordon MS, Srour EF, Cooper RJ, Orazi A, McNiece I, Hoffman R: In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cells. Blood 82:784, 1993
51. Uoshima N, Ozawa M, Kimura S, Tanaka K, Wada K, Kobayashi Y, Kondo M: Changes in c-kit expression and effects of SCF during differentiation of human erythroid progenitor cells. Br J Haematol 91:30, 1995
52. Morstyn G, Glaspy J, Shpall EJ, LeMaistre F, Briddell R, Menchaca D, Lill M, Jones RB, Tami J, Brown S, Yan XQ, McNiece IK: Clinical applications of filgrastim and stem cell factor in vivo and in vitro. J Hematother 3:353, 1994
53. Yan XQ, Briddell R, Hartley C, Stoney G, Samal B, McNiece I: Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem cell factor plus granulocyte colony-stimulating factor. Blood 84:795, 1994
54. Drize N, Chertkov J, Zander A: Hematopoietic progenitor cell mobilization into the peripheral blood of mice using a combination of recombinant rat stem cell factor (rrSCF) and recombinant human granulocyte colony-stimulating factor (rhG-CSF). Exp Hematol 23:1180, 1995
55. Huhn RD, Yurkow EJ, Tushinski R, Clarke L, Sturgill MG, Hoffman R, Sheay W, Cody R, Philipp C, Resta D, George M: Recombinant human interleukin-3 (rhIL-3) enhances the mobilization of peripheral blood progenitor cells by recombinant human granulocyte colony-stimulating factor (rhG-CSF) in normal volunteers. Exp Hematol 24:839, 1996
56. Weaver A, Ryder D, Crowther D, Dexter TM, Testa NG: Increased numbers of long-term culture-initiating cells in the apheresis product of patients randomized to receive increasing doses of stem cell factor administered in combination with chemotherapy and a standard dose of granulocyte colony-stimulating factor. Blood 88:3323, 1996
57. Sudo Y, Shimazaki C, Ashihara E, Kikuta T, Hirai H, Sumikuma T, Yamagata N, Goto H, Inaba T, Fujita N, Nakagawa M: Synergistic effect of FLT-3 ligand on the granulocyte colony-stimulating factor-induced mobilization of hematopoietic stem cells and progenitor cells into blood in mice. Blood 89:3186, 1997
58. Mauch P, Lamont C, Neben TY, Quinto C, Goldman SJ, Witsell A: Hematopoietic stem cells in the blood after stem cell factor and interleukin-11 administration: Evidence for different mechanisms of mobilization. Blood 86:4674, 1995
59. dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease. Blood 86:2842, 1995