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Volumn 7, Issue 1, 1997, Pages 75-79

Signal transduction from multiple Ras effectors

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PHOSPHATIDYLINOSITOL KINASE; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN; RAS PROTEIN;

EID: 0031043776     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(97)80112-8     Document Type: Article
Times cited : (280)

References (50)
  • 1
    • 0027285320 scopus 로고
    • Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target
    • Polakis P, McCormick F. Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target. J Biol Chem. 268:1993;9157-9160.
    • (1993) J Biol Chem , vol.268 , pp. 9157-9160
    • Polakis, P.1    McCormick, F.2
  • 2
    • 0029147166 scopus 로고
    • Different structural requirements within the switch II region of the Ras protein for interaction with specific downstream targets
    • Moodie SA, Paris M, Villafranca E, Kirshmeier P, Willumsen BM, Wolfman A. Different structural requirements within the switch II region of the Ras protein for interaction with specific downstream targets. Oncogene. 11:1995;447-454.
    • (1995) Oncogene , vol.11 , pp. 447-454
    • Moodie, S.A.1    Paris, M.2    Villafranca, E.3    Kirshmeier, P.4    Willumsen, B.M.5    Wolfman, A.6
  • 3
    • 0030009645 scopus 로고    scopus 로고
    • The differential effects of the gly-60 to ala mutation on the interaction H-Ras p21 with different downstream targets
    • Hwang M-CC, Sung Y-J, Hwang Y-W. The differential effects of the gly-60 to ala mutation on the interaction H-Ras p21 with different downstream targets. J Biol Chem. 271:1996;8196-8202.
    • (1996) J Biol Chem , vol.271 , pp. 8196-8202
    • Hwang, M.-C.1    Sung, Y.-J.2    Hwang, Y.-W.3
  • 4
    • 0027335964 scopus 로고
    • The effector interactions of p21ras
    • Marshall MS. The effector interactions of p21ras. Trends Biochem Sci. 18:1993;250-254.
    • (1993) Trends Biochem Sci , vol.18 , pp. 250-254
    • Marshall, M.S.1
  • 6
    • 0024336096 scopus 로고
    • The ras oncogene - an important regulatory element in lower eukaryotic organisms
    • Gibbs JB, Marshall MS. The ras oncogene - an important regulatory element in lower eukaryotic organisms. Microbiol Rev. 53:1989;171-185.
    • (1989) Microbiol Rev , vol.53 , pp. 171-185
    • Gibbs, J.B.1    Marshall, M.S.2
  • 7
    • 0026639821 scopus 로고
    • Triggering signaling cascades by receptor tyrosine kinases
    • Pazin MJ, Williams LT. Triggering signaling cascades by receptor tyrosine kinases. Trends Biochem Sci. 17:1992;374-378.
    • (1992) Trends Biochem Sci , vol.17 , pp. 374-378
    • Pazin, M.J.1    Williams, L.T.2
  • 8
    • 0028175091 scopus 로고
    • Raf meets ras: Completing the framework of a signal transduction pathway
    • Avruch J, Zhang X-f, Kyriakis JM. Raf meets ras: completing the framework of a signal transduction pathway. Trends Biochem Sci. 19:1994;279-283.
    • (1994) Trends Biochem Sci , vol.19 , pp. 279-283
    • Avruch, J.1    Zhang, X.-F.2    Kyriakis, J.M.3
  • 9
    • 0028825531 scopus 로고
    • Ras target proteins in eukaryotic cells
    • Marshall M. Ras target proteins in eukaryotic cells. FASEB J. 9:1995;1311-1318.
    • (1995) FASEB J , vol.9 , pp. 1311-1318
    • Marshall, M.1
  • 10
    • 0028807377 scopus 로고
    • Ras-related proteins in signal transduction and growth control
    • McCormick F. Ras-related proteins in signal transduction and growth control. Mol Reproduc Dev. 42:1995;500-506.
    • (1995) Mol Reproduc Dev , vol.42 , pp. 500-506
    • McCormick, F.1
  • 11
    • 0029912981 scopus 로고    scopus 로고
    • Co-purificaiton and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains
    • Song KS, Li S, Okamoto T, Quilliam LA, Sargiacomo M, Lisanti MP. Co-purificaiton and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. J Biol Chem. 271:1996;9690-9697.
    • (1996) J Biol Chem , vol.271 , pp. 9690-9697
    • Song, K.S.1    Li, S.2    Okamoto, T.3    Quilliam, L.A.4    Sargiacomo, M.5    Lisanti, M.P.6
  • 12
    • 15844431258 scopus 로고    scopus 로고
    • Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane
    • Mineo C, James GL, Smart EJ, Anderson RGW. Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane. J Biol Chem. 271:1996;11930-11935.
    • (1996) J Biol Chem , vol.271 , pp. 11930-11935
    • Mineo, C.1    James, G.L.2    Smart, E.J.3    Anderson, R.G.W.4
  • 13
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • Hill CS, Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell. 80:1995;199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 14
    • 0029058730 scopus 로고
    • Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins
    • of special interest. Ras could not be shown to activate c-Raf-1 in vitro, suggesting that Ras simply acted as a shuttle vehicle for moving Raf to the plasma membrane where it could be activated by other mechanisms. These authors, however, demonstrated that Ras could do far more by showing that GTP-Ras directly activated B-Raf in a pure cell-free system.
    • Yamamori B, Kuroda S, Shimizu K, Fukui K, Ohtsuka T, Takai Y. Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins. of special interest J Biol Chem. 270:1995;11723-11726 Ras could not be shown to activate c-Raf-1 in vitro, suggesting that Ras simply acted as a shuttle vehicle for moving Raf to the plasma membrane where it could be activated by other mechanisms. These authors, however, demonstrated that Ras could do far more by showing that GTP-Ras directly activated B-Raf in a pure cell-free system.
    • (1995) J Biol Chem , vol.270 , pp. 11723-11726
    • Yamamori, B.1    Kuroda, S.2    Shimizu, K.3    Fukui, K.4    Ohtsuka, T.5    Takai, Y.6
  • 15
    • 0027285638 scopus 로고
    • A branched signaling pathway for nerve growth factor is revealed by src-, ras-, and raf-mediated gene inductions
    • D'Arcangelo G, Halegoua S. A branched signaling pathway for nerve growth factor is revealed by src-, ras-, and raf-mediated gene inductions. Mol Cell Biol. 13:1993;3146-3155.
    • (1993) Mol Cell Biol , vol.13 , pp. 3146-3155
    • D'Arcangelo, G.1    Halegoua, S.2
  • 16
    • 0028133410 scopus 로고
    • Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy
    • Thorburn J, Frost JA, Thornburn A. Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy. Cell Biol. 126:1994;1565-1572.
    • (1994) Cell Biol , vol.126 , pp. 1565-1572
    • Thorburn, J.1    Frost, J.A.2    Thornburn, A.3
  • 17
    • 0022470480 scopus 로고
    • Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins
    • Bar-Sagi D, Feramisco JR. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science. 233:1986;1061-1068.
    • (1986) Science , vol.233 , pp. 1061-1068
    • Bar-Sagi, D.1    Feramisco, J.R.2
  • 18
    • 12044259376 scopus 로고
    • Membrane ruffling and signal transduction
    • Ridley AJ. Membrane ruffling and signal transduction. Bioessays. 16:1994;321-327.
    • (1994) Bioessays , vol.16 , pp. 321-327
    • Ridley, A.J.1
  • 19
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • of special interest. By expressing effector loop mutants of V12 Ras in cells, these authors demonstrated that Ras is a common upstream element of at least two distinct signaling pathways. One is the classic MAPK pathway and the other is pathway that regulates the actin cytoskeleton; both appear to be required for the optimal mitogenic signal from activated Ras. (This work is an application of an approach pioneered by Michael White and Mike Wigler.)
    • Joneson T, White MA, Wigler MH, Bar-Sagi D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. of special interest Science. 271:1996;810-812 By expressing effector loop mutants of V12 Ras in cells, these authors demonstrated that Ras is a common upstream element of at least two distinct signaling pathways. One is the classic MAPK pathway and the other is pathway that regulates the actin cytoskeleton; both appear to be required for the optimal mitogenic signal from activated Ras. (This work is an application of an approach pioneered by Michael White and Mike Wigler.).
    • (1996) Science , vol.271 , pp. 810-812
    • Joneson, T.1    White, M.A.2    Wigler, M.H.3    Bar-Sagi, D.4
  • 20
    • 0029968827 scopus 로고    scopus 로고
    • Rho family GTPases: The cytoskeleton and beyond
    • Symons M. Rho family GTPases: the cytoskeleton and beyond. Trends Biochem Sci. 21:1996;178-181.
    • (1996) Trends Biochem Sci , vol.21 , pp. 178-181
    • Symons, M.1
  • 21
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature. 366:1993;643-654.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 22
    • 0028074621 scopus 로고
    • Ras-dependent growth factor regulation of MEK kinase in PC12 cells
    • Lange-Carter CA, Johson GL. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science. 265:1994;1458-1461.
    • (1994) Science , vol.265 , pp. 1458-1461
    • Lange-Carter, C.A.1    Johson, G.L.2
  • 23
    • 0029077563 scopus 로고
    • Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1)
    • Russell M, Lange C, Johnson GL. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J Biol Chem. 270:1995;11757-11760.
    • (1995) J Biol Chem , vol.270 , pp. 11757-11760
    • Russell, M.1    Lange, C.2    Johnson, G.L.3
  • 27
    • 0027373678 scopus 로고
    • Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation
    • Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell P, Kuriyama K, et al. Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. Cancer Res. 53:1993;5624-5628.
    • (1993) Cancer Res , vol.53 , pp. 5624-5628
    • Prasad, R.1    Gu, Y.2    Alder, H.3    Nakamura, T.4    Canaani, O.5    Saito, H.6    Huebner, K.7    Gale, R.P.8    Nowell, P.9    Kuriyama, K.10
  • 28
    • 0028859266 scopus 로고
    • A human protein selected for interference with Ras functions interacts directly with Ras and competes with Raf
    • of special interest. This is a validation of earlier work from Colicelli using suppression of Ras function in yeast by expressed human cDNAs as a screen for proteins that bind to activated Ras at the effector site. The authors also point out the conserved nature of the Ras pathway among eukaryotes and how this can be exploited to identify novel effectors.
    • Han LM, Colicelli J. A human protein selected for interference with Ras functions interacts directly with Ras and competes with Raf. of special interest Mol Cell Biol. 15:1995;1318-1323 This is a validation of earlier work from Colicelli using suppression of Ras function in yeast by expressed human cDNAs as a screen for proteins that bind to activated Ras at the effector site. The authors also point out the conserved nature of the Ras pathway among eukaryotes and how this can be exploited to identify novel effectors.
    • (1995) Mol Cell Biol , vol.15 , pp. 1318-1323
    • Han, L.M.1    Colicelli, J.2
  • 29
    • 0029588204 scopus 로고
    • The ksr-1 gene encodes a novel protein kinase involved in ras-mediated signaling in C. elegans
    • Kornfeld K, Db H, Horvitz HR. The ksr-1 gene encodes a novel protein kinase involved in ras-mediated signaling in C. elegans. Cell. 83:1995;903-913.
    • (1995) Cell , vol.83 , pp. 903-913
    • Kornfeld, K.1    Db, H.2    Horvitz, H.R.3
  • 30
    • 0029559183 scopus 로고
    • The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in ras-mediated signal transduction
    • Sundaram M, Han M. The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in ras-mediated signal transduction. Cell. 83:1995;889-901.
    • (1995) Cell , vol.83 , pp. 889-901
    • Sundaram, M.1    Han, M.2
  • 32
    • 0027518574 scopus 로고
    • Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase
    • Albright CF, Giddings BW, Liu J, Vito M, Weinberg RA. Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. EMBO J. 12:1993;339-347.
    • (1993) EMBO J , vol.12 , pp. 339-347
    • Albright, C.F.1    Giddings, B.W.2    Liu, J.3    Vito, M.4    Weinberg, R.A.5
  • 33
    • 0028153277 scopus 로고
    • Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator
    • Holer F, Fields S, Schneider C, Martin GS. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Proc Natl Acad Sci USA. 91:1994;11089-11093.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11089-11093
    • Holer, F.1    Fields, S.2    Schneider, C.3    Martin, G.S.4
  • 35
    • 0028577298 scopus 로고
    • Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, and Rap
    • Spaargaren M, Bischoff JR. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, and Rap. Proc Natl Acad Sci USA. 91:1994;12609-12613.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12609-12613
    • Spaargaren, M.1    Bischoff, J.R.2
  • 36
    • 0030068806 scopus 로고    scopus 로고
    • Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase
    • Kikuchi A, Williams LT. Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase. J Biol Chem. 271:1996;588-594.
    • (1996) J Biol Chem , vol.271 , pp. 588-594
    • Kikuchi, A.1    Williams, L.T.2
  • 37
    • 0030022174 scopus 로고    scopus 로고
    • Ral-GTPases mediate a distinct downstream signaling pathway from ras that facilitates transformation
    • Urano T, Emkey R, Feig LA. Ral-GTPases mediate a distinct downstream signaling pathway from ras that facilitates transformation. EMBO J. 15:1996;810-816.
    • (1996) EMBO J , vol.15 , pp. 810-816
    • Urano, T.1    Emkey, R.2    Feig, L.A.3
  • 38
    • 0029950722 scopus 로고    scopus 로고
    • A role for the ral guanine nucleotide dissociation stimulator in mediating ras-induced transformation
    • White MA, Vale T, Camonis JH, Schaefer E, Wigler MH. A role for the ral guanine nucleotide dissociation stimulator in mediating ras-induced transformation. J Biol Chem. 271:1996;16439-16442.
    • (1996) J Biol Chem , vol.271 , pp. 16439-16442
    • White, M.A.1    Vale, T.2    Camonis, J.H.3    Schaefer, E.4    Wigler, M.H.5
  • 40
    • 0028486018 scopus 로고
    • Phosphatidylinositol 3-kinase
    • Kapeller R, Cantley LC. Phosphatidylinositol 3-kinase. Bioessays. 16:1994;565-576.
    • (1994) Bioessays , vol.16 , pp. 565-576
    • Kapeller, R.1    Cantley, L.C.2
  • 42
    • 0029990003 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
    • Rodriguez-Viciana P, Warne PH, Waterfield MD, Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15:1996;2242-2251.
    • (1996) EMBO J , vol.15 , pp. 2242-2251
    • Rodriguez-Viciana, P.1    Warne, P.H.2    Waterfield, M.D.3    Downward, J.4
  • 44
    • 0028948382 scopus 로고
    • Multiple ras functions can contribute to mammalian cell transformation
    • of outstanding interest. Brilliant demonstration of the power of effector mutants to dissect Ras signaling pathways. This approach has been invaluable for the Ras field and is now being applied equally successfully to dissection of multiple Rac signaling pathways.
    • White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH. Multiple ras functions can contribute to mammalian cell transformation. of outstanding interest Cell. 80:1995;533-541 Brilliant demonstration of the power of effector mutants to dissect Ras signaling pathways. This approach has been invaluable for the Ras field and is now being applied equally successfully to dissection of multiple Rac signaling pathways.
    • (1995) Cell , vol.80 , pp. 533-541
    • White, M.A.1    Nicolette, C.2    Minden, A.3    Polverino, A.4    Van Aelst, L.5    Karin, M.6    Wigler, M.H.7
  • 46
    • 0029286303 scopus 로고
    • Control of signal transduction and morphogenesis by ras
    • Hughes DA. Control of signal transduction and morphogenesis by ras. Semin Cell Biol. 6:1995;89-94.
    • (1995) Semin Cell Biol , vol.6 , pp. 89-94
    • Hughes, D.A.1
  • 48
    • 0028917954 scopus 로고
    • Regulation of Ras-mediated signaling: More than one way to skin a cat
    • Boudewijn M, Burgering T, Bos J. Regulation of Ras-mediated signaling: more than one way to skin a cat. Trends Biochem Sci. 20:1995;18-23.
    • (1995) Trends Biochem Sci , vol.20 , pp. 18-23
    • Boudewijn, M.1    Burgering, T.2    Bos, J.3
  • 49
    • 0029847051 scopus 로고    scopus 로고
    • Modulation of ξ-protein kinase-C by cyclic-AMP in PC12 cells occurs through phosphorylation by protein kinase-A
    • Wooten MW, Seibenhener ML, Matthews LH, Zhou GS, Coleman ES. Modulation of ξ-protein kinase-C by cyclic-AMP in PC12 cells occurs through phosphorylation by protein kinase-A. J Neurochem. 67:1996;1023-1031.
    • (1996) J Neurochem , vol.67 , pp. 1023-1031
    • Wooten, M.W.1    Seibenhener, M.L.2    Matthews, L.H.3    Zhou, G.S.4    Coleman, E.S.5
  • 50
    • 0027170176 scopus 로고
    • RapV12 antagonizes ras-dependent activation of ERK-1 and ERK-2 by LPA and EGF in Rat-1 fibroblasts
    • Cook SJ, Rubinfeld B, Albert I, McCormick F. RapV12 antagonizes ras-dependent activation of ERK-1 and ERK-2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12:1993;3475-3485.
    • (1993) EMBO J , vol.12 , pp. 3475-3485
    • Cook, S.J.1    Rubinfeld, B.2    Albert, I.3    McCormick, F.4


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