Genetic determinants of p53-induced apoptosis and growth arrest

Genes and Development

Volumn 10, Issue 15, 1996, Pages 1945-1952

  Polyak, Kornelia ^a,b   Waldman, Todd ^b   He, Tong Chuan ^a,b   Kinzler, Kenneth W ^a,b   Vogelstein, Bert ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

apoptosis; growth arrest; p21(WAF1 Cip1); p53

Indexed keywords

PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL FUSION; CELL PROLIFERATION; COLORECTAL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0029811984     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.15.1945     Document Type: Article

References (36)

1. Baker, S.J., A.C. Preisinger, J.M. Jessup, C. Paraskeva, S. Markowitz, J.K. Willson, S.R. Hamilton, and B. Vogelstein. 1990. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res. 50: 7717-7722.
2. Brugarolas, J., C. Chandrasekaran, J.I. Gordon, D. Beach, T. Jacks, and G.J. Hannon. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552-557.
3. Caelles, C., A. Helmberg, and M. Karin. 1994. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370: 220-223.
4. Canman, C.E., T.M. Gilmer, S.B. Coutts, and M.B. Kastan. 1995. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes & Dev. 9: 600-611.
5. Casey, G., M. Lo-Hsueh, M.E. Lopez, B. Vogelstein, and E.J. Stanbridge. 1991. Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene. Oncogene 6: 1791-1797.
6. Clarke, A.R., C.A. Purdie, D.J. Harrison, R.G. Morris, C.C. Bird, M.L. Hooper, and A.M. Wyllie. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849-852.
7. Clarke, A.R., S. Gledhill, M.L. Hooper, C.C. Bird, and A.H. Wyllie. 1994. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogens 9: 1767-1773.
8. Deng, C., P. Zhang, J.W. Harper, S.J. Elledge, and P. Leder. 1995. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
9. El-Deiry, W.S., T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
10. El-Deiry, W.S., J.W. Harper, P.M. O'Connor, V.E. Velculescu, C.E. Canman, J. Jackman, J.A. Pietenpol, M. Burrell, D.E. Hill, Y. Wang, K.G. Wilman, W.E. Mercer, M.B. Kastan, K.W. Kohn, S.J. Elledge, K.W. Kinzler, and B. Vogelstein. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54: 1169-1174.
11. Gomez-Manzano, C., J. Fueyo, A.P. Kyritsis, P.A. Steck, J.A. Roth, T.J. McDonnel, K.D. Steck, V.A. Levin, and W.K.A. Yung. 1996. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res. 56: 694-699.
12. Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816.
13. Harris, M.P., S. Sutjipto, K.N. Wills, W. Hancock, D.C. Cornell, D.E. Johnson, R.J. Gregory, H.M. Shepard, and D.C. Maneval. 1996. Adenovirus-mediated gene transfer inhibits growth of human tumor cells expressing mutant p53 protein. Cancer Gene Ther. 3: 121-130.
14. Haupt, Y., S. Rowan, E. Shaulian, K.H. Vousden, and M. Oren. 1995. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes & Dev. 9: 2170-2183.
15. Hollstein, M., D. Sidransky, B. Vogelstein, and C.C. Harris. 1991. p53 mutations in human cancers. Science 253: 49-53.
16. Kumar, S. 1995. ICE-like proteases in apoptosis. Trends Biochem. Sci. 20: 198-202.
17. Lazebnik, Y.A., S.H. Kaufmann, S. Desnoyers, G.G. Poirier, and W.C. Earnshaw. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347.
18. Lin, Y. and S. Benchimol. 1995. Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest. Mol. Cell. Biol. 15: 6045-6054.
19. Liu, T.J., A.K. el-Naggar, T.J. McDonnell, K.D. Steck, M. Wang, D.L. Taylor, and G.L. dayman. 1995. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res. 55: 3117-3122.
20. Liu, T.J., W.W. Zhang, D.L. Taylor, J.A. Roth, H. Goepfert, and G.L. Clayman. 1994. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 54: 3662-3667.
21. Lowe, S.W., E.M. Schmitt, S.W. Smith, B.A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849.
22. Merritt, A.J., C.S. Potten, C.J. Kemp, J.A. Hickman, A. Balmain, D.P. Lane, and P.A. Hall. 1994. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54: 614-617.
23. Miyashita, T. and J.C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
24. Oltvai, Z.N. and S.J. Korsmeyer. 1994. Checkpoints of dueling dimers foil death wishes. Cell 79: 189-192.
25. Owen-Schaub, L.B., W. Zhang, J.C. Cusack, L.S. Angelo, S.M. Santee, T. Fujiwara, J.A. Roth, A.B. Deisseroth, W.W. Zhang, E. Kruzel, and R. Radinsky. 1995. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. Cell. Biol. 15: 3032-3040.
26. Poluha, W., D.K. Poluha, B. Chang, N.E. Crosbie, C.M. Schonhoff, D.L. Kilpatrick, and A.H. Ross. 1996. The cyclin-dependent kinase inhibitor p21WAF1 is required for survival of differentiating neuroblastoma cells. Mol. Cell. Biol. 16: 1335-1341.
27. Sabbatini, P., J. Lin, A.J. Levine, and E. White. 1995. Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes & Dev. 9: 2184-2192.
28. Shaw, P., R. Bovey, S. Tardy, R. Sahli, B. Sordat, and J. Costa. 1992. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. 89: 4495-4499.
29. Symonds, H., L. Krall, L. Remington, M. Saenz-Robles, S. Lowe, T. Jacks, and T. Van Dyke. 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78: 703-711.
30. Takahashi, A. and W.C. Earnshaw. 1996. ICE-related proteases in apoptosis. Curr. Opin. Genet. Dev. 6: 50-55.
31. Tewari, M., L.T. Quan, K. O'Rouke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, and V.M. Dixit. 1995. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly[ADP-ribose] polymerase. Cell 81: 801-809.
32. Waldman, T., K.W. Kinzler, and B. Vogelstein. 1995. P21 is necessary for the P53-mediated G[1] arrest in human cancer cells. Cancer Res. 55: 5187-5190.
33. Waldman, T., C. Lengauer, K.W. Kinzler, and B. Vogelstein. 1996. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381: 713-716.
34. Xiong, Y., G.J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704.
35. Yang, C., C. Cirielli, M.C. Capogrossi, and A. Passaniti. 1995. Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of prostatic tumor cells. Cancer Res. 55: 4210-4213.
36. Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi, and M. Oren. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347.