Phosphatidylinositol-3′ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase

Journal of Biological Chemistry

Volumn 271, Issue 33, 1996, Pages 20075-20081

  Beslu, Nathalie ^a   LaRose, Jose ^b   Casteran, Nathalie ^a   Birnbaum, Daniel ^a   Lecocq, Eric ^a   Dubreuil, Patrice ^a   Rottapel, Robert ^b,c  

^a INSERM   (France)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; INTERNALIZATION; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BINDING SITES; CELL LINE; CYTOPLASM; ENZYME ACTIVATION; FMS-LIKE TYROSINE KINASE 3; MITOSIS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PHOSPHOTYROSINE; POINT MUTATION; PROTEIN BINDING; PROTEINS; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MURINAE; RODENTIA;

EID: 0029810842     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.33.20075     Document Type: Article

References (107)

1. Till, J. E., and McCulloch, E. A. (1980) Biochim. Biophys. Acta 605, 431-459
2. McKearn, J. P., McCubrey, J., and Fagg, B. (1985) Proc. Natl. Acad. Sei. U. S. A. 82, 7414-7418
3. Jordan, C. T., McKearn, J. P., and Lcmischka, I. R. (1990) Cell 61, 953-962
4. Fleming, W. H., Alpem, E. J., Uchika, N., Ikuta, K., Spangrude, G. J., and Weissman, I. L. (1993) J. Cell Biol. 122, 897-902
5. Papayannopoulou, T., Brice, M., Broudy, V. C., and Zsebo, K M. (1991) Blood 78, 1403-1412
6. Okada, S., Nakauchi, H., Nagayoshi, K, Nishikawa, S.-I., Miura, Y., and Suda, T. (1992) Blood 80, 3044-3050
7. Okada, S., Nakauchi, H., Nagayoshi, K., Nishikawa, S., Nishikawa, S., Miura, Y., and Suda, T. (1991) Blood 78, 1706-1712
8. Ogawa, M., Nishikawa, S., Yoshinaga, K., Hayashi, S.-I., Kunisada, T., Nakao, J., Kina, T., Sudo, T., Kodama, H., and Nishikawa, S.-I. (1993) Development (Comb.) 117, 1089-1098
9. Ogawa, M., Matsuzaki, Y., Nishikawa, S., Hayashi, S., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H., and Nishikawa, S. (1991) J. Eip. Aled. 174, 63-71
10. Ikuta, K, and Weissman, I. L. (1992) Proc. Natl. Acad. Sei. U. S. A. 89, 1502-1506
11. Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., and Lemischka, I. R. (1991) Cell 65, 1143-1152
12. Zeigler, F. C., Bcnnett, B. D., Jordan, C. T., Spencer, S. D., Baumhueter, S., Carroll, K. J., Hooley, J., Bauer, K., and Matthews, W. (1994) Blood 8, 2422-2430
13. McCulloch, E. A., Siminovitch, L., and Till, J. E. (1964) 144, 844-846
14. Bernstein, S., and Russell, E. (1959) Proc. Eip. Biol. Med. 101, 769-773
15. Russel, E. S. (1979) Adv. Genet. 20, 357-458
16. Mackarehtschian, K, Hardin, J. D., Moore, K. A., Boast, S., Golf, S. P., and Lemischka, I. R. (1995) Immunity 3, 147-161
17. Muench, M. O., Roncarolo, M. G., Menon, S., Xu, Y., Kastelein, R., Zurawski, S., Hannum, C. H., Culpepper, J., Lee, F., and Namikawa, R. (1995) Blood 85, 963-972
18. Lyman, S., James, L., Bos, T. V., de Vries, P., Brassel, K., Gliniak, B., Hollingworth, L. T., Picha, K., McKenna, H., Spielt, R., Fletcher, F., Marashovsky, E., Farrah, T., Foxworthe, D., Williams, D., and Beckmann, M. (1993) Cell 75, 1157-1167
19. Jacobsen, S. E. W., Okkenhaug, C., Myklebust, J., Veiby, O. P., and Lyman, S. D. (1995) J. Exp. Med. 181, 1357-1363
20. Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Zurawski, S., Bazan, J. F., Kastelein, R., Hudak, S., Wagner, J., Mattson, J., Luh, J., Duda, G., Martina, N., Peterson, D., Menon, S., Shanafelt, A., Muench, M., Keiner, G., Namikawa, R., Rennick, D., Roncarolo, M.-G., Zlotnik, A., Rosnet, O., Dubreuil, P., Birnbaum, D., and Lee, F. (1994) Nature 368, 643-648
21. Blume-Jensen, P., Wernstedt, C., Heldin, C.-H., and Rönnstrand, L. (1995) J. Biol. Chem. 270, 14192-14200
22. Arvidsson, A.-K, Rupp, E., Nånberg, E., Downward, J., Rönnstrand, L., Wennström, S., Schlessinger, J., Heldin, C.-H., and Claesson-Welsh, L. (1994) Mol. Cell. Biol. 14, 6715-6726
23. Kazlauskas, A., and Cooper, J. A. (1989) Cell 58, 1121-1133
24. Escobedo, J. A., Kaplan, D. R., Kavanaugh, W. M., Turck, C. W., and Williams, L. T. (1991) Mol. Cell. Biol. 11, 1125-1132
25. Nishimura, R., Li, W., Kashishian, A., Mondino, A., Zhou, M., Cooper, J., and Schlessinger, J. (1993) Mol. Cell. Biol. 13, 6889-6896
26. Kazlauskas, A., Kashishian, A., Cooper, J. A., and Valius, M. (1992) Mol. Cell. Biol. 12, 2534-2544
27. Fantl, W. J., Escobedo, J. A., Martin, G. A., Turck, C. W., del Rosario, M., McCormick, F., and Williams, L. T. (1992) Cell 69, 413-423
28. Yokote, K, Mori, S., Hansen, K, McGlade, J., Pawson, T., Heldin, C.-H., and Claesson-Welsh, L. (1994) J. Biol. Chem. 269, 15337-15343
29. Hawkins, P. T., Eguinoa, A., Rong-Guo, Q., Stokoe, D., Cooke, F. T., Walters, R., Wennstrom, S., Claesson-Welsh, L., and Symons, M. (1995) Curr. Biol. 5, 393-403
30. Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Science 268, 100-102
31. Rodriquez-Viciana, P., Warne, P., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M., Waterfield, M., and Downward, J. (1994) Nature 370, 527-532
32. Sjölander, A., Yamamoto, K., Huber, B. E., and Lapetina, E. G. (1991) Proc. Natl. Acad. Sei. U. S.A. 88, 7908-7912
33. Zheng, Y., Bagrodia, S., and Cerione, R. A. (1994) J. Biol. Chem. 269, 18727-18730
34. Franke, T. F., Yang, S.-I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) Cell 81, 727-736
35. Burgering, B. M. T., and Coffer, P. J. (1995) Nature 376, 599-602
36. Chung, J., Grammer, T. C., Lemon, K. P., Kazlauskas, A., and Blenis, J. (1994) Nature 370, 71-75
37. Valius, M., and Kazlauskas, A. (1993) Cell 73, 321-334
38. Serve, H., Yee, N. S., Stella, G., Sepp-Lorenzino, L., Tan, J. C., and Besmer, P. (1995) EMBO J. 14, 473-483
39. Karasuyama, H., and Melchers, F. (1988) Eur. J. Immunol. 18, 97-104
40. Maroc, N., Rottapcl, R., Rosnet, O., Marchetto, S., Lavezzi, C., Mannoni, P., Birnbaum, D., and Dubreuil, P. (1993) Oncogene B, 909-918
41. McGlade, C. J., Ellis, C., Reedijk, M., Anderson, D., Mbamalu, G., Reith, A. D., Panayotou, G., End, P., Bernstein, A., Kazlauskas, A., Waterfield, M. D., and Pawson, T. (1992) Mol. Cell. Biol. 12, 991-997
42. Markowitz, D., Goff, S., and Bank, A. (1988) J. Virol. 62, 1120-1124
43. Dubreuil, P., Forrester, L., Rottapel, R., Reedijk, M., Fujita, J., and Bernstein, A. (1991) Proc. Natl. Acad. Sei. U. S. A. 88, 2341-2345
44. Fukui, Y., and Hanafusa, H. (1989) Mol. Cell. Biol. 9, 1651-1658
45. Whitman, M., Kaplan, D. R., Roberts, T. M., and Cantley, L. (1987) Biochemistry 247, 165-174
46. Dosil, M., Wang, S., and Lemischka, I. R. (1993) Mol. Cell. Biol. 13, 6572-6585
47. Rottapel, R., Turck, C. W., Casteran, N., Liu, X., Birnbaum, D., Pawson, T., and Dubreuil, P. (1994) Oncogene 9, 1755-1765
48. Yu, J.-C., Heidaran, M. A., Pierce, J. H., Gutkind, J. S., Lombardi, D., Ruggiero, M., and Aaronson, S. A. (1991) Mol. Cell. Biol. 11, 3780-3785
49. Reedijk, M., Liu, X., van der Geer, P., Letwin, K, Waterfield, M. D., Hunter, T., and Pawson, T. (1992) EMBO J. 11, 1365-1372
50. Serve, H., Hsu, Y.-C., and Besmer, P. (1994) J. Biol. Chem. 269, 6026-6030
51. Rottapel, R., Reedijk, M., Williams, D. E., Lyman, S. D., Anderson, D. M., Pawson, T., and Bernstein, A. (1991) Mol. Cell. Biol. 11, 3043-3051
52. Lev, S., Givol, D., and Yarden, Y. (1992) Proc. Natl. Acad. Sei. U. S. A. 89, 678-682
53. Ponzetto, C., Bardelli, A., Maina, F., Longati, P., Panayotou, G., Dhand, R., Waterfield, M. D., and Comoglio, P. M. (1993) Mol. Cell. Biol. 13, 4600-4608
54. He, T. C., Zhuang, H., Jiang, N., Waterfield, M. D., and Wojchowski, D. M. (1993) Blood 82, 3530-3538
55. Mori, S., Ronnstrand, L., Yokote, K, Engstrom, A., Courtneidge, S. A., Claesson-Welsh, L., and Heldin, C.-H. (1993) EMBO J. 12, 2257-2264
56. Myles, G. M., Brandt, C. S., Carlberg, K., and Rohrschneider, L. R. (1994) Mol. Cell. Biol. 14, 4843-4854
57. Fixman, E. D., Naujokas, M. A., Rodrigues, G. A., Moran, M. F., and Park, M. (1995) Oncogene 10, 237-249
58. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, L, Grignani, F., Pawson, T., and Pelicci, P. G. (1992) Cell 70, 93-104
59. Rozakis-Adcock, M., McGlade, J., Mbamalu, G., Pelicci, G., Daly, R., Li, W., Batzer, A., Thomas, S., Brugge, J., Pelicci, P. G., Schlcssinger, J., and Pawson, T. (1992) Nature 360, 689-692
60. Liu, L., Damen, J. E., Cutler, R. L., and Krystal, G. (1994) Mol. Cell. Biol. 14, 6926-6935
61. Lioubin, M. N., Myles, G. M., Carlberg, K., Bowtell, D., and Rohrschneider, L. R. (1994) Mol. Cell. Biol. 14, 5682-5691
62. Blaikie, P., Immanuel, D., Wu, J., Li, N., Yajnik, V., and Margolis, B. (1994) J. Biol. Chem. 269, 32031-32034
63. Kavanaugh, W. M., and Williams, L. T. (1994) Science 266, 1862-1865
64. Segatto, O., Pelicci, G., Giuli, S., Digiesi, G., Di Fiore, P. P., McGlade, J., Pawson, T., and Pelicci, P. G. (1993) Oncogene 8, 2105-2112
65. Moran, M. F., Koch, C. A., Anderson, D., Ellis, C., England, L., Martin, G. S., and Pawson, T. (1990) Proc. Natl. Acad. Sei. U. S. A. 87, 8622-8626
66. Ellis, C., Moran, M., McCormick, F., and Pawson, T. (1990) 343, 377-381
67. Richard, S., Yu, D., Blumer, K. J., Hausladen, D., Olszowy, M. W., Connelly, P. A., and Shaw, A. S. (1995) Mol. Cell. Biol. 15, 186-197
68. Weng, Z., Thomas, S. M., Rickles, R. J., Taylor, J. A., Brauer, A. W., Seidel-Dugan, C., Michael, W. M., Dreyfuss, G., and Brugge, J. S. (1994) Mol. Cell. Biol. 14, 4509-4521
69. Maa, M. C., Leu, T. H., Trandel, B. J., Chang, J. H., and Parsons, S. J. (1994) Mol. Cell. Biol. 14, 5466-5473
70. Wang, L. L., Richard, S., and Shaw, A. S. (1995) J. Biol. Chem. 270, 2010-2013
71. Fumagalli, S.,Totty,N. F., Hsuan, J. J., and Courtneidge, S. A. (1994) Nature 368, 871-874
72. Taylor, S. J., and Shalloway, D. (1994) Nature 368, 867-871
73. Brott, B. K, Decker, S., Shafer, J., Gibbs, J. B., and Jove, R. (1991)Proc. Natl. Acad. Sci. U. S. A. 88, 755-759
74. Kazlauskas, A., Ellis, C., Pawson, T., and Cooper, J. (1990) Science 247, 1578-1581
75. Kaplan, D. R., Morrison, D., Wong, G., McCormick, F., and Williams, L. (1990) Cell 61, 125-133
76. Cantley, L. C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. (1991) Cell 64, 281-302
77. Weng, W.-K., Jarvis, L., and LeBien, T. W. (1994) J. Biol. Chem. 269, 32514-32521
78. Tuveson, D. A., Carter, R. H., Soltoff, S. P., and Fearon, D. T. (1993) Science 260, 986-989
79. Pages, F., Ragueneau, M., Rottapel, R., Truneh, A., Nunes, J., Imbert, J., and Olive, D. (1994) Nature 369, 327-329
80. Taichman, R., Merida, L, Torigoe, T., Gaulton, G. N., and Rced, J. C. (1993) J. Biol. Chem. 268, 20031-20036
81. Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C., and Hawkins, P. T. (1994) Cell 77, 83-93
82. Stephens, L., Eguinoa, A., Corey, S., Jackson, T., and Hawkins, P. T. (1993) EMBO J. 12, 2265-2273
83. Stephens, L., Jackson, T., and Hawkins, P. T. (1993) J. Biol. Chem. 268, 17162-17172
84. Serunian, L. A., Auger, K R., Roberts, T. M., and Cantley, L. C. (1990) J. Virol. 64, 4718-4725
85. Ullrich, A., and Schlessinger, J. (1990) Cell 61, 203-212
86. Joly, M., Kazlauskas, A-, and Corvera, S. (1995) J. Biol. Chem. 270, 13225-13230
87. Joly, M., Kazlauskas, A., Fay, F., and Corvera, S. (1994) Science 263, 684-687
88. Kapeller, R., Chakrabarti, R., Cantley, L., Fay, F., and Corvera, S. (1993) Mol. Cell. Biol. 13, 6052-6063
89. Yee, N. S., Hsiau, C.-W. M., Serve, H., Vosseller, K, and Besmer, P. (1994) J. Biol. Chem. 269, 31991-31998
90. Reedijk, M., Liu, X., van der Geer, P., Letwin, K, Wateriield, M. D., Hunter, T., and Pawson, T. (1992) EMBO J. 11, 1365-1372
91. Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R. J., Neel, B. G., Birge, R. B., Fajardo, J. E., Chou, M. M., Hanafusa, H., Schaflhausen, B., and Cantley, L. C. (1993) Cell 72, 767-778
92. Kavanaugh, W. M., Klippe), A., Escobedo, J. A., and Williams, L. T. (1992) Mol. Cell. Biol. 12, 3415-3424
93. Klippel, A., Escobedo, J. A. Fantl, W. J., and Williams, L. T. (1992) Mol. Cell. Biol. 12, 1451-1459
94. Kundra, V., Escobedo, J. A-, Kazlauskas, A., Kim, H. K, Rhee, S. G., Williams, L. T., and Zetter, B. R. (1994) Nature 367, 474-476
95. Yao, R., and Cooper, G. M. (1995) Science 267, 2003-2006
96. Stowers, L., Yelon, D., Berg, L. J., and Chant, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5027-5031
97. Liu, X., Marengere, L. M., Koch, C. A., and Pawson, T. (1993) Mol. Cell. Biol. 13, 5225-5232
98. Prasad, K. V. S., Janssen, 0., Kapeller, R., Raab, M., Cantley, L. C., and Rudd, C. E. (1993) Proc. Natl. Acad. Sei. U. S. A. 90, 7366-7370
99. van der Geer, P., and Hunter, T. (1993) EMBO J. 12, 5161-5172
100. Li, N., Schlessinger, J., and Margolis, B. (1994) Oncogene 9, 3457-3465
101. Gotoh, N., Tojo, A., Muroya, K., Hashimoto, Y., Hattori, S., Nakamura, S., Takenawa, T., Yazaki, Y., and Shibuya, M. (1994) Proc. Natl. Acad. Sei. U. S. A. 91, 167-171
102. Herman, P. K., Stack, J. H., DeModena, J. A., and Emr, S. D. (1991) Cell 64, 425-437
103. Gout, L, Dhand, R., Hiles, I. D., Fry, M. J., Panayotou, G., Das, P., Truong, O., Totty, N. F., Hsuan, J., Booker, G. W., Campbell, I. D., and Waterfield, M. D. (1993) CeH 75, 25-36
104. Nobes, C. D., and Hall, A. (1995) Cell 81, 53-62
105. Ray, B., Paige, C., Furlonger, C., Lyman, S., and Rottapel, R. (1996) Eur. J. Immunol. 26, 1504-1510
106. Liobin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, R., Rohrschneider, L. R. (1996) Genes & Dev. 10,1084-1095
107. Damen, J. E., Liu, L., Rosten, P., Humphries, R. K., Jefferson, A. B., Majerus, P. W., and Krystal, G. (1996) Proc. Natl. Acad. Sei. U. S. A. 93,1689-1693