Recent advances in chemokines and chemokine receptors

Critical Reviews in Immunology

Volumn 19, Issue 1, 1999, Pages 1-47

  Zlotnik, Albert ^b   Morales, Janine ^b   Hedrick, Joseph A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

Cell trafficking; Chemokine; Dendritic cells; G protein coupled receptor; Hematopoiesis; Inflammatory mediators; Leukocytes; Th1 Th2

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8;

ARTICLE; CELL MIGRATION; CELL TRANSPORT; DENDRITIC CELL; HELPER CELL; HEMATOPOIESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; LEUKOCYTE; LYMPHOID CELL; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHEMOKINES; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CHEMOKINE; SEQUENCE HOMOLOGY; T-LYMPHOCYTES, HELPER-INDUCER; VIRAL PHYSIOLOGY;

EID: 0032891619     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (198)

1. Rollins, B., Chemokines, Blood, 90(3), 909-928, 1997.
2. Pencev, D. and Grotendorst, G. R., Human peripheral blood monocytes secrete a unique form of PDGF, Oncogene Res., 3(4), 333-342, 1988.
3. Iida, N., Haisa, M., Igarashi, A., Pencev, D., and Grotendorst, G. R., Leukocyte-derived growth factor links the PDGF and CXC chemokine families of peptides, FASEB J., 10(11), 1336-1345, 1996.
4. Wenger, R. H., Wicki, A. N., Walz, A., Kieffer, N., and Clemetson, K. J., Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library, Blood, 73(6), 1498-1503, 1989.
5. Walz, A., Dewald, B., von Tscharner, V., and Baggiolini, M., Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils, J. Exp. Med., 170(5), 1745-1750, 1989.
6. Proost, P., De Wolf-Peeters, C., Conings, R., Opdenakker, G., Billiau, A., and Van Damme, J., Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8, J. Immunol., 150(3), 1000-1010, 1993.
7. Rovai, L. E., Herschman, H. R., and Smith, J. B., Cloning and characterization of the human granulocyte chemotactic protein-2 gene, J. Immunol., 158(11), 5257-5266, 1997.
8. Froyen, G., Proost, P., Ronsse, I., Mitera, T., Haelens, A., Wuyts, A., Opdenakker, G., Van Damme, J., and Billiau, A., Cloning, bacterial expression, and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs, Eur. J. Biochem., 243(3), 762-769, 1997.
9. Van Damme, J., Wuyts, A., Froyen, G., Van Coillie, E., Struyf, S., Billiau, A., Proost, P., Wang, J. M., and Opdenakker, G., Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage, J. Leukoc. Biol., 62(5), 563-569, 1997.
10. Smith, J. B. and Herschman, H. R., Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine, J. Biol. Chem., 270(28), 16756-16765, 1995.
11. Wuyts, A., Haelens, A., Proost, P., Lenaerts, J. P., Conings, R., Opdenakker, G., and Van Damme, J., Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2, J. Immunol., 157(4), 1736-1743, 1996.
12. Smith, J. B., Rovai, L. E., and Herschman, H. R., Sequence similarities of a subgroup of CXC chemokines related to murine LIX: implications for the interpretation of evolutionary relationships among chemokines, J. Leukoc. Biol., 62(5), 598-603, 1997.
13. Farber, J. M., A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines, Proc. Natl. Acad. Sci. U.S.A., 87(14), 5238-5242, 1990.
14. Liao, F., Rabin, R. L., Yanneili, J. R., Leonidas, G. K., Vanguri, P., and Farber, J. M., Human Mig chemokine: biochemical and functional characterization, J. Exp. Med., 182, 1301-1314, 1995.
15. Farber, J. M., HuMig: a new human member of the chemokine family of cytokines, Biochem. Biophys. Res. Commun., 192(1), 223-230, 1993.
16. Amichay, D., Gazzinelli, R., Karupiah, G., Moench, T., Sher, A., and Farber, J., Genes for chemokines MuMig and CRG-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo, J. Immunol., 157(10), 4511-4520, 1996.
17. Lee, H. H. and Farber, J. M., Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster", Cytogenet. Cell Genet., 74(4), 255-258, 1996.
18. Taub, D. D., Lloyd, A. R., Conlon, K., Wang, J. M., Ortaldo, J. R., Harada, A., Matsushima, K., Kelvin, D. J., and Oppenheim, J. J., Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells, J. Exp. Med., 177(6), 1809-1814, 1993.
19. Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M., and Moser, B., Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes [see comments], J. Exp. Med., 184(3), 963-969, 1996.
20. Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D. et al., The functional role of the ELR motif in CXC chemokine-mediated angiogenesis, J. Biol. Chem., 270(45), 27348-27357, 1995.
21. Sgadari, C., Farber, J. M., Angiolillo, A. L., Liao, F., Teruya-Feldstein, J., Burd, P. R., Yao, L., Gupta, G., Kanegane, C., and Tosato, G., Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo. Blood, 89(8), 2635-2643, 1997.
22. Farber, J. M., Mig and IP-10: CXC chemokines that target lymphocytes, J. Leukoc. Biol., 61(3), 246-257, 1997.
23. Rani, M. R. S., Foster, G. R., Leung, S., Leaman, D., Stark, G. R., and Ransohoff, R. M., Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha, J. Biol. Chem., 271(37), 22878-22884, 1996.
24. Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., Sahagan, B. G., and Neote, K., Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high-affinity binding to CXCR3, J. Exp. Med., 187(12), 2009-2021, 1998.
25. + myelin peptide-specific T cells: importance of IFN-inducible protein 10, J. Immunol., 160(1), 444-448, 1998.
26. Asensio, V. C. and Campbell, I. L., Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis, J. Virol., 71(10), 7832-7840, 1997.
27. Hausmann, E. H., Berman, N. E., Wang, Y. Y., Meara, J. B., Wood, G. W., and Klein, R. M., Selective chemokine mRNA expression following brain injury, Brain Res., 788(1-2), 49-59, 1998.
28. Lahrtz, F., Piali, L., Nadal, D., Pfister, H. W., Spanaus, K. S., Baggiolini, M., and Fontana, A., Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-gamma inducible protein-10 and monocyte chemotactic protein-1, Eur. J. Immunol., 27(10), 2484-2489, 1997.
29. Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T., and Honjo, T., Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins, Science, 261(5121), 600-603, 1993.
30. Nagasawa, T., Kikutani, H., and Kishimoto, T., Molecular cloning and struture of a pre-B-cell growth-stimulating factor, Proc. Natl. Acad. Sci. U.S.A., 91, 2305-2309, 1994.
31. Shirozu, M., Nakano, T., Inazawa, J., Tashiro, K., Tada, H., Shinohara, T., and Honjo, T., Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene, Genomics, 28(3), 495-500, 1995.
32. + progenitors to peripheral blood, J. Exp. Med., 185, 111-120, 1997.
33. D'Apuzzo, M., Rolink, A., Loetscher, M., Hoxie, J. A., Clark-Lewis, I., Melchers, F., Baggiolini, M., and Moser, B., The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4, Eur. J. Immunol., 27(7), 1788-1793, 1997.
34. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1, Blood, 91(12), 4523-4530, 1998.
35. Sozzani, S., Luini, W., Borsatti, A., Polentarutti, N., Zhou, D., Piemonti, L., D'Amico, G., Power, C. A., Wells, T. N., Gobbi, M., Allavena, P., and Mantovani, A., Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines, J. Immunol., 159(4), 1993-2000, 1997.
36. Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., and Kishimoto, T., Defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1, Nature, 382, 635-638, 1996.
37. Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronson, R. T., and Springer, T. A., Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice, Proc. Natl. Acad. Sci. U.S.A., 95(16), 9448-9453, 1998.
38. Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A., and Butcher, E. C., Chemokines and the arrest of lymphocytes rolling under flow conditions, Science, 279(5349), 381-384, 1998.
39. Wang, J. F., Liu, Z. Y., and Groopman, J. E., The alpha-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion [In Process Citation], Blood, 92(3), 756-764, 1998.
40. Hamada, T., M#hle, R., Hesselgesser, J., Hoxie, J., Nachman, R. L., Moore, M. A. S., and Rafii, S., Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation, J. Exp. Med., 188(3), 539-548, 1998.
41. Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J. L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J. M., Clark-Lewis, I., Legler, D. F., Loetscher, M., Baggiolini, M., and Moser, B., The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1, Nature, 382(6594), 833-835, 1996.
42. Bleul, C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., Sodroski, J., and Springer, T., The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/ fusin and blocks HIV-1 entry, Nature, 382(6594), 829-833, 1996.
43. Zou, Y. R., Kottmann, A. H., Kuroda, M., Taniuchi, I., and Littman, D. R., Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development, Nature, 393(6685), 595-599, 1998.
44. Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S., Kishimoto, T., and Nagasawa, T., The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract [see comments], Nature, 393(6685), 591-594, 1998.
45. Weng, Y., Siciliano, S. J., Waldburger, K. E., Sirotina-Meisher, A., Staruch, M. J., Daugherty, B. L., Gould, S. L., Springer, M. S., and DeMartino, J. A., Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors, J. Biol. Chem., 273(29), 18288-18291, 1998.
46. Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., and Springer, T. A., A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1), J. Exp. Med., 184(3), 1101-1109, 1996.
47. Dealwis, C., Fernandez, E. J., Thompson, D. A., Simon, R. J., Siani, M. A., and Lolis, E., Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1 alpha, a potent ligand for the HIV-1 "fusin" coreceptor, Proc. Natl. Acad. Sci. U.S.A., 95(12), 6941-6946, 1998.
48. Gunn, M., Ngo, Y., Ansel, K., Ekland, E., Cyster, J., and Williams, L., A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1, Nature, 391, 1998.
49. Legler, D., Loetscher, M., Roos, R., Clark-Lewis, I., Baggiolini, M., and Moser, B., B Cell attracting Chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5, J. Exp. Med., 187(4), 655-660, 1998.
50. Schulz-Knappe, P., Magert, H. J., Dewald, B., Meyer, M., Cetin, Y., Kubbies, M., Tomeczkowski, J., Kirchhoff, K., Raida, M., Adermann, K. et al., HCC-1, a novel chemokine from human plasma, J. Exp. Med., 183(1), 295-299, 1996.
51. Tsou, C.-L., Gladue, R., Carroll, L., Paradis, T., Boyd, J., Nelson, R., Neote, K., and Charo, I., Identification of C-C chemokine receptor 1 (CCR1) as the monocyte hemofiltrate chemokine (HCC)-1 receptor, J. Exp. Med., 188(3), 603-608, 1998.
52. Berger, M. S., Kozak, C. A., Gabriel, A., and Prystowsky, M. B., The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines, DNA Cell Biol., 12(9), 839-847, 1993.
53. Naruse, K., Ueno, M., Satoh, T., Nomiyama, H., Tei, H., Takeda, M., Ledbetter, D., Van Coillie, E., Opdenakker, G., Gunge, N., Sakaki, Y., Iio, M., and Miura, R., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2, Genomics, 34, 236-240, 1996.
54. Hedrick, J. A., Helms, A., Vicari, A., and Zlotnik, A., Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10, Blood, 91(11), 4242-4247, 1998.
55. Youn, B. S., Zhang, S., Broxmeyer, H. E., Antol, K., Fraser, M. J., Jr., Hangoc, G., and Kwon, B. S., Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity, Biochem. Biophys. Res. Commun., 247(2), 217-222, 1998.
56. Adema, G. J., Hartgers, F., Verstraten, R., de Vries, E., Marland, G., Menon, S., Foster, J., Xu, Y., Nooyen, P., McClanahan, T., Bacon, K. B., and Figdor, C. G., A dendritic cell-derived C-C chemokine that preferentially attracts naive T cells, Nature, 387(6634), 713-717, 1997.
57. Hieshima, K., Imai, T., Baba, M., Shoudai, K., Ishizuka, K., Nakagawa, T., Tsuruta, J., Takeya, M., Sakaki, Y., Takatsuki, K., Miura, R., Opdenakker, G., Van Damme, J., Yoshie, O., and Nomiyama, H., A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes, J. Immunol., 159(3), 1140-1149, 1997.
58. Kodelja, V., Müller, C., Politz, O., Hakij, N., Orfanos, C., and Goerdt, S., Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1a with a Th2-associated expression pattern, J. Immunol., 160(3), 1411-1418, 1998.
59. Godiska, R., Chantry, D., Raport, C. J., Sozzani, S., Allavena, P., Leviten, D., Mantovani, A., and Gray, P. W., Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells, J. Exp. Med., 185(9), 1595-1604, 1997.
60. Chang, M., McNinch, J., Elias, C. R., Manthey, C. L., Grosshans, D., Meng, T., Boone, T., and Andrew, D. P., Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes, J. Biol. Chem., 272(40), 25229-25237, 1997.
61. Imai, T., Chantry, D., Raport, C. J., Wood, C. L., Nishimura, M., Godiska, R., Yoshie, O., and Gray, P. W., Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4, J. Biol. Chem., 273(3):1764-1768, 1998.
62. Hoogewerf, A., Black, D., Proudfoot, A. E., Wells, T. N., and Power, C. A., Molecular cloning of murine CC CKR-4 and high-affinity binding of chemokines to murine and human CC CKR-4, Biochem. Biophys. Res. Commun., 218(1), 337-343, 1996.
63. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., and Yoshie, O., The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4, J. Biol. Chem., 272(23), 15036-15042, 1997.
64. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., and Sinigaglia, F., Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s, J. Exp. Med., 187(1), 129-134, 1998.
65. Rossi, D., Vicari, A., Franz-Bacon, K., McClanahan, T., and Zlotnik, A., Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta, J. Immunol., 158(3), 1033-1036, 1997.
66. Hieshima, K., Imai, T., Opdenakker, G., Van Damme, J., Kusuda, J., Tei, H., Sakaki, Y., Takatsuki, K., Miura, R., Yoshie, O., and Nomiyama, H., Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2, J. Biol. Chem., 272(9), 5846-5853, 1997.
67. Hromas, R., Gray, P. W., Chantry, D., Godiska, R., Krathwohl, M., Fife, K., Bell, G. I., Takeda, J., Aronica, S., Gordon, M., Cooper, S., Broxmeyer, H. E., and Klemsz, M. J., Cloning and characterization of exodus, a novel beta-chemokine, Blood, 89(9), 3315-3322, 1997.
68. Power, C. A., Church, D. J., Meyer, A., Alouani, S., Proudfoot, A. E., Clark-Lewis, I., Sozzani, S., Mantovani, A., and Wells, T. N., Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells, J. Exp. Med., 186(6), 825-835, 1997.
69. Liao, F., Alderson, R., Su, J., Ullrich, S. J., Kreider, B. L., and Farber, J. M., STRL22 is a receptor for the CC chemokine MIP-3alpha, Biochem. Biophys. Res. Commun., 236(1), 212-217, 1997.
70. Greaves, D. R., Wang, W., Dairaghi, D. J., Dieu, M. C., Saint-Vis, B., Franz-Bacon, K., Rossi, D., Caux, C., McClanahan, T., Gordon, S., Zlotnik, A., and Schall, T. J., CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells, J. Exp. Med., 186(6), 837-844, 1997.
71. Yoshida, R., Imai, T., Hieshima, K., Kusuda, J., Baba, M., Kitaura, M., Nishimura, M., Kakizaki, M., Nomiyama, H., and Yoshie, O., Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7, J. Biol. Chem., 272(21), 13803-13809, 1997.
72. Kim, C., Pelus, L., White, J., Applebaum, E., Johanson, K., and Broxmeyer, H., CKβ-11/macrophage inflammatory protein-3β/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells, J. Immunol., 160(5), 2418-2424, 1998.
73. Ngo, V. N., Lucy Tang, H., and Cyster, J. G., Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells, J. Exp. Med., 188(1), 181-191, 1998.
74. Burgstahler, R., Kempkes, B., Steube, K., and Lipp, M., Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2, Biochem. Biophys. Res. Commun., 215(2), 737-743, 1995.
75. Birkenbach, M., Josefsen, K., Yalamanchili, R., Lenoir, G., and Kieff, E., Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors, J. Virol., 67(4), 2209-2220, 1993.
76. Schweickart, V. L., Raport, C. J., Godiska, R., Byers, M. G., Eddy, R. L., Jr., Shows, T. B., and Gray, P. W., Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2, Genomics, 23(3), 643-650, 1994.
77. Imai, T., Yoshida, T., Baba, M., Nishimura, M., Kakizaki, M., and Yoshie, O., Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector, J. Biol. Chem., 271, 21514-21521, 1996.
78. Nomiyama, H., Imai, T., Kusuda, J., Miura, R., Callen, D. F., and Yoshie, O., Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13, Genomics, 40(1), 211-213, 1997.
79. Sallusto, F., Lenig, D., Mackay, C. R., and Lanzavecchia, A., Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes, J. Exp. Med., 187(6), 875-883, 1998.
80. Bernardini, G., Hedrick, J., Sozzani, S., Luini, W., Gaia, S., Weiss, M., Menon, S., Zlotnik, A., Mantovani, A., Santoni, A., and Napolitano, M., Identification of the CC chemokines TARC and macrophage inflammatory protein-1β as novel functional ligands for the CCR8 receptor, Eur. J. Immunol., 28(2), 582-588, 1998.
81. Vicari, A. P., Figueroa, D. J., Hedrick, J. A., Foster, J. S., Singh, K. P., Menon, S., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bacon, K. B., and Zlotnik, A., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development, Immunity, 7(2), 291-301, 1997.
82. Gonzalo, J.-A., Jia, G.-Q., Aguirre, V., Friend, D., Coyle, A. J., Jenkins, N. A., Lin, G.-S., Katz, H., Lichtman, A., Copeland, N., Kopf, M., and Guttierez-Ramos, J.-C., Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response, Immunity, 4, 1-14, 1996.
83. Uguccioni, M., Loetsche, R. P., Forssmann, U., Dewald, B., Li, H., Lima, S. H., Li, Y., Kreider, B., Garotta, G., Thelen, M., and M, B., Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin, J. Exp. Med., 185, 2379-2384, 1996.
84. Berger, M., Isolation of monocyte chemotactic protein-4, Clin. Res., 42, 305a, 1994.
85. Garcia-Zepeda, E., Combadiere, C., Rothenberg, M., Sarafi, M., Lavigne, F., Hamid, Q., Murphy, P., and Luster, A., Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3, J. Immunol., 157(12), 5613-5626, 1996.
86. Berkhout, T. A., Sarau, H. M., Moores, K., White, J. R., Elshourbagy, N., Appelbaum, E., Reape, R. J., Brawner, M., Makwana, J., Foley, J. J., Schmidt, D. B., Imburgia, C., McNulty, D., Matthews, J., O'Donnell, K., O'Shannessy, D., Scott, M., Groot, P. H. E., and Macphee, C., Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B, J. Biol. Chem., 272(26), 16404-16413, 1997.
87. Godiska, R., Chantry, D., Raport, C.J., Schweickart, V. L., Trong, H. L., and Gray, P. W., Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2, J. Leukoc. Biol., 61(3), 353-360, 1997.
88. Stellato, C., Collins, P., Ponath, P. D., Soler, D., Newman, W., La Rosa, G., Li, H., White, J., Schwiebert, L. M., Bickel, C., Liu, M., Bochner, B. S., Williams, T., and Schleimer, R. P., Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines, J. Clin. Invest., 99(5), 926-936, 1997.
89. Petering, H., Höchstetter, R., Kimmig, D., Smolarski, R., Kapp, A., and Elsner, J., Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils, J. Immunol., 160(2), 555-558, 1998.
90. Tenscher, K., Metzner, B., Hofmann, C., Schopf, E., and Norgauer, J., The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b upregulation via a pertussis toxin-sensitive G-protein in human eosinophils, Biochem. Biophys. Res. Commun., 240(1), 32-35, 1997.
91. Uguccioni, M., Mackay, C. R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G. J., Rao, P., Ponath, P. D., Baggiolini, M., and Dahinden, C. A., High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines, J. Clin. Invest., 100(5), 1137-1143, 1997.
92. Nibbs, R. J. B., Wylie, S. M., Yang, J., Landau, N. R., and Graham, G. J., Cloning and characterization of a novel promiscuous human β-chemokine receptor D6., J. Biol. Chem., 272(51), 32078-32083, 1997.
93. Jia, G.-Q., Gonzalo, J. A., LLoyd, C., Kremer, L., Lu, L., Martinez-A, C., Wershil, B. K., and Gutierrez-Ramos, J. C., Distinct expression and function of the novel mouse chemokine monocyte chemotactin protein-5 in lung allergic inflammation, J. Exp. Med., 184, 1939-1951, 1996.
94. Sarafi, M. N., Garcia-Zepeda, E. A., MacLean, J. A., Charo, I. F., and Luster, A. D., Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1, J. Exp. Med., 185(1), 99-109, 1997.
95. Patel, V. K., Kreider, B. L., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Pippalla, V., Gentz, S., Thoatakura, R., Parmelee, D., Gentz, R., and Garotta, G., Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors, J. Exp. Med., 185, 1163-1172, 1997.
96. Forssmann, U., Uguccioni, M., Loetscher, P., Dahinden, C. A., Langen, H., Thelen, M., and Baggiolini, M., Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes, J. Exp. Med., 185(12), 2171-6, 1997.
97. Nomiyama, H., Osborne, L. R., Imai, T., Kusuda, J., Miura, R., Tsui, L. C., and Yoshie, O., Assignment of the human CC chemokine MPIF-2/exotaxin-2 (SCYA24) to chromosome 7q11.23, Genomics, 49(2), 339-340, 1998.
98. White, J. R., Imburgia, C., Dul, E., Appelbaum, E., O'Donnell, K., O'Shannessy, D. J., Brawner, M., Fornwald, J., Adamou, J., Elshourbagy, N. A., Kaiser, K., Foley, J. J., Schmidt, D. B., Johanson, K., Macphee, C., Moores, K., McNulty, D., Scott, G. F., Schleimer, R. P., and Sarau, H. M., Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils, J. Leukoc. Biol., 62(5), 667-675, 1997.
99. Pardigol, A., Forssmann, U., Zucht, H.-D., Loetscher, P., Schulz-Knappe, P., Baggiolini, M., Forssmann, W.-G., and Mägert, H.-J., HCC-2, a human chemokine: genestructure, expression pattern, and biological activity, Proc. Natl. Acad. Sci. U.S.A., 95, 6308-6313, 1998.
100. Gao, J. L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J., and Murphy, P. M., Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1, J. Exp. Med., 185(11), 1959-1968, 1997.
101. Laning, J., Kawasaki, H., Tanaka, E., Luo, Y., and Dorf, M. E., Inhibition of in vivo tumor growth by the beta chemokine, TCA3, J. Immunol., 153(10), 4625-4635, 1994.
102. Luo, Y., Laning, J., Devi, S., Mak, J., Schall, T. J., and Dorf, M. E., Biologic activities of the murine beta-chemokine TCA3, J. Immunol., 153(10), 4616-4624, 1994.
103. Youn, B.-S., Zhang, S., Lee, E., Park, D., Broxmeyer, H., Murphy, P., Locati, M., Pease, J., Kim, K., Antol, K., and Kwon, B., Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3, J. Immunol., 159(11), 5201-5205, 1997.
104. Forssmann, U., Delgado, M. B., Uguccioni, M., Loetscher, P., Garotta, G., and Baggiolini, M., CKbeta8, a novel CC chemokine that predominantly acts on monocytes, FEBS Lett., 408(2), 211-216, 1997.
105. Poltorak, A. N., Bazzoni, F., Smirnova, II, Alejos, E., Thompson, P., Luheshi, G., Rothwell, N., and Beutler, B., MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo, J. Inflamm., 45(3), 207-219, 1995.
106. Youn, B. S., Jang, I. K., Broxmeyer, H. E., Cooper, S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Elick, T. A., Fraser, M. J., Jr., and Kwon, B. S., A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors, J. Immunol., 155(5), 2661-2667, 1995.
107. Hara, T., Bacon, K. B., Cho, L. C., Yoshimura, A., Morikawa, Y., Copland, N. G., Gilbert, D. J., Jenkins, N. A., Schall, T. J., and Miyajima, A., Molecular cloning and functional characterization of a novel member of the C-C chemokine family, J. Immunol., 155, 5352-5358, 1995.
108. Coulin, F., Power, C. A., Alouani, S., Peitsch, M. C., Schroeder, J. M., Moshizuki, M., Clark-Lewis, I., and Wells, T. N., Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines, Eur. J. Biochem., 248(2), 507-515, 1997.
109. Dairaghi, D. J., Oldham, E. R., Bacon, K. B., and Schall, T. J., Chemokine receptor CCR3 function is highly dependent on local pH and ionic strength, J. Biol. Chem., 272(45), 28206-28209, 1997.
110. Hedrick, J. A. and Zlotnik, A., Identification and characterization of a novel beta chemokine containing six conserved cysteines, J. Immunol., 159(4), 1589-1593, 1997.
111. Nagira, M., Imai, T., Hieshima, K., Kusuda, J., Ridanpaa, M., Takagi, S., Nishimura, M., Kakizaki, M., Nomiyama, H., and Yoshie, O., Molecular cloning of a novel human CC chemokine secondary lymphoid tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13, J. Biol. Chem., 272(31), 19518-19524, 1997.
112. Hromas, R., Kim, C. H., Klemsz, M., Krathwohl, M., Fife, K., Cooper, S., Schnizlein-Bick, C., and Broxmeyer, H. E., Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension, J. Immunol., 159(6), 2554-2558, 1997.
113. Tanabe, S., Lu, Z., Luo, Y., Quackenbush, E., Berman, M., Collins-Racie, L., Mi, S., Reilly, C., Lo, D., Jacobs, K., and Dorf, M., Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells, J. Immunol., 159(11), 5671-5679, 1997.
114. Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., and Williams, L. T., A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes, Proc. Natl. Acad. Sci. U.S.A., 95(1), 258-263, 1998.
115. Nagira, M., Imai, T., Yoshida, R., Takagi, S., Iwasaki, M., Baba, M., Tabira, Y., Akagi, J., Nomiyama, H., and Yoshie, O., A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells, Eur. J. Immunol., 28(5), 1516-1523, 1998.
116. Willimann, K., Legler, D. F., Loetscher, M., Roos, R. S., Delgado, M. B., Clark-Lewis, I., Baggiolini, M., and Moser, B., The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7, Eur. J. Immunol., 28(6), 2025-2034, 1998.
117. Soto, H., Wang, W., Strieter, R. M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Hedrick, J., and Zlotnik, A., The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3, Proc. Natl. Acad. Sci. U.S.A., 95(14), 8205-8210, 1998.
118. Campbell, J. J., Bowman, E. P., Murphy, K., Youngman, K. R., Siani, M. A., Thompson, D. A., Wu, L., Zlotnik, A., and Butcher, E. C., 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7, J. Cell. Biol., 141(4), 1053-1059, 1998.
119. Yoshida, R., Nagira, M., Kitaura, M., Imagawa, N., Imai, T., and Yoshie, O., Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7, J. Biol. Chem., 273(12), 7118-7122, 1998.
120. Keiner, G. S., Kennedy, J., Bacon, K. B., Kleyensteuber, S., Largaespada, D. A., Jenkins, N. A., Copeland, N. G., Bazan, J. F., Moore, K. W., Schall, T. J., and Zlotnik, A., Lymphotactin: a cytokine that represents a new class of chemokine, Science, 266, 1395-1399, 1994.
121. Yoshida, T., Imai, T., Kakizaki, M., Nishimura, M., and Yoshie, O., Molecular cloning of a novel C or γ chemokine, SCM-1, FEBS Lett., 360, 155-159, 1995.
122. Kennedy, J., Kelner, G. S., Kleyensteuber, S., Schall, T. J., Weiss, M. C., Yssel, H., Schneider, P. V., Cocks, B. G., Bacon, K. B., and Zlotnik, A., Molecular cloning and functional charaterization of human lymphotactin, J. Immunol., 155, 203-209, 1995.
123. + T lymphocytes, Eur. J. Immunol., 25, 1744-1748, 1995.
124. Yoshida, T., Imai, T., Takagi, S., Nishimura, M., Ishikawa, I., Yaoi, T., and Yoshie, O., Structure and expression of two highly related genes encoding SCM-1/human lymphotactin. FEBS Lett., 395(1), 82-88, 1996.
125. Hedrick, J. A., Saylor, V., Figueroa, D., Mizoue, L., Xu, Y., Menon, S., Abrams, J., Handel, T., and Zlotnik, A., Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo, J. Immunol., 158(4), 1533-1540, 1997.
126. Giancarlo, B., Silvano, S., Albert, Z., Mantovani, A., and Allavena, P., Migratory response of human natural killer cells to lymphotactin, Eur. J. Immunol., 26(12), 3238-3241, 1996.
127. Dilloo, D., Bacon, K., Holden, W., Zhong, W., Burdach, S., Zlotnik, A., and Brenner, M., Combined chemokine and cytokine gene transfer enhances antitumor immunity, Nat. Med., 2(10), 1090-1095, 1996.
128. Boismenu, R., Feng, L., Xia, Y. Y., Chang, J. C., and Havran, W. L., Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia, J. Immunol., 157(3), 985-992, 1996.
129. Rumsaeng, V., Vliagoftis, H., Oh, C. K., and Metcalfe, D. D., Lymphotactin gene expression in mast cells following Fc(epsilon) receptor I aggregation: modulation by TGF-beta, IL-4, dexamethasone, and cyclosporin A, J. Immunol., 158(3), 1353-1360, 1997.
130. Yoshida, T., Imai, T., Kakizaki, M., Nishimura, M., Takagi, S., and Yoshie, O., Identification of single C motif-1/lymphotactin receptor XCR1, J. Biol. Chem., 273(26), 16551-16554, 1998.
131. Heiber, M., Docherty, J. M., Shah, G., Nguyen, T., Cheng, R., Heng, H. H., Marchese, A., Tsui, L. C., Shi, X., George, S. R., et al., Isolation of three novel human genes encoding G protein-coupled receptors, DNA Cell. Biol., 14(1), 25-35, 1995.
132. Daugherty, B. L. and Springer, M. S., The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human
133. Samson, M., Soularue, P., Vassart, G., and Parmentier, M., The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3, Genomics, 36(3), 522-526, 1996.
134. Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A. and Schall, T. J., A new class of membrane-bound chemokine with a CX3C motif, Nature, 385(6617), 640-644, 1997.
135. Pan, Y., Lloyd, C., Zhou, H., Dolich, S., Deeds, J., Gonzalo, J. A., Vath, J., Gosselin, M., Ma, J., Dussault, B., Woolf, E., Alperin, G., Culpepper, J., Gutierrez-Ramos, J. C., and Gearing, D., Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation, Nature, 387(6633), 611-617, 1997.
136. Rossi, D. L., Hardiman, G., Copeland, N. G., Gilbert, D. J., Jenkins, N., Zlotnik, A., and Bazan, J. F., Cloning and characterization of a new type of mouse chemokine, Genomics, 47(2), 163-170, 1998.
137. Nomiyama, H., Imai, T., Kusuda, J., Miura, R., Callen, D. F., and Yoshie, O., Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q131 [In Process Citation], Cytogenet. Cell. Genet., 81(1), 10-11, 1998.
138. Imai, T., Hieshima, K., Haskell, C., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., and Yoshie, O., Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion [In Process Citation], Cell, 91(4), 521-530, 1997.
139. Raport, C. J., Schweickart, V. L., Eddy, R. J., Shows, T. B., and Gray, P. W., The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues, Gene, 163(2), 295-299, 1995.
140. Nishiyori, A., Minami, M., Ohtani, Y., Takami, S., Yamamoto, J., Kawaguchi, N., Kume, T., Akaike, A., and Satoh, M., Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett., 429(2), 167-172, 1998.
141. Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., and Mackay, C. R., The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions, J. Clin. Invest., 101(4), 746-754, 1998.
142. Piali, L., Weber, C., LaRosa, G., Mackay, C. R., Springer, T. A., Clark-Lewis, I., and Moser, B., The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig, Eur. J. Immunol., 28(3), 961-972, 1998.
143. Dobner, T., Wolf, I., Emrich, T., and Lipp, M., Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma, Eur. J. Immunol., 22(11), 2795-2799, 1992.
144. Kaiser, E., Forster, R., Wolf, I., Ebensperger, C., Kuehl, W. M., and Lipp, M., The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues, Eur. J. Immunol., 23(10), 2532-2539, 1993.
145. Kouba, M., Vanetti, M., Wang, X., Schafer, M., and Hollt, V., Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue, FEBS Lett., 321(2-3), 173-178, 1993.
146. Forster, R., Emrich, T., Kremmer, E., and Lipp, M., Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells, and a subset of T-helper memory cells, Blood, 84(3), 830-840, 1994.
147. Forster, R., Mattis, A. E., Kremmer, E., Wolf, E., Brem, G., and Lipp, M., A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen, Cell, 87(6), 1037-1047, 1996.
148. Barella, L., Loetscher, M., Tobler, A., Baggiolini, M., and Moser, B., Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation, Biochem. J., 309(Pt 3), 773-779, 1995.
149. Liao, F., Lee, H. H., and Farber, J. M., Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27, Genomics, 40(1), 175-180, 1997.
150. Zaballos, A., Varona, R., Gutierrez, J., Lind, P., and Marquez, G., Molecular cloning and RNA expression of two new human chemokine receptor-like genes [published erratum appears in Biochem. Biophys. Res. Commun., 1997 Feb. 13, 231(2), 519-520], Biochem. Biophys. Res. Commun., 227(3), 846-853, 1996.
151. Baba, M., Imai, T., Nishimura, M., Kakizaki, M., Takagi, S., Hieshima, K., Nomiyama, H., and Yoshie, O., Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC, J. Biol. Chem., 272(23), 14893-14898, 1997.
152. Dieu, M. C., Vanbervliet, B., Vicari, A., Bridon, J. M., Oldham, E., Ait-Yahia, S., Briere, F., Zlotnik, A., Lebecque, S., and Caux, C., Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites, J. Exp. Med., 188(2), 373-386, 1998.
153. Sozzani, S., Allavena, P., D'Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., and Mantovani, A., Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties, J. Immunol., 161(3), 1083-1086, 1998.
154. + T cells, J. Virol., 68(8), 5326-5329, 1994.
155. Napolitano, M., Zingoni, A., Bernardini, G., Spinetti, G., Nista, A., Storlazzi, C. T., Rocchi, M., and Santoni, A., Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues, J. Immunol., 157(7), 2759-2763, 1996.
156. Samson, M., Stordeur, P., Labbe, O., Soularue, P., Vassart, G., and Parmentier, M., Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor, Eur. J. Immunol., 26(12), 3021-3028, 1996.
157. Youn, B. S., Kim, S. H., Lyu, M. S., Kozak, C. A., Taub, D. D., and Kwon, B. S., Molecular cloning and characterization of a cDNA, CHEMRI, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4, Blood, 89(12), 4448-4460, 1997.
158. Tiffany, H. L., Lautens, L. L., Gao, J. L., Pease, J., Locati, M., Combadiere, C., Modi, W., Bonner, T. I., and Murphy, P. M., Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309, J. Exp. Med., 186(1), 165-170, 1997.
159. Roos, R. S., Loetscher, M., Legler, D. F., Clark-Lewis, I., Baggiolini, M., and Moser, B., Identification of CCR8, the receptor for the human CC chemokine I-309, J. Biol. Chem., 272(28), 17251-17254, 1997.
160. Goya, I., Gutiérrez, J., Varona, R., Kremer, L., Zaballos, A., and Márquez, G., Identification of CCR8 as the specific receptor for the human β-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3, J. Immunol., 160(4), 1975-1981, 1998.
161. Van Snick, J., Houssiau, F., Proost, P., Van Damme, J., and Renauld, J. C., I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis, J. Immunol., 157(6), 2570-2576, 1996.
162. Zingoni, A., Soto, H., Hedrick, J. A., Stoppacciaro, A., Storlazzi, C. T., Sinigaglia, F., D'Ambrosio, D., O'Garra, A., Robinson, D., Rocchi, M., Santoni, A., Zlotnik, A., and Napolitano, M., The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells, J. Immunol., 161(2), 547-551, 1998.
163. Nibbs, R. J. B., Wylie, S. M., Pragnell, I. B., and Graham, G. J., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1-alpha receptors, CCR-1, CCR-3, and CCR-5, J. Biol. Chem., 272(19), 12495-12504, 1997.
164. Bonini, J. A., Martin, S. K., Dralyuk, F., Roe, M. W., Philipson, L. H., and Steiner, D. F., Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3 [In Process Citation], DNA Cell. Biol., 16(10), 1249-1256, 1997.
165. Bonini, J. A. and Steiner, D. F., Molecular cloning and expression of a novel rat CC-chemokine receptor (rCCR10rR) that binds MCP-1 and MIP-1beta with high affinity, DNA Cell. Biol., 16(9), 1023-1030, 1997.
166. Savarese, T. M. and Fraser, C. M., In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors, Biochem. J., 283(Pt 1), 1-19, 1992.
167. Farzan, M., Choe, H., Martin, K. A., Sun, Y., Sidelko, M., Mackay, C. R., Gerard, N. P., Sodroski, J., and Gerard, C., HIV-1 entry and macrophage inflammatory protein-1-beta-mediated signaling are independent functions of the chemokine receptor CCR5, J. Biol. Chem., 272(11), 6854-6857, 1997.
168. Harrison, J. K., Barber, C. M., and Lynch, K. R., cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors, Neurosci. Lett., 169(1-2), 85-89, 1994.
169. Combadiere, C., Ahuja, S. K., and Murphy, P. M., Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene, DNA Cell. Biol., 14(8), 673-680, 1995.
170. Spriggs, M. K., One step ahead of the game: viral immunomodulatory molecules, Annu. Rev. Immunol., 14, 101-130, 1996.
171. Moore, J. P., Trkola, A., and Dragic, T., Coreceptors for HIV-1 entry, Curr. Opin. Immunol., 9(4), 551-562, 1997.
172. Broder, C. C. and Collman, R. G., Chemokine receptors and HIV, J. Leukoc. Biol., 62(1), 20-29, 1997.
173. Rucker, J., Edinger, A. L., Sharron, M., Samson, M., Lee, B., Berson, J. K., Yi, Y., Margulies, B., Collman, R. G., Doranz, B. J., Parmentier, M., and Doms, R. W., Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses, J. Virol., 71(12), 8999-9007, 1997.
174. Isegawa, Y., Ping, Z., Nakano, K., Sugimoto, N., and Yamanishi, K., Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor, J. Virol., 72(7), 6104-6112, 1998.
175. Moore, P. S., Boshoff, C., Weiss, R. A., and Chang, Y., Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV, Science, 274(5293), 1739-1744, 1996.
176. Boshoff, C., Endo, Y., Collins, P. D., Takeuchi, Y., Reeves, J. D., Schweickart, V. L., Siani, M. A., Sasaki, T., Williams, T. J., Gray, P. W., Moore, P. S., Chang, Y., and Weiss, R. A., Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines, Science, 278(5336), 290-294, 1997.
177. Kledal, T. N., Rosenkilde, M. M., Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Power, C. A., Luttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I., Wells, T. N. C., and Schwartz, T. W., A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus, Science, 277(5332), 1656-1659, 1997.
178. Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M. C., and Cesarman, E., Human herpesvirus KSHV encodes a constitutively active G-protein coupled receptor linked to cell proliferation [see comments], Nature, 385(6614), 347-350, 1997.
179. Bais, C., Santomasso, B., Coso, O., Arvanitakis, L., Raaka, E. G., Gutkind, J. S., Asch, A. S., Cesarman, E., Gerhengorn, M. C., and Mesri, E. A., G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus, Nature, 391(6662), 86-99, 1998.
180. Geras-Raaka, E., Varma, A., Ho, H., Clark-Lewis, I., and Gershengorn, M. C., Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor, J. Exp. Med., 188(2), 405-408, 1998.
181. Senkevich, T. G., Bugert, J. J., Sisler, J. R., Koonin, E. V., Darai, G., and Moss, B., Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes, Science, 273(5276), 813-816, 1996.
182. Krathwohl, M. D., Hromas, R., Brown, D. R., Broxmeyer, H. E., and Fife, K. H., Functional characterization of the C-C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2, Proc. Natl. Acad. Sci. U.S.A., 94(18), 9875-9880, 1997.
183. Clark-Lewis, I., Kim, K. S., Rajarathnam, K., Gong, J. H., Dewald, B., Moser, B., Baggiolini, M., and Sykes, B. D., Structure-activity relationships of chemokines, J. Leukoc. Biol., 57(5), 703-711, 1995.
184. Graham, G. J., Wilkinson, P. C., Nibbs, R. J., Lowe, S., Kolset, S. O., Parker, A., Freshney, M. G., Tsang, M. L., and Pragnell, I. B., Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1-alpha by mutagenesis of the proteoglycan binding site, EMBO J., 15(23), 6506-6515, 1996.
185. Graham, K. A., Lalani, A. S., Macen, J. L., Ness, T. L., Barry, M., Liu, L. Y., Lucas, A., Clark-Lewis, I., Moyer, R. W., and McFadden, G., The T1/35 kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues, Virology, 229(1), 12-24, 1997.
186. Smith, C. A., Smith, T. D., Smolak, P. J., Friend, D., Hagen, H., Gerhart, M., Park, L., Pickup, D. J., Torrance, D., Mohler, K., Schooley, K., and Goodwin, R. G., Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors, Virology, 236(2), 316-327, 1997.
187. Hedrick, J. and Zlotnik, A., Chemokines and lymphocyte biology, Curr. Opin. Immunol., 8(3), 343-347, 1996.
188. Sallusto, F., Mackay, C. R., and Lanzavecchia, A., Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells, Science, 277(5334), 2005-2007, 1997.
189. Siveke, J. and Hamann, A., T helper 1 and T helper 2 cells respond differentially to chemokines, J. Immnuol., 160(2), 550-554, 1998.
190. Karpus, W. J., Lukacs, N. W., Kennedy, K. J., Smith, W. S., Hurst, S. D., and Barrett, T. A., Differential CC chemokine-induced enhancement of T helper cell cytokine production, J. Immunol., 158(9), 4129-4136, 1997.
191. Lu, B., Rutledge, B. J., Gu, L., Fiorillo, J., Lukacs, N. W., Kunkel, S. L., North, R., Gerard, C., and Rollins, B. J., Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice, J. Exp. Med., 187(4), 601-608, 1998.
192. Karpus, W. J., Kennedy, K. J., Kunkel, S. L., and Lukacs, N. W., Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines, J. Exp. Med., 187(5), 733-741, 1998.
193. Mohamadzadeh, M., Poltorak, A.N.,Bergstressor, P. R., Beutler, B., and Takashima, A., Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family, J. Immunol., 156(9), 3102-3106, 1996.
194. Schaniel, C., Pardali, E., Sallusto, F., Speletas, M., Ruedl, C., Shimizu, T., Seidl, T., Andersson, J., Melchers, F., Rolink, A., and Sideras, P., Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectivity on activated T cells, J. Exp. Med., 188(3), 451-463, 1998.
195. Steinman, R. M., Pack, M., and Inaba, K., Dendritic cell development and maturation, Adv. Exp. Med. Biol., 417, 1-6, 1997.
196. Shortman, K. and Caux, C., Dendritic cell development: multiple pathways to nature's adjuvants, Stem Cells, 15(6), 409-419, 1997.
197. Shortman, K., Wu, L., Ardavin, C., Vremec, D., Stozik, F., Winkel, K., and Suss, G., Thymic dendritic cells: surface phenotype, developmental origin and function, Adv. Exp. Med. Biol., 378, 21-29, 1995.
198. Steinman, R. M., Pack, M., and Inaba, K., Dendritic cells in the T-cell areas of lymphoid organs, Immunol. Rev., 156, 25-37, 1997.