Involvement of p21(cip-1) and p27(kip-1) in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21(cip-1) in the maintenance of stem/progenitor cells in vivo

Blood

Volumn 88, Issue 10, 1996, Pages 3710-3719

  Mantel, Charlie ^b   Luo, Zaiming ^b   Canfield, Jeff ^b   Braun, Steve ^b   Deng, Chuxia ^b   Broxmeyer, Hal E ^a  

^a INDIANA UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROTEIN P21; PROTEIN P27; STEEL FACTOR; CDK2 PROTEIN, HUMAN; CDK2 PROTEIN, MOUSE; CDKN1A PROTEIN, HUMAN; CDKN1A PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; HYBRID PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; RETINOBLASTOMA PROTEIN; STEM CELL FACTOR; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPOTENTIATION; MITOGENESIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; STEM CELL; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HEMATOPOIETIC STEM CELL; LEUKEMIA; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

ANIMALS; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DRUG SYNERGISM; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RETINOBLASTOMA PROTEIN; STEM CELL FACTOR; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0029661875     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.10.3710.bloodjournal88103710     Document Type: Article

References (41)

1. Broxmeyer HE, Maze R, Miyazawa K, Carow C, Hendrie PC, Cooper S, Hangoc G, Vadhan-Raj S, Lu L: The Kit receptor and its ligand, steel factor, as regulators of hemopoiesis. Cancer Cells 3:480, 1991
2. Hendrie PC, Miyazawa K, Yang YC, Langefeld CD, Broxmeyer HE: Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of human factor dependent cell line, M07e. Exp Hematol 19:1031, 1991
3. Broxmeyer HE, Hangoc G, Cooper S, Ribeiro RC, Graves V, Yoder M, Wagner J, Vadhan-Raj S, Rubinstein P, Broun ER: Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation of adults. Proc Natl Acad Sci USA 89:4109, 1992
4. Miyazawa K, Hendrie PC, Mantel C, Wood K, Ashman LK, Broxmeyer HE: Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase. Exp Hematol 19:1110, 1991
5. Horie M, Broxmeyer HE: Involvement of immediate-early gene expression in the synergistic effects of steel factor in combination with granulocyte-macrophage colony stimulating factor or interleukin-3 on proliferation of a human factor-dependent cell line. J Biol Chem 268:968, 1993
6. Hallek M, Druker B, Lepisto EM, Wood KW, Ernst TJ, Griffin JD: Granulocyte-macrophage colony-stimulating factor and steel factor induce phosphorylation of both unique and overlapping signal transduction intermediates in a human factor-dependent hematopoietic cell line. J Cell Physiol 153:176, 1992
7. Mantel C, Luo Z, Broxmeyer HE: Synergistic induction of phospholipid metabolism by granulocyte-macrophage colony stimulating factor and steel factor in human growth factor-dependent cell line, M07e. Lipids 30:641, 1995
8. Hellek M, Ando K, Eder M, Slattery K, Ajchenbaum-Cymbalista F, Griffin JD: Signal transduction of steel factor and granulocyte-macrophage colony-stimulating factor and G1 cyclin gene expression and of proliferation in the human factor dependent cell line, M07e. Leukemia 8:740, 1994
9. Aronica SM, Mantel C, Gonin R, Marshall MS, Sarris A, Cooper S, Hague N, Zhang XF, Broxmeyer HE: Interferon-Inducible protein 10 and macrophage inflammatory protein-la inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. J Biol Chem 270:21998, 1995
10. Buchkovich K, Duffy LA, Harlow E: The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097, 1989
11. Chen PL, Scully P, Shew JY, Wang JY, Lee WH: Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193, 1989
12. De Caprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica-Worms CM, Huang CM, Livingston DM: The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulated element. Cell 58:1085, 1989
13. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA: Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993, 1992
14. Kato JH, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ: Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7:331, 1993
15. Ohtsubo M, Roberts JM: Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259:1908, 1993
16. Peter M, Heiskowitz I: Joining the complex: Cyclin-dependent kinase inhibitor proteins and the cell cycle. Cell 79:181, 1994
17. Xiong Y, Hannon GJ, Zhang H, Casso D. Kobayashi R, Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 366:701, 1993
18. kip-1 a cyclin-cdk inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59, 1994
19. kip-1) of cyclin-dependent kinase-4 activation. Cell 79:487, 1994
20. kip-1 for restriction point control of the fibroblast cell cycle. Science 272:877, 1996
21. kip-1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707, 1996
22. kip-1. Cell 85:721, 1996
23. kip-1 deficient mice. Cell 85:733, 1996
24. El-Diery WS, Tokino, T, Velculestu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kingler K, Vogelstein B: WAF1, a potential indicator of p53 tumor suppression. Cell 75:817, 1993
25. Jiang H, Lin J, Su ZZ, Collart FR, Huberman E, Fisher PB: Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21 WAF1/CIP1 expression in the absence of p53. Oncogene 9:3397, 1994
26. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, Housini ME: Induction of p21 (WAF1/CIP1) during differentiation. Oncogene 9:3389, 1994
27. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB: Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267:1018, 1995
28. cip-1 in muscle and other terminally differentiating cells. Science 267:1024, 1995
29. Chen, YQ, Cipriano SC, Arenkiel JM, Miller FR: Tumor suppression by p21WAF1. Cancer Res 55:4536, 1995
30. kip-1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570, 1994
31. Firpo E, Koff A, Solomon MJ, Roberts JM: Inactivation of a cdk2 inhibitor during interleukin 2-induced proliferation of human T-lymphocytes. Mol Cell Biol 14:4889, 1994
32. Michieli P, Chedid M, Lin D, Pierce J, Mercer WE, Givol D: Induction of WAF1/CIP1 by a p53 independent pathway. Cancer Res 54:3391, 1994
33. waf1/cip1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res 56:31, 1996
34. Avanzi GC, Lista P, Giovinazzo B, Miniero R, Saglio G, Benetton G, Coda R, Cattoretti G, Pegoraro L: Selective growth response to IL-3 of a human leukemic cell line with megakaryoblastic features. Br J Haematol 69:359, 1988
35. Tauchi T, Marshall MS, Shen R, Mantel C, Feng GS, Pawson T, Broxmeyer HE: The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb-2 in hematopoietic cells. J Biol Chem 269:25206, 1994
36. cip-1/waf1 undergo normal development, but are defective in Gl checkpoint control. Cell 82:675, 1995
37. Cooper S, Mantel C, Broxmeyer HE: Myelosuppressive effects in vivo with very low dosages of monomeric recombinant murine macrophage inflammatory protein-lα. Exp Hematol 22:186, 1994
38. Chen J, Jackson PK, Kirshner MW, Dutta A: Separate domains of p21 involved in the induction of cdk kinase and PCNA. Nature 374:386, 1995
39. waf-1 gene activities. Mol Cell Biol 16:1786, 1996
40. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, Fox MP, Wei N: Inhibitors of cyclin dependent kinase by p21. Mol Biol Cell 6:387, 1995
41. Zhang H, Hannon GJ, Beach D: p21-containing cyclin kinase exist in both active and inactive states. Genes Dev 8:1750, 1994