Biopharmaceuticals in Plants: Toward the Next Century of Medicine

Biopharmaceuticals in Plants: Toward the Next Century of Medicine

Volumn , Issue , 2009, Pages 1-211

  Hefferon, Kathleen Laura ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85057943120     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Book

References (467)

1. Baxby, D. (1999). Edward Jenner’s Inquiry: a bicentenary analysis. Vaccine 17: 301-307.
2. Benfey, P.N., Ren, L., and Chea, N.H. (1990). Combinatorial and synergistic properties of CaMV 35S enhancer subdomains. EMBO J. 9(6): 1683-1696.
3. Broothaerts, W., Mitchell, H.J., Weir, B., Kalnes, S., Smith, L.M.A., Yang, W., Mayer, J.E., Roa-Rodriguez, C., and Jefferson, R.A. (2005). Gene transfer to plants by diverse species of bacteria. Nature 433: 629-633.
4. Caddick, M.X., Greenland, A.J., Jepson, I., Krause, K.-P., Qu, N., Riddell, K.V., Selter, M.G., Schurch, W., Sonnewald, U., and Tomsett, A.B. (1998). An ethanol inducible gene switch for plants used to manipulate carbon metabolism. Nat. Biotechnol. 16: 177-180.
5. Christou, P. (1997). Rice transformation: bombardment. Plant Mol. Biol. 35: 197-203.
6. Deikman, J., Xu, R., Kneissl, M.L., Ciardi, J.A., Kim, K.N., and Pelah, D. (1998). Separation of cis elements responsive to ethylene, fruit development, and ripening in the 5′-flanking region of the ripening-related E8 gene. Plant Mol. Biol. 37(6): 1001-1011.
7. Dowson Day, M.J., Ashurt, J.L., Mathias, S.F., Watts, J.W., Wilson, T.M., and Dixon, R.A. (1993). Plant viral leaders influence expression of a reporter gene in tobacco. Plant Mol. Biol. 23(1): 97-109.
8. Fang, R.X., Nagy, F., Sivasubramaniam, S., and Chua, N.H. (1989). Multiple cis regulatory elements for maximal expression of the cauliflower mosaic virus 35S promoter in transgenic plants. Plant Cell 1(1): 141-150.
9. Filipecki, M. and Malepszy, S. (2006). Unintended consequences of plant transformation: a molecular insight. J. Appl. Genet. 47(4): 277-286.
10. Fischer, R. and Emans, N. (2000). Molecular farming of pharmaceutical proteins. Transgene Res. 9: 279-299.
11. Gelvin, S.B. (2003). Improving plant genetic engineering by manipulating the host. Trends Biotechnol. 21(3): 95-98.
12. Giddings, G., Allison, G., Brooks, D., and Carter, A. (2000). Transgenic plants as factories for biopharmaceuticals. Nat. Biotechnol. 18: 1151-1156.
13. Grierson, C., Du, J.S., de Torres Zabala, M., Beggs, K., Smith, C., Holdsworth, M., and Bevan, M. (1994). Separate cis sequences and trans factors direct metabolic and developmental regulation of a potato tuber storage protein gene. Plant J. 5(6): 815-826.
14. Gross, C.P. and Sepkowitz, K.A. (1998). The myth of the medical breakthrough: smallpox, vaccination and Jenner reconsidered. Int. J. Infect. Disease 3(1): 54-60.
15. Guillon, S.M., Tremoulliaux-Guiller, J., Kumar Pati, P., Rideau, M., and Gantet, P. (2006). Harnessing the potential of hairy roots: dawn of a new era. Trends Biotechnol. 24(9): 403-409.
16. Hefferon, K.L. (2007). Transgenic plants and biotechnology, in Biotechnology, [Ed. Horst W. Doelle], in Encyclopedia of Life Support Systems (EOLSS), Developed under the auspices of UNESCO, EOLSS Publishers, Oxford, UK [http://www.eolss.net].
17. Hefferon, K.L. and Fan, Y. (2004). Expression of a vaccine protein in a cell line using a geminivirus-based replicon system. Vaccine 23: 404-410.
18. Henderson, D.A. (1997). Edward Jenner’s vaccine. Public Health Rep. 112: 117-121.
19. Hiei, Y., Komari, T., and Kubo, T. (1997). Transformation of rice mediated by Agrobacterium tumefaciens. Plant Mol. Biol. 35: 205-218.
20. Jiang, X.L., He, Z.M., Peng, Z.O., Qi, Y., Chen, Q., and Yu, S.Y. (2007). Cholera toxin B protein in transgenic tomato fruit induces systemic immune response in mice. Transgenic Res. 16(2): 169-175.
21. Kang, T.J., Kang, K.H., Kim, J.A., Kwon, T.H., Jang, Y.S., and Yang, M.S. (2004). High-level expression of the neutralizing epitope of porcine epidemic diarrhea virus by a tobacco mosaic virus-based vector. Protein Expr. Purif.38(1): 129-135.
22. Komari, T., Hiei, Y., Ishida, Y., Kumashiro, T., and Kubo, T. (1999). Advances in cereal gene transfer. Curr. Opin. Plant Biol. 1: 161-165.
23. Koziel, M.G., Carozzi, N.B., and Desai, N. (1996). Optimizing expression of transgenes with an emphasis on post-transcriptional events. Plant Mol. Biol.32(1-2): 393-405.
24. Lacroix, B., Li, J., Tzfira, T., and Citovsky, V. (2006a). Will you let me use your nucleus? How Agrobacterium gets its T-DNA expressed in the host plant cell. Can. J. Pharmacol. 84: 333-345.
25. Lacroix, B., Tzfira, T., Vainstein, A., and Citovsky, V. (2006b). A case of promiscuity: Agrobacterium’s endless hunt for new partners. Trends Genet. 22(1): 29-37.
26. Liu, Y., Yang, H., and Sakanishi, A. (2006). Ultrasound: mechanical gene transfer into plant cells by sonoporation. Biotechnol. Adv. 24(1): 1-16.
27. Marillonnet, S., Thoeringer, C., Kandzia, R., Klimyuk, V., and Gleba, Y. (2005). Systemic Agrobacterium tumefaciens-mediated transfection of viral repli-cons for efficient transient expression in plants. Nat. Biotechnol. 23(6): 718-723.
28. McCullen, C.A. and Binnes, A.N. (2006). Agrobacterium tumefaciens and plant cell interactions and activities required for interkingdom macromolecular transfer. Annu. Rev. Cell Dev. Biol. 22: 101-27.
29. Miki, B. and McHugh, S. (2004). Selectable marker genes in transgenic plants: applications, alternatives and biosafety. J. Biotechnol. 107(3): 193-232.
30. Mitsuhara, I., Ugaki, M., Hirochika, H., Ohshima, M., Murakami, T., Gotoh, Y., Katayose, Y., Nakamura, S., Honkura, R., Nishimiya, S., Ueno, K., Mochizuki, A., Tanimoto, H., Tsugawa, H., Otsuki, Y., and Ohashi, Y. (1996). Efficient promoter cassettes for enhanced expression of foreign genes in dicotyledonous and monocotyledonous plants. Plant Cell Physiol. 37(1): 49-59.
31. Omirulleh, S., Abraham, M., Golovkin, M., Stefanov, I., Karabaev, M.K., Mustardy, L., Morocz, S., and Dudits, D. (1993). Activity of a chimeric promoter with the doubled CaMV 35S enhancer element in protoplast-derived cells and transgenic plants in maize. Plant Mol. Biol. 21(3): 415-428.
32. Padidam, M. (2003). Chemically regulated gene expression in plants. Curr. Opin. Plant Biol. 6(2): 169-177.
33. Rakoczy-Trojanowska, M. (2002). Alternative methods of plant transformation: a short review. Cell Mol. Biol. Lett. 7(3): 849-858.
34. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.
35. Richter, L.J., Thanavala, Y., Arntzen, C.J., and Mason, H.S. (2000). Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nat. Biotechnol. 18(11): 1167-1171.
36. Rocha-Sosa, M., Sonnewald, U., Frommer, W., Stratmann, M., Schell, J., and Willmitzer, L. (1989). Both developmental and metabolic signals activate the promoter of a class I patatin gene. EMBO J. 8(1): 23-29.
37. Roslan, H.A., Salter, M.G., Wood, C.D., White, M.R., Croft, K.P., Robson, F., Coupland, G., Doonan, J., Lauifs, P., Tomsett, A.B., and Caddick, M.X. (2001). Characterization of the ethanol-inducible alc-gene expression system in Arabidopsis thaliana. Plant J. 28(2): 225-235.
38. Sanders, P.R., Winter, J.A., Barnason, A.R., Rogers, S.G., and Fraley, R.T. (1987). Comparison of cauliflower mosaic virus 35S and nopaline synthesis promoters in transgenic plants. Nucleic Acids Res. 15(4): 1543-1558.
39. Sharawat, A.K., and Lorz, H. (2006). Agrobacterium-mediated transformation of cereals: a promising approach crossing barriers. Plant Biotechnol. J. 4(6): 575-603.
40. Stemmer, W.P.C., Crameri, A., Ha, K.D., Brennan, T.M., and Heyneker, H.L. (1995). Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Gene: 49-53.
41. Tacket, C.O. (2005). Plant-derived vaccines against diarrheal diseases. Vaccine23(15): 1866-1869.
42. Tompkins, S.M., Lo, C.Y., Tumpey, T.M., and Epstein, S.L. (2004). Protection against lethal influenza virus challenge by RNA interference in vivo. Proc. Natl. Acad. Sci. U. S. A. 101(23): 8682-8686. Epub June 1, 2004.
43. Tomsett, B., Tregova, A., Garoosi, A., and Caddick, M. (2004). Ethanol-inducible gene expression: first step towards a new green revolution? Trends Plant Sci. 9(4): 159-161.
44. Tzfira, T. and Citrovsky, V. (2002). Partners-in-infection: host proteins involved in transformation of plant cells by Agrobacterium. Trends Cell Biol. 12(3): 121-129.
45. Tzfira, T., Li, J., Lacroix, B., and Citovsky, V. (2004). Agrobacterium T-DNA integration: molecules and models. Trends Genet. 20(8): 375-383.
46. Tzfira, T., Citovsky, V. (2006). Agrobacterium-mediated genetic transformation of plants: biology and biotechnology. Curr. Opin. Biotechnol. 17: 147-154.
47. Wada, K., Wada, Y., Ishibashi, F., Gojobori, T., and Ikemura, T. (1992). Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res. 20: 2111-2118.
48. Waterhouse, P. and Helliwell, C. (2003). Constructs and methods for high-throughput gene silencing in plants. Methods 30: 289-295.
49. Yin, Z., Plader, W., and Malepszy, S. (2004). Transgene inheritance in plants. J. Appl. Genet. 45(2): 127-144.
50. Zuo, J., and Chun, N.H. (2000). Chemical-inducible systems for regulated expression of plant genes. Curr. Opin. Biotechnol. 11(2): 146-151.
51. Alvarez, M.L., Pinyerd, H.L., Crisantes, J.D., Rigano, M.M., Pinkhasov, J., Walmsley, A.M., Mason, H.S., and Cardineau, G.A. (2005). Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine 24(14): 2477-2490.
52. Arlen, P.A., Falconer, R., Cherukumilli, S., Cole, A., Cole, A.M., Oishi, K.K., and Daniell, H. (2007). Field production and functional evaluation of chloroplast-derived interferon-alpha2b. Plant Biotechnol. J. 5(4): 511-525.
53. Ashraf, S., Singh, P.K., Yadav, D.K., Shahnawuz, M., Mishra, S., Sawant, S.V., and Tuli, R. (2005). High level expression of surface glycoprotein of rabies virus in tobacco and its immunoprotective activity in mice. J. Biotechnol.119(1): 1-14.
54. Biemelt, S., Sonnewald, U., Galmbacher, P., Willmitzer, L., and Müller, M. (2003). Production of human papillomavirus type-16 virus-like particles in transgenic plants. J. Virol. 77(17): 9211-9220.
55. Boehm, R. (2007). Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann. N.Y. Acad. Sci. 1102: 121-134.
56. Bonis, H.E. (2002). Three criteria for establishing the usefulness of biotechnology for reducing micronutrient malnutrition. Food Nutr. Bull. 23(4): 351-353.
57. Brodzik, R., Glogowska, M., Bandurska, K., Okuliez, M., Deka, D., Ko, K., van der Linden, J., Leusen, J.H., Pogrebnyak, N., Golovkin, M., Steplewski, Z., and Koprowski, H. (2006). Plant-derived anti-Lewis Y MAb exhibits biological activities for immunotherapy against human cancer cells. Proc. Natl. Acad. Sci. U.S.A. 103(23): 8804-8809.
58. Chen, H.F., Chang, M.H., Chiang, B.L., and Jong, S.T. (2006). Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71. Vaccine 24(15): 2944-2951.
59. Chowdhury, K. and Bagasra, O. (2007). An edible vaccine for malaria using transgenic tomatoes of varying sizes, shapes and colors to carry different antigens. Med. Hypotheses 68(1): 22-30.
60. Cramer, C.L., Boothe, J.G., and Oishi, K.K. (1999). Transgenic plants for therapeutic proteins: linking upstream and downstream strategies. Curr. Top. Microbiol. Immunol. 240: 95-118.
61. De Neva, M., De Buck, S., De Wilde, C., Van Houdi, H., Strobbe, I., Jacobs, A., Van, M., and Epicker, A. (1999). Gene silencing results in instability of antibody production in transgenic plants. Mol. Gen. Genet. 260: 582-592.
62. Dhama, K., Chauban, R.S., Mahendran, M., and Malik, S.V. (2008). Rotavirus diarrhea in bovines and other domestic animals. Vet. Res. Commun. 33(1): 1-23.
63. Dong, J.L., Liang, B.G., Jin, Y.S., Zhyang, W.J., and Wang, T. (2005). Oral immunization with pBsVP6-transgenic alfalfa protects mice against rotavirus infection. Virology 339(2): 153-163.
64. Donini, M., Lico, C., Baschieri, S., Conti, S., Magliani, W., Polonelli, L., and Benvenuto, E. (2005). Production of an engineered killer pepetide in Nicotiana benthamiana by using a potato vine virus X expansion system. Appl. Environ. Microbiol. 71(10): 6330-6367.
65. Drake, P.M., Chargelegue, D.M., Vine, N.D., van Dolleweerd, C.J., Obregon, P., and Ma, J.K. (2003). Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots. Plant Mol. Biol. 52: 233-241.
66. Dus Santos, M.J. and Wigdorovitz, A. (2005). Transgenic plants for the production of veterinary vaccines. Immunol. Cell Biol. 83: 229-238.
67. Evangelista, R.L., Kusnadi, A.R., Howard, J.A., and Nikolov, Z.L. (1998). Process and economic evaluation of the extraction and purification of recombinant beta-glucuronidase from transgenic corn. Biotechnol. Progress 14: 807-614.
68. Fischer, R., Schumann, D., Zimmermann, S., Drossard, J., Sack, M., and Schillberg, S. (1999). Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants. Eur. J. Biochem. 262: 810-816.
69. Fischer, R., Twyman, R.M., and Schillberg, S. (2003). Production of antibodies in plants and their use for global health. Vaccine 21(7-8): 820-825.
70. Galeffi, P., Lombardi, A., Donato, M.D., Latini, A., Sperandei, M., Cantale, C., and Giacomini, P. (2005). Expression of single-chain antibodies in transgenic plants. Vaccine 23(15): 1823-1827.
71. Gaume, A., Komamytsky, S., Borisjuk, N., and Raskin, I. (2003). Rhizosecretion of recombinant proteins from plant hairy roots. Plant Cell Rep. 21, 1188-1193.
72. Gil, F., Titarenko, E., Terrada, E., Arcalis, E., and Escribano, J.M. (2006). Successful oral prime-immunization with VP60 from rabbit haemorrhagic disease virus produced in transgenic plants using different fusion strategies. Plant Biotechnol. J. 4(10): 135-143.
73. Golovkin, M., Spitsin, S., Andrianov, V., Smirnov, Y., Xiao, Y., Pogrebnyak, N., Markley, K., Brodzik, R., Gleba, Y., Isaacs, S., and Koprowski, H. (2007). Smallpox subunit vaccine produced in plants confers protection in mice. Proc. Natl. Acad. Sci. U.S.A. 104(16): 6864-6869.
74. Gu, Q., Han, N., Liu, J., and Zhu, M. (2006). Expression of Heliobacter pylori urease subunit B gene in transgenic rice. Biotechnol. Lett. 28(20): 1661-1666.
75. Gutierrez-Ortega, A., Avila-Moreno, F., Saucedo-Arias, L.J., Sanches-Torres, C., and Gómez-Lim, M.A. (2004). Expression of a single-chain human interleukin-12 gene in transgenic tobacco plants and functional studies. Biotechnol. Bioeng. 85(7): 734-740.
76. Gutierrez-Ortega, A., Sandoval-Montes, C., de Olivera-Flores, T.J., Santos-Argumedo, L., Gomez-Lim, M.A. (2005). Expression of functional interleukin-12 from mouse in transgenic tomato plants. Transgenic Res. 14(6): 877-885.
77. Harzecha, H., Mason, H.S., Lane, C., Tryggvesson, A., Rybicki, E., Williamson, A.-L., Clements, J.D., Rose, R.C. (2003). Oral immunogenicity of human papillomavirus-like particles expressed in potato. J. Virol. 77(16): 8702-8711.
78. Hiatt, A., Caffertey, R., and Bowdish, K. (1989). Production of antibodies in transgenic plants. Nature 342: 76-78.
79. Hood, E.E., Woodard, S.L., and Hon, M.E. (2002). Monoclonal antibody manufacturing in transgenic plants: myths and realities. Curr. Opin. Biotechnol.13(6): 630-635.
80. Horvitz, M.A., Simon, P.W., and Tanumihardjo, S.A. (2004). Lycopene and beta-carotene are bioavailable from lycopene ‘rend’ carrots in humans. Eur. J. Clin. Nutr. 58(5): 803-811.
81. Ismaili, A., Jalali-Javaran, M., Rasaee, M.J., Rahbarizadeh, F., Forouzandeh-Maghadam, M., and Memari, H.R. (2007). Production and characterization of anti-(mucin MUC1). single-divalent antibody in tobacco (Nicotiana tabacum cultivar Xanthi). Biotechnol. Appl. Biochem. 47(1): 11-19.
82. Jobling, S.A., Jarman, J., The, M.M., Holmberg, N., Blake, C., and Verhoeyen, M.E. (2003). Immunomodulation of enzyme function in plants by singledomain antibody fragments. Nat. Biotechnol. 21: 77-80.
83. Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., Talwar, G.P., Fiecher, R., and Finnem, R. (2002). Efficacy of plant-produced recombinant antibodies against HCG. Hum. Reprod. 17: 2054-2061.
84. Khoudi, H., Laberge, S., Ferello, J.M., Bazin, R., Darveau, A., Castonguay, Y., Allard, G., Lemieux, R., and Vezina, L.P. (1999). Production of a diagnostic monoclonal antibody in perennial alfalfa plants. Biotechnol. Bioeng. 64: 135-143.
85. Ko, K., Takoah, Y., Rudd, P.M., Harvey, D.J., Dwek, R.A., Spitsin, S., Hanton, C. A., Rupprecht, C., Dietzschold, B., Golovkin, M., and Koprowski, H. (2003). Function and glycosylation of plant-derived antiviral monoclonal antibody. Proc. Natl. Acad. Sci. U.S.A. 100: 8013-8018.
86. Kohl, T., Hitzeroth, I.I., Stewart, D., Varsani, A., Govan, V.A., Christensen, N.D., Williamson, A.-L., and Rybicki, E.P. (2006). Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proof-of-concept study. Clin. Vaccine Immunol. 13(8): 845-853.
87. Koprowski, H. (2005). Vaccines and sera through plant biotechnology. Vaccine23(15): 1757-1763.
88. Korban, S.S., Krasnyanski, S.F., and Busetow, D.E. (2002). Foods as production and delivery vehicles for human vaccines. J. Am. Coll. Nutr. 21(3 Suppl): 2128-2178.
89. Kovacs, K., Zhang, L., Linforth, R.S., Whittaker, B., Hayes, C.J., and Fray, R.G. (2007). Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5), 11(12)-diene] in transgenic tomato fruit. Transgenic Res. 15(1): 121-126.
90. Lai, P., Ramachandran, V.G., Goyal, R., and Sharon, R. (2007). Edible vaccines: current status and future. Indian J. Med. Microbiol. 25(2): 93-102.
91. Lamphear, B.J., Jilka, J.M., Kesl, L., Welter, M., Howard, J.A., and Streatfield, S.J. (2004). A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine 22(19): 2420-2424.
92. Larrick, J.W., Yu, L., Naftzger, C., Jaiswal, S., and Wycoff, K. (2001). Production of secretory IgA antibodies in plants. Biomol. Eng. 18: 87-94.
93. 2+binding allergens from olive pollen exhibit biochemical and immunological activity when expressed in stable transgenic Arabidopsis. FEBS 273(19): 425-434.
94. Li, H.Y., Ramalingam, S., and Chye, M.L. (2006). Accumulation of recombinant SARS-CoCV spike protein in plant cytosol and chloroplasts indicate potential for development of plant-derived oral vaccines. Exp. Biol. Med. (Maywood) 231(8): 1346-1352.
95. Li, J.T., Fei, L., Mon, Z.R., Wei, J., Tang, Y., He, H.Y., Wang, L., and Wu, Y.Z. (2006). Immunogenicity of a plant-derived edible rotavirus subunit vaccine transformed over fifty generations. Virology 356(1-2): 171-178.
96. Liu, J., Dolan, M.C., Reidy, M., and Cramer, C.L. (2008). Expression of bioactive single-chain murine IL-12 in transgenic plants. J. Interferon Cytokine Res.28(6): 381-392.
97. Ludwig, D.L., Witte, L., Hicklin, D.J. Prewett, M., Bassi, R., Burtrum, D., Pereira, D. S., Jimenez, X., Fox, F., Saxena, B., Zhou, Q., Ma, Y., Kang, X., Patel, D., Barry, M., Kussie, P., Zhu, Z., Russell, D.A., Petersen, W.L., Jury, T.P., Gaitan-Gaitan, F., Moran, D.L., Delannay, X., Storrs, B.S., Tou, J., Zupec, M.E., Gustafson, K.S., McIntyre, J., Tarnowski, S.J., and Bohlen, P. (2004). Conservation of receptor antagonist anti-tumor activity by epidermal growth factor receptor antibody expressed in transgenic corn seed. Hum. Antibodies 13(3): 81-90.
98. Ma, J. K.-C., Drake, M.W., Chargelegue, D., Obregon, P., and Prada, A. (2004). Antibody processing and engineering in plants, and new strategies for vaccine production. Vaccine 23(15): 1814-1818.
99. Ma, J.K., Drake, P.M., and Christou, P. (2003). The production of recombinant pharmaceutical proteins in plants. Nat. Rev. Genet. 4: 794-805.
100. Ma, J.K., Hiatt, A., Hein, M., Vine, N.D., Wang, F., Stabila, P., van Dolleweerd, C., Mostov, K., and Lehner, T. (1995). Generation and assembly of secretory antibodies in plants. Science 258: 716-719.
101. Ma, J.K., Hikmat, A., Wycoff, K., Vine, N.D., Charelegue, D., Yu, L., Hein, M.B., and Lehner, T. (1998). Characterization of a recombinant plant monoclonal secretory antibody and preventative immunotherapy in humans. Nat. Med.4: 601-606.
102. Ma, S., Huang, Y., Davis, A., Yin, Z., Mi, Q., Menassa, R., Brandle, J.E., and Jevnikar, A.M. (2005). Production of biologically active human interleukin-4 in transgenic tomato and potato. Plant Biotechnol. J. 3(3): 309-318.
103. Magnuson, N.S., Linzmaier, P.M., Gao, J.W., Reeves, R., An, G., and Lee, J.M. (1996). Enhanced recovery of a secreted mammalian protein from suspension culture of genetically modified tobacco cells. Protein Exp. Purif. 7: 220-228.
104. Martin-Alonso, J.M., Castanon, S., Alonso, P., Parra, F., and Ordas, R. (2003). Oral immunization using tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Res. 12: 127-130.
105. Mayfield, S.P., Franklin, S.E., and Lerner, R.A. (2003). Expression and assembly of a fully active antibody in algae. Proc. Natl. Acad. Sci. U.S.A. 100: 438-442.
106. Miller, T., Fanton, M., and Webb, S. (2004). Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production. World Patent Application WO 2004/098530.
107. Mishra, H.N. and Das, C. (2003). A review on biological control and metabolism of aflatoxin. Crit. Rev. Food Sci. Nutr. 43(3): 245-264.
108. Molidrem, K.L., Li, J., Simon, P.W., and Tanumihardjo, S.A. (2004). Lutein and beta-carotene from lutein-containing yellow carrots are bioavailable in humans. Am. J. Clin. Nutrition 80(1): 131-136.
109. Molina, A., Hervas-Stubbs, S., Daniell, H., Mingo-Castel, A.M., and Veramendi J. (2004). High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnol J. 2(2): 141-153.
110. Molina, A., Veramendi, J., and Hervas-Stubbs, S. (2005). Induction of neutralizing antibodies by a tobacco chloroplast-derived vaccine based on a B cell epitope from canine parvovirus. Virology 342(2): 266-275.
111. Morant, M., Bak, S., Moller, H.L., and Woerck-Reichhart, D. (2003). Plant cytochromes P450: tools for pharmacology, plant protection, and phytoremediation. Curr. Opin. Biotechnol. 14(22): 151-162.
112. Moravec, T., Schmidt, M.A., Herman, E.M., and Woodford-Thomas, T. (2007). Production of Escherichia coli heat labile toxin (LT) B subunit in soybean seed and analysis of its immunogenicity as an oral vaccine. Vaccine 25(9): 1647-1657.
113. Nolke, G., Fischer, R., and Schillberg, S. (2006). Antibody-based metabolic engineering in plants. J. Biotechnol. 124(1): 271-283.
114. Ohya, K., Matsumura, T., Itchoda, N., Ohashi, K., Onuma, M., and Sugimoto, C. (2005). Ability of orally administered IFN-alpha-containing transgenic potato extracts to inhibit Listeria monocyogenes infection. J. Interferon. Cytokine Res. 25(8): 429-466.
115. Parmenter, D.L., Boothe, J.G.H., van Rooijen, G.J. Yeung, E.C., and Maloney, M.M. (1995). Production of biologically active hirudin in plant seeds using oleosin partitioning. Plant Mol. Biol. 29(6): 1167-1180.
116. Peeters, K., De Wilde, C., De Jaeger, G., Angenon, G., and Depicker, A. (2001). Production of antibodies and antibody fragments in plants. Vaccine 19: 2756-2761.
117. Peeters, K., De Wilde, C., and Depicker, A. (2001). Highly efficient targeting and accumulation of a F(ab) fragment within the secretory pathway and apoplast of Arabidopsis thaliana. Eur. J. Biochem. 268: 4251-4260.
118. Pickering, R.J., Smith, S.D., Strugnell, R.A., Wesselingh, S.L., and Webster, D.E. (2006). Crude saponins improve the immune response to an oral plant-made measles vaccine. Vaccine 24: 144-150.
119. Polkinghorne, I., Hamerili, D., Cowan, P., and Duckworth, J. (2005). Plant-based immunocontraceptive control of wildlife—“potentials, limitations and possums.” Vaccine 23(15): 1847-1850.
120. Rice, J., Ainley, W.M., and Shewen, P. (2005). Plant-made vaccines: biotechnology and immunology in animal health. Animal Health Res. Rev. 6(2): 199-209.
121. Rigano, M.M. and Walmsely, A.M. (2005). Expression systems and developments in plant-made vaccines. Immunol. Cell Biol. 83: 271-277.
122. Rigano, M.M., Dreitz, S., Kipnis, A. -P. Izzo, A.A., and Walmsley, A.M. (2006). Oral immunogenicity of a plant-made tuberculosis vaccine. Vaccine 24(6): 691-695.
123. Rodriguez, M., Ramirez, N.I., Ayala, M., Freyre, F., Perez, L., Triguero, A., Mateo, C., Selman-Housein, G., Gavilondo, J.V., and Pujol, M. (2005). Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor. Biotechnol. Bioeng.89(2): 188-194.
124. Santi, L., Huang, Z., and Mason, H. (2006). Virus-like particles production in green plants. Methods 40(1): 66-76.
125. Schillberg, S., Fischer, R., and Emans, N. (2003). Molecular farming of recombinant antibodies in plants. Cell Mol. Life. Sci. 60: 433-445.
126. Schillberg, S., Zimmermann, S., Voss, A., and Fischer, R. (1999). Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum. Transgenic Res. 8: 255-263.
127. Schillberg, S., Fischer, R., and Emans, N. (2003). Molecular farming of recombinant antibodies in plants. Cell Mol. Life Sci. 60(3): 433-445.
128. Schillberg, S., Fischer, R., and Emans, N. (2003). “Molecular farming” of antibodies in plants. Naturwissenschaften 90(4): 145-155.
129. Schouten, A., Roosien, J., Bakker, J., and Schots, A. (2002). Formation of disulfide bridges by a single-chain Fv antibody in the reducing ectopic environment of the plant cytosol. J. Biol. Chem. 277: 19339-19345.
130. Sexton, A., Drake, P.M., Mahmod, N., Harman, S.J., Shattock, R.J., and Ma, J.K-C. (2005). Transgenic plant production of Cyanovirin-N, an HIV microbi-cide. FASEB J. December, express article 10.1096/fj.05-4742fje
131. Sharp, J.M. and Doran, P.M. (2001). Strategies for enhancing monoclonal antibody accumulation in plant cell and organ cultures. Biotechnol. Progress17: 979-992.
132. Shoji, Y., Chichester, J.A., Bi, H., Musiychuk, K., de la Rosa, P., Goldschmidt, L., Horsey, A., Ugulava, N., Palmer, G.A., Mett, V., and Yusibov, V. (2008). Plant-expressed HA as a seasonal influenza vaccine candidate. Vaccine 26 (23): 2930-2934.
133. Song, L., Zhao, D.G., Wu, Y.J., and Li, Y. (2008). Transient expression of chicken alpha interferon gene in lettuce. J. Zhejiang Univ. Sci. B 9(5): 351-355.
134. Streatfield, S.J. (2006). Mucosal immunization using recombinant plant-based oral vaccines. Methods 38(2): 150-157.
135. Stoger, E., Vaquero, C., Torres, E., Sack, M., Nicholson, L., Drossard, J., Williams, S., Keen, D., Perris, Y., Christou, P., and Fischer, R. (2000). Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies. Plant Mol. Biol. 42: 583-590.
136. Stoger, E., Sack, M., Fischer, R., and Christou, P. (2002). Plantibodies: applications, advantages and bottlenecks. Curr. Opin. Biotechnol. 13: 161-166.
137. Tekoah, Y., Ko, H., Koprowski, H., Harvey, D.J., Wormald, M.R., Dwek, R.A., and Rudd, P.M. (2004). Controlled glycosylation of therapeutic antibodies in plants. Arch. Biochem. Biophys. 426: 266-278.
138. Vaquero, C., Sack, M., Schutster, F., Finnern, R., Drossard, J., Schumann, D., Reimann, A., and Fischer, R. (2002). A carcinoembryonic antigen-specific diabody produced in tobacco. FASEB J. 16(3): 408-410.
139. Verch, T., Hooger, D.C., Kiyathin, A., Stephewski, Z., and Koprowski, H. (2004). Immunization with a plant-produced colorectal cancer antigen. Cancer Immunol. Immunother. 53(2): 92-99.
140. Wang, D.M., Zhu, J.B. Peng, M., and Zhou, P. (2008). Induction of a protective antibody response to FMDV in mice following oral immunization with transgenic Stylosanthes spp. as a feedstuff additive. Transgenic Res. (Epub ahead of print).
141. Webster, D.E., Smith, S.D., Pickering, R.J., Strugnell, R.A., Dry, I.B., and Wesselingh, S.L. (2006). Measles virus hemagglutinin protein expressed in transgenic lettuce induces neutralizing antibodies in mice following mucosal vaccination. Vaccine 24(17): 3538-3544.
142. Webster, D.E., Thomas, M.C., Pickering, R., Whyte, A., Dry, I.B., Gorry, P.R., and Wesselingh, S.L. (2005). Is there a role for plant-made vaccines in the prevention of HIV/AIDS? Immunol. Cell Bio. 83(3): 239-247.
143. Wu, H., Singh, N.K., Locy, R.D., Scissum-Gunn, K., and Giambrone, J.J. (2004). Immunization of chickens with VP2 protein of infectious bursal disease virus expressed in Arabidopsis thaliana. Avian Dis. 48: 663-668.
144. Wu, J., Yu, L., Long, L., Hu, J., Zhou, J., and Zhou, X. (2007). Oral immunization with transgenic rice seeds expressing VP2 protein of infectious bursal disease virus induces protective immune responses in chickens. Plant Biotechnol. J. 5(5): 570-578.
145. Wycoff, K.L. (2005). Secretory IgA antibodies from plants. Curr. Pham. Des.11(19): 2429-2437.
146. Xu, B., Copolla, M., Herr, J.C., and Timko, M.P. (2007). Expression of a recombinant human sperm-agglutinating mini-antibody in tobacco (Nicotiana tabacum L.). Soc. Reprod. Fertil. Suppl. 63: b465-477.
147. Yang, Z.Q., Liu, Q.Q., Pan, Z.M., Yu, H.X., and Jiao, X.A. (2007). Expression of the fusion glycoprotein of Newcastle disease virus in transgenic rice and its immunogenicity in mice. Vaccine 25(4): 591-598.
148. Yano, A., Maeda, F., and Takekoshi, M. (2004). Transgenic tobacco cells producing the human monoclonal antibody to hepatitis B virus surface antigen. J. Med. Virol. 73: 208-215.
149. Zhang, B., Yang, Y.H., Lin, Y.M., Rao, Q., Zheng, G.G., and Wu, K.F. (2003). Expression and production of bioactive human interleukin-18 in tobacco plants. Biotechnol. Lett. 19: 1625-1635.
150. Zhang, H., Zhang, X., Liu, M., Zhang, J., Li, Y., and Zheng, C.C. (2006). Expression and characterization of Helicobacter pylori heat-shock protein A (HspA) protein in transgenic tobacco (Nicotiana tabacum) plants. Biotechnol. Appl. Biochem. 43 (Pt.1): 33-38.
151. Zhang, X., Buehner, N.A., Hutson, A.M., Estes, M.K., and Mason, H.S. (2006). Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol. J.4(4): 419-432.
152. Zeitlin, L., Olmsted, S.S., Moench, T.R., Co, M.S., Martinell, B.J., Paradkar, V.M., Russell, D.R., Queen, C., Cone, R., and Whaley, K.J. (1998). A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nat. Biotechnol. 16: 1361-1364.
153. Azthar Aziz, M., Sikriwal, D., Jarugula, S., Kumar, P.A., and Bhatnagar, R. (2005). Transformation of an edible crop with the pagA gene of Bacillus anthracis. FASEB J. 10: 1096-2031.
154. Block, M. D., Schell, J., and Montagu, M.V. (1985). Chloroplast transformation by Agrobacterium tumefaciens. EMBO J. 4: 1367-1372.
155. Bock, R. (2001). Transgenic plastids in basic research and plant biotechnology. J. Mol. Biol. 312: 425-438.
156. Bock, R. and Khan, M.S. (2004). Taming plastids for a green future. Trends Biotechnol. 22(6): 311-318.
157. Bogorad, L. (2000). Engineering chloroplasts: an alternative site for foreign genes, proteins, reactions and products. Trends Biotechnol. 18: 257-263.
158. Chebolu, S. and Daniell, H. (2009). Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly, and functionality. Curr. Top. Microbiol. Immunol. 332: 33-54.
159. Corneille, S. et al. (2001). Efficient elimination of selectable marker genes from the plastid genome by the CRE-lox site-specific recombination system. Plant J. 27: 171-178.
160. Daniell, H. (1999). GM crops: public perception and scientific solutions. Trends Plant Sci. 4(12): 467-469.
161. Daniell, H., Chebolu, S., Kumar, S., Singleton, M., and Falconer, R. (2005a). Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine23: 1779-1783.
162. Daniell, H. and Dhingra, A. (2002). Multigene engineering: dawn of an exciting new era in biotechnology. Curr. Opin. Biotechnol. 13: 1326-1341.
163. Daniell, H., Khan, M.S., and Allison, L. (2002). Milestones in chloroplast genetic engineering: an environmentally friendly era in biotechnology. Trends Plant Sci. 76: 84-91.
164. Daniell, H., Kumar, S., and Dufourmantel, N. (2005a). Breakthrough in chloroplast genetic engineering of agronomically important crops. Trends Biotechnol. 23(5): 238-245.
165. Daniell, H., Lee, S.-B., Panchal, T., and Wiebe, P.O. (2001). Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts. J. Mol. Biol. 311: 1001-1009.
166. Daniell, H. and McFadden, B.A. (1987). Uptake and expression of bacterial and cyanobacterial genes by isolated cucumber etioplasts. Proc. Natl. Acad. Sci U.S.A. 84: 6349-6353.
167. DeGray, G., Rajusokaran, K., Smith, F., Sanford, J., and Daniell, H. (2001). Expression of an antimicrobial peptide via the chloroplast genome to control phytopathogenic bacteria and fungi. Plant Physiol. 127: 852-862.
168. Fernandez-San Millan, A., Mingo-Castel, A., Miller, M., and Daniell, H. (2003). A chloroplast transgenic approach to hyperexpress and purify human serum albumin, a protein highly susceptible to proteolytic degradation. Plant Biotechnol. J. 1: 71-77.
169. Finer, J.J., Finer, K.R., and Ponappa, T. (1999). Particle bombardment mediated transformation. Curr. Top. Microbiol. Immunol. 240: 59-80.
170. Fischer, N. et al. (1996). Selectable marker recycling in the chloroplast. Mol. Gen. Genet. 251: 373-380.
171. Heifetz, P.B. (2000). Genetic engineering of the chloroplast. Biochimie 82: 655-666.
172. Hibbard, J.M. et al. (1998). Transient expression of green fluorescent protein in various plastid types following microprojectile bombardment. Plant J. 16: 627-632.
173. Iamtham, S. and Day, A. (2000). Removal of antibiotic resistance genes from transgenic tobacco plastids. Nat. Biotechnol. 18: 1172-1176.
174. Kang, T.-J., Loe, N.-H., Jang, M.-O., Jang, Y.-S., Kim, Y.-S., Seo, J.-E., and Yang, M.-S. (2003). Expression of the B subunit of E. coli heat-labile enterotoxin in the chloroplasts of plants and its characterization. Transgenic Res. 12: 683-691.
175. Khan, M.S. et al. (1999). Fluorescent antibiotic resistance marker for tracking plastid transformation in higher plants. Nat. Biotechnol. 17: 910-915.
176. Knoblauch, M. et al. (1999). A galinstan expansion femotosyringe for microinjection of eukaryotic organelles and prokaryotes. Nat. Biotechnol. 17: 906-909.
177. Koya, V., Moayeri, M., Leppla, S.H., and Daniell, H. (2005). Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun. 73(12): 8266-8274.
178. Kumar, S. and Daniell, H. (2004). Engineering the chloroplast genome for hyperexpression of human therapeutic antigens. In Recombinant Gene Expression. Methods Molecular Biology, volume 267. New York: Springer.
179. Leelavathi, S. and Reddy, V.S. (2003). Chloroplast expression of His-tagged GUS fusion: a general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors. Mol. Breed. 11: 49-58.
180. Maliga, P. (2003). Progress towards commercialization of plastid transformation technology. Trends Biotechnol. 21(1): 20-28.
181. Maliga, P. (2004). Plastid transformation in higher plants. Annu. Rev. Plant Biol. 55: 289-313.
182. McBride, K.E. et al. (1995). Amplification of a chimeric Bacillus gene in chloro-plasts leads to an extraordinary level of an insecticidal protein in tobacco. Biotechnology (NY) 13: 362-365.
183. Molina, A., Hervds-Stubbs, S., Daniell, H., Mingo-Castel, A.M., and Veramendi, J. (2004). High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnol. J. 2: 141-153.
184. Molina, A. Veramendi, J., and Hervas-Stubbs, S. (2005). Induction of neutralizing antibodies by a tobacco chloroplast-derived vaccine based on a B cell epitope from canine parvovirus. Virology 342: 2666-2675.
185. Quesada-Vargas, T., Ruiz, O.N., and Daniell, H. (2005). Characterization of heterologous multigene operons in transgenic chloroplasts, transcription processing and translation. Plant Physiol. 138: 1746-1762.
186. Ruf, S., Hermann, M., Berger, I.J., Carrer, H., and Bock, R. (2001). Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit. Nat. Biotechnol. 18: 870-875.
187. Staub, J.M., Garcia, B., Graves, J., Hajdukiewicz, P.T.J., Hunter, P., Nehra, N., Paradkar, V., Schlittler, M., Carroll, J.A., Spatola, L., Ward, D., Ve, G., and Russell, D.A. (2000). High yield production of a human therapeutic protein in tobacco chloroplasts. Nat. Biotechnol. 18: 333-338.
188. Staub, J.M. and Maliga, P. (1994). Extrachromosomal elements in tobacco plastids. Proc. Natl. Acad. Sci. U.S.A. 91: 7468-7472.
189. Staub, J.M. and Maliga, P. (1995). Marker rescue from the Nicotiana tabacum plastid genome using a plastid Escherichia coli shuttle vector. Mol. Gen. Genet. 249: 37-42.
190. Svab, Z. and Maliga, P. (1993). High-frequency plastid transformation in tobacco by selection for a chimeric aadA gene. Proc. Natl. Acad. Sci. U.S.A. 90: 913-917.
191. Tregoning, J.S., Nixon, P., Kuroda, H., Svab, Z., Clare, S., Bowe, F., Fairweather, N., Ytterberg, J., van Wijl, K., Dougan, G., and Matiga, P. (2003). Expression of tetanus toxin Fragment C in tobacco chloroplasts. Nucleic Acids Res. 31(4): 1174-1179.
192. Ward, D.V. et al. (2002). Agrobacterium VirE2 gets the VIP1 treatment in plant nuclear import. Trends Plant Sci. 7: 1-3.
193. Watson, J., Koya, V., Leppia, S.H., and Daniell, H. (2004). Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop. Vaccine 22: 4374-4384.
194. Zhou, Y.-X., Lee, M., Ng, J. M.-H., Chye, M.-L., Yip, W.-K., and Lam, E. (2006). A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice. World J. Gastroenterol. 14: 12(2): 306-312.
195. Belanger, H., Fleysh, N., Cox, S. et al. (2000). Human respiratory syncytial virus vaccine antigen produced in plants. FASEB J. 14: 2323-2328.
196. Bendahmane, M., Koo, M., Karrer, E., and Beachy, R.N. (1999). Display of epitopes on the surface of tobacco mosaic virus: impact of charge and isoelectric point of the epitope on virus-host interactions. J. Mol. Biol.290, 9-20.
197. Burton, R.A., Gibeaut, D.M., Bacic, A., Findlay, K., Roberts, K. et al. (2000). Virus-induced silencing of a plant cellulose synthase gene. Plant Cell 12: 691-706.
198. Canizares, M.C., Nicholson, L., and Lomonossoff, G.P. (2005). Use of viral vectors for vaccine production in plants. Immunol. Cell Biol. 83: 263-270.
199. Chapman, S., Kavanagh, T., and Baulcombe, D. (1992). Potato virus X as a vector for gene expression in plants. Plant J. 2(4): 549-557.
200. Charterji, A., Burns, L.L., Taylor, S.S. et al. (2002). Cowpea mosaic virus: from the presentation of antigenic peptides to the display of active biomaterials. Intervirology 45: 362-370.
201. Dalsgaard, K., Uttenthal, A., Jones, T.D., Xu, F., Merryweather, A., and Hamilton, W.D.O. (1997). Plant-derived vaccine protects target animals against viral disease. Nat. Biotechnol. 15: 248-252.
202. Fernandez-Fernandez, M.R., Martinez-Torrecuadrada, J.L., Casal, J.I., and Garcia, J.A. (1998). Development of an antigen presentation system based on plum pox potyvirus. FEBS Lett. 427: 229-235.
203. Fernandez-Fernandez, M.R., Mourino, M., Rivera, J. et al. (2001). Protection of rabbits against rabbit hemorrhagic disease virus by immunization with the VP60 protein expressed in plants with a potyvirus-based vector. Virology280: 283-291.
204. Fitchen, J., Beachy, R.N., and Hein, M.B. (1995). Plant virus expressing hybrid coat protein with added murine epitope elicits autoantibody response. Vaccine, 13: 1051-7.
205. Fitzmaurice, W.P., Holtzberg, S., Lindbo, J.A., Padgett, H.S., Palmer, K.E., Wolfe, G.M., and Pogue, G.P. (2002). Epigenetic modification of plants with systemic RNA viruses. OMICS 6(2): 137-151.
206. Gils, M., Kandzia, R., Marillonnet, S., Kilmyuk, V., and Gleba, Y. (2005). High-yield production of authentic human growth hormone using a plant virus-based expression system. Plant Biotechnol. J. 3(6): 613-620.
207. Gleba, Y., Marillonnet, S., and Klimyuk, V. (2004). Engineering viral expression vectors for plants: the “full virus” and the “deconstructed virus” strategies. Curr. Opin. Plant Biol., 7: 182-188.
208. Gopinanth, K., Wellink, J., Porta, C. et al. (2000). Engineering cowpea mosaic virus RNA-2 into a vector to express heterologous proteins in plants. Virology 267: 159-173.
209. Hamamoto, H., Sugiyama, Y., and Nakagawa, N. et al. (1993). A new tobacco mosaic virus vector and its use for the systemic production of angiotensin-I-converting enzyme inhibitor in transgenic tobacco and tomato. Bio/Technology 11: 930-932.
210. Hefferon, K.L. and Dugdale, B.G. (2003). Independent expression of Rep and RepA and their roles in regulating bean yellow dwarf virus replication J. Gen. Virol. 84: 3465-3472.
211. Hefferon, K.L. and Fan, Y. (2004). Expression of a vaccine protein in a cell line using a geminivirus-based replicon system. Vaccine 23: 404-410.
212. Helliwell, C. and Waterhouse, P. (2003). Constructs and methods for high-throughput gene silencing in plants. Methods 30: 289-295.
213. Holzberg, S., Brosio, P., Gross, C., and Pogue, G.P. (2002). Barley stripe mosaic virus-induced gene silencing in a monocot plant. Plant J. 30: 315-327.
214. Johnson, J., Lin, T., and Lomonosoff, G. (1997). Presentation of heterologous peptides on plant viruses: genetics, structure and function. Annu. Rev. Phytopathol. 35: 67-86.
215. Kopertekh, L., Juttner, G., and Schiemann, J. (2004). PVX-Cre-mediated marker gene elimination from transgenic plants. Plant Mol. Biol. 55(4): 491-500.
216. Koprowski, H. and Yusibov, V. (2001). The green revolution: plants as heterologous expression vectors. Vaccine 19: 2735-2741.
217. Kumangai, M.H., Turpen, T.H., Weinzenttl, N., della-Cioppa, G., Turpen, A.M., and Donson, J. (1993). Rapid, high-level expression of biologically active alpha-trichosanthin in transfected plants by an RNA viral vector. Proc. Natl. Acad. Sci. U.S.A. 90: 427-430.
218. LaComme, C., Hrubikova, K., and Hein, I. (2003). Enhancement of virus-induced gene silencing through viral-based production of inverted-repeats. Plant J. 34: 543-553.
219. LaComme, C., Pogue, G.P., Wilson, T.M.A., and Santa Cruz, S. (2001). Plant viruses as gene expression vectors. In Genetically Engineered Viruses, ed. C.J.A. Ring, E.D. Blair, 59-99. Oxford, UK: BIOS Sci.
220. Lindbo, J.A., Fitzmaurice, W.P., and della-Cioppa, G. (2001). Virus-mediated reprogramming of gene expression in plants. Curr. Opin. Plant Biol. 4, 181-185.
221. Lomonossoff, G.P. and Hamilton, W.D. (1999). Cowpea mosaic virus-based vaccines. Curr. Top. Microbiol. Immunol. 240: 177-189.
222. Lomonossoff, G.P. and Johnson, G.E. (1996). Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines. Curr. Opin. Struct. Biol. 6: 176-182.
223. Lopez-Moya, J.J., Fernandez-Fernandez, M.R., and Cambra, M. et al. (2000). Biotechnological aspects of plum pox virus. J. Biotechnol. 76: 121-136.
224. Lu, R., Martin-Hernandez, A.M., Peart, J.R., Malcuit, I., Baulcombe, D.C. (2003). Virus-induced gene silencing in plants. Methods 30: 296-303.
225. Mallory, A.C., Parks, G., Endres, M.W., Baulecombe, D., Bowman, L.H., Pruss, G.J., and Vance, V.B. (2002). The amplicon-plus system for high-level expression of transgenes in plants. Nat. Biotechnol. 20: 622-625.
226. Marillonnet, S., Giritch, A., Gils, M., Kandzia, R., Klimyuk, V., and Gleba, Y. (2003). In plant engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc. Natl. Acad. Sci. U.S.A. 101(18): 6852-6857.
227. Marillonnet, S., Thoeringer, C., Kandzia, R., Klimyuk, V., and Gleba, Y. (2005). Systemic Agrobacterium tumefaciens-mediated transfection of viral repli-cons for efficient transient expression in plants. Nat. Biotechnol. 10: 1038-.
228. McCormick, A.A., Kumangai, M.H., Hanley, K., Turpen, Y.H., Hakim, I., and Grill, L.K. (1999). Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants. Proc. Natl. Acad. Sci. U.S.A. 96:703-708.
229. Modelska, A., Dietzschold, B., Fleysh, N., Fu, Z.F., Steplewski, K., and Hooper, C. (1998). Immunization against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. U.S.A. 95: 2481-2485.
230. Moon, Y.-S. and Hefferon, K.L. (2005). Geminivirus Replication: Recent Advances in DNA Virus Replication. Transworld Sciences International.
231. Monger, W., Alamillo, J.M., Sola, I., Perrin, Y., Bestagno, M., Burrone, O.R., Sabella, P., Plana-Duran, J., Enjuanes, L., Garcia, J.A., and Lomonossoff, G.P. (2006). An antibody derivative expressed from viral vectors passively immunizes pigs against transmissible gastroenteritis virus infection when supplied orally in crude plant extracts. Plant Biotechnol. J. 4(6): 623-631.
232. Mori, M., Fujihara, N., Mise, K., and Furusawa, I. (2001). Inducible high-level mRNA amplification system by viral replicase in transgenic plants. Plant J. 27(1): 78-86.
233. Natilla, A., Piazolla, G., and Nuzzaci, M. et al. (2004). Cucumber mosaic virus as a carrier of a hepatitis C virus-derived epitope. Arch Virol. 149: 137-154.
234. Perez-Filgueira, D.M., Mozgovoj, M., Wigdorovitz, A., Dus Santos, M.J., Parreno, V., Trono, K., Fernandez, F.M., Carrillo, C., Babiuk, L.A., Morris, T. J., and Borca, M.V. (2004). Passive protection to bovine rotavirus (BRV) infection induced by a BRV VP8 produced in plants using a TMV-based vector. Arch. Virol. 149: 2337-2348.
235. Perez-Filgueira, D.M., Zamorano, P.I., Dominguez, M.G., Taboga, O., Del Medico Zajac, M.P., Puntel, M., Romera, S.A., Morris, T.J., Borca, M.V., Sadir, A.M. (2003). Bovine herpes virus gD protein produced in plants using a recombinant tobacco mosaic virus (TMV) vector possesses authentic antigenicity. Vaccine 21: 4201-4209.
236. Piazolla, G., Nuzzaci, M., and Tortorella, C. et al. (2005). Immunogenic properties of a chimeric plant virus expressing hepatitis C virus (HCV)-derived epitope: new prospects for an HCV vaccine. J. Clin. Immunol. 25: 142-152.
237. Pogue, G.P., Lindbo, J.A., Garger, S.J., and Fitzmaurice, W.P. (2002). Making an ally from an enemy: plant virology and the new agriculture. Annu. Rev. Phytopathol. 40: 45-74.
238. Porta, C., Spall, V.E., Findlay, K.C., Gergerich, R.C., Farrance, C.E., and Lomonossoff, G.P. (2003). Cowpea mosaic virus-based chimeras: effects of inserted peptides on the phenotype, host-range and transmissibility of the modified viruses. Virology 310: 50-63.
239. Porta, C., Spall, W.E., Lin, T., Johnson, J.E., Lomonossoff, G.P. (1996). The development of cowpea mosaic virus as a potential source of novel vaccines. Intervirology 39: 79-84.
240. Porta, C., Spall, V.E., Loveland, J., Johnson, J.E., Barker, P.J., and Lomonossoff, G.P. (1994). Development of cowpea mosaic virus as a high-yielding system for the presentation of foreign peptides. Virology 202: 949-955.
241. Rabindram, S. and Dawson, W.O. (2002). Assessment of recombinants that arise from the use of a TMV-based transient expression vector. Virology 284: 182-189.
242. Robertson, D. (2004). VIGS vectors for gene silencing: many targets, many tools. Annu. Rev. Plant Biol. 55: 495-519.
243. Scholthof, H.B., Scholthof, K.-B.G., and Jackson, A.O. (1996). Plant virus gene vectors for transient expression of foreign proteins in plants. Annu. Rev. Phytopathol. 34: 299-323.
244. Shivprasad, S., Pogue, G.P., Lewandowski, D.J., Hidalgo, J., Donson, J., and Grill, L.K. (1999). Heterologous sequences greatly affect foreign gene expression in tobacco mosaic virus-based vectors. Virology 255: 312-323.
245. Timmermans, M.C.P., Das, O.P., and Messing, J. (1994). Geminiviruses and their uses as extrachromosomal replicons. Annu. Rev. Plant Physiol. Plant. Mol. Biol. 45: 79-112.
246. Toth, R.L., Chapman, S., Carr, F., and Santa Cruz, S. (2001). A novel strategy for the expression of foreign genes from plant virus vectors. FEBS Lett. 489: 215-219.
247. Toth, R.L., Pogue, G.P., and Chapman, S. (2002). Improvement of the movement and host range properties of a plant virus vector through DNA shuffling. Plant J. 30(5): 593-600.
248. Turpen, T.H., Reinl, S.J., Charoenvit, Y., Hoffman, S.L., Fallarme, V., and Grill, L.K. (1995). Malarial epitopes expressed on the surface of recombinant tobacco mosaic virus. Biotechnology 13: 53-57.
249. Uhde, K., Fischer, R., and Commandeur, U. (2005). Expression of multiple foreign epitopes presented as synthetic antigens on the surface of potato virus X particles. Arch. Virol. 150: 327-340.
250. Usha, R., Rohl, J.B., Spall, V.E., Shanks, M., Maule, A.J., Johnson, J.E., and Lomonossoff, G.P. (1193). Expression of an animal virus antigenic site on the surface of a plant virus particle. Virology 197(1): 366-374.
251. Verver, J., Wellink, J., and Van Lent, J. et al. (1998). Studies on the movement of cowpea mosaic virus using the jellyfish green fluorescent protection. Virology 242: 22-27.
252. Voinnet, O., Pinto, Y.M., and Baulcombe, D.C. (1999). Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants. Proc. Natl. Acad. Sci. U.S.A. 96: 14147-14152.
253. Wagner, B., Fuchs, H., Adhami, F., Ma, Y., Scheiner, O., and Breiteneder, H. (2004). Plant virus expression systems for transient production of recombinant allergens in Nicotiana benthamiana. Methods 32: 227-234.
254. Wang, M.B. and Waterhouse, P.M. (2002). Application of gene silencing in plants. Curr. Opin. Plant Biol. 5: 146-150.
255. Waterhouse, P.M. and Helliwell, C.A. (2003). Exploring plant genomes by RNA-induced gene silencing. Nat. Rev. Genet. 4: 29-38.
256. Waterhouse, P.M., Wang, M.B., and Lough, T. (2001). Gene silencing as an adaptive defence against viruses. Nature 411: 834-842.
257. Wigdorovitz, A., Perez Filgueira, D.M., Robertson, N., Carrillo, C., Sadir, A.M., and Morris, TJ. (1999). Protection of mice against challenge with foot and mouse disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1. Virology 255: 312-323.
258. Wu, X., Dinneny, J.R., Crawford, K.M., Rhee, Y., and Citovsky, V. et al. (2003). Modes of intercellular transcription factor movement in the Arabidopsis apex. Development 130: 3735-3745.
259. Yusibov, V., Hooper, D.C., Spitsin, S.V., Fleysh, N., Kean, R.B., Mikheeva, T., Deka, D., Karasev, A., Cox, S., Randall, J., and Koprowski, H. (2002). Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine. Vaccine 20: 3155-3164.
260. Yusibov, V., Mett, V., and Mett, V. et al. (2005). Peptide-based candidate vaccine against respiratory syncytial virus. Vaccine 23: 2261-2265.
261. Yusibov, V., Modelska, A., Steplewski, K., Agadjanyan, M., Weiner, D., and Hooper, C. (1997). Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1. Proc. Natl. Acad. Sci. U.S.A. 94: 5784-5788.
262. Yusibov, V., Shivprasad, S., Turpen, T.H., Dawson, W., and Koprowski, H. (1999). Plant viral vectors based on tobacco mosaic viruses. Curr. Top. Microbiol. Immunol. 240: 81-94.
263. Zelada, A.M., Calamante, G., de la Paz Santangelo, M., Bigi, F., Verna, F., Mentaberry, A., and Cataldi, A. (2006). Expression of tuberculosis antigen ESAT-6 in Nicotiana tabacum using a potato virus X-based vector. Tuberculosis (Edinb.) 86(3-4): 263-267. Epub 2006 Apr. 27.
264. Bakker, H., Bardor, M., Molthoff, J.W., Gomord, V., Elbers, I., Stevens, L., Jordi, W., Lommen, A., Faye, L., Lerouge, P., and Bosch, D. (2001). Galactose-extended glycans of antibodies produced by transgenic plants. Proc. Natl. Acad. Sci. U.S.A. 98(5): 2899-2904.
265. Bardor, M., Faveeuw, C., Fitchettew, A.-C., Gilbert, D., Galas, L., Trottein, F., Faye, L., and Lerouge, P. (2003). Immunoreactivity in mammals of two typical plant glyco-epitopes, core α(1, 3)-fucose and core β(1, 2)-xylose. Glycobiology 13(6): 427-434.
266. Benchabane, M., Goulet, C., Rivard, D., Faye, L., Gomord, V., and Michaud, D. (2008). Preventing unintended proteolysis in plant protein biofactories. Plant Biotechnol. J. 6(7): 633-648.
267. Cabanes-Macheteau, M., Fitchette-Laine, A.-C., Loutelier-Bourhis, C., Lange, C., Vine, N.D., Ma, J.K.C., Lerouge, P., and Faye, L. (1999). N-glycosylation of a mouse IgG expressed in transgenic tobacco plants. Glycobiology 9(4): 365-372.
268. Capell, T., Claparois, L., Del Duca, S., Bassie, L., Miro, B., Rodriguez-Montesinos, J., Christou, P., and Serafini-Fracassini, D. (2004). Producing transglutaminases by molecular farming in plants: minireview article. Amino Acids 26: 419-423.
269. Chargelegue, D., Vine, N.D., van Dolleweerd, C.J., Drake, P.M., and Ma, J.K. (2000). A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice. Transgenic Res. 9: 187-194.
270. Chen, Y., Vandenbussche, F., Rouge, P., Poroost, P, Zeumans, W.J., and Van Damme, E.J.M. (2002). A complex fruit-specific type-2 ribosome-inactivating protein from elderberry (Sambucus nigra) is currently processed and assembled in transgenic tobacco plants. Eur. J. Biochem. 269: 2897-2906.
271. Chen, M., Liu, X., Wang, Z., Song, J., Qi, Q., and Wang, P.G. (2005). Modification of plant N-glycans processing: the future of producing therapeutic protein by transgenic plants. Med. Res. Rev. 25(3): 343-360.
272. Daniell, H., Streatfield, S.J., and Wycoff, K. (2001). Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci. 6(5): 219-226.
273. Denecke, J., Botterman, J., and Deblaere, R. (1990). Protein secretion in plant cells can occur via a default pathway. Plant Cell 2, 51-59.
274. Elbers, I.J.W., Stoopen, G.M., Bakker, H., Stevens, L.H., Bardor, M., Molthoff, J.W., Jordi, W.J.R.M., Bosch, D., and Lommen, A. (2001). Influence of growth conditions and developmental stage on N-glycan heterogeneity of transgenic immunoglobulin G and endogenous proteins in tobacco leaves. Plant Physiol. 126: 1314-1322.
275. Fitchette, A,-C, Cabanes-Macheteau, M., Marvin, L., Martin, B., Stiat-Jeunemaitre, B., Gomord, V., Crooks, K., Lerouge, P., Faye, L., and Hawes, C. (1999). Biosynthesis and immunolocalization of Lewis a-containing N-glycans in the plant cell. Plant Physiol. 121: 333-343.
276. Frigerio, L., Vine, N.D., Pedrazzini, E., Hein, M.B., Wang, F., Ma, J.K.-C, and Vitale, A. (2000). Assembly, secretion and vacuolar delivery of a hybrid immunoglobulin in plants. Plant Physiol. 123: 1483-1493.
277. Galeffi, P., Lombardi, A., Di Donato, M., Latini, A., Sperandei, M., Cantale, C., and Giacomini, P. (2005). Expression of single-chain antibodies in transgenic plants. Vaccine 23: 1823-1827.
278. Gomord, V. and Faye, L. (2004). Posttranslational modification of therapeutic proteins in plants. Curr. Opin. Plant Biol. 7: 171-181.
279. Gomord, V., Chamberlain, P., Jefferis, R., and Faye, L. (2005). Biopharmaceutical production in plants: problems, solutions, and opportunities. Trends Biotechnol. 24(4): 147-149.
280. Joshi, L. and Lopez, L. (2005). Bioprospecting in plants for engineered proteins. Curr. Opin. Biol. 8: 223-226.
281. Ko, K. and Koprowski, H. (2005). Plant biopharming of monoclonal antibodies. Virus Res. 111: 93-100.
282. Ko, K., Techosh, Y., Rudd, P.M., Harvey, D.J., Dwek, R.A., Spitsin, S., Hanlon, C. A., Rupprecht, C., Dietzschold, B., Golovkin, M., and Koprowski, H. (2003). Function and glycosylation of plant-derived antiviral monoclonal antibody. Proc. Natl. Acad. Sci. U.S.A. 100(13): 8013-8018.
283. Larrick, J.W., Yu, L., Naftzger, C., Jaiswal, S., and Wycoff, K. (2001). Production of secretory antibodies in plants. Biomol. Eng. 18: 87-94.
284. Lerouge, P., Cabanes-Macheteau, M., Rayon, C., Fischette-Laine, A.-C., Gomord, V., and Faye, L. (1998). N-glycoprotein biosynthesis in plants: recent developments and future trends. Plant Mol. Biol. 3: 31-48.
285. Lerouge, P., Bardor, M., Pagney, S., Gomord, V., and Faye, L. (2000). N-glycosylation of recombinant pharmaceutical glycoproteins produced in transgenic plants: towards a humanisation of plant N-glycans. Curr. Pharm. Biotechnol. 1: 347-354.
286. Lienard, D., Sourrouille, C., Gomord, V., and Faye, L. (2007). Pharming and transgenic plants. Biotechnol. Annu. Rev. 13: 115-147
287. Ma, J.K.-C. and Hein, M. (1995). Immunotherapeutic potential of antibodies produced in plants. Trends Biotechnol. 13: 522-527.
288. Ma, J.K.-C., Drake, P.M., Chargelgue, D., Obregon, P., and Prada, A. (2005). Antibody processing and engineering in plants, and new strategies for vaccine production. Vaccine 23: 1814-1818.
289. Misaki, R., Kimura, Y., Palacpac, N.Q., Yoshida, S., Fujiyama, K., and Seki, T. (2003). Plant cultured cells expressing human ß1,4-galactosyltransferase secrete glycoproteins with galactose-extended N-linked glycans. Glycobiology 13(3): 199-205.
290. Mokrzycki-Issartel, N., Bouchon, B., Farrat, S., Berland, P., Laparra, H., Madelmont, J.-C., and Theisen, M. (2003). A transient tobacco expression system coupled to MALDI-TOF-MS allows validation of the impact of differential targeting on structure and activity of a recombinant therapeutic glycoprotein produced in plants. FEBS Lett. 552: 170-176.
291. Paccalet, T. et al. (2007). Engineering of a sialic acid synthesis pathway in transgenic plants by expression of bacterial Neu5AC-synthesizing enzymes. Plant Biotechnol. J. 5(1): 16-25.
292. Pagny, S., Cabanes-Macheteau, M., Gilikin, J.W., Leborgne-Castel, N., Lerouge, P., Boston, R.S., Faye, L., and Gomord, V. (2000). Protein recycling from the Golgi apparatus to the endoplasmic reticulum in plants and its minor contribution to calreticulin retention. Plant Cell 12: 739-755.
293. Palacpac, N.Q., Yoshida, S., Sakai, H., Kimura, Y., Fujiyama, K., Yoshida, T., and Seki, T. (1999). Stable expression of human ß1,4-galactosyltransferase in plant cells modifies N-linked glycosylation patterns. Proc. Natl. Acad. Sci. U.S.A. 96: 4692-4697.
294. Rayon, C., Cabanes-Macheteau, M., Loutelier-Bourhis, C., Salliot-Marie, I., Lemoine, J., Reiter, W.-D., Lerouge, P., and Faye, L. (1999). Characterization of N-glycans from Arabidopsis. Application to a fucose-deficient mutant. Plant Physiol. 119: 725-733.
295. Richter, L.J., Thanavala, Y., Arntzen, C.J., and Mason, H.S. (2000). Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nat. Biotechnol. 18: 1167-1171.
296. Saint-Jore-Dupas, C., Faye, L., and Gomord, V. (2007). From planta to pharma with glycosylation in the toolbox. Trends Biotechnol. 25(7): 317-323.
297. Schillberg, S., Fischer, R., and Emans, N. (2003). “Molecular farming” of antibodies in plants. Naturwissenschaften 90: 145-155.
298. Semenza, J.C., Hardwick, K.G., Dean, N., and Pelham, H.R. (1990). ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway. Cell 61: 1349-1357.
299. Shah, M.M., Fojiyama, K., Flynn, C.R., and Joshi, L. (2003). Sialylated endogenous glycoconjugates in plant cells. Nat. Biotechnol. 21(12): 1470-1471.
300. Sojikul, P., Buehner, N., and Mason, H.S. (2003). A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells. Proc. Natl. Acad. Sci. U.S.A. 100(5): 2209-2214.
301. Stoger, E., Sack, M., Tischer, R., and Christou, P. (2002). Plantibodies: applications, advantages and bottlenecks. Curr. Opin. Biotechnol. 13: 161-166.
302. Strasser, R., Altmann, F., Mach, L., Glossl, J., and Steinkellner, H. (2004). Generation of Arabidopsis thaliana plants with complex N-glycans lacking P1,2-linked xylose and core a1,3-linked fucose. FEBS Lett. 561: 132-136.
303. Teloah, Y., Ko, K., Koprowski, H., Harvey, D.J., Wormald, M.R., Dwek, R.A., and Rudd, P.M. (2004). Controlled glycosylation of therapeutic antibodies in plants. Arch. Biochem. Biophys. 426: 266-278.
304. Torres, E., Gonzalez-Melendi, P., Stuger, E., Shaw, P., Twyman, R.M., Nicholson, L., Vaquero, C., Fischer, R., Christou, P., and Perrin, Y. (2001). Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments. Plant Physiol. 127: 1212-1223.
305. Van Ree, R., Cabanes-Macheteau, M., Akkerdaas, J., Milazzo, J.-P., Loutelier-Bourhis, C., Rayon, C., Villalba, M., Koppelman, S., Aalberse, R., Rodriguez, R., Faye, L., and Lerouge, P. (2000). β(1, 2)-xylose and α(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens. J. Biol. Chem. 273(15): 11451-11458.
306. Vitale, A. and Denecke, J. (1999). The endoplasmic reticulum: gateway of the secretory pathway. Plant Cell 11: 615-628.
307. Von Schaewen, A., Sturm, A., O’Neill, J., and Chripeels, M. (1993). Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans. Plant Physiol. 102: 1109-1118.
308. Alvarez, M.L., Pinyerd, H.L., Crisantes, J.D., Rigano, M.M., Pinkhasov, J., Walmsley, A.M., Mason, H.S., and Cardineau, G.A. (2005). Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine 24(14): 2477-2490.
309. Arlen, P.A., Falconer, R., Cherukumilli, S., Cole, A., Cole, A.M., Oishi, K.K., and Daniell, H. (2007). Field production and functional evaluation of chloro-plast-derived interferon-alpha2b. Plant Biotechnol. J. 5(4): 511-525.
310. Azhakanandam, K., Weissinger, S.M., Nicholson, J.S., Qu, R., and Weissinger, A.K. (2007). Amplicon-plus targeting technology (APTT) for rapid production of a highly unstable vaccine protein in tobacco plants. Plant Mol. Biol.63: 393-404.
311. Azhar, A.M., Singh, S., Anand Kumar, P., and Bhutnagar, R. (2002). Expression of protective antigen in transgenic plants: a step towards an edible vaccine against anthrax. Biochem. Biophys. Res. Commun. 299(3): 345-351.
312. Azzoni, A.R., Kusnadi, A.B., Miranda, E.A., and Nikolov, Z.L. (2002). Recombinant aprotinin produced in transgenic corn seed: extraction and purification studies. Biotechnol. Bioeng. 80(3): 268-276.
313. Berghman, L.R., Abi-Ghanem, D., Waghela, S.D. and Ricke, S.C. (2005). Antibodies: an alternative for antibiotics? Symposium: antibiotics in animal feed: are there viable alternatives? 660-666.
314. Boehm, R. (2007). Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann. N.Y. Acad. Sci. 1102: 121-134.
315. Borisjuk, N.V., Borisjuk, L.G., Logendra, S., Petersen, F., Gleba, Y., and Raskin, I. (1999). Production of recombinant proteins in plant root exudates. Nat. Biotechnol. 17(9): 466-469.
316. Cove, D. (2005). The Moss Physcomitrella patens. Annu. Rev. Genet. 39, 339-358.
317. Crofcheck, C., Loiselle, M., Weekley, J., Maiti, I., Pattanaik, S., Bummer, P.M., and Jay, M. (2003). Histidine tagged protein recovery from tobacco extract by foam fractionation. Biotechnol. Prog. 19(2): 680-682.
318. Crofcheck, C., Maiti, I., Pattanaik, S., and Jay, M. (2004). Effect of ion and surfactant choice on the recovery of a histidine-tagged protein from tobacco extract using foam fractionation. Appl. Biochem. Biotechnol. 119(1): 79-92.
319. Daniell, H., Streatfield, S.J., and Wycoff, K. (2001). Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci. 6(5): 219-226.
320. Decker, E.L. and Reski, R. (2007). Moss bioreactors producing improved biopharmaceuticals. Curr. Opin. Biotechnol. 18(5): 393-398.
321. Decker, E.L. and Reski, R. (2008). Current achievements in the production of complex biopharmaceuticals with moss bioreactors. Bioprocess. Biosyst. Eng. 31(1): 3-9.
322. Evangelista, R.L., Kusnadi, A.R., Howard, J.A., and Nikolov, Z.L. (1998). Process and economic evaluation of the extraction and purification of recombinant beta-glucuronidase from transgenic corn. Biotechnol. Prog. 14(4): 607-614.
323. Fischer, R. Emans, N., Schuster, F., Hellwig, S., and Drossard, J. (1999). Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors. Biotechnol. Appl. Biochem. 30(Pt. 2): 109-112.
324. Fischer, R., Stoger, E., Schillberg, S., Christou, P., and Twyman, R.M. (2004). Plant-based production of biopharmaceuticals. Curr. Opin. Plant Biol. 7: 152-158.
325. Floss, D.M., Sack, M., Stadlmann, J., Rademacher, T., Scheller, J., Stoger, E., Fischer, R., and Conrad, U. (2008). Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants. Plant Biotechnol. J. Epub ahead of print.
326. Gao, J., Hooker, B.S., and Anderson, D.B. (2004). Expression of functional human coagulation factor XIII A-domain in plant cell suspension s and whole plants. Protein Exp. Purif. 37(1): 89-96.
327. Giddings, G., Allison, G., Brooks, D., and Carter, A. (2000). Transgenic plants as factories for biopharmaceuticals. Nat. Biotechnol. 18: 1151-1156.
328. Girard, L.S., Fabis, M.J., Bastin, M., Courtois, D., Petiard, V., and Koprowski, H. (2006). Expression of a human anti-rabies virus monoclonal antibody in tobacco cell culture. Biochem. Biophys. Res. Commun. 345(2): 602-607.
329. Guillon, S.M., Tremoulliaux-Guiller, J., Kumar Pati, P., Rideau, M., and Gantet, P. (2006). Harnessing the potential of hairy roots: dawn of a new era. Trends Biotechnol. 24(9): 403-409.
330. Hefferon, K.L. and Fan, Y. (2004). Expression of a vaccine protein in plants using a geminivirus-based replicon system. Vaccine 23(3): 404-410.
331. Hellwig, S., Drossard, J., Twyman, R.M., and Fischer, R. (2004). Plant cell cultures for the production of recombinant proteins. Nat. Biotechnol. 22(11): 1415-1422.
332. Hilleman, M.R. (2002). Overview: cause and prevention in biowarfare and bioterrorism. Vaccine 20(25-26): 3055-3067.
333. Hood, E.E. and Jilka, J.M. (1999). Plant-based production of xenogenic proteins. Curr. Opin. Biotechnol. 10(4): 382-386.
334. Hood, E.E., Kusnadi, A., Nikolov, Z., and Howard, J.A. (1999). Molecular farming of industrial proteins from transgenic maize. Adv. Exp. Med. Biol. 464: 127-147.
335. Kuhner, B., Alcantara, J. Boothe, J., van Rooijen, G., and Moloney, M. (2003). Precise and efficient cleavage of recombinant fusion proteins using mammalian aspartic proteases. Protein Eng. 16(10): 777-783.
336. Kusnadi, A.R., Hood, E.E., Witcher, D. R., Howard, J.A., and Nikolov, Z.L. (1998). Production and purificationof two recombinant proteins from transgenic corn. Biotechnol. Prog. 14(1): 149-155.
337. Kwon, T.H., Kim, Y.S., Lee, J.H., and Yang, M.S. (2003). Production and secretion of biologically active human granulocyte-macrophage colony stimulating factor in transgenic tomato suspension cultures. Biotechnol. Lett. 25(18): 1571-1574.
338. Lai, P., Ramachandran, V.G., Goyal, R., and Sharma, R. (2007). Edible vaccines: current status and future. Indian J. Med. Microbiol. 25(2): 93-102.
339. Larrick, J.W. and Thomas, D.W. (2003). Producing proteins in transgenic plants and animals. Curr. Opin. Biotechnol. 12: 411-418.
340. Lin, M., Rose-John, S., Gotzinger, J., Conrad, U., and Scheller, J. (2006). Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling. Biochem. J. 398: 577-583.
341. Ma, J.K.-C, Barros, E., Bock, R., Christou, P., Dale, P.J., Dix, P.J., Fischer, R., Irwin, J., Mahoney, R., Pezzotti, M., Schillberg, S., Sparrow, P., Stoger, E., and Twyman, R.M. (2005). Molecular farming for new drugs and vaccines. EMBO Rep. 6(7): 593-599.
342. Magnuson, N.S., Linzmaier, P.M., Reeves, R., An, G., HayGlass, K., and Lee, J.M. (1998). Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture. Protein Exp. Purif. 13(1): 45-52.
343. Medina-Bolivar, F. and Cramer, C. (2004). Production of recombinant proteins by hairy roots cultured in plastic sleeve bioreactors. Methods Mol. Biol. 267: 351-363.
344. Menkhaus, TJ., Bai, Y., Zhang, C., Nikolov, Z.L., and Glatz, C.E. (2004). Considerations for the recovery of recombinant proteins from plants. Biotechnol Prog. 20(4): 1001-1014.
345. Modelska, A., Dietzschold, B., Fleysh, N., Fu, Z.F., Steplewski, K., and Hooper, C. (1998). Immunization against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. U.S.A., 95: 2481-2485.
346. Monger, W., Alamillo, J.M., Sola, I., Perrin, Y., Bestagno, M., Burrone, O.R., Sabella, P., Plana-Duran, J., Enjuanes, L., Garcia, J.A., and Lomonossoff, G.P. (2006). An antibody derivative expressed from viral vectors passively immunizes pigs against transmissible gastroenteritis virus infection when supplied orally in crude plant extracts. Plant Biotechnol J. 4(6): 623-631.
347. Perez-Filgueira, D.M., Zamorano, P.I., Dominguez, M.G., Taboga, O., Del Medico Zajac, M.P., Puntel, M., Romera, S.A., Morris, TJ., Borca, M.V., and Sadir, A.M. (2003). Bovine herpes virus gD protein produced in plants using a recombinant tobacco mosaic virus (TMV) vector possesses authentic antigenicity. Vaccine 21: 4201-4209.
348. Platis, D. and Lebrou, N.E. (2006). Development of an aqueous two-phase partitioning system for fractionating therapeutic proteins from tobacco extract. J. Chromatogr. A 1128(1-2): 114-124.
349. Platis, D., and Labrou, N.E. (2008). Affinity chromatography for the purification of therapeutic proteins from transgenic maize using immobilized histamine. J. Sep. Sci. 31(4): 636-643.
350. Pogue, G.P., Lindbo, J.A., Garger, S.J., and Fitzmaurice, W.P. (2002). Making an ally from an enemy: plant virology and the new agriculture. Annu. Rev. Phytopathol. 40: 45-74.
351. Pujol, M., Ramírez, N.I., Ayala, M., Gavilondo, J.V., Valdés, R., Rodríguez, M., Brito, J., Padilla, S., Gómez, L., Reyes, B., Peral, R., Pérez, M., Marcelo, J.L., Milá, L., Sánchez, R.F., Páez, R., Cremata, J.A., Enriquez, G., Mendoza, O., Ortega, M., and Borroto, C. (2005). An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine production. Vaccine 23(15): 1833-1837.
352. Rice, J., Ainsley, W.M., and Showen, P. (2005). Plant-made vaccines: biotechnology and immunology in animal health. Anim. Health Res. Rev. 6(2): 199-209.
353. Rigano, M.M. and Walmsley, A.M. (2005). Expression systems and developments of plant-made vaccines. Immunol. Cell Biol. 83: 271-277.
354. Santi, L., Huang, Z., and Mason, H. (2006). Virus-like particles production in green plants. Methods 40(1): 66-76.
355. Schillberg, S., Twyman, R.M., and Fischer, R. (2005). Opportunities for recombinant antigen and antibody expression in transgenic plants-technology assessment. Vaccine 23: 1764-1769.
356. Schinkel, H., Schiermeyer, A., Soeur, R., Fischer, R., and Schillberg, S. (2005). Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells. Transgenic Res. 14(3): 251-259.
357. Schmale, K., Rademacher, T., Fischer, R., and Hellwig, S. (2006). Towards industrial usefulness—cryo-cell-banking of transgenic BY-2 cell cultures. J. Biotechnol. 104(1): 302-311.
358. Shin, Y.J., Hong, S.Y., Kwon, T.H., Jang, Y.S., and Yang, H.S. (2003). High level of expression of recombinant human granulocyte-macrophage colony stimulating factor in transgenic rice cell suspension culture. Biotechnol. Bioeng.B82(7): 778-783.
359. Smith, M.L., Mason, H.S. and Shuler, M.L. (2002). Hepatitis B surface antigen (HbsAg) expression in plant cell cultures: kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnol. Bioeng. 80(7): 612-619.
360. Sparrow, P.A., Irwin, J.A., Dale, P.I., Twyman, R.M., and Ma, J.K. (2007). Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals. Transgenic Res. 16(2): 147-161.
361. Takeda, Y., Hirokawa, H., and Nagata, T. (1992). The replication origin of proplas-tid DNA in cultured cells of tobacco. Mol. Gen. Genet. 232(2): 191-198.
362. Thomas, B.R., van Deynze, A., and Bradford, K.J. (2002). Production of Therapeutic Proteins in Plants. Agricultural Biotechnology in California Series, Publication 8078.
363. Trexler, M.M., McDonald, K.A., and Jackman, A.P. (2005). A cyclical semicontinuous process for production of human alpha 1-antitrypsin using metabolically induced plant cell suspension cultures. Biotechnol. Prog. 21(2): 321-328.
364. Turpen, T.H., Reinl, S.J., Charoenvit, Y., Hoffman, S.L., Fallarme, V., and Grill, L.K. (1995). Malarial epitopes expressed on the surface of recombinant tobacco mosaic virus. Biotechnology, 13: 53-57.
365. Twyman, R.M., Stoger, E., Schillberg, S., Christou, P., and Fischer, R. (2003). Molecular farming in plants: host systems and expression technology. Trends Biotechnol. 21(12): 570-579.
366. Wagner, B., Fuchs, H., Adhami, F., Ma, Y., Scheiner, O. and Breiteneder, H. (2004). Plant virus expression systems for transient production of recombinant allergens in Nicotiana benthamiana. Methods 32: 227-234.
367. Walsh, G. (2006). Biopharmaceutical benchmarks. Nat. Biotechnol. 24: 769-776.
368. Woodard, S.L., Mayor, J.M., Bailey, M.R., Barker, D.K., Love, R.T., Lane, J.R., Delaney, D.E., McComas-Wagner, J.M., Mallubhotla, H.D., Hood, E.E., Dangott, L.J., Tichy, S.E., and Howard, J.A. (2003). Maize (Zea mays)-derived bovine trypsin: characterization of the first large-scale, commercial protein product from transgenic plants. Biotechnol. Appl. Biochem. 28(Pt. 2): 123-130.
369. Wu, X., Dinneny, J.R., Crawford, K.M., Rhee, Y., Citovsky, V., Zambryski, P.C., and Weigel, D. (2003). Modes of intercellular transcription factor movement in the Arabidopsis apex. Development 130: 3735-3745.
370. Zhong, Q., Xu, L., Zhang, C., and Glatz, C.E. (2007). Purification of recombinant aprotinin from transgenic corn germ fraction using ion exchange and hydrophobic interaction chromatography. Appl. Microbiol. Biotechnol. 76(3): 607-613.
371. Alvarez, M.L., Pinyerd, H.L, Crisantes, J.D., Rigano, M.M., Pinkhasov, J., Walmsley, A.M., Mason, H.S., and Cardineau, G.A. (2005). Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine 24(14): 2477-2490.
372. Aziz, M.A., Singh, S., Kumar, P.A., and Bhatnagar, R. (2002). Expression of protective antigen in transgenic plants: a step towards edible vaccine against anthrax. Biochem. Biophys. Res. Commun. 299: 345-351.
373. Beyer, A., Wang, K., Umble, A.N., Wolt, J.D., and Cunnick, J.E. (2007). Low-dose exposure and immunogenicity of transgenic maize expressing the Escherichia coli heat-labile toxin B subunit. Environ. Health Perspect.115(3): 354-360.
374. Biemelt, S., Sonnewald, U., Galmbacher, P., Willmitzer, L., and Muller, M. (2003). Production of human papillomavirus type 16 virus-like particles in transgenic plants. J. Virol. 77(17): 9211-9220.
375. Botturi, K., Vervloet, D., and Magnan, A. (2007). T cells and allergens relationships: are they that specific? Clin Exp. Allergy. 37(8): 1121-1123.
376. Brennan, F.R., Bellaby, T., Helliwell, S.M., Jones, T.D., Kamstrup, S., Dalsgaard, K., Flock, J.-I., and Hamilton, D.O. (1999). Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice. J. Virol. 73(2): 930-938.
377. Brodzik, Glogowska, M., Bandurska, K., Okulicz, M., Deka, D., Ko, K., van der Linden, J., Leusen, J.H.W., Pogrebnyak, N., Golovkin, M., Steplewski, Z., and Koprowski, H. (2006). Plant-derived anti-Lewis Y MAb exhibits biological activities for efficient immunotherapy against human cancer cells. Proc. Natl. Acad. Sci. U.S.A. 103(923): 8804-8809.
378. Chalmers, W.S.K. (2006). Overview of new vaccines and technologies. Veterinary Microbiol. 117: 25-31.
379. Chikwamba, R., Cunnick, J., Hathaway, D., McMurray, J., Mason, H., and Wang, K. (2002). A functional antigen in a practical crop: LT-B producing maize protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT). Transgenic Res. 11(5): 479-493.
380. Clavel, T. and Haller, D. (2007). Molecular interactions between bacteria, the epithelium, and the mucosal immune system in the intestinal tract: implications for chronic inflammation. Curr. Issues Intestinal Microbiol. 8(2): 25-43.
381. Corthesy, B. (2007). Roundtrip ticket for secretory IgA: role in mucosal homeostasis? J. Immunol. 178: 27-32.
382. Daniell, H., Lee, S.-B., Panchal, T., and Wiebe, P.O. (2001). Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts J. Mol. Biol. 311: 1001-1009.
383. Faria, A.M. and Weiner, H.L. (2006). Oral tolerance: therapeutic implications for autoimmune diseases. Clin. Dev. Immunol. 13(2-4): 143-157.
384. Fazilleau, N., McHeyzer-Williams, L.J., and McHeyzer-Williams M.G. (2007). Local development of effector and memory T helper cells. Curr. Opin. Immunol. 19(3), 259-267. Epub 2007 Apr 8.
385. Foss, D.L. and Murtaugh, M.P. (2000). Mechanisms of vaccine adjuvanticity at mucosal surfaces. Anim. Health Res. Rev. 1(1): 3-24.
386. Hajishengallis, G., Arce, S., Gockel, C.M., Connell, T.D., and Russell, M.W. (2005). Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: applications for oral infections. J. Dental Res. 84(12): 1104-1116.
387. Huang, Y., Liang, W., Pan, A., Zhou, Z., Huang, C., Chern, J., and Zhang, D. (2003). Production of FaeG, the major subunit of K88 fimbriae, in transgenic tobacco plants and its immunogenicity in mice. Infect. Immun. 71(9): 5436-5439.
388. Janeway, C.A. et al. (eds.). (1999). Immunobiology. The Immune System in Health and Disease, 4th ed., New York: Garland.
389. Judge, N.A., Mason, H.S., and O’Brien, A.D. (2004). Plant cell-based intimin vaccine given orally to mice primed with intimin reduces times of Escherichia coli O157:H7 shedding in feces. Infect. Immun. 72(1): 168-175.
390. Kang, W. and Kudsk, K.A. (2007). Is there evidence that the gut contributes to mucosal immunity in humans? J. Parenter. Gen. Nutr. 31(3): 246-258.
391. Kohl, T., Hitzweoth, I.I., Stewart, D., Varsani, A., Govan, V.A., Christensen, N.D., Williamson, A.-L., and Rybicki, E.P. (2006). Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proof of concept study. Clin. Vaccine Immunol. 13(8): 845-853.
392. Kong, Q., Richter, L., Yang, Y.F., Arntzen, C., Mason, H.S., and Thanavala, Y. (2001). Oral administration with hepatitis B surface antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. U.S.A. 98(20): 11539-11544.
393. Koya, V., Moayeri, M., Leppin, S.H., and Daniell, H. (2005). Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun. 73(12): 8266-8274.
394. Lamphear, B.J., Jilka, J.M., Kesl, L., Welt, M., Howard, J.A., and Streatfield, S.J. (2004) A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine 22(19): 2420-2424.
395. Lauterslager, T.G., Florack, D.E., van der Wal, T.J., Molthoff, J.W., Langeveld, J.P., Bosch, D., Boersma, W.J., Hilgers, L.A. (2001). Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B. Vaccine 19: 2749-2755.
396. Lauterslager, T.G.M. and Hilgers, L.A.T. (2002). Efficacy of oral administration and oral intake of edible vaccines. Immunol. Lett. 84: 183-190.
397. Lee, J.-Y., Yu, J., Henderson, D., Langridge, W.H.R. (2004). Plant-synthesized E. coli CFA/I fibrial protein protects Caco-2 cells from bacterial attachment. Vaccine 23(2): 222-231.
398. Limaye, A., Koya, V., Samsam, M., and Daniell, H. (2006). Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J. 20(7): 959-961.
399. Lu, B. (2006). The molecular mechanisms that control function and death of effector CD4+ T cells. Immunol. Res. 36(1-3): 275-282.
400. Lu, D. and Hickey, A.J. (2007). Pulmonary vaccine delivery. Expert Rev. Vaccines6(2): 213-226.
401. Macperson, A.J. and Uhr, T. (2004) Compartmentalization of the mucosal immune responses to commensal intestinal bacteria. Ann. NY Acad. Sci.1029: 36-43.
402. Mason, H.S., Ball, J.M., Jian-Jian Shi, Jiang, X., Estes, M.K., and Arntzen, C.J. (1996). Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc. Natl. Acad. Sci. U. S. A. 93: 5335-5340.
403. Martin-Alonso, J.M., Castanon, S., Alondso, P., Patra, F., and Ordas, R. (2003). Oral immunization using tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Res. 12: 127-130.
404. Modelska, A., Dietzschold, B., Sleysh, N., Fu, Z.F., Steplewski, K., Hoopwer, D.C., Koprowski, H., and Yusibov, V. (1998). Immunization against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. U.S.A. 95: 2481-2485.
405. Molina, A., Veramendi, J., and Hervas-Stubbs, S. (2005). Induction of neutralizing antibodies by a tobacco chloroplast-derived vaccine based on a B-cell epitope from canine parvovirus. Virology 342 (2): 266-275.
406. Montufar-Sulis, D., Garza, T., and Klein, J.R. (2007). T-cell activation in the intestinal mucosa. Immunol. Rev. 215: 189-201.
407. Ogra, P., Faden, H., and Welliver, R.C. (2001) Vaccination strategies for mucosal immune responses. Clin. Microbiol. Rev. 14(2): 430-445.
408. Parham, P. (2005). The Immune System, 2nd ed. New York: Garland Science.
409. Pickering, R.J., Smith, S.D., Strugnell, R.A., Wesselingh, S.L., and Webster, D.E. (2006). Crude saponins improve the immune response to an oral plant-made measles vaccine. Vaccine 24: 144-150.
410. Pogrebnyak, N., Golovkin, M., Andrianov, V., Spitsin, S., Smirnov, Y., Egolf, R., and Koprowski, H. (2005). Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine. Proc. Natl. Acad. Sci. U.S.A. 102(25): 9062-9067.
411. Prlic, M. and Bevan, M.J. (2006). An antibody paradox, resolved. Science311(5769):1875-1876.
412. Reiner, S.L. (2007). Development in motion: helper T cells at work. Cell 6,129(1): 33-36.
413. Rigano, M.M., Dreitz, S., Kipnis, A.-P., Izzo, A.A., and Walmsley, A.M. (2005). Oral immunogenicity of a plant-made subunit tuberculosis vaccine. Vaccine24(5): 691-695.
414. Roitt, I. et al. (eds.). (2002). Immunology, 5th ed. London: Mosby.
415. Rojas, R. and Apodaca, G. (2002). Immunoglobulin transport across polarized epithelial cells. Nat. Rev. Mol. Cell Biol. 3: 1-12.
416. Sandhu, J.S., Krasnyanski, S.F., Domier, L.L., Korban, S.S., Osadjan, M.D., and Buetow, D.E. (2000). Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response. Transgenic Res. 9(2): 127-135.
417. Shoji, Y., Chichester, J.A., Bi, H., Musiychuk, K., de la Rosa, P., Goldschmidt, L., Horsey, A., Ugulava, N., Palmer, G.A., Mett, V., and Yusibov, V. (2008). Plant-expressed HA as a seasonal influenza vaccine candidate. Vaccine26(23): 2930-2934.
418. Smart, V., Foster, P.S., Rothenbwerg, M.E., Higgens, T.J., and Hogan, S.P. (2003). A plant-based allergy vaccine suppresses experimental asthma via an IFN-gamma and CD4+CD45Rblow T cell-dependent mechanism. J. Immunol.171(4): 2116-2126.
419. Streatfield, S.J. (2005a). Mucosal immunization using recombinant plant-based oral vaccines. Methods. 38(2): 150-157.
420. Streatfield, S.J. (2006). Delivery of plant-derived vaccines. Exp. Opin. Drug Delivery 2(4): 719-728.
421. Streatfield, S.J., Jilka, J.M., Hood, E.E., Turner, D.D., Bailey, M.R., Mayor, J.M., Woodard, S.L., Beifuss, K.K., Horn, M.E., Delaney, D.E., Tizard, I.R., and Howard, J.A. (2001). Plant-based vaccines: unique advantages. Vaccine 19: 2742-2748.
422. Tacket, C.O. (2007). Plant-based vaccines against diarrheal diseases. Trans. Am. Climatol. Assoc. 118: 79-87.
423. Tacket, C.O. (2009). Plant-based oral vaccines: results of human trials. Curr. Top. Micro. Immunol. 332: 103-117.
424. Tacket, C.O., Passeti, M.F., Edelman, R.E., Howad, J.A., and Streeatfield, S.J. (2004). Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn. Vaccine 22: 4385-4389.
425. Takagi, H., Hiroi, T., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., and Takaiwa, F. (2005). A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. PNAS 102(48): 17525-17530.
426. Thanavala, Y., Mahoney, M., Pal, S., Scott, A., Richter, L., Natarajan, N., Goodwin, P., Arntzen, C.J., and Mason, H.S. (2005). Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci. U.S.A.102(9): 3378-3382.
427. Thanavala, Y, Huang, Z., and Mason, H. (2006). Plant-derived vaccines: a look back at the highlights and a view to the challenges on the road ahead. Exp. Rev. Vaccines 5(2): 249-260.
428. Tregoning, J.S., Clare, S., Bowe, F., Edwards, L., Fairweather, N., Qazi, O., Nixon, P.J., Maliga, G., Dougan, G., Hussell, T. (2005). Protection against tetanus toxin using a plant-based vaccine. Eur. J. Immunol. 35: 1320-1326.
429. Twigg, H.L. (2005). Humoral immune defence (antibodies). Proc. Am. ThoracicSoc. 2: 417-421.
430. Vajdy, M. (2006). Generation and maintenance of mucosal memory B cell responses? Curr. Med. Chem. 13(25): 3023-3037.
431. Walker, R.I. (1994). New strategies for using mucosal vaccination to achieve more effective immunization. Vaccine 12(5): 387-400.
432. Warzecha, H., Mason, H.S., Lane, C., Tryggvesson, A., Rybicki, E., Williamson, A.-L., Clements, J.D., and Rose, R.C. (2005). Oral immunogenicity of human papillomavirus-like particles expressed in potato. J. Virol. 77(16): 8702-8711.
433. Webster, D.E., Cooney, M.L., Huang, Z., Drew, D.R., Ramshaw, I.A., Dry, I.B., Strugnell, R.A., Martinm, J.L., and Wesselingh, S. L. (2002). Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine. J. Virol. 76(15): 7910-7912.
434. Webster, D.E., Smith, S.D., Pickering, R.J., Strugnell, R.A., Dry, I.B., and Wesselingh, S.L. (2006). Measles virus hemagglutinin protein expressed in transgenic lettuce induces neutralising antibodies in mice following mucosal vaccination. Vaccine 24(17): 3544-3548.
435. Wigdorovitz, A., Carrillo, C., Dus Santos, M.J., Trono, K., Peralta, A., Gomez, M.C., Rios, R.D., Franzone, P.M., Sadir, A.M., Escribano, J.M., and Borca, M.V. (1999) Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the structural protein VP1. Virology 255: 347-353.
436. Woodfolk, J.A. (2007). T-cell responses to allergens. J. Allergy Clin. Immunol.119(2): 280-294.
437. Yusibov, V., Shivprasad, S., Turpen, T.H., Dawson, W., and Koprowski, H. (1999). Plant viral vectors based on tobamoviruses. Curr. Top. Microbiol. Immunol.240: 81-94.
438. Ciliberti, R. and Molinelli, A. (2005). Towards a GMO discipline: ethical remarks. Veterinary Res. Commun. 29(Suppl. 2): 27-30.
439. Conner, A.J. and Jacobs, J.M.E. (1999). Genetic engineering of crops as potential source of genetic hazard in the human diet. Mutation Res. 443: 223-234.
440. Dale, P.J., Clarke, B., and Fontes, E.M.G. (2002). Potential for the environmental impact of transgenic crops. Nat. Biotechnol. 20(6): 567-574.
441. Daniell, H. (2002). Molecular strategies for gene containment in transgenic crops. Nat. Biotechnol. 20: 581-586.
442. Davies, H.V. (2005). GM organisms and the EU regulatory environment: allergenicity as a risk component. Proc. Nutr. Soc. 64: 481-486.
443. De Wilde, C., Van Houdt, H., De Buck, S., Angenon, G., De Jaeger, G., and Depicker, A. (2000). Plants as bioreactors for protein production: avoiding the problem of transgene silencing. Plant Mol. Biol. 43: 347-358.
444. Docket 02D-0324 Drugs, Biologics and Medical Devices derived from bioengineered plants Comment Number: EC-43: volume 9.
445. Farrow, S. (2004). Using risk assessment, benefit-cost analysis, and real options to implement a precautionary principle. Risk Anal. 24(3): 727-738.
446. Garrick, D., Fiering, S. Martin, D.I., and Whitelaw, E. (1998). Repeat-induced gene silencing in mammals. Nat. Genet. 18(1): 56-59.
447. Gepts, P. and Papa, R. (2003). Possible effects of (trans)gene flow from crops on the genetic diversity from land races and wild relatives. Environ. Biosafety Res. 2: 89-103.
448. Goldstein, D.A. and Thomas, J.A. (2004). Biopharmaceuticals derived from genetically modified plants. Q. J. Med. 97: 705-716.
449. Howard, J.A. and Donnelly, K.C. (2004). A quantitative safety assessment model for transgenic protein products produced in agricultural crops. J. Agric. Environ. Ethics 17: 545-558.
450. Jaffe, G. (2004a). Sowing Secrecy: The Biotech Industry, USDA, and America’s Secret Pharm Belt. Washington, DC: Center for Science in the Public Interest.
451. Jaffe, G. (2004b). Regulating transgenic crops: a comparative analysis of different regulatory processes. Transgenic Res. 13: 5-19.
452. Jones, P.B.C. (2004). Plant-made pharmaceuticals: progress and protests. ISB News Report. Information Systems for Biotechnology. October Issue.
453. Kirk, D.D., McIntosh, K., Walmsley, A.M., and Peterson, R.K.D. (2005). Risk analysis for plant-made vaccines. Transgenic Res. 14: 449-462.
454. Ma, J.K.-C., Drake, P.M.W., and Christou, P. (2003). The production of recombinant pharmaceutical proteins in plants. Nat. Rev. Genet. 4: 172-185.
455. Ma, J.K.-C., Chikwamba, R., Sparrow, P., Fischer, R., Mahoney, R., and Twyman, R.M. (2005). Plant-derived pharmaceuticals: the road forward. Trends Plant Sci. 10(12), 580-585.
456. Mascia, P.N. and Flavell, R.B. (2004). Safe and acceptable strategies for producing foreign molecules in plants. Curr. Opin. Plant Biol. 7: 189-195.
457. Miele, L. (1997). Plants as bioreactors for biopharmaceuticals: Regulatory considerations. Trends Biotechnol. 15: 45-50.
458. Miller, H.J. and Longtin, D. (2006). Down on the Biopharm. Policy Review Online
459. Miraglia, M., Berdal, K.G., Brera, C., Corbisier, P., Holst-Jensen, A., Kok, E.J., Marvin, H.J.P., Schimmel, H., Rentsch, J., van Rie, J.P.P.F., and Zagon, J. (2004). Detection and traceability of genetically modified organisms in the food production chain. Food Chem. Toxicol. 42: 1157-1180.
460. Peterson, R.K.D. (2000). Public perception of agricultural biotechnology and pesticides: recent understandings and implications for risk communication. Am. Entomol. 46, 8-16.
461. Peterson, R.K.D. and Arntzen, C.J. (2004). On risk and plant-based biopharmaceuticals. Trends Biotechnol. 22(2): 64-66.
462. Poortinga, W. and Pidgeon, N.F. (2005). Trust in risk regulation: cause or consequence of the acceptability of GM food? Risk Anal. 25(1): 199-209.
463. Rigano, M.M. and Walmsley, A.M. (2005). Expression systems and developments in plant-made vaccines. Immunol. Cell Biol. 83: 271-277.
464. Shama, L.M. and Peterson, R.K.D. (2004). The benefits and risks of producing pharmaceutical proteins in plants. Risk Manage. Matters 2(4): 28-33.
465. Srivastava, V., Anderson, O.D., and Ow, D.W. (1999). Single-copuy transgenic wheat generated through the resolution of complex integration patterns. PNAS 96(20): 11117-111121.
466. Wolt, J.D. and Peterson, R.K.D. (2000). Agricultural biotechnology and societal decision-making: the role of risk analysis. AgBio Forum 3(1): 39-46.
467. Wu, F. (2004). Explaining public resistance to genetically modified corn: an analysis of the distribution of benefits and risks. Risk Anal. 24(3): 715-729.