A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice

Transgenic Research

Volumn 9, Issue 3, 2000, Pages 187-194

  Chargelegue, D ^a   Vine, N D ^a   Van Dolleweerd, C J ^a   Drake, P M W ^a   Ma, J K C ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Immunogenicity; Plant glycans; Recombinant antibody; Therapeutic agents; Transgenic plants

Indexed keywords

ANTIBODY PRODUCTION; GLYCOPROTEIN; HORSERADISH; IMMUNIZATION; IMMUNOANALYSIS; MONOCLONAL ANTIBODY; MOUSE; PEROXIDASE; TOBACCO; TRANSGENIC PLANT;

ANIMAL; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BIOSENSING TECHNIQUES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HORSERADISH PEROXIDASE; IMMUNIZATION; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULINS, KAPPA-CHAIN; LECTINS; MICE; MICE, INBRED BALB C; PLANTS, GENETICALLY MODIFIED; PLANTS, TOXIC; POLYSACCHARIDES; RECOMBINANT FUSION PROTEINS; STREPTOCOCCUS MUTANS; SUPPORT, NON-U.S. GOV'T; TOBACCO;

EID: 0033805614     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008976219939     Document Type: Article

References (24)

1. The glycosylation of glycoprotein lectins. Intra- and inter-genus variation in N-linked oligosaccharide expression
2. N-glycosylation of a mouse IgG expressed in transgenic tobacco plants
3. A peptide mimic of a protective epitope of respiratory syncytial vires selected from a combinatorial library induces virus-neutralizing antibodies and reduces viral load in vivo
4. The plant Golgi apparatus: A factory for complex polysaccharides and glycoproteins
5. Affinity purification of antibodies specific for Asn-linked glycans containing alpha 1 → 3 fucose or beta 1 → 2 xylose
6. Advancing AIDSVAX to phase 3. Safety, immunogenicity, and plans for phase 3
7. Immunogenicity of two doses of yeast recombinant hepatitis B vaccine in healthy older adults
8. Production of antibodies in transgenic plants
9. Characterization and applications of antibodies produced in plants
10. Combination of B- and T-cell epitopes based vaccine induces protection against RSV infection in mice. Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against RSV
11. Sensitivity enhancement of optical immunosensors with nanoparticles
12. Local passive immunization by monoclonal antibodies against streptococcal antigen I/II in the prevention of dental caries
13. N-glycoprotein biosynthesis in plants: Recent developments and future trends
14. Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants
15. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
16. Antibody production and engineering in plants
17. Plant expression systems for the production of vaccines
18. A study of maturation events in Jackbeans (Canavalia ensiformis)
19. Immunological analysis of the protective responses to the chimeric synthetic peptide representing T- and B-cell epitopes from the fusion protein of measles virus
20. The (1 → 3)-linked alpha-L-fucosyl group of the N-glycans of the Wistaria floribunda lectins is recognized by a rabbit anti-serum
21. Haptens and Carriers
22. Antibody affinity: Measurement and biological significance
23. Immunogenicity of the N-glycans of peanut peroxidase
24. Core alpha 1,3-fucose is a key part of the epitope recognized by antibodies reacting against plant N-linked oligosaccharides and is present in a wide variety of plant extracts