Monoclonal antibody manufacturing in transgenic plants - Myths and realities

Current Opinion in Biotechnology

Volumn 13, Issue 6, 2002, Pages 630-635

  Hood, Elizabeth E ^a   Woodard, Susan L ^a   Horn, Michael E ^a  

^a Prodigene Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; MONOCLONAL ANTIBODY;

CELL CULTURE; CORN; ECONOMIC ASPECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENIC PLANT; BIOSYNTHESIS; DRUG INDUSTRY; ECONOMICS; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; IMMUNOLOGY; INTERPERSONAL COMMUNICATION; MAIZE; METABOLISM; METHODOLOGY; PLANT SEED;

MAMMALIA; ZEA MAYS;

ANTIBODIES, MONOCLONAL; DRUG INDUSTRY; GENE EXPRESSION REGULATION, PLANT; GLYCOLYSIS; PLANTS, GENETICALLY MODIFIED; SEEDS; TRUTH DISCLOSURE; ZEA MAYS;

EID: 0036901079     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(02)00351-8     Document Type: Review

References (19)

1. Larrick J., Yu L., Naftzger C., Jaiswal S., Wycoff K. Production of secretory IgA antibodies in plants. Biomol Eng. 18:2001;87-94.
2. Giddings G. Transgenic plants as protein factories. Curr Opin Biotechnol. 12:2001;450-454.
3. Larrick J., Thomas D. Producing proteins in transgenic plants and animals. Curr Opin Biotechnol. 12:2001;411-418.
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6. Emlay D. Regulatory considerations in a changing environment. Hood E.E., Howard J. Plants as Factories for Protein Production. 2002;175-180 Kluwer Academic, Dordrecht.
7. Ginsberg P.L., Bhatia S., McMinn R.L. The Road Ahead for Biologics Manufacturing. 2002;1-23 US Bancorp Piper Jaffray. Market analysis of the state of manufacturing of biologics including mAbs.
8. Molowa D, Shenouda M, Meyers A, Tublin P, Fein A. The state of biologics manufacturing: part 2, JP Morgan; 2002:1-16.Market analysis of the state of manufacturing of biologics including mAbs.
9. Morrow J. Biopharm manufacturing capacities. Genet Eng News. 21:2001;1-85.
10. Chargelegue D., Vine N.D., van Dolleweerd C.J., Drake P.M., Ma J.K. A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice. Transgenic Res. 9:2000;187-194. First and only published reference on the immunogenicity of plant glycans on recombinant protein.
11. Morrow J. Glycosylation in scale-up of antibody production. Genet Eng News. 12:2002;54-59.
12. Warner T.G. Metabolic engineering glycosylation: biotechnology's challenge to the glycobiologist in the new millennium. Ernst B., Hart G.W., Sanay P. Carbohydrates in Chemistry and Biology. 2000;1043-1064 Wiley-VCH, New York. A comprehensive review article on controlling glycosylation in a variety of expression systems including plants. The paper includes a diagram of the necessary genes to engineer the sialic acid pathway.
13. Bakker H., Bardor M., Molthoff J.W., Gomord V., Elbers I., Stevens L.H., Jordi W., Lommen A., Faye L., Lerouge P., Bosch D. Galactose-extended glycans of antibodies produced by transgenic plants. Proc Natl Acad Sci USA. 98:2001;2899-2904. This paper is the first publication describing the modification of a foreign protein produced in a plant host using a human glycosyltransferase.
14. Morrow J. Economics of antibody production. Genet Eng News. 22:2002;1-39.
15. Nikolov Z., Hammes D. Production of recombinant proteins from transgenic crops. Hood E.E., Howard J. Plants as Factories for Protein Production. 2002;159-174 Kluwer Academic, Dordrecht. Excellent review of recombinant protein production and processing issues and considerations.
16. Biotechnology Industry Organization: Confinement and Development of Plant-made Pharmaceuticals in the United States. 2002:1-15.
17. Daniell H., Streatfield S., Wycoff K. Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci. 6:2002;219-226.
18. Streatfield S.J., Jilka J.M., Hood E.E., Turner D.D., Bailey M.R., Mayor J.M., Woodard S.L., Beifuss K.K., Horn M.E., Delaney D.E., et al. Plant-based vaccines: unique advantages. Vaccine. 19:2001;2742-2748.
19. Hood E.E. From green plants to industrial enzymes. Enzyme Microbial Technol. 30:2002;279-283. Discussion of expression issues for recombinant proteins in plants.