-
3
-
-
2142730100
-
Central memory and effector memory T cell subsets: function, generation, and maintenance
-
Sallusto F., Geginat J., and Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22 (2004) 745-763
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 745-763
-
-
Sallusto, F.1
Geginat, J.2
Lanzavecchia, A.3
-
5
-
-
16544371809
-
Visualizing dendritic cell networks in vivo
-
Lindquist R.L., Shakhar G., Dudziak D., Wardemann H., Eisenreich T., Dustin M.L., and Nussenzweig M.C. Visualizing dendritic cell networks in vivo. Nat Immunol 5 (2004) 1243-1250
-
(2004)
Nat Immunol
, vol.5
, pp. 1243-1250
-
-
Lindquist, R.L.1
Shakhar, G.2
Dudziak, D.3
Wardemann, H.4
Eisenreich, T.5
Dustin, M.L.6
Nussenzweig, M.C.7
-
6
-
-
12444297666
-
The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
-
Sixt M., Kanazawa N., Selg M., Samson T., Roos G., Reinhardt D.P., Pabst R., Lutz M.B., and Sorokin L. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22 (2005) 19-29
-
(2005)
Immunity
, vol.22
, pp. 19-29
-
-
Sixt, M.1
Kanazawa, N.2
Selg, M.3
Samson, T.4
Roos, G.5
Reinhardt, D.P.6
Pabst, R.7
Lutz, M.B.8
Sorokin, L.9
-
7
-
-
21144444056
-
Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
-
Kissenpfennig A., Henri S., Dubois B., Laplace-Builhe C., Perrin P., Romani N., Tripp C.H., Douillard P., Leserman L., Kaiserlian D., et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22 (2005) 643-654
-
(2005)
Immunity
, vol.22
, pp. 643-654
-
-
Kissenpfennig, A.1
Henri, S.2
Dubois, B.3
Laplace-Builhe, C.4
Perrin, P.5
Romani, N.6
Tripp, C.H.7
Douillard, P.8
Leserman, L.9
Kaiserlian, D.10
-
8
-
-
33845455093
-
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
-
An outstanding study using intravital imaging to track the movement of T cells on the fibroblastic reticular cell (FRC) network in the T cell zones and B cell movement on the follicular dendritic cell network (FDC) of the B cell zones. This result provides a new level of regulation to the steady-state organization of movement within lymph nodes.
-
Bajenoff M., Egen J.G., Koo L.Y., Laugier J.P., Brau F., Glaichenhaus N., and Germain R.N. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25 (2006) 989-1001. An outstanding study using intravital imaging to track the movement of T cells on the fibroblastic reticular cell (FRC) network in the T cell zones and B cell movement on the follicular dendritic cell network (FDC) of the B cell zones. This result provides a new level of regulation to the steady-state organization of movement within lymph nodes.
-
(2006)
Immunity
, vol.25
, pp. 989-1001
-
-
Bajenoff, M.1
Egen, J.G.2
Koo, L.Y.3
Laugier, J.P.4
Brau, F.5
Glaichenhaus, N.6
Germain, R.N.7
-
9
-
-
33645087653
-
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
-
Boscardin S.B., Hafalla J.C., Masilamani R.F., Kamphorst A.O., Zebroski H.A., Rai U., Morrot A., Zavala F., Steinman R.M., Nussenzweig R.S., et al. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med 203 (2006) 599-606
-
(2006)
J Exp Med
, vol.203
, pp. 599-606
-
-
Boscardin, S.B.1
Hafalla, J.C.2
Masilamani, R.F.3
Kamphorst, A.O.4
Zebroski, H.A.5
Rai, U.6
Morrot, A.7
Zavala, F.8
Steinman, R.M.9
Nussenzweig, R.S.10
-
10
-
-
33846636409
-
Differential antigen processing by dendritic cell subsets in vivo
-
Surprising finding that locally activated DC sub-populations are intrinsically programmed to process peptides for either MHCI or MHCII pathways. These studies define new ways for priming DCs that will have substantial impact to the design of new adjuvants in future vaccines.
-
Dudziak D., Kamphorst A.O., Heidkamp G.F., Buchholz V.R., Trumpfheller C., Yamazaki S., Cheong C., Liu K., Lee H.W., Park C.G., et al. Differential antigen processing by dendritic cell subsets in vivo. Science 315 (2007) 107-111. Surprising finding that locally activated DC sub-populations are intrinsically programmed to process peptides for either MHCI or MHCII pathways. These studies define new ways for priming DCs that will have substantial impact to the design of new adjuvants in future vaccines.
-
(2007)
Science
, vol.315
, pp. 107-111
-
-
Dudziak, D.1
Kamphorst, A.O.2
Heidkamp, G.F.3
Buchholz, V.R.4
Trumpfheller, C.5
Yamazaki, S.6
Cheong, C.7
Liu, K.8
Lee, H.W.9
Park, C.G.10
-
11
-
-
33745133006
-
Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
-
Intravital imaging of antigen loaded DC priming antigen-specific B cells as they enter lymph node via high endothelial venules. These interactions induce B cell receptor activation, migration arrest and accumulation of primed B cells in the T cell zones. It was suspected that even thymus-dependent antigens would be presented by DC in vivo, but this had not been demonstrated.
-
Qi H., Egen J.G., Huang A.Y., and Germain R.N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312 (2006) 1672-1676. Intravital imaging of antigen loaded DC priming antigen-specific B cells as they enter lymph node via high endothelial venules. These interactions induce B cell receptor activation, migration arrest and accumulation of primed B cells in the T cell zones. It was suspected that even thymus-dependent antigens would be presented by DC in vivo, but this had not been demonstrated.
-
(2006)
Science
, vol.312
, pp. 1672-1676
-
-
Qi, H.1
Egen, J.G.2
Huang, A.Y.3
Germain, R.N.4
-
12
-
-
33646181088
-
How TCRs bind MHCs, peptides, and coreceptors
-
Rudolph M.G., Stanfield R.L., and Wilson I.A. How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol 24 (2006) 419-466
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 419-466
-
-
Rudolph, M.G.1
Stanfield, R.L.2
Wilson, I.A.3
-
13
-
-
33745435793
-
A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection
-
Risueno R.M., van Santen H.M., and Alarcon B. A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection. Proc Natl Acad Sci USA 103 (2006) 9625-9630
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9625-9630
-
-
Risueno, R.M.1
van Santen, H.M.2
Alarcon, B.3
-
14
-
-
14944346245
-
How T cells 'see' antigen
-
Krogsgaard M., and Davis M.M. How T cells 'see' antigen. Nat Immunol 6 (2005) 239-245
-
(2005)
Nat Immunol
, vol.6
, pp. 239-245
-
-
Krogsgaard, M.1
Davis, M.M.2
-
15
-
-
15044358353
-
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
-
An outstanding study that demonstrates the incorporation of endogenous peptide-MHCII (pMHCII) complexes together with foreign agonist pMHCII complexes as a co-operative event that creates high valency interactions and leads to Th cell activation.
-
Krogsgaard M., Li Q.J., Sumen C., Huppa J.B., Huse M., and Davis M.M. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434 (2005) 238-243. An outstanding study that demonstrates the incorporation of endogenous peptide-MHCII (pMHCII) complexes together with foreign agonist pMHCII complexes as a co-operative event that creates high valency interactions and leads to Th cell activation.
-
(2005)
Nature
, vol.434
, pp. 238-243
-
-
Krogsgaard, M.1
Li, Q.J.2
Sumen, C.3
Huppa, J.B.4
Huse, M.5
Davis, M.M.6
-
16
-
-
27144474449
-
Selection of T cell clones expressing high-affinity public TCRs within human cytomegalovirus-specific CD8 T cell responses
-
Trautmann L., Rimbert M., Echasserieau K., Saulquin X., Neveu B., Dechanet J., Cerundolo V., and Bonneville M. Selection of T cell clones expressing high-affinity public TCRs within human cytomegalovirus-specific CD8 T cell responses. J Immunol 175 (2005) 6123-6132
-
(2005)
J Immunol
, vol.175
, pp. 6123-6132
-
-
Trautmann, L.1
Rimbert, M.2
Echasserieau, K.3
Saulquin, X.4
Neveu, B.5
Dechanet, J.6
Cerundolo, V.7
Bonneville, M.8
-
17
-
-
23844527133
-
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
-
Kedzierska K., La Gruta N.L., Davenport M.P., Turner S.J., and Doherty P.C. Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses. Proc Natl Acad Sci USA 102 (2005) 11432-11437
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 11432-11437
-
-
Kedzierska, K.1
La Gruta, N.L.2
Davenport, M.P.3
Turner, S.J.4
Doherty, P.C.5
-
18
-
-
33845190339
-
Structural determinants of T-cell receptor bias in immunity
-
An excellent review of the complicated literature on TCR repertoire analysis. This review focuses mainly on CD8 responses but also includes many valuable references to the comparisons and contrasts to CD4 responses.
-
Turner S.J., Doherty P.C., McCluskey J., and Rossjohn J. Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol 6 (2006) 883-894. An excellent review of the complicated literature on TCR repertoire analysis. This review focuses mainly on CD8 responses but also includes many valuable references to the comparisons and contrasts to CD4 responses.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 883-894
-
-
Turner, S.J.1
Doherty, P.C.2
McCluskey, J.3
Rossjohn, J.4
-
19
-
-
20144386628
-
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
-
Turner S.J., Kedzierska K., Komodromou H., La Gruta N.L., Dunstone M.A., Webb A.I., Webby R., Walden H., Xie W., McCluskey J., et al. Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol 6 (2005) 382-389
-
(2005)
Nat Immunol
, vol.6
, pp. 382-389
-
-
Turner, S.J.1
Kedzierska, K.2
Komodromou, H.3
La Gruta, N.L.4
Dunstone, M.A.5
Webb, A.I.6
Webby, R.7
Walden, H.8
Xie, W.9
McCluskey, J.10
-
20
-
-
30044449525
-
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function
-
Weber K.S., Donermeyer D.L., Allen P.M., and Kranz D.M. Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci USA 102 (2005) 19033-19038
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 19033-19038
-
-
Weber, K.S.1
Donermeyer, D.L.2
Allen, P.M.3
Kranz, D.M.4
-
21
-
-
22544455376
-
The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance
-
An excellent study that indicates the basis for immunodominance for complex proteins with multiple epitopes is at the level of peptide binding to MHCII molecules. Immunodominant peptides have substantially longer half-lives than cryptic peptides.
-
Lazarski C.A., Chaves F.A., Jenks S.A., Wu S., Richards K.A., Weaver J.M., and Sant A.J. The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance. Immunity 23 (2005) 29-40. An excellent study that indicates the basis for immunodominance for complex proteins with multiple epitopes is at the level of peptide binding to MHCII molecules. Immunodominant peptides have substantially longer half-lives than cryptic peptides.
-
(2005)
Immunity
, vol.23
, pp. 29-40
-
-
Lazarski, C.A.1
Chaves, F.A.2
Jenks, S.A.3
Wu, S.4
Richards, K.A.5
Weaver, J.M.6
Sant, A.J.7
-
22
-
-
8444236620
-
Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties
-
Malherbe L., Hausl C., Teyton L., and McHeyzer-Williams M.G. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. Immunity 21 (2004) 669-679
-
(2004)
Immunity
, vol.21
, pp. 669-679
-
-
Malherbe, L.1
Hausl, C.2
Teyton, L.3
McHeyzer-Williams, M.G.4
-
23
-
-
33646122005
-
T helper cell effector fates - who, how and where?
-
Reinhardt R.L., Kang S.J., Liang H.E., and Locksley R.M. T helper cell effector fates - who, how and where?. Curr Opin Immunol 18 (2006) 271-277
-
(2006)
Curr Opin Immunol
, vol.18
, pp. 271-277
-
-
Reinhardt, R.L.1
Kang, S.J.2
Liang, H.E.3
Locksley, R.M.4
-
24
-
-
33746575650
-
The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?
-
Shevach E.M., and Stephens G.L. The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?. Nat Rev Immunol 6 (2006) 613-618
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 613-618
-
-
Shevach, E.M.1
Stephens, G.L.2
-
25
-
-
33645318217
-
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
-
Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6 (2006) 329-333
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 329-333
-
-
Dong, C.1
-
27
-
-
1342287073
-
Developmentally distinct Th cells control plasma cell production in vivo
-
McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Developmentally distinct Th cells control plasma cell production in vivo. Immunity 20 (2004) 231-242
-
(2004)
Immunity
, vol.20
, pp. 231-242
-
-
McHeyzer-Williams, L.J.1
McHeyzer-Williams, M.G.2
-
28
-
-
0028283841
-
Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
-
Forster R., Emrich T., Kremmer E., and Lipp M. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 84 (1994) 830-840
-
(1994)
Blood
, vol.84
, pp. 830-840
-
-
Forster, R.1
Emrich, T.2
Kremmer, E.3
Lipp, M.4
-
29
-
-
0030582773
-
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
-
Forster R., Mattis A.E., Kremmer E., Wolf E., Brem G., and Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87 (1996) 1037-1047
-
(1996)
Cell
, vol.87
, pp. 1037-1047
-
-
Forster, R.1
Mattis, A.E.2
Kremmer, E.3
Wolf, E.4
Brem, G.5
Lipp, M.6
-
30
-
-
0033214348
-
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
-
Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., and Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99 (1999) 23-33
-
(1999)
Cell
, vol.99
, pp. 23-33
-
-
Forster, R.1
Schubel, A.2
Breitfeld, D.3
Kremmer, E.4
Renner-Muller, I.5
Wolf, E.6
Lipp, M.7
-
31
-
-
0032753621
-
Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
-
Walker L.S., Gulbranson-Judge A., Flynn S., Brocker T., Raykundalia C., Goodall M., Forster R., Lipp M., and Lane P. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med 190 (1999) 1115-1122
-
(1999)
J Exp Med
, vol.190
, pp. 1115-1122
-
-
Walker, L.S.1
Gulbranson-Judge, A.2
Flynn, S.3
Brocker, T.4
Raykundalia, C.5
Goodall, M.6
Forster, R.7
Lipp, M.8
Lane, P.9
-
32
-
-
0032701695
-
In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
-
Ansel K.M., McHeyzer-Williams L.J., Ngo V.N., McHeyzer-Williams M.G., and Cyster J.G. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 190 (1999) 1123-1134
-
(1999)
J Exp Med
, vol.190
, pp. 1123-1134
-
-
Ansel, K.M.1
McHeyzer-Williams, L.J.2
Ngo, V.N.3
McHeyzer-Williams, M.G.4
Cyster, J.G.5
-
33
-
-
0034606359
-
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
-
Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., Lipp M., and Forster R. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192 (2000) 1545-1552
-
(2000)
J Exp Med
, vol.192
, pp. 1545-1552
-
-
Breitfeld, D.1
Ohl, L.2
Kremmer, E.3
Ellwart, J.4
Sallusto, F.5
Lipp, M.6
Forster, R.7
-
34
-
-
0034606348
-
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
-
Schaerli P., Willimann K., Lang A.B., Lipp M., Loetscher P., and Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192 (2000) 1553-1562
-
(2000)
J Exp Med
, vol.192
, pp. 1553-1562
-
-
Schaerli, P.1
Willimann, K.2
Lang, A.B.3
Lipp, M.4
Loetscher, P.5
Moser, B.6
-
35
-
-
0035554935
-
Separable effector T cell populations specialized for B cell help or tissue inflammation
-
Campbell D.J., Kim C.H., and Butcher E.C. Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat Immunol 2 (2001) 876-881
-
(2001)
Nat Immunol
, vol.2
, pp. 876-881
-
-
Campbell, D.J.1
Kim, C.H.2
Butcher, E.C.3
-
36
-
-
24744448228
-
Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
-
Hardtke S., Ohl L., and Forster R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106 (2005) 1924-1931
-
(2005)
Blood
, vol.106
, pp. 1924-1931
-
-
Hardtke, S.1
Ohl, L.2
Forster, R.3
-
37
-
-
0037448564
-
SAP is required for generating long-term humoral immunity
-
Crotty S., Kersh E.N., Cannons J., Schwartzberg P.L., and Ahmed R. SAP is required for generating long-term humoral immunity. Nature 421 (2003) 282-287
-
(2003)
Nature
, vol.421
, pp. 282-287
-
-
Crotty, S.1
Kersh, E.N.2
Cannons, J.3
Schwartzberg, P.L.4
Ahmed, R.5
-
38
-
-
33745032268
-
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
-
This study dissociates cytokine production from the expression of cell surface modifiers as separable effector Th cell attributes in the control of B cell immunity. Regulated decrease in CD40L and increase in ICOS was all that was needed to promote the development of the GC reaction in SAP-deficient Th cells.
-
Cannons J.L., Yu L.J., Jankovic D., Crotty S., Horai R., Kirby M., Anderson S., Cheever A.W., Sher A., and Schwartzberg P.L. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med 203 (2006) 1551-1565. This study dissociates cytokine production from the expression of cell surface modifiers as separable effector Th cell attributes in the control of B cell immunity. Regulated decrease in CD40L and increase in ICOS was all that was needed to promote the development of the GC reaction in SAP-deficient Th cells.
-
(2006)
J Exp Med
, vol.203
, pp. 1551-1565
-
-
Cannons, J.L.1
Yu, L.J.2
Jankovic, D.3
Crotty, S.4
Horai, R.5
Kirby, M.6
Anderson, S.7
Cheever, A.W.8
Sher, A.9
Schwartzberg, P.L.10
-
39
-
-
21144438325
-
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
-
FH cells, IL-21 and GC formation in vivo. In the absence of roquin the animals have the propensity to develop autoimmunity.
-
FH cells, IL-21 and GC formation in vivo. In the absence of roquin the animals have the propensity to develop autoimmunity.
-
(2005)
Nature
, vol.435
, pp. 452-458
-
-
Vinuesa, C.G.1
Cook, M.C.2
Angelucci, C.3
Athanasopoulos, V.4
Rui, L.5
Hill, K.M.6
Yu, D.7
Domaschenz, H.8
Whittle, B.9
Lambe, T.10
-
40
-
-
23444434705
-
+ follicular B helper T cell maintenance in vivo
-
+ follicular B helper T cell maintenance in vivo. J Immunol 175 (2005) 2340-2348
-
(2005)
J Immunol
, vol.175
, pp. 2340-2348
-
-
Akiba, H.1
Takeda, K.2
Kojima, Y.3
Usui, Y.4
Harada, N.5
Yamazaki, T.6
Ma, J.7
Tezuka, K.8
Yagita, H.9
Okumura, K.10
-
41
-
-
28244485491
-
CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses
-
Junt T., Fink K., Forster R., Senn B., Lipp M., Muramatsu M., Zinkernagel R.M., Ludewig B., and Hengartner H. CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. J Immunol 175 (2005) 7109-7116
-
(2005)
J Immunol
, vol.175
, pp. 7109-7116
-
-
Junt, T.1
Fink, K.2
Forster, R.3
Senn, B.4
Lipp, M.5
Muramatsu, M.6
Zinkernagel, R.M.7
Ludewig, B.8
Hengartner, H.9
-
43
-
-
4644325602
-
Unique gene expression program of human germinal center T helper cells
-
Kim C.H., Lim H.W., Kim J.R., Rott L., Hillsamer P., and Butcher E.C. Unique gene expression program of human germinal center T helper cells. Blood 104 (2004) 1952-1960
-
(2004)
Blood
, vol.104
, pp. 1952-1960
-
-
Kim, C.H.1
Lim, H.W.2
Kim, J.R.3
Rott, L.4
Hillsamer, P.5
Butcher, E.C.6
-
44
-
-
2942755979
-
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
-
Chtanova T., Tangye S.G., Newton R., Frank N., Hodge M.R., Rolph M.S., and Mackay C.R. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 173 (2004) 68-78
-
(2004)
J Immunol
, vol.173
, pp. 68-78
-
-
Chtanova, T.1
Tangye, S.G.2
Newton, R.3
Frank, N.4
Hodge, M.R.5
Rolph, M.S.6
Mackay, C.R.7
-
46
-
-
21844450539
-
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
-
Okada T., Miller M.J., Parker I., Krummel M.F., Neighbors M., Hartley S.B., O'Garra A., Cahalan M.D., and Cyster J.G. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3 (2005) e150
-
(2005)
PLoS Biol
, vol.3
-
-
Okada, T.1
Miller, M.J.2
Parker, I.3
Krummel, M.F.4
Neighbors, M.5
Hartley, S.B.6
O'Garra, A.7
Cahalan, M.D.8
Cyster, J.G.9
-
47
-
-
33846635838
-
Imaging of germinal center selection events during affinity maturation
-
FH cells are discriminating GC B cells with the highest affinity B cell receptor.
-
FH cells are discriminating GC B cells with the highest affinity B cell receptor.
-
(2007)
Science
, vol.315
, pp. 528-531
-
-
Allen, C.D.1
Okada, T.2
Tang, H.L.3
Cyster, J.G.4
-
48
-
-
33847206141
-
In vivo imaging of germinal center reveals a dynamic open structure
-
••], this work demonstrates the bi-directional movement of germinal center (GC) B cells between light and dark zones of the GCs. Here, the authors emphasize the open nature of the GC demonstrating the capacity of naïve B cells to traverse active GCs.
-
••], this work demonstrates the bi-directional movement of germinal center (GC) B cells between light and dark zones of the GCs. Here, the authors emphasize the open nature of the GC demonstrating the capacity of naïve B cells to traverse active GCs.
-
(2007)
Nature
, vol.446
, pp. 83-87
-
-
Schwickert, T.A.1
Lindquist, R.L.2
Shakar, G.3
Livshits, G.4
Skokos, D.5
Kosco-Vilbois, M.H.6
Dustin, M.L.7
Nussenzweig, M.C.8
-
49
-
-
33847152240
-
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation
-
Ford M.L., Koehn B.H., Wagener M.E., Jiang W., Gangappa S., Pearson T.C., and Larsen C.P. Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. J Exp Med 204 (2007) 299-309
-
(2007)
J Exp Med
, vol.204
, pp. 299-309
-
-
Ford, M.L.1
Koehn, B.H.2
Wagener, M.E.3
Jiang, W.4
Gangappa, S.5
Pearson, T.C.6
Larsen, C.P.7
-
51
-
-
23944461953
-
+ T cell lineage commitment
-
These studies clearly demonstrate the impact of precursor frequency on the development of different cell fates in vivo. This work emphasizes the need to attempt to mimic near normal precursor frequencies when using adoptive transfer of TCR transgenic T cells.
-
+ T cell lineage commitment. Nat Immunol 6 (2005) 793-799. These studies clearly demonstrate the impact of precursor frequency on the development of different cell fates in vivo. This work emphasizes the need to attempt to mimic near normal precursor frequencies when using adoptive transfer of TCR transgenic T cells.
-
(2005)
Nat Immunol
, vol.6
, pp. 793-799
-
-
Marzo, A.L.1
Klonowski, K.D.2
Le Bon, A.3
Borrow, P.4
Tough, D.F.5
Lefrancois, L.6
-
52
-
-
0034613685
-
Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses
-
Panus J.F., McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses. J Exp Med 192 (2000) 1301-1316
-
(2000)
J Exp Med
, vol.192
, pp. 1301-1316
-
-
Panus, J.F.1
McHeyzer-Williams, L.J.2
McHeyzer-Williams, M.G.3
-
53
-
-
33645870691
-
CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40
-
A comprehensive analysis of an MHCII restricted Th cell response over the primary and memory responses in lymph nodes. These studies demonstrate the requirement for co-stimulation at the original priming for development of effective memory responses.
-
MacLeod M., Kwakkenbos M.J., Crawford A., Brown S., Stockinger B., Schepers K., Schumacher T., and Gray D. CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. J Exp Med 203 (2006) 897-906. A comprehensive analysis of an MHCII restricted Th cell response over the primary and memory responses in lymph nodes. These studies demonstrate the requirement for co-stimulation at the original priming for development of effective memory responses.
-
(2006)
J Exp Med
, vol.203
, pp. 897-906
-
-
MacLeod, M.1
Kwakkenbos, M.J.2
Crawford, A.3
Brown, S.4
Stockinger, B.5
Schepers, K.6
Schumacher, T.7
Gray, D.8
-
54
-
-
0033532540
-
Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs
-
McHeyzer-Williams L.J., Panus J.F., Mikszta J.A., and McHeyzer-Williams M.G. Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J Exp Med 189 (1999) 1823-1838
-
(1999)
J Exp Med
, vol.189
, pp. 1823-1838
-
-
McHeyzer-Williams, L.J.1
Panus, J.F.2
Mikszta, J.A.3
McHeyzer-Williams, M.G.4
-
55
-
-
19344376093
-
Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
-
Obst R., van Santen H.M., Mathis D., and Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med 201 (2005) 1555-1565
-
(2005)
J Exp Med
, vol.201
, pp. 1555-1565
-
-
Obst, R.1
van Santen, H.M.2
Mathis, D.3
Benoist, C.4
-
56
-
-
27744502556
-
CD4 T cells integrate signals delivered during successive DC encounters in vivo
-
Celli S., Garcia Z., and Bousso P. CD4 T cells integrate signals delivered during successive DC encounters in vivo. J Exp Med 202 (2005) 1271-1278
-
(2005)
J Exp Med
, vol.202
, pp. 1271-1278
-
-
Celli, S.1
Garcia, Z.2
Bousso, P.3
-
57
-
-
24344435571
-
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation
-
The first demonstration for persistent depots of pMHCII in draining lymphoid tissue even after the local clearance of pathogen. These adoptive transfer studies unequivocally demonstrate the capacity of these depots to induce extensive clonal expansion of naïve Th cells. The role of these depots in the maintenance and correct placement of memory Th cell is discussed.
-
Jelley-Gibbs D.M., Brown D.M., Dibble J.P., Haynes L., Eaton S.M., and Swain S.L. Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med 202 (2005) 697-706. The first demonstration for persistent depots of pMHCII in draining lymphoid tissue even after the local clearance of pathogen. These adoptive transfer studies unequivocally demonstrate the capacity of these depots to induce extensive clonal expansion of naïve Th cells. The role of these depots in the maintenance and correct placement of memory Th cell is discussed.
-
(2005)
J Exp Med
, vol.202
, pp. 697-706
-
-
Jelley-Gibbs, D.M.1
Brown, D.M.2
Dibble, J.P.3
Haynes, L.4
Eaton, S.M.5
Swain, S.L.6
-
58
-
-
33645971304
-
Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration
-
Zammit D.J., Turner D.L., Klonowski K.D., Lefrancois L., and Cauley L.S. Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity 24 (2006) 439-449
-
(2006)
Immunity
, vol.24
, pp. 439-449
-
-
Zammit, D.J.1
Turner, D.L.2
Klonowski, K.D.3
Lefrancois, L.4
Cauley, L.S.5
-
60
-
-
0032589687
-
Class II-independent generation of CD4 memory T cells from effectors
-
Swain S.L., Hu H., and Huston G. Class II-independent generation of CD4 memory T cells from effectors. Science 286 (1999) 1381-1383
-
(1999)
Science
, vol.286
, pp. 1381-1383
-
-
Swain, S.L.1
Hu, H.2
Huston, G.3
-
61
-
-
0033485767
-
Antigen-driven selection of TCR in vivo: related TCR alpha-chains pair with diverse TCR beta-chains
-
Mikszta J.A., McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Antigen-driven selection of TCR in vivo: related TCR alpha-chains pair with diverse TCR beta-chains. J Immunol 163 (1999) 5978-5988
-
(1999)
J Immunol
, vol.163
, pp. 5978-5988
-
-
Mikszta, J.A.1
McHeyzer-Williams, L.J.2
McHeyzer-Williams, M.G.3
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