Expression and production of bioactive human interleukin-18 in transgenic tobacco plants

Biotechnology Letters

Volumn 25, Issue 19, 2003, Pages 1629-1635

  Zhang, Bin ^a   Yang, Ying Hua ^a   Lin, Yong Ming ^a   Rao, Qing ^a   Zheng, Guo Guang ^a   Wu, Ke Fu ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Bioactivity; Human IL 18; Interleukin 18; Tobacco; Transgenic plants

Indexed keywords

INTERLEUKIN 18; RECOMBINANT PROTEIN;

ARTICLE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFORMATION; GENETICS; HUMAN; LEUKEMIA; METABOLISM; METHODOLOGY; PLANT LEAF; PROTEIN ENGINEERING; RHIZOBIUM RADIOBACTER; TOBACCO; TRANSGENIC PLANT; TUMOR CELL LINE;

CELL LINE, TUMOR; GENE EXPRESSION REGULATION, PLANT; HUMANS; INTERLEUKIN-18; LEUKEMIA; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; RHIZOBIUM RADIOBACTER; TOBACCO; TRANSFORMATION, GENETIC;

AGROBACTERIUM; AGROBACTERIUM TUMEFACIENS; INSERTION SEQUENCES; NICOTIANA; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM;

EID: 0141638584     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025638623770     Document Type: Article

References (20)

1. An G, Ebert PR, Mitra A, Ha SB (1988) Binary vectors. In: Gelvin SB, Schilperoort RA, eds. Plant Molecular Biology Manual. Dordrecht: Kluwer Academic Publishers, pp. 1-19.
2. Arakawa T, Chong DKX, Langridge WHR (1998) Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nat. Biotechnol. 16, 292-297.
3. Chong DK, Roberts W, Arakawa T, Illes K, Bagi G, Slattery CW, Langridge WH (1997) Expression of the human milk protein beta-casein in transgenic potato plants. Transgenic Res. 6: 289-296.
4. Gallie DR, Feder JN, Schimk RT, Walbot V (1991) Post-transcriptional regulation in higher eukaryotes. Mol. Gen. Genet. 228, 258-264.
5. Gracie JA, Robertson SE, McInnes IB (2003) Interleukin-18. J. Leukoc. Biol. 73: 213-224.
6. Kirkpatrick RB, McDevitt PJ, Matico RE, Nwagwu S, Trulli SH, Mao J, Moore DD, Yorke AF, McLaughlin MM, Knecht KA, Elefante LC, Calamari AS, Fornwald JA, Trill JJ, Jonak ZL, Kane J, Patel PS, Sathe GM, Shatzman AR, Tapley PM, Johanson KO (2003) A bicistronic expression system for bacterial production of authentic human interleukin-18. Protein Exp. Purif. 27: 279-292
7. Lee JS, Choi SJ, Kang HS, Oh WG, Cho KH, Kwon TH, Kim DH, Jang YS, Yang MS (1997) Establishment of a transgenic tobacco cell suspension culture system for producing murine granulocyte-macrophage colonystimulating factor. Mol. Cells 7: 783-787.
8. Liu B, Novick D, Kim SH, Rubinstein M (2000) Production of a biologically active human interleukin 18 requires its prior synthesis as PRO-IL-18. Cytokine 12: 1519-1525.
9. Magnuson NS, Linzmaier PM, Reeves R, An G, Hayglass K, Lee JM (1998) Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture. Protein Exp. Purif. 13, 45-52.
10. Murray MG. Thompson WF (1980) Rapid isolation of high molecular weight plant DNA. Nucl. Acids Res. 8, 4321-4325.
11. Odell JT, Knowlton S, Lin W, Mauvais CJ (1988) Properties of an isolated transcription stimulating sequence derived from the cauliflower mosaic virus 35S promoter. Plant Mol. Biol. 10: 263-272.
12. Ohya K, Itchoda N, Ohashi K, Onuma M, Sugimoto C, Matsumura T (2002) Expression of biologically active human tumor necrosis factor-alpha in transgenic potato plant. J Interferon Cytokine Res. 22: 371-378.
13. Ohya K, Matsumura T, Ohashi K, Onuma M, Sugimoto C (2001) Expression of two subtypes of human interferon alpha in transgenic potato plants. J. Interferon Cytokine Res. 21: 596-602.
14. Okamura H, Tsutsui H, Komastu T, Yutsudo M, Hakura A, Takimito T, Torigoe K, Okura T, Nukada Y, Hattori K (1995) Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378: 88-91.
15. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85.
16. Tacket CO, Mason HS, Losonsky G, Clements JD, Levine MM, Arnitzen CJ (1998) Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nature Med. 4: 607-609.
17. Zhang B, Ma XT, Zheng GG, Li G, Qao Q, Wu KF (2003) Expression of IL-18 and its receptor in human leukemia cells. Leukemia Res. 27: 813-822.
18. Zhang B, Wang Y, Zheng GG, Ma XT, Li G, Wu KF (2002) Clinical significance of IL-18 over-expression in AML. Leukemia Res. 26: 887-892.
19. Zhou Y, Tian Y, Wu B, Mang K (1998) Inhibition effect of transgenic tobacco plants expressing snowdrop lectin on the population development of Myzus persicae. Chin. J. Biotechnol. 14: 9-16.
20. Wang Y, Li G, Zheng GG, Song YH, Wu KF (2001) Detection and sequencing analysis of IL-18 expression in J6-1 leukemic cells. Leukemia Res. 25: 273-274.