Production of hepatitis B surface antigen in transgenic plants for oral immunization

Nature Biotechnology

Volumn 18, Issue 11, 2000, Pages 1167-1171

  Richter, Liz J ^a   Thanavala, Yasmin ^b   Arntzen, Charles J ^a   Mason, Hugh S ^a  

^a United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Edible vaccine; Hepatitis B surface antigen; Oral vaccine; Potato; Protein engineering; Transgenic plants

Indexed keywords

HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HEPATITIS VACCINE; HYBRID PROTEIN;

ACTIVE IMMUNIZATION; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA FLANKING REGION; ENDOPLASMIC RETICULUM; HEPATITIS B; MOUSE; NONHUMAN; PLANT CELL; POLYADENYLATION; POTATO; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN TARGETING; TRANSGENIC PLANT;

ADMINISTRATION, ORAL; ANIMALS; BLOTTING, NORTHERN; CHOLERA TOXIN; ENDOPLASMIC RETICULUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HUMANS; MICE; MODELS, GENETIC; PLANTS, GENETICALLY MODIFIED; PLANTS, TOXIC; PLASMIDS; PLASTIDS; POLY A; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RNA, MESSENGER; SOLANUM TUBEROSUM; TIME FACTORS; TOBACCO; TRANSFORMATION, GENETIC; VACCINES;

ANIMALIA; DNA VIRUSES; EMBRYOPHYTA; SOLANUM TUBEROSUM;

EID: 0033758177     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/81153     Document Type: Article

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