A transient tobacco expression system coupled to MALDI-TOF-MS allows validation of the impact of differential targeting on structure and activity of a recombinant therapeutic glycoprotein produced in plants

FEBS Letters

Volumn 552, Issue 2-3, 2003, Pages 170-176

  Mokrzycki Issartel, Nathalie ^a   Bouchon, Bernadette ^b   Farrer, Sibille ^a   Berland, Patricia ^a   Laparra, Hélène ^a   Madelmont, Jean Claude ^b   Theisen, Manfred ^a  

^a UNIVERSITÉ DE HAUTE ALSACE   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Differential targeting; Gastric lipase; MALDI TOF MS; N linked glycosylation; Recombinant therapeutic proteins from plants; Transient expression

Indexed keywords

GASTRIC LIPASE; GLYCAN DERIVATIVE; GLYCOPROTEIN; MANNOSE; RECOMBINANT PROTEIN; TRIACYLGLYCEROL LIPASE; TRYPSIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DEGLYCOSYLATION; DRUG STRUCTURE; DRUG TARGETING; ENZYME STRUCTURE; GENE EXPRESSION SYSTEM; GLYCOSYLATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOBACCO; VALIDATION PROCESS;

NICOTIANA TABACUM;

EID: 0141537290     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(03)00916-5     Document Type: Article

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