메뉴 건너뛰기




Volumn 6, Issue 5, 2001, Pages 219-226

Medical molecular farming: Production of antibodies, biopharmaceuticals and edible vaccines in plants

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035212386     PISSN: 13601385     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1360-1385(01)01922-7     Document Type: Review
Times cited : (629)

References (52)
  • 1
    • 0033564752 scopus 로고    scopus 로고
    • Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants
    • R Fischer Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants Eur. J. Biochem. 262 1999 810 816
    • (1999) Eur. J. Biochem. , vol.262 , pp. 810-816
    • Fischer, R1
  • 2
    • 0031711457 scopus 로고    scopus 로고
    • Potato tubers as a biofactory for recombinant antibodies
    • O Artsaenko Potato tubers as a biofactory for recombinant antibodies Mol. Breed. 4 1998 313 319
    • (1998) Mol. Breed. , vol.4 , pp. 313-319
    • Artsaenko, O1
  • 3
    • 0031790556 scopus 로고    scopus 로고
    • A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes
    • L Zeitlin A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes Nat. Biotechnol. 16 1998 1361 1364
    • (1998) Nat. Biotechnol. , vol.16 , pp. 1361-1364
    • Zeitlin, L1
  • 4
    • 0033587793 scopus 로고    scopus 로고
    • Production of a diagnostic monoclonal antibody in perennial alfalfa plants
    • H Khoudi Production of a diagnostic monoclonal antibody in perennial alfalfa plants Biotechnol. Bioeng. 64 1999 135 143
    • (1999) Biotechnol. Bioeng. , vol.64 , pp. 135-143
    • Khoudi, H1
  • 5
    • 0342748410 scopus 로고    scopus 로고
    • Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies
    • E Stoger Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies Plant Mol. Biol. 42 2000 583 590
    • (2000) Plant Mol. Biol. , vol.42 , pp. 583-590
    • Stoger, E1
  • 6
    • 0033498455 scopus 로고    scopus 로고
    • Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies
    • E Torres Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies Transgenic Res. 8 1999 441 449
    • (1999) Transgenic Res. , vol.8 , pp. 441-449
    • Torres, E1
  • 7
    • 0030731752 scopus 로고    scopus 로고
    • Optimization of scFv antibody production in transgenic plants
    • U Fiedler Optimization of scFv antibody production in transgenic plants Immunotechnology 3 1997 205 216
    • (1997) Immunotechnology , vol.3 , pp. 205-216
    • Fiedler, U1
  • 8
    • 0031835622 scopus 로고    scopus 로고
    • Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
    • J Ma Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans Nat. Med. 4 1998 601 606
    • (1998) Nat. Med. , vol.4 , pp. 601-606
    • Ma, J1
  • 9
    • 0033582277 scopus 로고    scopus 로고
    • Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants
    • A McCormick Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants Proc. Natl. Acad. Sci. USA 96 1999 703 708
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 703-708
    • McCormick, A1
  • 10
    • 0031732939 scopus 로고    scopus 로고
    • Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector
    • T Verch Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector J. Immunol. Methods 220 1998 69 75
    • (1998) J. Immunol. Methods , vol.220 , pp. 69-75
    • Verch, T1
  • 11
    • 0029035201 scopus 로고
    • Generation and assembly of secretory antibodies in plants
    • J.K Ma Generation and assembly of secretory antibodies in plants Science 268 1995 716 719
    • (1995) Science , vol.268 , pp. 716-719
    • Ma, J.K1
  • 12
    • 0032931237 scopus 로고    scopus 로고
    • N-glycosylation of a mouse IgG expressed in transgenic tobacco plants
    • M Cabanes-Macheteau N-glycosylation of a mouse IgG expressed in transgenic tobacco plants Glycobiology 9 1999 365 372
    • (1999) Glycobiology , vol.9 , pp. 365-372
    • Cabanes-Macheteau, M1
  • 13
    • 0033613072 scopus 로고    scopus 로고
    • Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
    • C Vaquero Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves Proc. Natl. Acad. Sci. USA 96 1999 11128 11133
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11128-11133
    • Vaquero, C1
  • 14
    • 0029055060 scopus 로고
    • Oral immunization with a recombinant bacterial antigen produced in transgenic plants
    • T.A Haq Oral immunization with a recombinant bacterial antigen produced in transgenic plants Science 268 1995 714 716
    • (1995) Science , vol.268 , pp. 714-716
    • Haq, T.A1
  • 15
    • 0027048769 scopus 로고
    • Expression of hepatitis B surface antigen in transgenic plants
    • H.S Mason Expression of hepatitis B surface antigen in transgenic plants Proc. Natl. Acad. Sci. USA 89 1992 11745 11749
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11745-11749
    • Mason, H.S1
  • 16
    • 0029891823 scopus 로고    scopus 로고
    • Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
    • H.S Mason Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice Proc. Natl. Acad. Sci. USA 93 1996 5335 5340
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5335-5340
    • Mason, H.S1
  • 17
    • 0028863460 scopus 로고
    • Expression of the rabies virus glycoprotein in transgenic tomatoes
    • P.B McGarvey Expression of the rabies virus glycoprotein in transgenic tomatoes Biotechnology 13 1995 1484 1487
    • (1995) Biotechnology , vol.13 , pp. 1484-1487
    • McGarvey, P.B1
  • 18
    • 0031281621 scopus 로고    scopus 로고
    • Expression of cholera toxin B subunit oligomers in transgenic potato plants
    • T Arakawa Expression of cholera toxin B subunit oligomers in transgenic potato plants Transgenic Res. 6 1997 403 413
    • (1997) Transgenic Res. , vol.6 , pp. 403-413
    • Arakawa, T1
  • 19
    • 0031935290 scopus 로고    scopus 로고
    • Efficacy of a food plant-based oral cholera toxin B subunit vaccine
    • T Arakawa Efficacy of a food plant-based oral cholera toxin B subunit vaccine Nat. Biotechnol. 16 1998 292 297
    • (1998) Nat. Biotechnol. , vol.16 , pp. 292-297
    • Arakawa, T1
  • 20
    • 0031907101 scopus 로고    scopus 로고
    • Protective immune response to foot-and-mouth disease virus with VP1 expressed in transgenic plants
    • C Carrillo Protective immune response to foot-and-mouth disease virus with VP1 expressed in transgenic plants J. Virol. 72 1998 1688 1690
    • (1998) J. Virol. , vol.72 , pp. 1688-1690
    • Carrillo, C1
  • 21
    • 0032581989 scopus 로고    scopus 로고
    • Expression of immunogenic glycoprotein S polypeptides from transmissible gastroenteritis coronavirus in transgenic plants
    • N Gomez Expression of immunogenic glycoprotein S polypeptides from transmissible gastroenteritis coronavirus in transgenic plants Virology 249 1998 352 358
    • (1998) Virology , vol.249 , pp. 352-358
    • Gomez, N1
  • 22
    • 0032146489 scopus 로고    scopus 로고
    • Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene
    • H.S Mason Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene Vaccine 16 1998 1336 1343
    • (1998) Vaccine , vol.16 , pp. 1336-1343
    • Mason, H.S1
  • 23
    • 0028944992 scopus 로고
    • Immunogenicity of transgenic plant-derived hepatitis B surface antigen
    • Y Thanavala Immunogenicity of transgenic plant-derived hepatitis B surface antigen Proc. Natl. Acad. Sci. USA 92 1995 3358 3361
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3358-3361
    • Thanavala, Y1
  • 24
    • 0033558771 scopus 로고    scopus 로고
    • Induction of a protective antibody response to foot and mouth disease in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1
    • A Wigdorovitz Induction of a protective antibody response to foot and mouth disease in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1 Virology 255 1999 347 353
    • (1999) Virology , vol.255 , pp. 347-353
    • Wigdorovitz, A1
  • 25
    • 0031863854 scopus 로고    scopus 로고
    • Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato
    • C.O Tacket Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato Nat. Med. 4 1998 607 609
    • (1998) Nat. Med. , vol.4 , pp. 607-609
    • Tacket, C.O1
  • 26
    • 0013651896 scopus 로고    scopus 로고
    • Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes
    • C.O Tacket Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes J. Infect. Dis. 182 2000 302 305
    • (2000) J. Infect. Dis. , vol.182 , pp. 302-305
    • Tacket, C.O1
  • 27
    • 0032863164 scopus 로고    scopus 로고
    • A plant-derived edible vaccine against hepatitis B virus
    • J Kapusta A plant-derived edible vaccine against hepatitis B virus FASEB J. 13 1999 1796 1799
    • (1999) FASEB J. , vol.13 , pp. 1796-1799
    • Kapusta, J1
  • 28
    • 0032947946 scopus 로고    scopus 로고
    • Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus
    • S Castanon Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus J. Virol. 73 1999 4452 4455
    • (1999) J. Virol. , vol.73 , pp. 4452-4455
    • Castanon, S1
  • 29
    • 0034003792 scopus 로고    scopus 로고
    • Immunogenicity of porcine transmissible gastroenteritis virus spike protein expressed in plants
    • T Tuboly Immunogenicity of porcine transmissible gastroenteritis virus spike protein expressed in plants Vaccine 18 2000 2023 2028
    • (2000) Vaccine , vol.18 , pp. 2023-2028
    • Tuboly, T1
  • 30
    • 0035925713 scopus 로고    scopus 로고
    • Plant-based vaccines: unique advantages
    • S.J Streatfield Plant-based vaccines: unique advantages Vaccine 19 2000 2742 2748
    • (2000) Vaccine , vol.19 , pp. 2742-2748
    • Streatfield, S.J1
  • 31
    • 0033758177 scopus 로고    scopus 로고
    • Production of hepatitis B surface antigen in transgenic plants for oral immunization
    • L.J Richter Production of hepatitis B surface antigen in transgenic plants for oral immunization Nat. Biotechnol. 18 2001 1167 1171
    • (2001) Nat. Biotechnol. , vol.18 , pp. 1167-1171
    • Richter, L.J1
  • 32
    • 0033529588 scopus 로고    scopus 로고
    • Development of biopharmaceuticals in plant expression systems: cloning, expression and immunological reactivity of human cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco
    • E.S Tackaberry Development of biopharmaceuticals in plant expression systems: cloning, expression and immunological reactivity of human cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco Vaccine 17 1999 3020 3029
    • (1999) Vaccine , vol.17 , pp. 3020-3029
    • Tackaberry, E.S1
  • 33
    • 0030791484 scopus 로고    scopus 로고
    • Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance
    • S-W Ma Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance Nat. Med. 3 1997 793 796
    • (1997) Nat. Med. , vol.3 , pp. 793-796
    • Ma, S-W1
  • 34
    • 0031555505 scopus 로고    scopus 로고
    • Production of recombinant proteins in transgenic plants: practical considerations
    • A Kusnadi Production of recombinant proteins in transgenic plants: practical considerations Biotechnol. Bioeng. 56 1997 473 484
    • (1997) Biotechnol. Bioeng. , vol.56 , pp. 473-484
    • Kusnadi, A1
  • 35
    • 85120104852 scopus 로고    scopus 로고
    • Application of transgenic plants as production systems for pharmaceuticals
    • G.D May Application of transgenic plants as production systems for pharmaceuticals G Fuller Agricultural Materials as Renewable Resources: Nonfood and Industrial Applications (ACS Symposium Series 647 1996 American Chemical Society, Clarendon Hills, Il USA 196 204
    • (1996) , pp. 196-204
    • May, G.D1
  • 36
    • 0032952346 scopus 로고    scopus 로고
    • Transgenic plants for therapeutic proteins: linking upstream and downstream technologies
    • C Cramer Transgenic plants for therapeutic proteins: linking upstream and downstream technologies Curr. Top. Microbiol. Immunol. 240 1999 95 118
    • (1999) Curr. Top. Microbiol. Immunol. , vol.240 , pp. 95-118
    • Cramer, C1
  • 37
    • 0035162968 scopus 로고    scopus 로고
    • Hyper-expression of the Bt Cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals
    • B DeCosa Hyper-expression of the Bt Cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals Nat. Biotechnol. 19 2001 71 74
    • (2001) Nat. Biotechnol. , vol.19 , pp. 71-74
    • DeCosa, B1
  • 38
    • 0032695044 scopus 로고    scopus 로고
    • GM crops: public perception and scientific solutions
    • H Daniell GM crops: public perception and scientific solutions Trends Plant Sci. 4 1999 467 469
    • (1999) Trends Plant Sci. , vol.4 , pp. 467-469
    • Daniell, H1
  • 39
    • 0032733466 scopus 로고    scopus 로고
    • Environmentally friendly approaches to genetic engineering. In vitro
    • H Daniell Environmentally friendly approaches to genetic engineering. In vitro Cell. Dev. Biol.–Plant 35 1999 361 368
    • (1999) Cell. Dev. Biol.–Plant , vol.35 , pp. 361-368
    • Daniell, H1
  • 40
    • 0032922625 scopus 로고    scopus 로고
    • Regulation of chloroplast enzyme activities by thioredoxins: activation or relief from inhibition
    • E Reulland M Miginiac-Maslow Regulation of chloroplast enzyme activities by thioredoxins: activation or relief from inhibition Trends Plant Sci. 4 1999 136 141
    • (1999) Trends Plant Sci. , vol.4 , pp. 136-141
    • Reulland, E1    Miginiac-Maslow, M2
  • 41
    • 0031452439 scopus 로고    scopus 로고
    • Protein disulfide isomerase as a regulator of chloroplast translational activation
    • J Kim P.S Mayfield Protein disulfide isomerase as a regulator of chloroplast translational activation Science 278 1997 1954 1957
    • (1997) Science , vol.278 , pp. 1954-1957
    • Kim, J1    Mayfield, P.S2
  • 42
    • 0034016818 scopus 로고    scopus 로고
    • High-yield production of a human therapeutic protein in tobacco chloroplasts
    • J.M Staub High-yield production of a human therapeutic protein in tobacco chloroplasts Nat. Biotechnol. 18 2000 333 338
    • (2000) Nat. Biotechnol. , vol.18 , pp. 333-338
    • Staub, J.M1
  • 43
    • 0029637157 scopus 로고
    • Computer-aided process analysis and economic evaluation for biosynthetic human insulin production: a case study
    • D Petridis Computer-aided process analysis and economic evaluation for biosynthetic human insulin production: a case study Biotechnol. Bioeng. 48 1995 529 541
    • (1995) Biotechnol. Bioeng. , vol.48 , pp. 529-541
    • Petridis, D1
  • 44
    • 0031391390 scopus 로고    scopus 로고
    • Molecular farming in plants: oil seeds as vehicles for production of pharmaceutical proteins
    • J.G Boothe Molecular farming in plants: oil seeds as vehicles for production of pharmaceutical proteins Drug Dev. Res. 42 1997 172 181
    • (1997) Drug Dev. Res. , vol.42 , pp. 172-181
    • Boothe, J.G1
  • 45
    • 0030631869 scopus 로고    scopus 로고
    • Hyperexpression of an environmentally friendly synthetic polymer gene
    • H Daniell Hyperexpression of an environmentally friendly synthetic polymer gene Methods Mol. Biol. 63 1997 359 371
    • (1997) Methods Mol. Biol. , vol.63 , pp. 359-371
    • Daniell, H1
  • 46
    • 0031979072 scopus 로고    scopus 로고
    • Containment of herbicide resistance through genetic engineering of the chloroplast genome
    • H Daniell Containment of herbicide resistance through genetic engineering of the chloroplast genome Nat. Biotechnol. 16 1998 345 348
    • (1998) Nat. Biotechnol. , vol.16 , pp. 345-348
    • Daniell, H1
  • 47
    • 0008845297 scopus 로고
    • Induction of male sterility in plants by a chimaeric ribonuclease gene
    • C Mariani Induction of male sterility in plants by a chimaeric ribonuclease gene Nature 347 1990 737 741
    • (1990) Nature , vol.347 , pp. 737-741
    • Mariani, C1
  • 48
    • 0034235895 scopus 로고    scopus 로고
    • Removing selectable marker genes: taking the shortcut
    • H Puchta Removing selectable marker genes: taking the shortcut Trends Plant Sci. 5 2000 273 274
    • (2000) Trends Plant Sci. , vol.5 , pp. 273-274
    • Puchta, H1
  • 49
    • 85120143897 scopus 로고    scopus 로고
    • Daniell, H. et al. Engineering chloroplast genome without the use of antibiotic resistance genes. Curr. Genet . (in press)
  • 50
    • 0033758021 scopus 로고    scopus 로고
    • Transgenic plants as factories for biopharmaceuticals
    • G Giddings Transgenic plants as factories for biopharmaceuticals Nat. Biotechnol. 18 2000 1151 1155
    • (2000) Nat. Biotechnol. , vol.18 , pp. 1151-1155
    • Giddings, G1
  • 51
    • 0034598976 scopus 로고    scopus 로고
    • Triple helix assembly and processing of human collagen produced in transgenic tobacco plants
    • F Ruggiero Triple helix assembly and processing of human collagen produced in transgenic tobacco plants FEBS Lett. 469 2000 132 136
    • (2000) FEBS Lett. , vol.469 , pp. 132-136
    • Ruggiero, F1
  • 52
    • 0034030703 scopus 로고    scopus 로고
    • Expression of full length bioactive antimicrobial human lactoferrin in potato plants
    • D.K.X Chong Expression of full length bioactive antimicrobial human lactoferrin in potato plants Transgenic Res. 9 2000 71 78
    • (2000) Transgenic Res. , vol.9 , pp. 71-78
    • Chong, D.K.X1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.